{"id":"https://openalex.org/W2145383224","doi":null,"title":"Candidate genes for chromosomes 6 and 10 quantitative trait loci for age-related retinal degeneration in mice.","display_name":"Candidate genes for chromosomes 6 and 10 quantitative trait loci for age-related retinal degeneration in mice.","publication_year":2010,"publication_date":"2010-06-05","ids":{"openalex":"https://openalex.org/W2145383224","mag":"2145383224","pmid":"https://pubmed.ncbi.nlm.nih.gov/20577653","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2890552"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2890552","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2890552/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2890552/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Vis","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2890552/pdf/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065436861","display_name":"Diego G. Ogando","orcid":"https://orcid.org/0000-0002-3632-9954","observed_orcids":["https://orcid.org/0000-0002-3632-9954"]},"institutions":[{"id":"https://openalex.org/I35566140","display_name":"Loyola Marymount University","ror":"https://ror.org/00xhj8c72","country_code":"US","type":"education","lineage":["https://openalex.org/I35566140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Diego G Ogando","raw_affiliation_strings":["Department of Biology, Loyola Marymount University, Los Angeles, CA 90045-2659, USA. dieogando@gmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Loyola Marymount University, Los Angeles, CA 90045-2659, USA. dieogando@gmail.com","institution_ids":["https://openalex.org/I35566140"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000271407","display_name":"Kam D Dahlquist","orcid":"https://orcid.org/0000-0003-1973-3311","observed_orcids":["https://orcid.org/0000-0003-1973-3311"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kam D Dahlquist","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058233763","display_name":"Mitra Alizadeh","orcid":"https://orcid.org/0000-0002-3708-4725","observed_orcids":["https://orcid.org/0000-0002-3708-4725"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mitra Alizadeh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071069975","display_name":"Kannan Kunchithapautham","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kannan Kunchithapautham","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100361966","display_name":"Jun Li","orcid":"https://orcid.org/0000-0002-8664-4813","observed_orcids":["https://orcid.org/0000-0002-8664-4813"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jun Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111803468","display_name":"Nicole Yu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nicole Yu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111937357","display_name":"Matthew M. LaVail","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Matthew M LaVail","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055321629","display_name":"B\u00e4rbel Rohrer","orcid":"https://orcid.org/0000-0003-2758-3771","observed_orcids":["https://orcid.org/0000-0003-2758-3771"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B\u00e4rbel Rohrer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088012092","display_name":"Douglas Vollrath","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Douglas Vollrath","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5073653912","display_name":"Michael Danciger","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Danciger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"16","issue":null,"first_page":"1004","last_page":"18"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.007799999788403511,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/age-related-retinal-degeneration","display_name":"age-related retinal degeneration","score":0.9879999756813049},{"id":"https://openalex.org/keywords/quantitative-trait-loci","display_name":"quantitative trait loci","score":0.8289999961853027},{"id":"https://openalex.org/keywords/candidate-genes","display_name":"candidate genes","score":0.871999979019165},{"id":"https://openalex.org/keywords/chromosome-6","display_name":"chromosome 6","score":0.7089999914169312},{"id":"https://openalex.org/keywords/chromosome-10","display_name":"chromosome 10","score":1.0},{"id":"https://openalex.org/keywords/tnfaip3","display_name":"A20","score":0.9319999814033508},{"id":"https://openalex.org/keywords/dock1","display_name":"DOCK1","score":0.656000018119812},{"id":"https://openalex.org/keywords/hexokinase-2","display_name":"hexokinase 2","score":0.9599999785423279},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.8759999871253967},{"id":"https://openalex.org/keywords/outer-nuclear-layer-thickness","display_name":"outer nuclear layer thickness","score":0.8029999732971191},{"id":"https://openalex.org/keywords/differential-gene-expression","display_name":"differential gene expression","score":0.7329999804496765},{"id":"https://openalex.org/keywords/stress-response","display_name":"stress response","score":0.3919999897480011},{"id":"https://openalex.org/keywords/cell-remodeling","display_name":"cell remodeling","score":0.7009999752044678},{"id":"https://openalex.org/keywords/retinal-aging","display_name":"retinal aging","score":0.39399999380111694}],"concepts":[{"id":"https://openalex.org/C81941488","wikidata":"https://www.wikidata.org/wiki/Q853421","display_name":"Quantitative trait locus","level":3,"score":0.8908159732818604},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.813140869140625},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.7851386070251465},{"id":"https://openalex.org/C69991583","wikidata":"https://www.wikidata.org/wiki/Q1423575","display_name":"Candidate gene","level":3,"score":0.7378202676773071},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6638951301574707},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.6578478217124939},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5168126821517944},{"id":"https://openalex.org/C168393362","wikidata":"https://www.wikidata.org/wiki/Q5421706","display_name":"Expression quantitative trait loci","level":5,"score":0.5043250322341919},{"id":"https://openalex.org/C21249469","wikidata":"https://www.wikidata.org/wiki/Q5433313","display_name":"Family-based QTL mapping","level":5,"score":0.4826643764972687},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.45261791348457336},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.2746594250202179},{"id":"https://openalex.org/C122735190","wikidata":"https://www.wikidata.org/wiki/Q715789","display_name":"Gene mapping","level":4,"score":0.22650566697120667},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.19167184829711914}],"mesh":[{"descriptor_ui":"D000072598","descriptor_name":"Tumor Necrosis Factor alpha-Induced Protein 3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000074923","descriptor_name":"High-Temperature Requirement A Serine Peptidase 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003546","descriptor_name":"Cysteine Endopeptidases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012162","descriptor_name":"Retinal Degeneration","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024101","descriptor_name":"Mitochondrial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D046228","descriptor_name":"Microarray Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056726","descriptor_name":"Genetic Association Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:2890552","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2890552/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2890552/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Vis","raw_type":"Text"},{"id":"pmid:20577653","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20577653","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular vision","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.354.2835","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.354.2835","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/cb/70/Mol_Vis_2010_Jun_5_16_1004-1018.tar.gz","raw_type":"text"},{"id":"mag:2145383224","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20577653","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2890552","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2890552/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2890552/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Vis","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3020038908","display_name":"P30 - Core Grant for Vision Research","funder_award_id":"P30EY002162","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G4116677685","display_name":"Cellular Mechanisms of Inherited Retinal Degeneration","funder_award_id":"R01EY001919","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G5387261882","display_name":"COMPUTATIONAL METHODS FOR PROTEOMIC ANALYSIS","funder_award_id":"K22HG000044","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G6176678837","display_name":"Gene Modifiers of Retinal Degeneration","funder_award_id":"R01EY013280","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G893756386","display_name":"ROD NEURODEGENERATIVE AND PROTECTIVE GENES","funder_award_id":"R01EY013520","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G9000887391","display_name":"Institutional Training Grant in Genome Science","funder_award_id":"T32HG000044","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"}],"funders":[{"id":"https://openalex.org/F4320306811","display_name":"Research to Prevent Blindness","ror":"https://ror.org/04drjs621"},{"id":"https://openalex.org/F4320309383","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78"},{"id":"https://openalex.org/F4320311945","display_name":"E. Matilda Ziegler Foundation for the Blind","ror":"https://ror.org/00zj09521"},{"id":"https://openalex.org/F4320317381","display_name":"That Man May See","ror":"https://ror.org/00yawa228"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332622","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54"},{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2145383224.pdf","grobid_xml":"https://content.openalex.org/works/W2145383224.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W61809690","https://openalex.org/W66541472","https://openalex.org/W88307080","https://openalex.org/W1591403455","https://openalex.org/W1978437552","https://openalex.org/W1980615786","https://openalex.org/W1989316780","https://openalex.org/W1989762673","https://openalex.org/W1989771503","https://openalex.org/W1990834153","https://openalex.org/W1999412010","https://openalex.org/W2003147175","https://openalex.org/W2005381472","https://openalex.org/W2005528779","https://openalex.org/W2007262700","https://openalex.org/W2021122140","https://openalex.org/W2024516416","https://openalex.org/W2027654900","https://openalex.org/W2034249851","https://openalex.org/W2038997703","https://openalex.org/W2039433370","https://openalex.org/W2045338351","https://openalex.org/W2048601306","https://openalex.org/W2074180312","https://openalex.org/W2074832091","https://openalex.org/W2075177078","https://openalex.org/W2084944408","https://openalex.org/W2092913781","https://openalex.org/W2102165670","https://openalex.org/W2106323366","https://openalex.org/W2110295814","https://openalex.org/W2115687796","https://openalex.org/W2116616059","https://openalex.org/W2121777852","https://openalex.org/W2126549314","https://openalex.org/W2127978145","https://openalex.org/W2131989143","https://openalex.org/W2159999364","https://openalex.org/W2167309966"],"related_works":["https://openalex.org/W7097253699","https://openalex.org/W2027654900","https://openalex.org/W2068843638","https://openalex.org/W7097138356","https://openalex.org/W1132693469","https://openalex.org/W1591403455","https://openalex.org/W1151818208","https://openalex.org/W1177351802","https://openalex.org/W1768795272","https://openalex.org/W2038615863"],"abstract_inverted_index":{"PURPOSE:":[0],"In":[1,317],"a":[2,18,170],"previous":[3],"study,":[4],"several":[5],"quantitative":[6,279],"trait":[7,280],"loci":[8,44],"(QTL)":[9],"that":[10,95,274,292,429],"influence":[11],"age-related":[12],"degeneration":[13],"(ageRD)":[14],"were":[15,37,53,78,134,151,184,196,202,215,271,374],"identified":[16,216],"in":[17,62,204,212,262,303,383,434],"cross":[19],"between":[20,391],"the":[21,38,60,81,109,142,205,250,278,284,304,310,318,324,334,352,359,401,404,415,420,426],"albino":[22],"strains":[23,84],"B6(Cg)-Tyr(c-2J)/J":[24],"(B6a)":[25],"and":[26,33,40,45,57,87,99,119,141,159,192,223,231,234,249,266,298,333,351,362,372,385,393,409],"BALB/cByJ":[27],"(C).":[28],"The":[29,51,288,345],"Chromosome":[30],"(Chr)":[31],"6":[32,361,417],"Chr":[34,285,360,363,405,416],"10":[35,286,364,406],"QTL":[36,52,70,150],"strongest":[39],"most":[41,376],"highly":[42],"significant":[43],"both":[46],"involved":[47,433],"B6a":[48,311,320,392],"protective":[49],"alleles.":[50],"responsible":[54],"for":[55,80,153,198,219,232,242,283,358,403,414],"21%":[56],"9%":[58],"of":[59,90,108,144,208,252,336,347,379,388],"variance":[61],"phenotypes,":[63],"respectively.":[64],"We":[65],"focused":[66],"on":[67,137,169],"these":[68],"two":[69,82,253],"to":[71,92,101,115,246],"identify":[72,93,116,125],"candidate":[73,356],"genes.":[74,210],"METHODS:":[75],"DNA":[76],"microarrays":[77],"used":[79],"mouse":[83],"at":[85,228,236],"four":[86,229],"eight":[88,209,237],"months":[89,230],"age":[91,314],"genes":[94,112,148,350,357],"are":[96,301,340],"differentially":[97,110,348],"regulated":[98],"map":[100],"either":[102],"QTL.":[103,287,365,418],"Gene":[104],"Ontology":[105],"(GO)":[106],"analysis":[107,158,290,423],"expressed":[111,349],"was":[113,174,240,260,398],"performed":[114],"possible":[117],"processes":[118],"pathways":[120],"associated":[121,295,329],"with":[122,186,296,309,313,323,330,342],"ageRD.":[123,199,435],"To":[124],"additional":[126],"candidates,":[127],"database":[128,354],"analyses":[129,346],"(Positional":[130],"Medline":[131],"or":[132],"PosMed)":[133],"used.":[135],"Based":[136],"differential":[138,247],"expression,":[139],"PosMed,":[140],"presence":[143,251],"reported":[145],"polymorphisms,":[146],"five":[147],"per":[149],"selected":[152,241],"further":[154,424],"study":[155],"by":[156,217],"sequencing":[157],"qRT-PCR.":[160],"Tumor":[161],"necrosis":[162],"factor,":[163],"alpha-":[164],"induced":[165],"protein":[166,225],"3":[167],"(Tnfaip3;":[168],"C57BL/6J":[171],"(B6)":[172],"background)":[173],"phenotypically":[175],"tested.":[176],"Single":[177],"nucleotide":[178],"polymorphisms":[179],"(SNPs)":[180],"flanking":[181],"this":[182],"gene":[183,213,281],"correlated":[185],"outer":[187],"nuclear":[188],"layer":[189],"thickness":[190,259],"(ONL),":[191],"eight-month-old":[193,263],"Tnfaip3(+/-)":[194,265],"mice":[195],"tested":[197],"RESULTS:":[200],"Polymorphisms":[201],"found":[203],"coding":[206],"regions":[207],"Changes":[211],"expression":[214,248],"qRT-PCR":[218],"Hexokinase":[220],"2":[221,369],"(Hk2)":[222],"Docking":[224],"1":[226],"(Dok1)":[227],"Dok1":[233,408],"Tnfaip3":[235,239,275,373,397],"months.":[238],"phenotypic":[243],"testing":[244],"due":[245],"nonsynonymous":[254,389],"mutations.":[255],"However,":[256],"when":[257],"ONL":[258],"compared":[261,308,322],"congenic":[264],"Tnfaip3(+/+)":[267],"mice,":[268],"no":[269],"differences":[270],"found,":[272],"suggesting":[273],"is":[276,432],"not":[277],"(QTG)":[282],"GO":[289,293,327,421],"revealed":[291],"terms":[294,328],"stress":[297,431],"cell":[299],"remodeling":[300],"overrepresented":[302,341],"ageRD-sensitive":[305],"C":[306,325,394],"strain":[307,312],"(eight":[315],"months).":[316],"ageRD-resistant":[319],"strain,":[321,326],"antioxidant":[331],"response":[332],"regulation":[335],"blood":[337],"vessel":[338],"size":[339],"age.":[343],"CONCLUSIONS:":[344],"PosMed":[353],"yielded":[355],"HtrA":[366],"serine":[367],"peptidase":[368],"(Htra2),":[370],"Dok1,":[371],"deemed":[375],"promising":[377],"because":[378],"their":[380],"known":[381],"roles":[382],"apoptosis":[384],"our":[386],"finding":[387],"substitutions":[390],"strains.":[395],"While":[396],"excluded":[399],"as":[400],"QTG":[402],"QTL,":[407],"Htra2":[410],"remain":[411],"good":[412],"candidates":[413],"Finally,":[419],"term":[422],"supports":[425],"general":[427],"hypothesis":[428],"oxidative":[430]},"counts_by_year":[{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}