{"id":"https://openalex.org/W2145257181","doi":"https://doi.org/10.1093/jb/mvv029","title":"Ral GTPases: crucial mediators of exocytosis and tumourigenesis","display_name":"Ral GTPases: crucial mediators of exocytosis and tumourigenesis","publication_year":2015,"publication_date":"2015-03-20","ids":{"openalex":"https://openalex.org/W2145257181","doi":"https://doi.org/10.1093/jb/mvv029","mag":"2145257181","pmid":"https://pubmed.ncbi.nlm.nih.gov/25796063"},"language":"en","primary_location":{"id":"doi:10.1093/jb/mvv029","doi":"https://doi.org/10.1093/jb/mvv029","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jb/mvv029","pdf_url":null,"source":{"id":"https://openalex.org/S184547178","display_name":"The Journal of Biochemistry","issn_l":"0021-924X","issn":["0021-924X","1756-2651"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biochemistry","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065164908","display_name":"Ryutaro Shirakawa","orcid":"https://orcid.org/0000-0002-2561-9796","observed_orcids":["https://orcid.org/0000-0002-2561-9796"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]},{"id":"https://openalex.org/I4405286073","display_name":"Institute of Development, Aging and Cancer, Tohoku University","ror":"https://ror.org/012s2xh05","country_code":"JP","type":"facility","lineage":["https://openalex.org/I201537933","https://openalex.org/I4405286073"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"R. Shirakawa","raw_affiliation_strings":["Department of Molecular and Cellular Biology, Institute of Development, Aging, and Cancer, Tohoku University, Seiryo-machi 4-1, Aoba-ku, Sendai 980-8575, Japan shirakawa@idac.tohoku.ac.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Biology, Institute of Development, Aging, and Cancer, Tohoku University, Seiryo-machi 4-1, Aoba-ku, Sendai 980-8575, Japan shirakawa@idac.tohoku.ac.jp","institution_ids":["https://openalex.org/I201537933","https://openalex.org/I4405286073"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065422848","display_name":"Hisanori Horiuchi","orcid":"https://orcid.org/0000-0003-1436-0093","observed_orcids":["https://orcid.org/0000-0003-1436-0093"]},"institutions":[{"id":"https://openalex.org/I4405286073","display_name":"Institute of Development, Aging and Cancer, Tohoku University","ror":"https://ror.org/012s2xh05","country_code":"JP","type":"facility","lineage":["https://openalex.org/I201537933","https://openalex.org/I4405286073"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H. Horiuchi","raw_affiliation_strings":["Department of Molecular and Cellular Biology, Institute of Development, Aging, and Cancer, Tohoku University, Seiryo-machi 4-1, Aoba-ku, Sendai 980-8575, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Biology, Institute of Development, Aging, and Cancer, Tohoku University, Seiryo-machi 4-1, Aoba-ku, Sendai 980-8575, Japan","institution_ids":["https://openalex.org/I4405286073"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5065164908"],"corresponding_institution_ids":["https://openalex.org/I201537933","https://openalex.org/I4405286073"],"apc_list":{"value":3276,"currency":"USD","value_usd":3276},"apc_paid":null,"fwci":0.9001,"has_fulltext":true,"cited_by_count":82,"citation_normalized_percentile":{"value":0.65888199,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"157","issue":"5","first_page":"285","last_page":"299"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.5429999828338623,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.5429999828338623,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.4507000148296356,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ral-gtpase","display_name":"Ral GTPase","score":0.9980000257492065},{"id":"https://openalex.org/keywords/rala","display_name":"RalA","score":0.9909999966621399},{"id":"https://openalex.org/keywords/ralb","display_name":"RalB","score":1.0},{"id":"https://openalex.org/keywords/ras-superfamily","display_name":"Ras superfamily","score":0.8330000042915344},{"id":"https://openalex.org/keywords/exocytosis","display_name":"exocytosis","score":0.9330000281333923},{"id":"https://openalex.org/keywords/exocyst","display_name":"exocyst","score":0.8220000267028809},{"id":"https://openalex.org/keywords/tumourigenesis","display_name":"tumourigenesis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/oncogenic-ras","display_name":"oncogenic Ras","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cancer-therapy-targets","display_name":"cancer therapy targets","score":0.6740000247955322}],"concepts":[{"id":"https://openalex.org/C207332259","wikidata":"https://www.wikidata.org/wiki/Q769143","display_name":"GTPase","level":2,"score":0.9362490177154541},{"id":"https://openalex.org/C2778448323","wikidata":"https://www.wikidata.org/wiki/Q5420527","display_name":"Exocyst","level":4,"score":0.933796226978302},{"id":"https://openalex.org/C2781335528","wikidata":"https://www.wikidata.org/wiki/Q24781762","display_name":"Ras superfamily","level":4,"score":0.7139694094657898},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6389426589012146},{"id":"https://openalex.org/C175969161","wikidata":"https://www.wikidata.org/wiki/Q323426","display_name":"Exocytosis","level":3,"score":0.6256194710731506},{"id":"https://openalex.org/C126619667","wikidata":"https://www.wikidata.org/wiki/Q901088","display_name":"Guanine nucleotide exchange factor","level":3,"score":0.6017263531684875},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.509100615978241},{"id":"https://openalex.org/C118716","wikidata":"https://www.wikidata.org/wiki/Q5514725","display_name":"GTP'","level":3,"score":0.13808926939964294},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06672444939613342},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.05770748853683472},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005089","descriptor_name":"Exocytosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020725","descriptor_name":"ral GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020725","descriptor_name":"ral GTP-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D063646","descriptor_name":"Carcinogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1093/jb/mvv029","doi":"https://doi.org/10.1093/jb/mvv029","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jb/mvv029","pdf_url":null,"source":{"id":"https://openalex.org/S184547178","display_name":"The Journal of Biochemistry","issn_l":"0021-924X","issn":["0021-924X","1756-2651"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biochemistry","raw_type":"journal-article"},{"id":"pmid:25796063","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25796063","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biochemistry","raw_type":"Journal Article"},{"id":"pmh:oai:open-archive.highwire.org:jbiochem:mvv029v1","doi":null,"is_oa":false,"landing_page_url":"http://jb.oxfordjournals.org/cgi/content/short/mvv029v1","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"},{"id":"pmh:oai:open-archive.highwire.org:jbiochem:mvv029v2","doi":null,"is_oa":false,"landing_page_url":"http://jb.oxfordjournals.org/cgi/content/short/mvv029v2","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2733529486","display_name":"Elucidation of roles of small GTPase Ral and its negative regulator RalGAP in tumorigenesis, and cancer invasion and metastasis","funder_award_id":"25290041","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8628426682","display_name":"Analysis of Tumorigenesis and Malignant Transformation Induced by Aberrant Ral Signaling","funder_award_id":"26860181","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":141,"referenced_works":["https://openalex.org/W35071699","https://openalex.org/W1545398558","https://openalex.org/W1597449753","https://openalex.org/W1601647648","https://openalex.org/W1608131302","https://openalex.org/W1780670592","https://openalex.org/W1943068820","https://openalex.org/W1946879166","https://openalex.org/W1970338125","https://openalex.org/W1970338715","https://openalex.org/W1970555551","https://openalex.org/W1970615437","https://openalex.org/W1971102429","https://openalex.org/W1973834617","https://openalex.org/W1975359970","https://openalex.org/W1977077130","https://openalex.org/W1977918009","https://openalex.org/W1980704197","https://openalex.org/W1981453024","https://openalex.org/W1982166082","https://openalex.org/W1982967858","https://openalex.org/W1984427686","https://openalex.org/W1985501548","https://openalex.org/W1986492134","https://openalex.org/W1987087186","https://openalex.org/W1988911160","https://openalex.org/W1989756466","https://openalex.org/W1993735775","https://openalex.org/W1994023206","https://openalex.org/W1994736776","https://openalex.org/W1998170956","https://openalex.org/W1999692754","https://openalex.org/W2001717872","https://openalex.org/W2001854956","https://openalex.org/W2001865432","https://openalex.org/W2005155951","https://openalex.org/W2005768432","https://openalex.org/W2005984686","https://openalex.org/W2006603416","https://openalex.org/W2007375100","https://openalex.org/W2008838494","https://openalex.org/W2010755278","https://openalex.org/W2012479646","https://openalex.org/W2018991789","https://openalex.org/W2020530030","https://openalex.org/W2022076650","https://openalex.org/W2026403140","https://openalex.org/W2031494860","https://openalex.org/W2032143990","https://openalex.org/W2035998109","https://openalex.org/W2037852398","https://openalex.org/W2039195585","https://openalex.org/W2042750069","https://openalex.org/W2043227433","https://openalex.org/W2043246560","https://openalex.org/W2046400987","https://openalex.org/W2053668936","https://openalex.org/W2055611855","https://openalex.org/W2056177945","https://openalex.org/W2059566494","https://openalex.org/W2063063619","https://openalex.org/W2066663644","https://openalex.org/W2066793047","https://openalex.org/W2068137415","https://openalex.org/W2068876164","https://openalex.org/W2070449068","https://openalex.org/W2070992726","https://openalex.org/W2071141495","https://openalex.org/W2073245743","https://openalex.org/W2073379000","https://openalex.org/W2075055741","https://openalex.org/W2076865122","https://openalex.org/W2078948761","https://openalex.org/W2085350573","https://openalex.org/W2089695492","https://openalex.org/W2092329631","https://openalex.org/W2094933851","https://openalex.org/W2095020121","https://openalex.org/W2095508126","https://openalex.org/W2096387776","https://openalex.org/W2097424141","https://openalex.org/W2098377849","https://openalex.org/W2098660054","https://openalex.org/W2100449908","https://openalex.org/W2100469448","https://openalex.org/W2104235973","https://openalex.org/W2109110743","https://openalex.org/W2109718825","https://openalex.org/W2112078762","https://openalex.org/W2116104243","https://openalex.org/W2117571939","https://openalex.org/W2119264345","https://openalex.org/W2120637632","https://openalex.org/W2122509620","https://openalex.org/W2122514972","https://openalex.org/W2124241990","https://openalex.org/W2124520431","https://openalex.org/W2124598062","https://openalex.org/W2124775559","https://openalex.org/W2125313133","https://openalex.org/W2126024374","https://openalex.org/W2126960848","https://openalex.org/W2127063807","https://openalex.org/W2127684282","https://openalex.org/W2128339707","https://openalex.org/W2128434997","https://openalex.org/W2128529669","https://openalex.org/W2130560835","https://openalex.org/W2131291909","https://openalex.org/W2132206752","https://openalex.org/W2136940817","https://openalex.org/W2137452721","https://openalex.org/W2138287913","https://openalex.org/W2141008194","https://openalex.org/W2146926552","https://openalex.org/W2148047023","https://openalex.org/W2148496054","https://openalex.org/W2149189973","https://openalex.org/W2149517464","https://openalex.org/W2152130273","https://openalex.org/W2153604383","https://openalex.org/W2153872405","https://openalex.org/W2155342222","https://openalex.org/W2156875265","https://openalex.org/W2158690845","https://openalex.org/W2162857699","https://openalex.org/W2163228224","https://openalex.org/W2165928290","https://openalex.org/W2166075210","https://openalex.org/W2166606571","https://openalex.org/W2169722759","https://openalex.org/W2171002377","https://openalex.org/W2321348439","https://openalex.org/W2325991334","https://openalex.org/W2329515361","https://openalex.org/W2383259826","https://openalex.org/W2399765077","https://openalex.org/W2416111196","https://openalex.org/W2614667111","https://openalex.org/W4233423117","https://openalex.org/W4299676702"],"related_works":["https://openalex.org/W1977696467","https://openalex.org/W3108657664","https://openalex.org/W2024182435","https://openalex.org/W2773731465","https://openalex.org/W2526995965","https://openalex.org/W2100543878","https://openalex.org/W2170817287","https://openalex.org/W2509002447","https://openalex.org/W2004216400","https://openalex.org/W2085245164"],"abstract_inverted_index":{"The":[0],"Ral":[1,19,60,79,102],"guanosine":[2],"triphosphatases":[3],"(GTPases),":[4],"RalA":[5],"and":[6,21,39,46],"RalB,":[7],"are":[8],"members":[9],"of":[10,14,34,59,64,68,90,101],"the":[11,25,31,56,65,88,99],"Ras":[12],"superfamily":[13],"small":[15],"GTPases.":[16,103],"Research":[17],"on":[18],"GTPases":[20,36,61],"their":[22],"functions":[23],"over":[24],"past":[26],"25":[27],"years":[28],"has":[29],"revealed":[30],"essential":[32],"involvement":[33],"these":[35],"in":[37,98],"unique":[38],"diverse":[40],"cellular":[41,48],"processes":[42],"including":[43],"exocyst-mediated":[44],"exocytosis":[45],"related":[47],"activities.":[49],"Moreover,":[50],"it":[51],"is":[52,62],"increasingly":[53],"appreciated":[54],"that":[55,78],"aberrant":[57],"activation":[58],"one":[63],"major":[66],"causes":[67],"human":[69,91],"tumourigenesis":[70],"induced":[71],"by":[72],"oncogenic":[73],"Ras.":[74],"Recent":[75],"evidence":[76],"suggests":[77],"signalling":[80],"pathways":[81],"may":[82],"be":[83],"potential":[84],"therapeutic":[85],"targets":[86],"for":[87],"treatment":[89],"cancers.":[92],"This":[93],"review":[94],"summarizes":[95],"recent":[96],"advance":[97],"investigation":[100]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":8}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
