{"id":"https://openalex.org/W2145223979","doi":"https://doi.org/10.1085/jgp.201310974","title":"Neurotoxic unc-8 mutants encode constitutively active DEG/ENaC channels that are blocked by divalent cations","display_name":"Neurotoxic unc-8 mutants encode constitutively active DEG/ENaC channels that are blocked by divalent cations","publication_year":2013,"publication_date":"2013-07-29","ids":{"openalex":"https://openalex.org/W2145223979","doi":"https://doi.org/10.1085/jgp.201310974","mag":"2145223979","pmid":"https://pubmed.ncbi.nlm.nih.gov/23898007","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3727304"},"language":"en","primary_location":{"id":"doi:10.1085/jgp.201310974","doi":"https://doi.org/10.1085/jgp.201310974","is_oa":false,"landing_page_url":"https://doi.org/10.1085/jgp.201310974","pdf_url":null,"source":{"id":"https://openalex.org/S168548653","display_name":"The Journal of General Physiology","issn_l":"0022-1295","issn":["0022-1295","1540-7748"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of General Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/articles/PMC3727304","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100347091","display_name":"Ying Wang","orcid":"https://orcid.org/0000-0002-4290-218X","observed_orcids":["https://orcid.org/0000-0002-4290-218X"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ying Wang","raw_affiliation_strings":["Department of Physiology and Biophysics, University of Miami, Miller School of Medicine, Miami, FL, 33136 1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, University of Miami, Miller School of Medicine, Miami, FL, 33136 1","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067596030","display_name":"Cristina Matthewman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cristina Matthewman","raw_affiliation_strings":["Department of Physiology and Biophysics, University of Miami, Miller School of Medicine, Miami, FL, 33136 1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, University of Miami, Miller School of Medicine, Miami, FL, 33136 1","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102895696","display_name":"Lu Han","orcid":"https://orcid.org/0000-0002-7636-4519","observed_orcids":["https://orcid.org/0000-0002-7636-4519"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lu Han","raw_affiliation_strings":["Department of Physiology and Biophysics, University of Miami, Miller School of Medicine, Miami, FL, 33136 1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, University of Miami, Miller School of Medicine, Miami, FL, 33136 1","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016826447","display_name":"Tyne W. Miller\u2010Fleming","orcid":"https://orcid.org/0000-0002-0398-5162","observed_orcids":["https://orcid.org/0000-0002-0398-5162"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tyne Miller","raw_affiliation_strings":["Department of Cell and Developmental Biology 2 and 3","Neuroscience Program, Vanderbilt University, Nashville, TN 37232 2 and 3"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Developmental Biology 2 and 3","institution_ids":[]},{"raw_affiliation_string":"Neuroscience Program, Vanderbilt University, Nashville, TN 37232 2 and 3","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102000361","display_name":"David M. Miller","orcid":"https://orcid.org/0000-0001-9048-873X","observed_orcids":["https://orcid.org/0000-0001-9048-873X"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David M. Miller","raw_affiliation_strings":["Department of Cell and Developmental Biology 2 and 3","Neuroscience Program, Vanderbilt University, Nashville, TN 37232 2 and 3"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Developmental Biology 2 and 3","institution_ids":[]},{"raw_affiliation_string":"Neuroscience Program, Vanderbilt University, Nashville, TN 37232 2 and 3","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037709673","display_name":"Laura K. Bianchi","orcid":"https://orcid.org/0000-0003-2615-5345","observed_orcids":["https://orcid.org/0000-0003-2615-5345","https://orcid.org/0000-0002-3140-1056"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Laura Bianchi","raw_affiliation_strings":["Department of Physiology and Biophysics, University of Miami, Miller School of Medicine, Miami, FL, 33136 1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, University of Miami, Miller School of Medicine, Miami, FL, 33136 1","institution_ids":["https://openalex.org/I145608581"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5037709673"],"corresponding_institution_ids":["https://openalex.org/I145608581"],"apc_list":null,"apc_paid":null,"fwci":0.5022,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.62553198,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"142","issue":"2","first_page":"157","last_page":"169"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.011599999852478504,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12331","display_name":"Hereditary Neurological Disorders","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/deg-enac-channels","display_name":"DEG/ENaC channels","score":0.9319999814033508},{"id":"https://openalex.org/keywords/unc-8","display_name":"unc-8","score":0.9620000123977661},{"id":"https://openalex.org/keywords/mec-4","display_name":"mec-4","score":0.9480000138282776},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.7139999866485596},{"id":"https://openalex.org/keywords/divalent-cation-inhibition","display_name":"divalent cation inhibition","score":0.7419999837875366},{"id":"https://openalex.org/keywords/calcium","display_name":"calcium","score":0.7300000190734863},{"id":"https://openalex.org/keywords/magnesium","display_name":"magnesium","score":0.984000027179718},{"id":"https://openalex.org/keywords/cholinergic-motor-neurons","display_name":"cholinergic motor neurons","score":0.8339999914169312},{"id":"https://openalex.org/keywords/touch-neurons","display_name":"touch neurons","score":0.5920000076293945},{"id":"https://openalex.org/keywords/selective-neuronal-death","display_name":"selective neuronal death","score":0.7179999947547913},{"id":"https://openalex.org/keywords/caenorhabditis-elegans","display_name":"Caenorhabditis elegans","score":0.8669999837875366},{"id":"https://openalex.org/keywords/xenopus-oocytes","display_name":"Xenopus oocytes","score":0.9229999780654907}],"concepts":[{"id":"https://openalex.org/C2779535977","wikidata":"https://www.wikidata.org/wiki/Q1342298","display_name":"Xenopus","level":3,"score":0.7718698382377625},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.7289546728134155},{"id":"https://openalex.org/C74884574","wikidata":"https://www.wikidata.org/wiki/Q171407","display_name":"Divalent","level":2,"score":0.7273582220077515},{"id":"https://openalex.org/C6507245","wikidata":"https://www.wikidata.org/wiki/Q424948","display_name":"Epithelial sodium channel","level":3,"score":0.698036253452301},{"id":"https://openalex.org/C2778944004","wikidata":"https://www.wikidata.org/wiki/Q91703","display_name":"Caenorhabditis elegans","level":3,"score":0.6349478960037231},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5327629446983337},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5220101475715637},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.49061718583106995},{"id":"https://openalex.org/C50254741","wikidata":"https://www.wikidata.org/wiki/Q62536","display_name":"Ion channel","level":3,"score":0.46905070543289185},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.42180556058883667},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4044732451438904},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3872247636318207},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.36601439118385315},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.179031103849411},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17255008220672607},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.06725391745567322},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005799","descriptor_name":"Genes, Dominant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007473","descriptor_name":"Ion Channels","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D007473","descriptor_name":"Ion Channels","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007473","descriptor_name":"Ion Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008274","descriptor_name":"Magnesium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009046","descriptor_name":"Motor Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009046","descriptor_name":"Motor Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014981","descriptor_name":"Xenopus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D029742","descriptor_name":"Caenorhabditis elegans Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D029742","descriptor_name":"Caenorhabditis elegans Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029742","descriptor_name":"Caenorhabditis elegans Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D059329","descriptor_name":"Cholinergic Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D059329","descriptor_name":"Cholinergic Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1085/jgp.201310974","doi":"https://doi.org/10.1085/jgp.201310974","is_oa":false,"landing_page_url":"https://doi.org/10.1085/jgp.201310974","pdf_url":null,"source":{"id":"https://openalex.org/S168548653","display_name":"The Journal of General Physiology","issn_l":"0022-1295","issn":["0022-1295","1540-7748"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of General Physiology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2894794","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3727304","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3727304","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3727304","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Gen Physiol","raw_type":"Text"},{"id":"pmid:23898007","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23898007","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of general physiology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2894794","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3727304","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3204767367","display_name":"Genes Controlling Assembly and Function of Serotonin Systems","funder_award_id":"P50MH078028","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G3525667365","display_name":"Molelcular determinants of synaptic plasticity","funder_award_id":"R01NS081259","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G3590856881","display_name":null,"funder_award_id":"NIH RO1NS26115","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G4376645998","display_name":null,"funder_award_id":"MH078028","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G4720930892","display_name":"Identification of Synaptic remodeling Genes in C. elegans","funder_award_id":"R21MH077302","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G5327853655","display_name":"Molecular Genetics of Neural Specificity","funder_award_id":"R01NS026115","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G5627790238","display_name":"Glia in Touch Sensation","funder_award_id":"R01NS070969","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G6121924544","display_name":null,"funder_award_id":"NIH RO1NS070969","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G7117550215","display_name":"Molecular Genetics of Synaptic Plasticity","funder_award_id":"R01NS106951","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W168944070","https://openalex.org/W324231377","https://openalex.org/W1546862061","https://openalex.org/W1827209814","https://openalex.org/W1887384647","https://openalex.org/W1944127002","https://openalex.org/W1971207325","https://openalex.org/W1972115823","https://openalex.org/W1973899245","https://openalex.org/W1974052375","https://openalex.org/W1974216293","https://openalex.org/W1978823643","https://openalex.org/W1982816670","https://openalex.org/W1984303048","https://openalex.org/W1987211464","https://openalex.org/W1988358598","https://openalex.org/W1988957848","https://openalex.org/W1993712354","https://openalex.org/W1997625078","https://openalex.org/W2002099577","https://openalex.org/W2008483636","https://openalex.org/W2009118272","https://openalex.org/W2012222668","https://openalex.org/W2012329129","https://openalex.org/W2013711061","https://openalex.org/W2014022632","https://openalex.org/W2014482685","https://openalex.org/W2036902033","https://openalex.org/W2045794496","https://openalex.org/W2047283239","https://openalex.org/W2048586894","https://openalex.org/W2057602646","https://openalex.org/W2075856434","https://openalex.org/W2076323521","https://openalex.org/W2085673468","https://openalex.org/W2086688096","https://openalex.org/W2090117730","https://openalex.org/W2091719660","https://openalex.org/W2092744441","https://openalex.org/W2106223740","https://openalex.org/W2113034211","https://openalex.org/W2116064075","https://openalex.org/W2119228805","https://openalex.org/W2119336577","https://openalex.org/W2133464980","https://openalex.org/W2150514270","https://openalex.org/W2154184264","https://openalex.org/W2155624357","https://openalex.org/W2157166663","https://openalex.org/W2159565935","https://openalex.org/W2160938187","https://openalex.org/W2164204379","https://openalex.org/W2169380154","https://openalex.org/W2169731496","https://openalex.org/W2395427107"],"related_works":["https://openalex.org/W2533903452","https://openalex.org/W2014482685","https://openalex.org/W2800842771","https://openalex.org/W1982816670","https://openalex.org/W1973708385","https://openalex.org/W2155624357","https://openalex.org/W1887384647","https://openalex.org/W4211157461","https://openalex.org/W2000892197","https://openalex.org/W2015901891"],"abstract_inverted_index":{"Ion":[0],"channels":[1,100],"of":[2,38,76,111,138],"the":[3,30,39,51,73,81,135],"DEG/ENaC":[4,19,54],"family":[5],"can":[6],"induce":[7],"neurodegeneration":[8],"under":[9],"conditions":[10],"in":[11,29,43,50,59,80,86,118,143],"which":[12,44],"they":[13],"become":[14],"hyperactivated.":[15],"The":[16],"Caenorhabditis":[17],"elegans":[18,53],"channel":[20,25,55],"MEC-4(d)":[21],"encodes":[22],"a":[23,27],"mutant":[24,93],"with":[26,72],"substitution":[28],"pore":[31],"domain":[32],"that":[33,65,91,101,122,140],"causes":[34],"swelling":[35],"and":[36,96,108,131],"death":[37,75,137],"six":[40],"touch":[41],"neurons":[42,79,139],"it":[45],"is":[46,70],"expressed.":[47],"Dominant":[48],"mutations":[49],"C.":[52],"subunit":[56],"UNC-8":[57,129,142],"result":[58],"uncoordinated":[60],"movement.":[61],"Here":[62],"we":[63],"show":[64],"this":[66],"unc-8":[67],"movement":[68],"defect":[69],"correlated":[71],"selective":[74,136],"cholinergic":[77],"motor":[78],"ventral":[82],"nerve":[83],"cord.":[84],"Experiments":[85],"Xenopus":[87],"laevis":[88],"ooctyes":[89],"confirm":[90],"these":[92],"proteins,":[94],"UNC-8(G387E)":[95,116],"UNC-8(A586T),":[97],"encode":[98],"hyperactivated":[99],"are":[102],"strongly":[103],"inhibited":[104],"by":[105,124],"extracellular":[106,112,125],"calcium":[107],"magnesium.":[109],"Reduction":[110],"divalent":[113,126],"cations":[114,127],"exacerbates":[115],"toxicity":[117,130],"oocytes.":[119],"We":[120],"suggest":[121],"inhibition":[123],"limits":[128],"may":[132],"contribute":[133],"to":[134],"express":[141],"vivo.":[144]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}