{"id":"https://openalex.org/W2145343046","doi":null,"title":"Lewis and secretor gene dosages affect CA19-9 and DU-PAN-2 serum levels in normal individuals and colorectal cancer patients.","display_name":"Lewis and secretor gene dosages affect CA19-9 and DU-PAN-2 serum levels in normal individuals and colorectal cancer patients.","publication_year":1998,"publication_date":"1998-02-01","ids":{"openalex":"https://openalex.org/W2145343046","mag":"2145343046","pmid":"https://pubmed.ncbi.nlm.nih.gov/9458099"},"language":"en","primary_location":{"id":"pmid:9458099","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9458099","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033004946","display_name":"Hisashi Narimatsu","orcid":"https://orcid.org/0000-0002-8402-133X","observed_orcids":["https://orcid.org/0000-0002-8402-133X"]},"institutions":[{"id":"https://openalex.org/I4210088637","display_name":"Soka University","ror":"https://ror.org/003qdfg20","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210088637"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H Narimatsu","raw_affiliation_strings":["Division of Cell Biology, Institute of Life Science, Soka University, Hachioji, Toyko, Japan. hisashi@scc1.t.soka.ac.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cell Biology, Institute of Life Science, Soka University, Hachioji, Toyko, Japan. hisashi@scc1.t.soka.ac.jp","institution_ids":["https://openalex.org/I4210088637"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028815367","display_name":"Hiroko Iwasaki","orcid":"https://orcid.org/0000-0002-5682-6835","observed_orcids":["https://orcid.org/0000-0002-5682-6835"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Iwasaki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"F Nakayama","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F Nakayama","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014499294","display_name":"Yuzuru Ikehara","orcid":"https://orcid.org/0000-0002-1915-9172","observed_orcids":["https://orcid.org/0000-0002-1915-9172"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Ikehara","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087276601","display_name":"Takashi Kudo","orcid":"https://orcid.org/0000-0001-5477-7235","observed_orcids":["https://orcid.org/0000-0001-5477-7235"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Kudo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025429263","display_name":"Shoko Nishihara","orcid":"https://orcid.org/0000-0002-1668-2603","observed_orcids":["https://orcid.org/0000-0002-1668-2603"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Nishihara","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057745107","display_name":"Koukichi Sugano","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Sugano","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"H Okura","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Okura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101112163","display_name":"Shin Fujita","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Fujita","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5113642726","display_name":"S Hirohashi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Hirohashi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.5191,"has_fulltext":false,"cited_by_count":204,"citation_normalized_percentile":{"value":0.90478367,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"58","issue":"3","first_page":"512","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.73580002784729,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.73580002784729,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11660","display_name":"Blood groups and transfusion","score":0.20419999957084656,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.008500000461935997,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/secretor-gene","display_name":"secretor gene","score":0.9860000014305115},{"id":"https://openalex.org/keywords/ca19-9","display_name":"CA19-9","score":0.8460000157356262},{"id":"https://openalex.org/keywords/dupan-2","display_name":"DUPAN-2","score":0.9919999837875366},{"id":"https://openalex.org/keywords/serum-tumor-markers","display_name":"serum tumor markers","score":0.6019999980926514},{"id":"https://openalex.org/keywords/gene-dosage","display_name":"gene dosage","score":0.7020000219345093},{"id":"https://openalex.org/keywords/lewis-antigens","display_name":"Lewis antigens","score":0.3409999907016754},{"id":"https://openalex.org/keywords/secretor-status","display_name":"secretor status","score":0.777999997138977},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9089999794960022},{"id":"https://openalex.org/keywords/cancer-diagnosis","display_name":"cancer diagnosis","score":0.5569999814033508},{"id":"https://openalex.org/keywords/cutoff-values","display_name":"cut-off values","score":0.5770000219345093},{"id":"https://openalex.org/keywords/normal-individuals","display_name":"normal individuals","score":0.4909999966621399},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.4729999899864197},{"id":"https://openalex.org/keywords/lewis-a-antigen","display_name":"Lewis a antigen","score":0.7089999914169312},{"id":"https://openalex.org/keywords/lewis-x-antigen","display_name":"Lewis X antigen","score":0.5059999823570251},{"id":"https://openalex.org/keywords/lewis-y-antigen","display_name":"Lewis Y antigen","score":0.5640000104904175}],"concepts":[{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.5276238918304443},{"id":"https://openalex.org/C144369459","wikidata":"https://www.wikidata.org/wiki/Q182517","display_name":"CA19-9","level":4,"score":0.5006556510925293},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4777090549468994},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.47371214628219604},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3857736587524414},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.317508727312088},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.30037587881088257},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.28545016050338745},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24273815751075745},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20839783549308777},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.1620389223098755}],"mesh":[{"descriptor_ui":"D000097631","descriptor_name":"Galactoside 2-alpha-L-fucosyltransferase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000951","descriptor_name":"Antigens, Neoplasm","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000951","descriptor_name":"Antigens, Neoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002240","descriptor_name":"Carbohydrate Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005647","descriptor_name":"Fucosyltransferases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006031","descriptor_name":"Glycosylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018395","descriptor_name":"CA-19-9 Antigen","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D018395","descriptor_name":"CA-19-9 Antigen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018628","descriptor_name":"Gene Dosage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:9458099","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9458099","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:2145343046","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9458099","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9907000064849854}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1505719156","https://openalex.org/W1522834771","https://openalex.org/W1558984579","https://openalex.org/W1602574787","https://openalex.org/W1754937767","https://openalex.org/W2016590404","https://openalex.org/W2037686150","https://openalex.org/W2045478474","https://openalex.org/W2061211069","https://openalex.org/W2073142557","https://openalex.org/W2073196985","https://openalex.org/W2078179498","https://openalex.org/W2094438579","https://openalex.org/W2101543964","https://openalex.org/W2105311240","https://openalex.org/W2136911663","https://openalex.org/W2399460951","https://openalex.org/W2401833872","https://openalex.org/W2700239370"],"related_works":["https://openalex.org/W2029523909","https://openalex.org/W7096895605","https://openalex.org/W2145420930","https://openalex.org/W2522275215","https://openalex.org/W7100827065","https://openalex.org/W2107693408","https://openalex.org/W2037686150","https://openalex.org/W2255029149","https://openalex.org/W2886957599","https://openalex.org/W2399460951"],"abstract_inverted_index":{"The":[0,59,122,144,208,258],"effect":[1],"of":[2,4,16,162,186,263,302,312,326],"doses":[3],"the":[5,13,31,38,44,50,56,139,163,168,187,225,234,273,313],"secretor":[6],"(Se)":[7],"and":[8,18,40,53,71,79,84,89,94,99,104,109,114,116,120,132,174,194,214,237,245,260,272,275],"Lewis":[9],"(Le)":[10],"genes":[11],"on":[12],"serum":[14],"levels":[15],"CA19-9":[17,39,51,142,145,179,244,274,294,321,332],"DU-PAN-2":[19,41,57,200,221,276,307,330,339,352],"was":[20,27],"investigated":[21],"in":[22,152,158,205,211,228,248,357],"400":[23,60],"normal":[24,61],"individuals.":[25],"It":[26],"clearly":[28,147],"demonstrated":[29],"that":[30,233],"Se":[32,72,129,188,238,261],"gene":[33,46],"dosage":[34,47],"negatively":[35,54],"affected":[36,49,55],"both":[37],"values,":[42,180,295,322],"whereas":[43,323],"Le":[45,70,135,236,259],"positively":[48],"value":[52,146,201,222],"value.":[58,143],"individuals":[62,165,192,204,210,227],"were":[63,269,278],"separated":[64],"into":[65],"nine":[66],"groups":[67,212,229],"by":[68],"their":[69],"genotypes,":[73],"as":[74],"follows:":[75],"group":[76,81,86,91,96,101,106,111,117,123,153,159],"1,":[77],"Le/Le":[78,88,98],"se/se;":[80,85,110],"2,":[82],"Le/le":[83,93,103],"3,":[87],"Se/se;":[90,95,115],"4,":[92],"5,":[97],"Se/Se;":[100,105],"6,":[102],"7,":[107,172],"le/le":[108,113,119,169],"8,":[112,173],"9,":[118],"Se/Se.":[121],"1":[124,154],"individuals,":[125],"having":[126],"homozygous":[127,133],"inactive":[128],"alleles":[130,136],"(se/se)":[131],"active":[134],"(Le/Le),":[137],"exhibited":[138,304,328],"highest":[140],"mean":[141,199,220],"ranged":[148],"from":[149],"a":[150,156,197,218],"high":[151],"to":[155],"low":[157],"9.":[160],"All":[161,283],"Le-negative":[164,209,285,350,358],"who":[166],"had":[167,176,319],"genotype":[170],"(groups":[171],"9)":[175],"completely":[177],"negative":[178],"i.e.,":[181,296],"under":[182,297],"1.0":[183,298],"unit/ml,":[184,299],"irrespective":[185],"genotype.":[189],"Group":[190],"7":[191],"(le/le":[193],"se/se)":[195],"showed":[196,217,292],"higher":[198,219],"than":[202,223,337],"did":[203,224],"other":[206],"groups.":[207],"8":[213],"9":[215],"also":[216,270],"Le-positive":[226,314,342],"1-6.":[230],"We":[231],"recommend":[232],"revised":[235],"genotype-dependent":[239],"positive/negative":[240],"cutoff":[241],"values":[242,277],"for":[243,253,341,349,360],"DU-PAN-2,":[246],"determined":[247],"this":[249],"study,":[250],"be":[251,355],"applied":[252],"more":[254,335],"accurate":[255],"cancer":[256,268,290,361],"diagnoses.":[257],"genotypes":[262],"168":[264],"patients":[265,286,315,359],"with":[266,288],"colorectal":[267,289],"examined,":[271],"measured":[279],"before":[280],"surgical":[281],"resection.":[282],"15":[284],"(le/le)":[287],"again":[291],"undetectable":[293],"but":[300,344],"many":[301,311],"them":[303,327],"highly":[305],"positive":[306,320,329],"values.":[308,331],"In":[309],"contrast,":[310],"(Le/Le":[316],"or":[317],"Le/le)":[318],"very":[324],"few":[325],"measurement":[333,340,353],"is":[334,338,346],"useful":[336,348],"patients,":[343],"it":[345],"not":[347],"ones.":[351],"should":[354],"performed":[356],"diagnosis.":[362]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":16},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}