{"id":"https://openalex.org/W2145239463","doi":"https://doi.org/10.1073/pnas.0308515101","title":"Heterodimeric interactions among the 1-amino-cyclopropane-1-carboxylate synthase polypeptides encoded by the Arabidopsis gene family","display_name":"Heterodimeric interactions among the 1-amino-cyclopropane-1-carboxylate synthase polypeptides encoded by the Arabidopsis gene family","publication_year":2004,"publication_date":"2004-02-17","ids":{"openalex":"https://openalex.org/W2145239463","doi":"https://doi.org/10.1073/pnas.0308515101","mag":"2145239463","pmid":"https://pubmed.ncbi.nlm.nih.gov/14983000","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/356941"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.0308515101","doi":"https://doi.org/10.1073/pnas.0308515101","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0308515101","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC356941","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050841942","display_name":"Atsunari Tsuchisaka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210144282","display_name":"Plant Gene Expression Center","ror":"https://ror.org/03rafms67","country_code":"US","type":"government","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210094889","https://openalex.org/I4210144282","https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Atsunari Tsuchisaka","raw_affiliation_strings":["Plant Gene Expression Center, 800 Buchanan Street, Albany, CA 94710","Plant Gene Expression Center, 800 Buchanan Street, Albany, CA 94710, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Plant Gene Expression Center, 800 Buchanan Street, Albany, CA 94710","institution_ids":["https://openalex.org/I4210144282"]},{"raw_affiliation_string":"Plant Gene Expression Center, 800 Buchanan Street, Albany, CA 94710, USA","institution_ids":["https://openalex.org/I4210144282"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090711057","display_name":"Athanasios Theologis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210144282","display_name":"Plant Gene Expression Center","ror":"https://ror.org/03rafms67","country_code":"US","type":"government","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210094889","https://openalex.org/I4210144282","https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Athanasios Theologis","raw_affiliation_strings":["Plant Gene Expression Center, 800 Buchanan Street, Albany, CA 94710","Harvard Medical School, Boston, MA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Plant Gene Expression Center, 800 Buchanan Street, Albany, CA 94710","institution_ids":["https://openalex.org/I4210144282"]},{"raw_affiliation_string":"Harvard Medical School, Boston, MA,","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":14.4376,"has_fulltext":false,"cited_by_count":138,"citation_normalized_percentile":{"value":0.99007329,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"101","issue":"8","first_page":"2275","last_page":"2280"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10473","display_name":"Postharvest Quality and Shelf Life Management","score":0.5429999828338623,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10473","display_name":"Postharvest Quality and Shelf Life Management","score":0.5429999828338623,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11882","display_name":"Plant biochemistry and biosynthesis","score":0.15049999952316284,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10184","display_name":"Plant Molecular Biology Research","score":0.1071000024676323,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/1-aminocyclopropane-1-carboxylic-acid-synthase","display_name":"1-aminocyclopropane-1-carboxylate synthase","score":0.9950000047683716},{"id":"https://openalex.org/keywords/heterodimerization","display_name":"heterodimerization","score":0.9580000042915344},{"id":"https://openalex.org/keywords/homodimer","display_name":"homodimer","score":0.7210000157356262},{"id":"https://openalex.org/keywords/ethylene-production","display_name":"ethylene production","score":0.9290000200271606},{"id":"https://openalex.org/keywords/pyridoxal-phosphate-dependent-enzymes","display_name":"pyridoxal phosphate-dependent enzymes","score":0.722000002861023},{"id":"https://openalex.org/keywords/isozyme-polymorphism","display_name":"isozyme polymorphism","score":0.718999981880188},{"id":"https://openalex.org/keywords/acs1","display_name":"ACS1","score":0.621999979019165},{"id":"https://openalex.org/keywords/s-adenosylmethionine","display_name":"S-adenosylmethionine","score":0.8740000128746033},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.6010000109672546},{"id":"https://openalex.org/keywords/arabidopsis-thaliana","display_name":"Arabidopsis thaliana","score":0.9330000281333923}],"concepts":[{"id":"https://openalex.org/C188082640","wikidata":"https://www.wikidata.org/wiki/Q1780899","display_name":"Complementation","level":4,"score":0.7688286304473877},{"id":"https://openalex.org/C2779491563","wikidata":"https://www.wikidata.org/wiki/Q157892","display_name":"Arabidopsis","level":4,"score":0.6603914499282837},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6339926719665527},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6040260195732117},{"id":"https://openalex.org/C123243835","wikidata":"https://www.wikidata.org/wiki/Q863465","display_name":"Bimolecular fluorescence complementation","level":3,"score":0.5782191157341003},{"id":"https://openalex.org/C5911399","wikidata":"https://www.wikidata.org/wiki/Q2278983","display_name":"Gene family","level":4,"score":0.5751124620437622},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5262293815612793},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.49133244156837463},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4611437916755676},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.4587538242340088},{"id":"https://openalex.org/C103077935","wikidata":"https://www.wikidata.org/wiki/Q5508811","display_name":"Functional divergence","level":5,"score":0.4587107300758362},{"id":"https://openalex.org/C2776376580","wikidata":"https://www.wikidata.org/wiki/Q407355","display_name":"Transferase","level":3,"score":0.457502156496048},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.2495003044605255}],"mesh":[{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D005810","descriptor_name":"Multigene Family","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005816","descriptor_name":"Genetic Complementation Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008190","descriptor_name":"Lyases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008190","descriptor_name":"Lyases","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D008190","descriptor_name":"Lyases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017360","descriptor_name":"Arabidopsis","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D017360","descriptor_name":"Arabidopsis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029681","descriptor_name":"Arabidopsis Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D029681","descriptor_name":"Arabidopsis Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D029681","descriptor_name":"Arabidopsis Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.0308515101","doi":"https://doi.org/10.1073/pnas.0308515101","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0308515101","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:304021","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC356941","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:356941","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/356941","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:14983000","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14983000","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:304021","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC356941","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G6025645090","display_name":"The ACC Synthase Genes and Polypeptides","funder_award_id":"9982895","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306114","display_name":"U.S. Department of Agriculture","ror":"https://ror.org/01na82s61"},{"id":"https://openalex.org/F4320332605","display_name":"Agricultural Research Service","ror":"https://ror.org/02d2m2044"},{"id":"https://openalex.org/F4320332682","display_name":"Medical School, University of Michigan","ror":"https://ror.org/00jmfr291"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W1528121124","https://openalex.org/W1530807068","https://openalex.org/W1564923665","https://openalex.org/W1570376951","https://openalex.org/W1773196754","https://openalex.org/W1963834514","https://openalex.org/W1964666615","https://openalex.org/W1965169361","https://openalex.org/W1968236048","https://openalex.org/W1972216879","https://openalex.org/W1984874903","https://openalex.org/W1990761413","https://openalex.org/W1993657586","https://openalex.org/W1996525958","https://openalex.org/W2002164796","https://openalex.org/W2004024897","https://openalex.org/W2005955710","https://openalex.org/W2012103484","https://openalex.org/W2012970553","https://openalex.org/W2014440450","https://openalex.org/W2019229910","https://openalex.org/W2023666553","https://openalex.org/W2023874889","https://openalex.org/W2041951055","https://openalex.org/W2053126950","https://openalex.org/W2063051241","https://openalex.org/W2066704242","https://openalex.org/W2069275373","https://openalex.org/W2081360933","https://openalex.org/W2085415453","https://openalex.org/W2086246918","https://openalex.org/W2090582665","https://openalex.org/W2096371677","https://openalex.org/W2108712457","https://openalex.org/W2113019448","https://openalex.org/W2123206362","https://openalex.org/W2138026076","https://openalex.org/W2143922328","https://openalex.org/W2147170044","https://openalex.org/W2148299987","https://openalex.org/W2152961480","https://openalex.org/W2162728101","https://openalex.org/W2174475512","https://openalex.org/W6819750734"],"related_works":["https://openalex.org/W1964666615","https://openalex.org/W2019229910","https://openalex.org/W2104743494","https://openalex.org/W2104978938","https://openalex.org/W1982507986","https://openalex.org/W2041951055","https://openalex.org/W2082806806","https://openalex.org/W1992943635","https://openalex.org/W2005955710","https://openalex.org/W2085415453"],"abstract_inverted_index":{"The":[0,20,158],"pyridoxal":[1],"phosphate-dependent":[2],"enzyme,":[3],"1-aminocyclopropane-1-carboxylate":[4],"synthase":[5],"(ACS;":[6],"EC":[7],"4.4.1.14),":[8],"catalyzes":[9],"the":[10,14,40,49,53,68,82,101,104,128,133,154,185,194,205,218,222,259],"rate-limiting":[11],"step":[12],"in":[13,18,63,235,242],"ethylene":[15],"biosynthetic":[16],"pathway":[17],"plants.":[19],"Arabidopsis":[21],"genome":[22],"encodes":[23],"nine":[24],"ACS":[25,159,223],"polypeptides":[26,55,75],"that":[27,77,96,184,203,214],"form":[28,57,141,165],"eight":[29],"functional":[30,58,87,117,142,215],"(ACS2,":[31],"ACS4-9,":[32],"ACS11)":[33],"and":[34,70,168,178,226,248],"one":[35,99],"nonfunctional":[36,134],"(ACS1)":[37],"homodimers.":[38],"Because":[39],"enzyme":[41],"is":[42,109,190],"a":[43,137,236,255],"homodimer":[44],"with":[45,119,144],"shared":[46,206],"active":[47,207],"sites,":[48],"question":[50],"arises":[51],"whether":[52],"various":[54,243],"can":[56,139,163],"heterodimers.":[59],"Intermolecular":[60],"complementation":[61,177],"experiments":[62],"Escherichia":[64],"coli":[65],"by":[66,230],"coexpressing":[67],"K278A":[69],"Y92A":[71],"mutants":[72],"of":[73,79,103,122,146,170,187,196,221,239],"different":[74],"show":[76,183],"all":[78],"them":[80],"have":[81],"capacity":[83],"to":[84,98,112,193,200,233],"heterodimerize.":[85],"However,":[86],"heterodimers":[88,118,143,169,189],"are":[89,173],"formed":[90],"only":[91],"among":[92],"gene":[93,160,224],"family":[94,161,225],"members":[95,121,145],"belong":[97],"or":[100],"other":[102],"two":[105],"phylogenetic":[106,148],"branches.":[107],"ACS7":[108],"an":[110],"exception":[111],"this":[113],"rule,":[114],"which":[115,171],"forms":[116],"some":[120],"both":[123],"branches":[124],"when":[125,150],"it":[126],"provides":[127,227],"wt":[129,155],"K278":[130,156],"residue.":[131,157],"ACS1,":[132],"polypeptide":[135],"as":[136],"homodimer,":[138],"also":[140,253],"its":[147,151],"branch":[149],"partners":[152],"provide":[153],"products":[162],"potentially":[164],"45":[166],"homo-":[167],"25":[172],"functional.":[174,211],"Bimolecular":[175],"fluorescence":[176],"biochemical":[179],"coaffinity":[180],"purification":[181],"assays":[182],"inactivity":[186],"certain":[188],"not":[191],"due":[192],"absence":[195],"heterodimerization":[197,216,251],"but":[198],"rather":[199],"structural":[201],"restraint(s)":[202],"prevents":[204],"sites":[208],"from":[209],"being":[210,231],"We":[212],"propose":[213],"enhances":[217],"isozyme":[219],"diversity":[220],"physiological":[228],"versatility":[229],"able":[232],"operate":[234],"broad":[237],"gradient":[238],"S-adenosylmethionine":[240],"concentration":[241],"cells/tissues":[244],"during":[245,258],"plant":[246,260],"growth":[247],"development.":[249],"Nonfunctional":[250],"may":[252],"play":[254],"regulatory":[256],"role":[257],"life":[261],"cycle.":[262]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
