{"id":"https://openalex.org/W2145368185","doi":"https://doi.org/10.1111/j.1523-5378.2005.00308.x","title":"Interleukin\u20102 Gene Polymorphisms Associated with Increased Risk of Gastric Atrophy from Helicobacter pylori Infection","display_name":"Interleukin\u20102 Gene Polymorphisms Associated with Increased Risk of Gastric Atrophy from Helicobacter pylori Infection","publication_year":2005,"publication_date":"2005-05-16","ids":{"openalex":"https://openalex.org/W2145368185","doi":"https://doi.org/10.1111/j.1523-5378.2005.00308.x","mag":"2145368185","pmid":"https://pubmed.ncbi.nlm.nih.gov/15904474"},"language":"en","primary_location":{"id":"doi:10.1111/j.1523-5378.2005.00308.x","doi":"https://doi.org/10.1111/j.1523-5378.2005.00308.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1523-5378.2005.00308.x","pdf_url":null,"source":{"id":"https://openalex.org/S45434965","display_name":"Helicobacter","issn_l":"1083-4389","issn":["1083-4389","1523-5378"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Helicobacter","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001762900","display_name":"Shozo Togawa","orcid":"https://orcid.org/0000-0003-2554-2802","observed_orcids":["https://orcid.org/0000-0003-2554-2802"]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shozo Togawa","raw_affiliation_strings":["Department of Internal Medicine and Bioregulation, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine and Bioregulation, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008458565","display_name":"Takashi Joh","orcid":"https://orcid.org/0000-0002-3624-0597","observed_orcids":["https://orcid.org/0000-0002-3624-0597"]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Takashi Joh","raw_affiliation_strings":["Department of Internal Medicine and Bioregulation, Nagoya City University Graduate School of Medical Sciences,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine and Bioregulation, Nagoya City University Graduate School of Medical Sciences,","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101606337","display_name":"Makoto Itoh","orcid":"https://orcid.org/0000-0001-6558-5191","observed_orcids":["https://orcid.org/0000-0001-6558-5191"]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Makoto Itoh","raw_affiliation_strings":["Department of Internal Medicine and Bioregulation, Nagoya City University Graduate School of Medical Sciences,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine and Bioregulation, Nagoya City University Graduate School of Medical Sciences,","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022200025","display_name":"Nobuyuki Katsuda","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nobuyuki Katsuda","raw_affiliation_strings":["Nagoya Kita Health Center,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nagoya Kita Health Center,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037334743","display_name":"Hidemi M. Ito","orcid":"https://orcid.org/0000-0002-8023-4581","observed_orcids":["https://orcid.org/0000-0002-8023-4581"]},"institutions":[{"id":"https://openalex.org/I4405286296","display_name":"Aichi Cancer Center Research Institute","ror":"https://ror.org/01rsenb03","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210133851","https://openalex.org/I4405286296"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hidemi Ito","raw_affiliation_strings":["Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, and","institution_ids":["https://openalex.org/I4405286296"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066277266","display_name":"Keitaro Matsuo","orcid":"https://orcid.org/0000-0003-1761-6314","observed_orcids":["https://orcid.org/0000-0003-1761-6314"]},"institutions":[{"id":"https://openalex.org/I4405286296","display_name":"Aichi Cancer Center Research Institute","ror":"https://ror.org/01rsenb03","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210133851","https://openalex.org/I4405286296"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Keitaro Matsuo","raw_affiliation_strings":["Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, and","institution_ids":["https://openalex.org/I4405286296"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103384293","display_name":"Kazuo Tajima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405286296","display_name":"Aichi Cancer Center Research Institute","ror":"https://ror.org/01rsenb03","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210133851","https://openalex.org/I4405286296"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuo Tajima","raw_affiliation_strings":["Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, and","institution_ids":["https://openalex.org/I4405286296"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072163194","display_name":"Nobuyuki Hamajima","orcid":"https://orcid.org/0000-0003-2870-3341","observed_orcids":["https://orcid.org/0000-0003-2870-3341"]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nobuyuki Hamajima","raw_affiliation_strings":["Department of Preventive Medicine/Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Medicine/Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Nagoya, Japan","institution_ids":["https://openalex.org/I60134161"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5008458565"],"corresponding_institution_ids":["https://openalex.org/I33858575"],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":3.4657,"has_fulltext":false,"cited_by_count":75,"citation_normalized_percentile":{"value":0.92343239,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"10","issue":"3","first_page":"172","last_page":"178"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.843999981880188},{"id":"https://openalex.org/keywords/atrophic-gastritis","display_name":"atrophic gastritis","score":0.9710000157356262},{"id":"https://openalex.org/keywords/helicobacter-pylori-infection","display_name":"Helicobacter pylori infection","score":0.9649999737739563},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.6729999780654907},{"id":"https://openalex.org/keywords/cytokine-gene-polymorphisms","display_name":"cytokine gene polymorphisms","score":0.7179999947547913},{"id":"https://openalex.org/keywords/gastric-cancer-risk","display_name":"gastric cancer risk","score":0.7369999885559082},{"id":"https://openalex.org/keywords/japanese-population","display_name":"Japanese population","score":0.5419999957084656}],"concepts":[{"id":"https://openalex.org/C2776409635","wikidata":"https://www.wikidata.org/wiki/Q180556","display_name":"Helicobacter pylori","level":2,"score":0.7982067465782166},{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.71142578125},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.6876717805862427},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.6859089732170105},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6130462884902954},{"id":"https://openalex.org/C2780342937","wikidata":"https://www.wikidata.org/wiki/Q1826391","display_name":"Atrophic gastritis","level":4,"score":0.5255857110023499},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5205686688423157},{"id":"https://openalex.org/C2778677798","wikidata":"https://www.wikidata.org/wiki/Q183130","display_name":"Gastritis","level":3,"score":0.5198257565498352},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.4355645775794983},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.41162630915641785},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.37557855248451233},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.23238927125930786},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2138366401195526},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1079045832157135}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005757","descriptor_name":"Gastritis, Atrophic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005757","descriptor_name":"Gastritis, Atrophic","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015847","descriptor_name":"Interleukin-4","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015847","descriptor_name":"Interleukin-4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016480","descriptor_name":"Helicobacter pylori","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D016481","descriptor_name":"Helicobacter Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D018793","descriptor_name":"Interleukin-13","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018793","descriptor_name":"Interleukin-13","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1523-5378.2005.00308.x","doi":"https://doi.org/10.1111/j.1523-5378.2005.00308.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1523-5378.2005.00308.x","pdf_url":null,"source":{"id":"https://openalex.org/S45434965","display_name":"Helicobacter","issn_l":"1083-4389","issn":["1083-4389","1523-5378"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Helicobacter","raw_type":"journal-article"},{"id":"pmid:15904474","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15904474","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Helicobacter","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1500891430","https://openalex.org/W1502563456","https://openalex.org/W1594560215","https://openalex.org/W1876978392","https://openalex.org/W1983182914","https://openalex.org/W1983353174","https://openalex.org/W1989107717","https://openalex.org/W1992945893","https://openalex.org/W2020358242","https://openalex.org/W2022729264","https://openalex.org/W2045778097","https://openalex.org/W2056990434","https://openalex.org/W2072380472","https://openalex.org/W2077040835","https://openalex.org/W2077298810","https://openalex.org/W2090681869","https://openalex.org/W2094471618","https://openalex.org/W2094837603","https://openalex.org/W2112116525","https://openalex.org/W2113045990","https://openalex.org/W2133343738","https://openalex.org/W2142326463","https://openalex.org/W2160410700","https://openalex.org/W2160504871","https://openalex.org/W2162904322","https://openalex.org/W2250073450","https://openalex.org/W2330584642","https://openalex.org/W2396979281","https://openalex.org/W2438321426","https://openalex.org/W4294640205"],"related_works":["https://openalex.org/W2610150936","https://openalex.org/W1971511394","https://openalex.org/W3150795731","https://openalex.org/W7096743616","https://openalex.org/W1898389597","https://openalex.org/W2170446482","https://openalex.org/W2089607850","https://openalex.org/W2049877091","https://openalex.org/W7095800614","https://openalex.org/W2102647767"],"abstract_inverted_index":{"BACKGROUND:":[0],"Gastric":[1],"atrophy":[2,28,150,183,230],"induced":[3,231],"by":[4,69,232],"Helicobacter":[5],"pylori":[6,79,92,168,234],"is":[7,222],"thought":[8],"to":[9,12,89,118,131,161,239],"predispose":[10,238],"patients":[11],"noncardiac":[13],"gastric":[14,27,46,137,149,182,211,229,240],"cancer":[15],"development.":[16],"However,":[17],"the":[18,24,38,103,140,176,192,196,218],"host":[19],"genetic":[20],"factors":[21],"that":[22,217],"influence":[23],"progression":[25],"of":[26,40,143,228],"have":[29],"not":[30],"been":[31],"elucidated.":[32],"In":[33,191],"this":[34],"study,":[35],"we":[36],"examined":[37,175],"effects":[39],"cytokine":[41],"polymorphisms":[42,66,180],"on":[43],"H.":[44,91,167,186,193,233],"pylori-induced":[45],"atrophy.":[47,212],"METHODS:":[48],"Blood":[49],"samples":[50],"were":[51,67,87,133,164],"taken":[52],"from":[53],"454":[54],"Japanese":[55],"subjects.":[56],"The":[57,98],"interleukin-2":[58],"(IL-2;":[59],"T-330G),":[60],"IL-4":[61,121],"(C-33T),":[62],"and":[63,82,85,94,159,181,188,236],"IL-13":[64,144],"(C-1111T)":[65],"genotyped":[68],"polymerase":[70],"chain":[71],"reaction":[72],"with":[73,136,148,210,224],"confronting":[74],"two-pair":[75],"primers":[76],"(PCR-CTPP).":[77],"Anti-H.":[78],"IgG":[80],"antibody":[81],"pepsinogen":[83],"I":[84],"II":[86],"measured":[88],"diagnose":[90],"infection":[93,235],"atrophic":[95],"gastritis.":[96],"RESULTS:":[97],"odds":[99],"ratios":[100],"(ORs)":[101],"for":[102],"association":[104,209],"between":[105,171,178],"IL-2":[106,197,219],"polymorphism":[107,122,145,221],"[OR":[108,123,151],"=":[109,115,124,128,152,156,200,204],"2.78,":[110,201],"95%":[111,126,154,202],"CI":[112,127,155,203],"(confidence":[113],"interval)":[114],"1.26-6.17":[116],"(T/T":[117],"G/G)]":[119],"or":[120],"2.22,":[125],"1.01-4.89":[129],"(T/C":[130],"C/C)]":[132],"increased":[134,226],"significantly":[135],"atrophy,":[138],"whereas":[139],"corresponding":[141],"OR":[142],"was":[146],"decreased":[147],"0.61,":[153],"0.39-0.96":[157],"(C/T":[158],"T/T":[160,198],"C/C)].":[162],"There":[163],"no":[165],"significant":[166,208],"seropositivity-related":[169],"differences":[170],"these":[172,179],"polymorphisms.":[173],"We":[174],"relationship":[177],"separately":[184],"in":[185],"pylori-seropositive":[187,194],"-seronegative":[189],"groups.":[190],"group,":[195],"(OR":[199],"1.12-6.93)":[205],"had":[206],"a":[207],"CONCLUSIONS:":[213],"These":[214],"results":[215],"reveal":[216],"gene":[220],"associated":[223],"an":[225],"risk":[227],"might":[237],"cancer.":[241]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}