{"id":"https://openalex.org/W2145404792","doi":"https://doi.org/10.1055/s-2008-1072911","title":"Noninvasive quantification of intracerebral GABA by 1H-MRS \u2013 How reproducible are the results?","display_name":"Noninvasive quantification of intracerebral GABA by 1H-MRS \u2013 How reproducible are the results?","publication_year":2008,"publication_date":"2008-03-01","ids":{"openalex":"https://openalex.org/W2145404792","doi":"https://doi.org/10.1055/s-2008-1072911","mag":"2145404792"},"language":"en","primary_location":{"id":"doi:10.1055/s-2008-1072911","doi":"https://doi.org/10.1055/s-2008-1072911","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-2008-1072911","pdf_url":null,"source":{"id":"https://openalex.org/S44826309","display_name":"Klinische Neurophysiologie","issn_l":"1434-0275","issn":["1434-0275","1439-4081"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1","norway-1"],"host_organization":"https://openalex.org/P4310321135","host_organization_name":"Georg Thieme Verlag","host_organization_lineage":["https://openalex.org/P4310321135","https://openalex.org/P4310320000"],"host_organization_lineage_names":["Georg Thieme Verlag","Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Klinische Neurophysiologie","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042970721","display_name":"Thilo Hammen","orcid":"https://orcid.org/0000-0003-4195-9464","observed_orcids":["https://orcid.org/0000-0003-4195-9464"]},"institutions":[{"id":"https://openalex.org/I4210088053","display_name":"Universit\u00e4tsklinikum Erlangen","ror":"https://ror.org/0030f2a11","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210088053"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"T Hammen","raw_affiliation_strings":["Universit\u00e4t Erlangen, Klinik f\u00fcr Neurologie, Epilepsiezentrum Erlangen, Erlangen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e4t Erlangen, Klinik f\u00fcr Neurologie, Epilepsiezentrum Erlangen, Erlangen","institution_ids":["https://openalex.org/I4210088053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023652216","display_name":"Wolfgang Bogner","orcid":"https://orcid.org/0000-0002-0130-3463","observed_orcids":["https://orcid.org/0000-0002-0130-3463"]},"institutions":[{"id":"https://openalex.org/I2802328216","display_name":"Vienna General Hospital","ror":"https://ror.org/05f0zr486","country_code":"AT","type":"healthcare","lineage":["https://openalex.org/I2802328216"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"W Bogner","raw_affiliation_strings":["AKH Wien, MR-Exzellenszentrum, Wien, \u00d6sterreich"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AKH Wien, MR-Exzellenszentrum, Wien, \u00d6sterreich","institution_ids":["https://openalex.org/I2802328216"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020686316","display_name":"Andreas Stadlbauer","orcid":"https://orcid.org/0000-0001-8348-2620","observed_orcids":["https://orcid.org/0000-0001-8348-2620"]},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]},{"id":"https://openalex.org/I4210088053","display_name":"Universit\u00e4tsklinikum Erlangen","ror":"https://ror.org/0030f2a11","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210088053"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"A Stadlbauer","raw_affiliation_strings":["Universit\u00e4t Erlangen, Klinik f\u00fcr Neurochirurgie, Erlangen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e4t Erlangen, Klinik f\u00fcr Neurochirurgie, Erlangen","institution_ids":["https://openalex.org/I181369854","https://openalex.org/I4210088053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059653476","display_name":"Marc Thorsten Doelken","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]},{"id":"https://openalex.org/I4210088053","display_name":"Universit\u00e4tsklinikum Erlangen","ror":"https://ror.org/0030f2a11","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210088053"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M Doelken","raw_affiliation_strings":["Universit\u00e4t Erlangen, Klinik f\u00fcr Neuroradiologie, Erlangen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e4t Erlangen, Klinik f\u00fcr Neuroradiologie, Erlangen","institution_ids":["https://openalex.org/I181369854","https://openalex.org/I4210088053"]}]},{"author_position":"middle","author":{"id":null,"display_name":"A Doerfler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]},{"id":"https://openalex.org/I4210088053","display_name":"Universit\u00e4tsklinikum Erlangen","ror":"https://ror.org/0030f2a11","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210088053"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"A Doerfler","raw_affiliation_strings":["Universit\u00e4t Erlangen, Klinik f\u00fcr Neuroradiologie, Erlangen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e4t Erlangen, Klinik f\u00fcr Neuroradiologie, Erlangen","institution_ids":["https://openalex.org/I181369854","https://openalex.org/I4210088053"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068808056","display_name":"Hermann Stefan","orcid":"https://orcid.org/0000-0002-6506-6292","observed_orcids":["https://orcid.org/0000-0002-6506-6292"]},"institutions":[{"id":"https://openalex.org/I4210088053","display_name":"Universit\u00e4tsklinikum Erlangen","ror":"https://ror.org/0030f2a11","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210088053"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"H Stefan","raw_affiliation_strings":["Universit\u00e4t Erlangen, Klinik f\u00fcr Neurologie, Epilepsiezentrum Erlangen, Erlangen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e4t Erlangen, Klinik f\u00fcr Neurologie, Epilepsiezentrum Erlangen, Erlangen","institution_ids":["https://openalex.org/I4210088053"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.24785973,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"39","issue":"01","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11809","display_name":"Advanced NMR Techniques and Applications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gaba","display_name":"GABA","score":0.9340000152587891},{"id":"https://openalex.org/keywords/gaba-quantification","display_name":"GABA quantification","score":0.8489999771118164},{"id":"https://openalex.org/keywords/reproducibility","display_name":"reproducibility","score":0.8040000200271606},{"id":"https://openalex.org/keywords/inter-individual-variability","display_name":"interindividual variability","score":0.6660000085830688},{"id":"https://openalex.org/keywords/intra-individual-variability","display_name":"within-person variability","score":0.7900000214576721},{"id":"https://openalex.org/keywords/signal-integration","display_name":"signal integration","score":0.6600000262260437},{"id":"https://openalex.org/keywords/cerebrospinal-fluid-contamination","display_name":"cerebrospinal fluid contamination","score":0.8880000114440918},{"id":"https://openalex.org/keywords/occipital-lobe","display_name":"occipital lobe","score":0.8659999966621399},{"id":"https://openalex.org/keywords/single-voxel-spectroscopy","display_name":"single voxel spectroscopy","score":0.7020000219345093}],"concepts":[{"id":"https://openalex.org/C2776219046","wikidata":"https://www.wikidata.org/wiki/Q162657","display_name":"Neurotransmitter","level":3,"score":0.7246254086494446},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6827695369720459},{"id":"https://openalex.org/C2777771985","wikidata":"https://www.wikidata.org/wiki/Q210021","display_name":"gamma-Aminobutyric acid","level":3,"score":0.5509464144706726},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3746264576911926},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3546665906906128},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3377741575241089},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1559697687625885},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.13727200031280518},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0915687084197998}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1055/s-2008-1072911","doi":"https://doi.org/10.1055/s-2008-1072911","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-2008-1072911","pdf_url":null,"source":{"id":"https://openalex.org/S44826309","display_name":"Klinische Neurophysiologie","issn_l":"1434-0275","issn":["1434-0275","1439-4081"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1","norway-1"],"host_organization":"https://openalex.org/P4310321135","host_organization_name":"Georg Thieme Verlag","host_organization_lineage":["https://openalex.org/P4310321135","https://openalex.org/P4310320000"],"host_organization_lineage_names":["Georg Thieme Verlag","Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Klinische Neurophysiologie","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.46000000834465027,"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W2082860237","https://openalex.org/W2130076355","https://openalex.org/W2064687417","https://openalex.org/W1426763493","https://openalex.org/W2158974754","https://openalex.org/W2061688783","https://openalex.org/W4306149982","https://openalex.org/W2188884430"],"abstract_inverted_index":{"Purpose:":[0],"Gamma-aminobutyric":[1],"acid":[2],"(GABA)":[3],"is":[4,232],"an":[5,17],"important":[6],"inhibitatory":[7],"neurotransmitter":[8,39],"in":[9,20,40,72,88],"human":[10],"brain":[11],"with":[12,53,67],"anticonvulsive":[13],"character.":[14],"Because":[15],"of":[16,27,37,50,69,76,98,107,116,127,144,215,239],"increased":[18],"interest":[19,70],"GABA":[21,174,236,251],"metabolism":[22],"we":[23],"tested":[24],"the":[25,48,122,220],"reliability":[26],"a":[28,54,61,213,226],"special":[29],"editing":[30,56],"sequence":[31,57],"which":[32,231],"allows":[33],"non-invasive":[34],"intracerebral":[35],"measurements":[36,190],"this":[38],"healthy":[41],"adults.":[42],"Methods":[43],"and":[44,79,109,142,178,182,186,209,228,250],"Materials:":[45],"We":[46],"determined":[47],"reproducibility":[49,81,200],"results":[51],"obtained":[52],"J-difference":[55],"using":[58,131],"MEGA-suppression":[59],"on":[60,93,191],"3T-TIM-Trio":[62],"(Siemens)":[63],"by":[64],"single-voxel-spectroscopy":[65],"(SVS)":[66],"regions":[68],"(ROIs)":[71],"left/right":[73,102],"occipital":[74],"lobe":[75],"subjects.":[77],"Intra-":[78],"inter-subject":[80,199],"was":[82,104,124,205],"evaluated.":[83],"11":[84],"volunteers":[85],"were":[86,111,129,147],"measured":[87],"total,":[89],"3":[90,192],"probands":[91],"repeatedly":[92],"4":[94,188],"different":[95,118],"days.":[96],"Comparison":[97],"side":[99],"differences":[100],"between":[101],"hemispheres":[103],"calculated.":[105],"Results":[106],"GABA/Cr":[108,167],"GABA/H2O-ratios":[110,243],"compared.":[112],"A":[113],"detailed":[114],"comparison":[115],"2":[117],"post-processing":[119],"routines":[120],"for":[121,162,218],"evaluation":[123],"accomplished.":[125],"Signals":[126],"GABA/Cr/H2O":[128],"integrated":[130],"MestreC,":[132],"compared":[133,164],"to":[134,165,224,234],"time-domain":[135],"line-fitting-routine":[136],"(AMARES-jMRUI).":[137],"Mean,":[138],"standard":[139],"deviation":[140],"(SD)":[141],"coefficient":[143],"variation":[145],"(CV)":[146],"calculated":[148],"among":[149],"groups.":[150],"Results:":[151],"Using":[152],"data":[153],"from":[154],"all":[155],"subjects":[156,193],"lower":[157],"CVs":[158],"can":[159],"be":[160,225],"observed":[161],"line-fitting":[163,254],"integration.":[166,259],"ratio":[168],"performs":[169],"better":[170,196,257],"than":[171,198,248,258],"GABA/H20":[172],"or":[173],"alone":[175],"(GABA/Cr:":[176],"13.6%":[177],"21.55%;":[179],"GABA/H2O:":[180],"14.8%":[181],"21.68%;":[183],"GABA:":[184],"20.62%":[185],"26.42%).":[187],"day":[189],"showed":[194],"slightly":[195],"intra-":[197],"(GABA/H2O":[201],"13.71%).":[202],"No":[203],"left/right-difference":[204],"found":[206],"(GABA/H2O*1000:":[207],"0.139\u00b10.022":[208],"0.133\u00b10.018).":[210],"Conclusion:":[211],"With":[212],"CV":[214],"about":[216],"13%":[217],"GABA/Cr,":[219],"technique":[221],"turns":[222],"out":[223],"precise":[227],"promising":[229],"tool":[230],"able":[233],"detect":[235],"confidently.":[237],"Despite":[238],"minor":[240],"liquor":[241],"contamination":[242],"are":[244],"generally":[245],"more":[246],"reliable":[247],"GABA/tCr":[249],"alone.":[252],"Automated":[253],"performed":[255],"much":[256]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2025-10-10T00:00:00"}