{"id":"https://openalex.org/W2145294053","doi":"https://doi.org/10.2337/diab.27.9.895","title":"Reduced Erythrocyte Deformability in Diabetes","display_name":"Reduced Erythrocyte Deformability in Diabetes","publication_year":1978,"publication_date":"1978-09-01","ids":{"openalex":"https://openalex.org/W2145294053","doi":"https://doi.org/10.2337/diab.27.9.895","mag":"2145294053","pmid":"https://pubmed.ncbi.nlm.nih.gov/689301"},"language":"en","primary_location":{"id":"doi:10.2337/diab.27.9.895","doi":"https://doi.org/10.2337/diab.27.9.895","is_oa":false,"landing_page_url":"https://doi.org/10.2337/diab.27.9.895","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113553673","display_name":"D. E. McMillan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801628713","display_name":"Sansum Medical Clinic","ror":"https://ror.org/04rx0dh54","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801628713"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donald E McMillan","raw_affiliation_strings":["Sansum Medical Research Foundation\u2008Santa Barbara, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sansum Medical Research Foundation\u2008Santa Barbara, California","institution_ids":["https://openalex.org/I2801628713"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003856707","display_name":"Nyle Gene Utterback","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801628713","display_name":"Sansum Medical Clinic","ror":"https://ror.org/04rx0dh54","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801628713"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nyle G Utterback","raw_affiliation_strings":["Sansum Medical Research Foundation\u2008Santa Barbara, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sansum Medical Research Foundation\u2008Santa Barbara, California","institution_ids":["https://openalex.org/I2801628713"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045973047","display_name":"John La Puma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801628713","display_name":"Sansum Medical Clinic","ror":"https://ror.org/04rx0dh54","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801628713"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John La Puma","raw_affiliation_strings":["Sansum Medical Research Foundation\u2008Santa Barbara, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sansum Medical Research Foundation\u2008Santa Barbara, California","institution_ids":["https://openalex.org/I2801628713"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2801628713"],"apc_list":null,"apc_paid":null,"fwci":10.7441,"has_fulltext":false,"cited_by_count":349,"citation_normalized_percentile":{"value":0.98815648,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"27","issue":"9","first_page":"895","last_page":"901"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12286","display_name":"Erythrocyte Function and Pathophysiology","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11379","display_name":"Rheology and Fluid Dynamics Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1507","display_name":"Fluid Flow and Transfer Processes"},"field":{"id":"https://openalex.org/fields/15","display_name":"Chemical Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/erythrocyte-deformability","display_name":"erythrocyte deformability","score":0.9990000128746033},{"id":"https://openalex.org/keywords/membrane-viscosity","display_name":"membrane viscosity","score":0.5950000286102295},{"id":"https://openalex.org/keywords/intracellular-viscosity","display_name":"intracellular viscosity","score":0.7760000228881836},{"id":"https://openalex.org/keywords/hba1c","display_name":"HbA1c","score":0.8460000157356262},{"id":"https://openalex.org/keywords/hereditary-spherocytosis","display_name":"hereditary spherocytosis","score":0.9539999961853027},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.9760000109672546},{"id":"https://openalex.org/keywords/alloxan-induced-diabetes","display_name":"alloxan-induced diabetes","score":0.8090000152587891},{"id":"https://openalex.org/keywords/capillary-hemodynamics","display_name":"capillary hemodynamics","score":0.6100000143051147}],"concepts":[{"id":"https://openalex.org/C2776185378","wikidata":"https://www.wikidata.org/wiki/Q5396464","display_name":"Erythrocyte deformability","level":3,"score":0.8034337759017944},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5794094800949097},{"id":"https://openalex.org/C2778917026","wikidata":"https://www.wikidata.org/wiki/Q43041","display_name":"Hemoglobin","level":2,"score":0.5772533416748047},{"id":"https://openalex.org/C12722491","wikidata":"https://www.wikidata.org/wiki/Q1632335","display_name":"Microcirculation","level":2,"score":0.5681776404380798},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5476993918418884},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5419512391090393},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.501354455947876},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.49966859817504883},{"id":"https://openalex.org/C2994203641","wikidata":"https://www.wikidata.org/wiki/Q5712543","display_name":"Blood viscosity","level":2,"score":0.49469777941703796},{"id":"https://openalex.org/C2776557347","wikidata":"https://www.wikidata.org/wiki/Q37187","display_name":"Red blood cell","level":2,"score":0.48587340116500854},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.44454145431518555},{"id":"https://openalex.org/C2993443003","wikidata":"https://www.wikidata.org/wiki/Q37187","display_name":"Erythrocyte membrane","level":3,"score":0.4241645932197571},{"id":"https://openalex.org/C2777208419","wikidata":"https://www.wikidata.org/wiki/Q4347672","display_name":"Red Cell","level":2,"score":0.4184782803058624},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3552306294441223},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.33750563859939575},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23432981967926025},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.21766459941864014},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18912971019744873}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011312","descriptor_name":"Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013103","descriptor_name":"Spherocytosis, Hereditary","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D013499","descriptor_name":"Surface Properties","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.2337/diab.27.9.895","doi":"https://doi.org/10.2337/diab.27.9.895","is_oa":false,"landing_page_url":"https://doi.org/10.2337/diab.27.9.895","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},{"id":"pmid:689301","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/689301","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":5,"referenced_works":["https://openalex.org/W2071354653","https://openalex.org/W2073620575","https://openalex.org/W2085831998","https://openalex.org/W2092768865","https://openalex.org/W2461110131"],"related_works":["https://openalex.org/W131699767","https://openalex.org/W2561018468","https://openalex.org/W2461720415","https://openalex.org/W7016818005","https://openalex.org/W2565280139","https://openalex.org/W2274460736","https://openalex.org/W2564934596","https://openalex.org/W2513368942","https://openalex.org/W2566518358","https://openalex.org/W2090479050"],"abstract_inverted_index":{"The":[0,16,49,184],"flow":[1,92,188,199],"properties":[2,189],"of":[3,68,151,190,200],"individual":[4,191,212],"erythrocytes":[5,44,69,108,132,192,213],"have":[6],"been":[7],"studied":[8],"in":[9,30,37,46,80,187],"glass":[10],"micropipets":[11],"4":[12],"\u03bc":[13],"internal":[14],"diameter.":[15],"pressure":[17,50,105,209],"gradient":[18],"required":[19,81,103],"to":[20,118,148,159,162],"establish":[21],"a":[22,27,31,77,112,119],"standard":[23],"oscillatory":[24],"movement":[25],"over":[26],"130-\u03bc":[28],"path":[29],"three-second":[32],"time":[33],"period":[34],"was":[35,52],"measured":[36],"paired":[38],"studies":[39],"comparing":[40,70],"diabetic":[41,57,95,131],"and":[42,97,206],"control":[43,74],"suspended":[45],"Ringer":[47],"solution.":[48],"requirement":[51],"regularly":[53,166],"elevated":[54],"for":[55],"the":[56,65,198,208,215],"erythrocytes,":[58,140],"averaging":[59],"50":[60],"per":[61],"cent":[62],"greater":[63],"than":[64,94,138,158],"controls.":[66],"Studies":[67],"alloxan-diabetic":[71],"rats":[72,75],"with":[73,87,168],"demonstrated":[76],"similar":[78],"elevation":[79,150],"pressure.":[82],"Red":[83],"cells":[84,99],"from":[85,100,111],"subjects":[86],"hereditary":[88],"spherocytosis":[89],"offered":[90],"less":[91,136],"resistance":[93,161],"cells,":[96],"red":[98],"rheumatoid":[101],"arthritics":[102],"no":[104],"increment.":[106],"When":[107],"are":[109],"ejected":[110],"4-\u03bc":[113],"micropipet":[114],"they":[115],"return":[116],"quickly":[117],"discoid":[120],"shape":[121,135],"using":[122],"stored":[123],"elastic":[124],"energy.":[125],"Slow":[126],"motion":[127],"photography":[128],"revealed":[129],"that":[130,142,177],"restore":[133],"their":[134,143],"rapidly":[137],"nondiabetic":[139],"indicating":[141],"reduced":[144],"deformability":[145],"is":[146,165,175,193],"due":[147],"an":[149,169],"either":[152],"intraerythrocyte":[153,182],"or":[154],"membrane":[155],"viscosity":[156],"rather":[157],"increased":[160,170],"bending.":[163],"Diabetes":[164],"associated":[167],"intracellular":[171],"hemoglobin":[172,178],"Alc;":[173],"it":[174],"possible":[176],"Ale":[179],"could":[180],"raise":[181],"viscosity.":[183],"observed":[185],"disturbance":[186],"subtle.":[194],"It":[195],"would":[196],"affect":[197],"blood,":[201],"particularly":[202],"through":[203],"active":[204],"muscle,":[205],"modify":[207],"exerted":[210],"by":[211],"on":[214],"muscle":[216],"capillary":[217],"wall.":[218]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
