{"id":"https://openalex.org/W2145376318","doi":null,"title":"Radiosynthesis of 191Os-2-acetylpyridine thiosemicarbazone complex, as an in vivo therapeutic radionuclide generator","display_name":"Radiosynthesis of 191Os-2-acetylpyridine thiosemicarbazone complex, as an in vivo therapeutic radionuclide generator","publication_year":2013,"publication_date":"2013-10-01","ids":{"openalex":"https://openalex.org/W2145376318","mag":"2145376318"},"language":"en","primary_location":{"id":"pmh:oai:CiteSeerX.psu:10.1.1.975.2166","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.975.2166","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://irjnm.tums.ac.ir/pdf_3242_b3e0e8b548ef45b4ea4fd3cc9a7b2517.html","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"B. Moghaddam","orcid":"https://orcid.org/0000-0002-0046-0731","observed_orcids":["https://orcid.org/0000-0002-0046-0731"]},"institutions":[{"id":"https://openalex.org/I102962589","display_name":"Atomic Energy Organization of Iran","ror":"https://ror.org/04feqxb79","country_code":"IR","type":"government","lineage":["https://openalex.org/I102962589"]},{"id":"https://openalex.org/I4392738327","display_name":"Nuclear Science and Technology Research Institute","ror":"https://ror.org/05cebxq10","country_code":"IR","type":"facility","lineage":["https://openalex.org/I102962589","https://openalex.org/I4392738327"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"B. Moghaddam","raw_affiliation_strings":["Nuclear Science and Technology Research Institute (NSTRI), #N#Atomic Energy Organization of Iran (AEOI), Tehran, Iran"],"raw_orcid":"https://orcid.org/0000-0002-0046-0731","affiliations":[{"raw_affiliation_string":"Nuclear Science and Technology Research Institute (NSTRI), #N#Atomic Energy Organization of Iran (AEOI), Tehran, Iran","institution_ids":["https://openalex.org/I102962589","https://openalex.org/I4392738327"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010691273","display_name":"Amir Reza Jalilian","orcid":"https://orcid.org/0000-0002-1948-0580","observed_orcids":["https://orcid.org/0000-0002-1948-0580"]},"institutions":[{"id":"https://openalex.org/I102962589","display_name":"Atomic Energy Organization of Iran","ror":"https://ror.org/04feqxb79","country_code":"IR","type":"government","lineage":["https://openalex.org/I102962589"]},{"id":"https://openalex.org/I4392738327","display_name":"Nuclear Science and Technology Research Institute","ror":"https://ror.org/05cebxq10","country_code":"IR","type":"facility","lineage":["https://openalex.org/I102962589","https://openalex.org/I4392738327"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Amir Reza Jalilian","raw_affiliation_strings":["Nuclear Science and Technology Research Institute (NSTRI), #N#Atomic Energy Organization of Iran (AEOI), Tehran, Iran"],"raw_orcid":"https://orcid.org/0000-0002-1948-0580","affiliations":[{"raw_affiliation_string":"Nuclear Science and Technology Research Institute (NSTRI), #N#Atomic Energy Organization of Iran (AEOI), Tehran, Iran","institution_ids":["https://openalex.org/I102962589","https://openalex.org/I4392738327"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001911627","display_name":"Mina Jamre","orcid":"https://orcid.org/0000-0003-3966-3568","observed_orcids":["https://orcid.org/0000-0003-3966-3568"]},"institutions":[{"id":"https://openalex.org/I158248296","display_name":"Amirkabir University of Technology","ror":"https://ror.org/04gzbav43","country_code":"IR","type":"education","lineage":["https://openalex.org/I158248296"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mina Jamre","raw_affiliation_strings":["Faculty of Nuclear Engineering and Physics, Amirkabir University of Technology, Tehran, Iran"],"raw_orcid":"https://orcid.org/0000-0003-3966-3568","affiliations":[{"raw_affiliation_string":"Faculty of Nuclear Engineering and Physics, Amirkabir University of Technology, Tehran, Iran","institution_ids":["https://openalex.org/I158248296"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068981290","display_name":"Nafise Salek","orcid":"https://orcid.org/0000-0001-6725-2809","observed_orcids":["https://orcid.org/0000-0001-6725-2809"]},"institutions":[{"id":"https://openalex.org/I158248296","display_name":"Amirkabir University of Technology","ror":"https://ror.org/04gzbav43","country_code":"IR","type":"education","lineage":["https://openalex.org/I158248296"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Nafise Salek","raw_affiliation_strings":["Faculty of Nuclear Engineering and Physics, Amirkabir University of Technology, Tehran, Iran"],"raw_orcid":"https://orcid.org/0000-0001-6725-2809","affiliations":[{"raw_affiliation_string":"Faculty of Nuclear Engineering and Physics, Amirkabir University of Technology, Tehran, Iran","institution_ids":["https://openalex.org/I158248296"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091747526","display_name":"Mohammad Mazidi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102962589","display_name":"Atomic Energy Organization of Iran","ror":"https://ror.org/04feqxb79","country_code":"IR","type":"government","lineage":["https://openalex.org/I102962589"]},{"id":"https://openalex.org/I4392738327","display_name":"Nuclear Science and Technology Research Institute","ror":"https://ror.org/05cebxq10","country_code":"IR","type":"facility","lineage":["https://openalex.org/I102962589","https://openalex.org/I4392738327"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mohammad Mazidi","raw_affiliation_strings":["Nuclear Science and Technology Research Institute (NSTRI), #N#Atomic Energy Organization of Iran (AEOI), Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuclear Science and Technology Research Institute (NSTRI), #N#Atomic Energy Organization of Iran (AEOI), Tehran, Iran","institution_ids":["https://openalex.org/I102962589","https://openalex.org/I4392738327"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033077917","display_name":"Mohammad Ghannadi\u2010Maragheh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102962589","display_name":"Atomic Energy Organization of Iran","ror":"https://ror.org/04feqxb79","country_code":"IR","type":"government","lineage":["https://openalex.org/I102962589"]},{"id":"https://openalex.org/I4392738327","display_name":"Nuclear Science and Technology Research Institute","ror":"https://ror.org/05cebxq10","country_code":"IR","type":"facility","lineage":["https://openalex.org/I102962589","https://openalex.org/I4392738327"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mohammad Ghannadi\u2010Maragheh","raw_affiliation_strings":["Nuclear Science and Technology Research Institute (NSTRI), #N#Atomic Energy Organization of Iran (AEOI), Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuclear Science and Technology Research Institute (NSTRI), #N#Atomic Energy Organization of Iran (AEOI), Tehran, Iran","institution_ids":["https://openalex.org/I102962589","https://openalex.org/I4392738327"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4376,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.65572026,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"21","issue":"2","first_page":"53","last_page":"59"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13561","display_name":"Chemical Reactions and Isotopes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/radiosynthesis","display_name":"radiotracer synthesis","score":0.7670000195503235},{"id":"https://openalex.org/keywords/2-acetylpyridine-thiosemicarbazone","display_name":"2-acetylpyridine thiosemicarbazone","score":0.9449999928474426},{"id":"https://openalex.org/keywords/thermal-neutron-irradiation","display_name":"thermal neutron irradiation","score":0.7540000081062317},{"id":"https://openalex.org/keywords/radiochemical-purity","display_name":"radiochemical purity","score":0.8009999990463257},{"id":"https://openalex.org/keywords/tissue-distribution","display_name":"tissue distribution","score":0.652999997138977},{"id":"https://openalex.org/keywords/partition-coefficient","display_name":"partition coefficient","score":0.6909999847412109},{"id":"https://openalex.org/keywords/serum-stability","display_name":"serum stability","score":0.6370000243186951},{"id":"https://openalex.org/keywords/antiproliferative-agents","display_name":"antiproliferative agents","score":0.5590000152587891}],"concepts":[{"id":"https://openalex.org/C2777807558","wikidata":"https://www.wikidata.org/wiki/Q4914764","display_name":"Biodistribution","level":3,"score":0.8014804124832153},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7491339445114136},{"id":"https://openalex.org/C83591994","wikidata":"https://www.wikidata.org/wiki/Q416105","display_name":"Semicarbazone","level":2,"score":0.7002390027046204},{"id":"https://openalex.org/C2776970183","wikidata":"https://www.wikidata.org/wiki/Q20155580","display_name":"Radiosynthesis","level":3,"score":0.694596529006958},{"id":"https://openalex.org/C177322064","wikidata":"https://www.wikidata.org/wiki/Q750955","display_name":"Radiochemistry","level":1,"score":0.6554635167121887},{"id":"https://openalex.org/C540285154","wikidata":"https://www.wikidata.org/wiki/Q751","display_name":"Osmium","level":4,"score":0.6236050128936768},{"id":"https://openalex.org/C192552737","wikidata":"https://www.wikidata.org/wiki/Q898797","display_name":"Partition coefficient","level":2,"score":0.5459647178649902},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.510363757610321},{"id":"https://openalex.org/C13965031","wikidata":"https://www.wikidata.org/wiki/Q243545","display_name":"Nuclear chemistry","level":1,"score":0.5095034241676331},{"id":"https://openalex.org/C155647269","wikidata":"https://www.wikidata.org/wiki/Q243455","display_name":"Medicinal chemistry","level":1,"score":0.35825833678245544},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.32544225454330444},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.17176419496536255},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.16649332642555237},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13510042428970337},{"id":"https://openalex.org/C555196967","wikidata":"https://www.wikidata.org/wiki/Q1086","display_name":"Ruthenium","level":3,"score":0.10295683145523071},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.09558987617492676},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:CiteSeerX.psu:10.1.1.975.2166","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.975.2166","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://irjnm.tums.ac.ir/pdf_3242_b3e0e8b548ef45b4ea4fd3cc9a7b2517.html","raw_type":"text"},{"id":"mag:2145376318","doi":null,"is_oa":false,"landing_page_url":"https://irjnm.tums.ac.ir/article_3242_b3e0e8b548ef45b4ea4fd3cc9a7b2517.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S2764371742","display_name":"Iranian Journal of Nuclear Medicine","issn_l":"1681-2824","issn":["1681-2824","2008-2509"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310319396","host_organization_name":"Knowledge E","host_organization_lineage":["https://openalex.org/P4310319396"],"host_organization_lineage_names":["Knowledge E"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Iranian Journal of Nuclear Medicine","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1918375086","https://openalex.org/W1995488409","https://openalex.org/W2006277511","https://openalex.org/W2008002124","https://openalex.org/W2011855362","https://openalex.org/W2017005182","https://openalex.org/W2017025137","https://openalex.org/W2017721707","https://openalex.org/W2017756722","https://openalex.org/W2065351549","https://openalex.org/W2069000149","https://openalex.org/W2078097134","https://openalex.org/W2081215792","https://openalex.org/W2084325811","https://openalex.org/W2089085124","https://openalex.org/W2119791735","https://openalex.org/W2271621094","https://openalex.org/W2409255035","https://openalex.org/W2409355667","https://openalex.org/W2520398131"],"related_works":["https://openalex.org/W7097606646","https://openalex.org/W2089085124","https://openalex.org/W2004172451","https://openalex.org/W2065351549","https://openalex.org/W1987638281","https://openalex.org/W2084894919","https://openalex.org/W4389509524","https://openalex.org/W2130005894","https://openalex.org/W4387765825","https://openalex.org/W1825554510"],"abstract_inverted_index":{"Introduction:":[0],"Due":[1],"to":[2,117,131],"the":[3,10,32,78,83,106,140],"anti-proliferative":[4],"properties":[5],"of":[6,12,47,77,91,99,110],"platinum":[7],"group-thiosemicarbazone":[8],"complexes,":[9],"production":[11],"191":[13,19,25,35,54,58],"Os-labeled":[14],"2-acetyl":[15],"pyridine":[16],"4-N-methylthiosemicarbazone":[17],"(":[18],"Os-APMTS)":[20],"was":[21,29,85,103,122],"investigated.":[22],"Methods:":[23],"[":[24,57],"Osmium":[26],"(T\u00bd=":[27],"15.4d)":[28],"produced":[30],"via":[31],"190":[33],"Os(n,\u03b3)":[34],"Os":[36,55],"nuclear":[37],"reaction":[38],"using":[39],"enriched":[40],"target":[41],"irradiated":[42],"with":[43,53,87],"thermal":[44],"neutrons.":[45],"Reaction":[46],"in-house":[48],"synthesized":[49],"2-acetylpyridine":[50],"thiosemicarbazone":[51],"(APMTS)":[52],"yielded":[56],"Os]APMTS":[59],"checked":[60],"by":[61,64],"ITLC":[62],"followed":[63],"stability,":[65],"partition":[66,120],"co-efficient":[67],"and":[68,74,96,102,108,144],"biodistribution":[69,128],"determination.":[70],"Results:":[71],"Following":[72],"synthesis":[73],"spectroscopic":[75],"determination":[76],"ligand":[79],"(>99%":[80],"chemical":[81],"purity),":[82],"complex":[84],"prepared":[86],"a":[88],"radiochemical":[89],"purity":[90],"more":[92],"than":[93],"95%":[94],"(RTLC)":[95],"specific":[97],"activity":[98],"21.5":[100],"GB/mM":[101],"stable":[104],"in":[105,139],"formulation":[107],"presence":[109],"human":[111],"serum":[112],"at":[113],"37\u00b0C":[114],"for":[115],"up":[116,130],"48h.":[118],"The":[119,127],"coefficient":[121],"determined":[123],"(log":[124],"P.":[125],"1.23).":[126],"study":[129],"4":[132],"days":[133],"demonstrated":[134],"significant":[135],"tissue":[136],"uptake":[137],"differences":[138],"bone,":[141],"blood,":[142],"heart":[143],"thyroid.":[145]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
