{"id":"https://openalex.org/W2145289684","doi":"https://doi.org/10.2337/diacare.26.9.2689","title":"Trials in Neuropathic Diabetic Foot Ulceration","display_name":"Trials in Neuropathic Diabetic Foot Ulceration","publication_year":2003,"publication_date":"2003-09-01","ids":{"openalex":"https://openalex.org/W2145289684","doi":"https://doi.org/10.2337/diacare.26.9.2689","mag":"2145289684","pmid":"https://pubmed.ncbi.nlm.nih.gov/12941739"},"language":"en","primary_location":{"id":"doi:10.2337/diacare.26.9.2689","doi":"https://doi.org/10.2337/diacare.26.9.2689","is_oa":true,"landing_page_url":"https://doi.org/10.2337/diacare.26.9.2689","pdf_url":"https://diabetesjournals.org/care/article-pdf/26/9/2689/665203/dc0903002689.pdf","source":{"id":"https://openalex.org/S49878492","display_name":"Diabetes Care","issn_l":"0149-5992","issn":["0149-5992","1935-5548"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes Care","raw_type":"journal-article"},"volume":null,"type":"editorial","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://diabetesjournals.org/care/article-pdf/26/9/2689/665203/dc0903002689.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033575514","display_name":"Andrew J.M. Boulton","orcid":"https://orcid.org/0000-0001-7856-1201","observed_orcids":["https://orcid.org/0000-0001-7856-1201"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]},{"id":"https://openalex.org/I2801926401","display_name":"Manchester Royal Infirmary","ror":"https://ror.org/03kr30n36","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801926401","https://openalex.org/I4210092852"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Andrew J. M. Boulton","raw_affiliation_strings":["Department of Medicine, Manchester Royal Infirmary, Manchester, U.K","Division of Endocrinology, Metabolism and Diabetes, University of Miami School of Medicine, Miami, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Manchester Royal Infirmary, Manchester, U.K","institution_ids":["https://openalex.org/I2801926401"]},{"raw_affiliation_string":"Division of Endocrinology, Metabolism and Diabetes, University of Miami School of Medicine, Miami, Florida","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034035627","display_name":"David G. Armstrong","orcid":"https://orcid.org/0000-0003-1887-9175","observed_orcids":["https://orcid.org/0000-0003-1887-9175","https://orcid.org/0000-0001-5533-8648","https://orcid.org/0000-0003-3652-9662","https://orcid.org/0000-0002-5067-5108"]},"institutions":[{"id":"https://openalex.org/I2801926401","display_name":"Manchester Royal Infirmary","ror":"https://ror.org/03kr30n36","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801926401","https://openalex.org/I4210092852"]},{"id":"https://openalex.org/I4210098770","display_name":"Southern Arizona VA Health Care System","ror":"https://ror.org/00xb4cb83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210098770","https://openalex.org/I4210138663"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"David G. Armstrong","raw_affiliation_strings":["Department of Medicine, Manchester Royal Infirmary, Manchester, U.K","Department of Surgery, Southern Arizona Veterans Affairs Medical Center, Tucson, Arizona"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Manchester Royal Infirmary, Manchester, U.K","institution_ids":["https://openalex.org/I2801926401"]},{"raw_affiliation_string":"Department of Surgery, Southern Arizona Veterans Affairs Medical Center, Tucson, Arizona","institution_ids":["https://openalex.org/I4210098770"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":27,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"26","issue":"9","first_page":"2689","last_page":"2690"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11227","display_name":"Diabetic Foot Ulcer Assessment and Management","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11227","display_name":"Diabetic Foot Ulcer Assessment and Management","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12433","display_name":"Skin Diseases and Diabetes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diabetic-foot-ulcer","display_name":"diabetic foot ulcer","score":0.9670000076293945},{"id":"https://openalex.org/keywords/neuropathic-ulcer","display_name":"neuropathic ulcer","score":0.859000027179718},{"id":"https://openalex.org/keywords/low-molecular-weight-heparin","display_name":"low molecular weight heparin","score":0.8809999823570251},{"id":"https://openalex.org/keywords/subcutaneous-anticoagulation","display_name":"subcutaneous anticoagulation","score":0.7879999876022339},{"id":"https://openalex.org/keywords/ulcer-healing","display_name":"ulcer healing","score":0.7379999756813049},{"id":"https://openalex.org/keywords/amputation-prevention","display_name":"amputation prevention","score":0.9440000057220459},{"id":"https://openalex.org/keywords/limb-ischemia","display_name":"limb ischemia","score":0.753000020980835},{"id":"https://openalex.org/keywords/randomized-controlled-trials","display_name":"randomized controlled trials","score":0.527999997138977}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9740238189697266},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.787028431892395},{"id":"https://openalex.org/C2777858829","wikidata":"https://www.wikidata.org/wiki/Q52856","display_name":"Diabetic foot","level":3,"score":0.6371449828147888},{"id":"https://openalex.org/C115076146","wikidata":"https://www.wikidata.org/wiki/Q1651051","display_name":"Foot (prosody)","level":2,"score":0.5342843532562256},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.42366528511047363},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36339515447616577},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.11307266354560852},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003925","descriptor_name":"Diabetic Angiopathies","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D003929","descriptor_name":"Diabetic Neuropathies","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017719","descriptor_name":"Diabetic Foot","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.2337/diacare.26.9.2689","doi":"https://doi.org/10.2337/diacare.26.9.2689","is_oa":true,"landing_page_url":"https://doi.org/10.2337/diacare.26.9.2689","pdf_url":"https://diabetesjournals.org/care/article-pdf/26/9/2689/665203/dc0903002689.pdf","source":{"id":"https://openalex.org/S49878492","display_name":"Diabetes Care","issn_l":"0149-5992","issn":["0149-5992","1935-5548"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes Care","raw_type":"journal-article"},{"id":"pmid:12941739","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12941739","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes care","raw_type":"Comment"}],"best_oa_location":{"id":"doi:10.2337/diacare.26.9.2689","doi":"https://doi.org/10.2337/diacare.26.9.2689","is_oa":true,"landing_page_url":"https://doi.org/10.2337/diacare.26.9.2689","pdf_url":"https://diabetesjournals.org/care/article-pdf/26/9/2689/665203/dc0903002689.pdf","source":{"id":"https://openalex.org/S49878492","display_name":"Diabetes Care","issn_l":"0149-5992","issn":["0149-5992","1935-5548"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes Care","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2145289684.pdf","grobid_xml":"https://content.openalex.org/works/W2145289684.grobid-xml"},"referenced_works_count":15,"referenced_works":["https://openalex.org/W1965083498","https://openalex.org/W1988354642","https://openalex.org/W2019116055","https://openalex.org/W2044268047","https://openalex.org/W2045730284","https://openalex.org/W2057880427","https://openalex.org/W2069157301","https://openalex.org/W2101004085","https://openalex.org/W2101175252","https://openalex.org/W2107085531","https://openalex.org/W2126874651","https://openalex.org/W2163459939","https://openalex.org/W2261212947","https://openalex.org/W4230561599","https://openalex.org/W4241328394"],"related_works":["https://openalex.org/W2779521819","https://openalex.org/W2890626748","https://openalex.org/W2042295015","https://openalex.org/W1468800924","https://openalex.org/W2189568502","https://openalex.org/W2145873932","https://openalex.org/W2330324607","https://openalex.org/W2786756527","https://openalex.org/W3117433682","https://openalex.org/W2350844655"],"abstract_inverted_index":{"Diabetic":[0],"foot":[1,30,48],"ulceration":[2],"is":[3,56,86],"a":[4,106],"serious":[5],"and":[6,78,84,139],"expensive":[7],"complication":[8],"with":[9,111,134],"considerable":[10],"morbidity":[11],"that":[12,50],"affects":[13],"up":[14],"to":[15,80,89,116,128,136],"15%":[16],"of":[17,25,45,63,66,93,101],"diabetic":[18],"patients":[19,110],"during":[20],"their":[21,42],"lifetime;":[22],"moreover,":[23],"\u223c80%":[24],"amputations":[26],"are":[27,142],"preceded":[28],"by":[29],"ulcers":[31,72,113],"(1).":[32],"Despite":[33],"these":[34],"facts,":[35],"Mason":[36],"et":[37,95],"al.":[38,96],"(2)":[39],"concluded":[40],"in":[41,98,151],"systematic":[43],"review":[44],"treatments":[46,55,69,147],"for":[47,54,70,148],"lesions":[49],"the":[51,61,91],"evidence":[52],"base":[53],"poor.":[57],"Furthermore,":[58],"they":[59],"criticized":[60],"majority":[62],"published":[64],"trials":[65],"potentially":[67,144],"promising":[68],"neuropathic":[71],"as":[73],"being":[74],"small,":[75],"inadequately":[76],"powered,":[77],"failing":[79],"use":[81],"standardized":[82],"methods":[83],"outcomes.\n\nIt":[85],"therefore":[87],"refreshing":[88],"read":[90],"work":[92],"Kalani":[94],"(3)":[97],"this":[99],"issue":[100],"Diabetes":[102],"Care":[103],".":[104],"In":[105],"well-designed":[107],"controlled":[108],"trial,":[109],"neuroischemic":[112],"were":[114],"randomized":[115,127],"receive":[117],"daily":[118],"subcutaneous":[119],"low-molecular":[120],"weight":[121],"heparin":[122],"(LMWH)":[123],"or":[124],"placebo.":[125],"Those":[126],"LMWH":[129],"had":[130],"significantly":[131],"better":[132],"outcomes":[133],"respect":[135],"healing":[137],"rates":[138],"amputation.":[140],"There":[141],"also":[143],"exciting":[145],"new":[146],"ischemic":[149],"limbs":[150],"diabetes":[152],"(4,5).":[153],"Therapeutic":[154],"\u2026":[155]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}