{"id":"https://openalex.org/W2145354356","doi":null,"title":"Mammary fibroblast influence on normal mouse mammary epithelial cell responses to estrogen in vitro.","display_name":"Mammary fibroblast influence on normal mouse mammary epithelial cell responses to estrogen in vitro.","publication_year":1986,"publication_date":"1986-01-01","ids":{"openalex":"https://openalex.org/W2145354356","mag":"2145354356","pmid":"https://pubmed.ncbi.nlm.nih.gov/3940197"},"language":"en","primary_location":{"id":"pmid:3940197","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3940197","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045100047","display_name":"Sandra Z. Haslam","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"S Z Haslam","raw_affiliation_strings":["Physiology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physiology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5045100047"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.0165,"has_fulltext":false,"cited_by_count":115,"citation_normalized_percentile":{"value":0.97450425,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"46","issue":"1","first_page":"310","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11134","display_name":"Breast Lesions and Carcinomas","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mammary-fibroblasts","display_name":"mammary fibroblasts","score":0.9890000224113464},{"id":"https://openalex.org/keywords/mammary-epithelial-cells","display_name":"mammary epithelial cells","score":0.9990000128746033},{"id":"https://openalex.org/keywords/estrogen-responsiveness","display_name":"estrogen response","score":0.7039999961853027},{"id":"https://openalex.org/keywords/progesterone-receptor","display_name":"progesterone receptor","score":0.9950000047683716},{"id":"https://openalex.org/keywords/epithelial-stromal-interactions","display_name":"stromal-epithelial interactions","score":0.9539999961853027},{"id":"https://openalex.org/keywords/co-culture","display_name":"co-culture","score":0.7139999866485596},{"id":"https://openalex.org/keywords/conditioned-medium","display_name":"conditioned medium","score":0.7979999780654907},{"id":"https://openalex.org/keywords/substrate-effects","display_name":"substrate effects","score":0.8510000109672546},{"id":"https://openalex.org/keywords/type-i-collagen","display_name":"type I collagen","score":0.7979999780654907},{"id":"https://openalex.org/keywords/intercellular-communication","display_name":"intercellular communication","score":0.6700000166893005},{"id":"https://openalex.org/keywords/dna-synthesis","display_name":"DNA synthesis","score":0.8270000219345093},{"id":"https://openalex.org/keywords/mammary-gland","display_name":"mammary gland","score":0.6150000095367432},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.3409999907016754}],"concepts":[{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.7136037349700928},{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.7083044052124023},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.5546501874923706},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5490997433662415},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5199557542800903},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.49753692746162415},{"id":"https://openalex.org/C64241487","wikidata":"https://www.wikidata.org/wiki/Q5205774","display_name":"DNA synthesis","level":3,"score":0.4913093149662018},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.47078078985214233},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4496137499809265},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.43578967452049255},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4307311773300171},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.4281570613384247},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.40393972396850586},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3872014582157135},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10151076316833496},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09485390782356262},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008321","descriptor_name":"Mammary Glands, Animal","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D008321","descriptor_name":"Mammary Glands, Animal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011980","descriptor_name":"Receptors, Progesterone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:3940197","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3940197","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.333.6244","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.333.6244","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://cancerres.aacrjournals.org/content/46/1/310.full.pdf","raw_type":"text"},{"id":"mag:2145354356","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3940197","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.428600013256073,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W203704018","https://openalex.org/W1502753042","https://openalex.org/W1548207273","https://openalex.org/W1568788836","https://openalex.org/W1569754307","https://openalex.org/W1983649348","https://openalex.org/W2038022884","https://openalex.org/W2041129279","https://openalex.org/W2045959446","https://openalex.org/W2049316862","https://openalex.org/W2062461352","https://openalex.org/W2090766667","https://openalex.org/W2109060646","https://openalex.org/W2113703378","https://openalex.org/W2123929920","https://openalex.org/W2152787725","https://openalex.org/W2153276715","https://openalex.org/W2165141978","https://openalex.org/W2413441027"],"related_works":["https://openalex.org/W7100001348","https://openalex.org/W2036012856","https://openalex.org/W2090766667","https://openalex.org/W2032643503","https://openalex.org/W1984836149","https://openalex.org/W1983624471","https://openalex.org/W1972954488","https://openalex.org/W1969947361","https://openalex.org/W1548207273","https://openalex.org/W1969363481"],"abstract_inverted_index":{"Estrogen-dependent":[0],"stimulation":[1,75,86,97,143,174],"of":[2,10,26,34,47,76,87,98,105,117,144,175,225,238],"progesterone":[3],"receptor":[4],"(PgR)":[5],"concentration":[6],"or":[7,61,63,83,111,198],"cell":[8,185,246],"proliferation":[9],"normal":[11,258],"mammary":[12,27,45,54,261],"epithelial":[13,38,41,162,169,182,226,245],"cells":[14,42,68,170,227],"in":[15,154,158,180,253],"vitro":[16],"has":[17],"been":[18],"shown":[19],"to":[20,210,228,248],"be":[21,211],"associated":[22],"with":[23,53,64,120,161],"the":[24,32,103,132,235],"presence":[25,104],"fibroblasts.":[28],"To":[29],"investigate":[30],"further":[31],"nature":[33,237],"fibroblast":[35,176,184],"influence":[36,221],"on":[37],"cells,":[39],"Percoll-purified":[40],"from":[43],"collagenase-dissociated":[44],"glands":[46],"mid-pregnant":[48],"BALB/c":[49],"mice":[50],"were":[51,57,69,152,187],"co-cultured":[52],"fibroblasts":[55,110,129,151,219],"that":[56,96,128,195,234],"either":[58,73,108],"untreated,":[59],"irradiated,":[60],"glutaraldehyde-killed":[62,109],"fibroblast-conditioned":[65],"medium.":[66],"Epithelial":[67],"then":[70],"assayed":[71],"for":[72,84],"estrogen-dependent":[74,85,142,173],"PgR":[77,99,133],"by":[78,90,217],"measuring":[79],"specific":[80,223,236],"[3H]R5020":[81],"binding":[82],"DNA":[88,145,177],"synthesis":[89,146],"[3H]thymidine":[91],"autoradiography.":[92],"The":[93,230],"results":[94,232],"demonstrate":[95,233],"does":[100],"not":[101],"require":[102],"live":[106,150],"fibroblasts;":[107],"conditioned":[112],"medium":[113],"was":[114,124],"effective.":[115],"Pretreatment":[116],"culture":[118],"dishes":[119],"type":[121],"I":[122],"collagen":[123],"equally":[125],"effective,":[126],"indicating":[127],"may":[130,251],"promote":[131],"response":[134],"via":[135],"a":[136],"substratum":[137],"effect.":[138],"In":[139],"distinct":[140],"contrast,":[141],"occurred":[147],"only":[148],"when":[149],"present":[153,231],"high":[155],"numbers":[156],"and/or":[157],"direct":[159],"contact":[160],"cells.":[163,262],"Furthermore,":[164],"under":[165,190],"these":[166],"latter":[167],"conditions,":[168,192],"also":[171,188],"promoted":[172],"synthesis.":[178],"Differences":[179],"both":[181],"and":[183,204,243,250,259],"morphologies":[186],"observed":[189],"co-culture":[191],"which":[193,218],"suggested":[194],"cell-cell":[196],"communication":[197],"another":[199],"interactive":[200],"phenomenon":[201],"takes":[202],"place":[203],"is":[205],"bidirectional.":[206],"Thus":[207],"there":[208],"appear":[209],"at":[212],"least":[213],"two":[214,222],"different":[215],"mechanisms":[216],"can":[220,241],"responses":[224,247],"estrogen.":[229],"epithelial-stromal":[239],"interactions":[240],"determine":[242],"modulate":[244],"estrogen":[249],"reflect":[252],"vivo":[254],"regulatory":[255],"processes":[256],"affecting":[257],"neoplastic":[260]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}