{"id":"https://openalex.org/W2145368449","doi":"https://doi.org/10.1177/019262337600400405","title":"Response of Hepatic Endoplasmic Reticulum to Drugs and Chemicals","display_name":"Response of Hepatic Endoplasmic Reticulum to Drugs and Chemicals","publication_year":1976,"publication_date":"1976-12-01","ids":{"openalex":"https://openalex.org/W2145368449","doi":"https://doi.org/10.1177/019262337600400405","mag":"2145368449"},"language":"en","primary_location":{"id":"doi:10.1177/019262337600400405","doi":"https://doi.org/10.1177/019262337600400405","is_oa":true,"landing_page_url":"https://doi.org/10.1177/019262337600400405","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/019262337600400405","source":{"id":"https://openalex.org/S4210227503","display_name":"The Bulletin of the Society of Pharmacological and Environmental Pathologists","issn_l":"0094-1824","issn":["0094-1824"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Bulletin of the Society of Pharmacological and Environmental Pathologists","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.sagepub.com/doi/pdf/10.1177/019262337600400405","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103597909","display_name":"F. George Zaki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"F. George Zaki","raw_affiliation_strings":["Pathology Department, The Squibb Institute for Medical Research, New Brunswick, NJ 08903"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology Department, The Squibb Institute for Medical Research, New Brunswick, NJ 08903","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5103597909"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5593,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.62920908,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"4","issue":"4","first_page":"11","last_page":"20"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9520999789237976,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9520999789237976,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.012799999676644802,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.01140000019222498,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-induced-liver-injury","display_name":"drug-induced liver injury","score":0.7929999828338623},{"id":"https://openalex.org/keywords/ultrastructural-pathology","display_name":"ultrastructural pathology","score":0.703000009059906},{"id":"https://openalex.org/keywords/subcellular-changes","display_name":"subcellular changes","score":0.7170000076293945},{"id":"https://openalex.org/keywords/drug-safety-assessment","display_name":"drug safety assessment","score":0.699999988079071}],"concepts":[{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.9206242561340332},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4584043622016907},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4515971541404724},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38833552598953247},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3283977508544922},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.252315878868103},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2465023696422577}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1177/019262337600400405","doi":"https://doi.org/10.1177/019262337600400405","is_oa":true,"landing_page_url":"https://doi.org/10.1177/019262337600400405","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/019262337600400405","source":{"id":"https://openalex.org/S4210227503","display_name":"The Bulletin of the Society of Pharmacological and Environmental Pathologists","issn_l":"0094-1824","issn":["0094-1824"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Bulletin of the Society of Pharmacological and Environmental Pathologists","raw_type":"journal-article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.1001.2325","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1001.2325","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://tpx.sagepub.com/content/4/4/11.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1177/019262337600400405","doi":"https://doi.org/10.1177/019262337600400405","is_oa":true,"landing_page_url":"https://doi.org/10.1177/019262337600400405","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/019262337600400405","source":{"id":"https://openalex.org/S4210227503","display_name":"The Bulletin of the Society of Pharmacological and Environmental Pathologists","issn_l":"0094-1824","issn":["0094-1824"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Bulletin of the Society of Pharmacological and Environmental Pathologists","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2145368449.pdf","grobid_xml":"https://content.openalex.org/works/W2145368449.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W60471571","https://openalex.org/W112314493","https://openalex.org/W1975038884","https://openalex.org/W1978387945","https://openalex.org/W1978879346","https://openalex.org/W1981389278","https://openalex.org/W1994146475","https://openalex.org/W1994459893","https://openalex.org/W2000100653","https://openalex.org/W2012403210","https://openalex.org/W2031347894","https://openalex.org/W2042058352","https://openalex.org/W2059973305","https://openalex.org/W2065817178","https://openalex.org/W2067917957","https://openalex.org/W2085680442","https://openalex.org/W2118266394","https://openalex.org/W2119303106","https://openalex.org/W2174407705","https://openalex.org/W2286291716","https://openalex.org/W2415028923","https://openalex.org/W2418627143","https://openalex.org/W2474460477","https://openalex.org/W3036020609","https://openalex.org/W3036630292","https://openalex.org/W3036681571","https://openalex.org/W4406985009"],"related_works":["https://openalex.org/W2416606801","https://openalex.org/W2120651331","https://openalex.org/W2442696505","https://openalex.org/W1984615524","https://openalex.org/W4301016407","https://openalex.org/W2498774838","https://openalex.org/W7017757260","https://openalex.org/W2417232154","https://openalex.org/W2469511718","https://openalex.org/W2415729413"],"abstract_inverted_index":{"The":[0,66],"close":[1],"association":[2],"of":[3,9,20,26,32,81,98,113,121],"biochemical":[4,18],"methods":[5],"and":[6,37,55,64,87],"high":[7,111],"resolution":[8,112],"electron":[10,47,67,115],"microscopy":[11,48,63],"has":[12,49],"introduced":[13],"a":[14,23,75,92],"new":[15,24,93],"pathology,":[16],"the":[17,30,33,51,79,96,102,110,114,130],"pathology":[19],"cell":[21,35,122],"organelles,":[22],"field":[25],"study":[27],"in":[28,58,78,129],"which":[29],"structure":[31],"altered":[34,39],"organelles":[36],"their":[38],"function":[40],"can":[41],"be":[42],"elucidated.":[43],"In":[44],"this":[45],"respect,":[46],"bridged":[50],"gap":[52],"between":[53,61],"morphology":[54],"function,":[56],"or":[57],"other":[59,88],"words,":[60],"light":[62,131],"biochemistry.":[65],"microscope":[68],"is":[69,106],"successfully":[70],"used":[71],"at":[72,101],"present":[73],"as":[74],"fundamental":[76],"tool":[77],"analysis":[80],"subcellular":[82],"changes":[83],"induced":[84],"by":[85],"drugs":[86],"agents,":[89],"thus":[90],"adding":[91],"dimension":[94],"to":[95,117],"evaluation":[97],"drug":[99],"safety":[100],"ultrastruc-turai":[103],"level.":[104],"It":[105],"now":[107],"possible,":[108],"with":[109],"microscope,":[116,132],"demonstrate":[118],"early":[119],"phases":[120],"injury":[123],"long":[124],"before":[125],"they":[126],"are":[127],"detected":[128]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
