{"id":"https://openalex.org/W2145203496","doi":"https://doi.org/10.1016/j.chembiol.2012.06.012","title":"Glucocorticoid Compounds Modify Smoothened Localization and Hedgehog Pathway Activity","display_name":"Glucocorticoid Compounds Modify Smoothened Localization and Hedgehog Pathway Activity","publication_year":2012,"publication_date":"2012-08-01","ids":{"openalex":"https://openalex.org/W2145203496","doi":"https://doi.org/10.1016/j.chembiol.2012.06.012","mag":"2145203496","pmid":"https://pubmed.ncbi.nlm.nih.gov/22921064","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3724998"},"language":"en","primary_location":{"id":"doi:10.1016/j.chembiol.2012.06.012","doi":"https://doi.org/10.1016/j.chembiol.2012.06.012","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.chembiol.2012.06.012","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1074552112002207/pdf","source":{"id":"https://openalex.org/S85134406","display_name":"Chemistry & Biology","issn_l":"1074-5521","issn":["1074-5521","1879-1301"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry & Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.sciencedirect.com/science/article/pii/S1074552112002207/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100445227","display_name":"Yu Wang","orcid":"https://orcid.org/0000-0002-5188-4622","observed_orcids":["https://orcid.org/0000-0002-5188-4622"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yu Wang","raw_affiliation_strings":["Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA","Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA","Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016618049","display_name":"Lance S. Davidow","orcid":"https://orcid.org/0000-0001-9055-7475","observed_orcids":["https://orcid.org/0000-0001-9055-7475"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210157861","display_name":"Harvard Stem Cell Institute","ror":"https://ror.org/04kj1hn59","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210157861"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lance Davidow","raw_affiliation_strings":["Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA","Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210157861"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057366101","display_name":"Anthony C. Arvanites","orcid":"https://orcid.org/0000-0002-0988-8347","observed_orcids":["https://orcid.org/0000-0002-0988-8347"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210157861","display_name":"Harvard Stem Cell Institute","ror":"https://ror.org/04kj1hn59","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210157861"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony\u00a0C. Arvanites","raw_affiliation_strings":["Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA","Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210157861"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027087812","display_name":"Joel Blanchard","orcid":"https://orcid.org/0000-0003-3142-2970","observed_orcids":["https://orcid.org/0000-0003-3142-2970"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210157861","display_name":"Harvard Stem Cell Institute","ror":"https://ror.org/04kj1hn59","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210157861"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joel Blanchard","raw_affiliation_strings":["Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA","Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210157861"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111525316","display_name":"Kelvin Lam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210157861","display_name":"Harvard Stem Cell Institute","ror":"https://ror.org/04kj1hn59","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210157861"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kelvin Lam","raw_affiliation_strings":["Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA","Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210157861"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012452987","display_name":"Ke Xu","orcid":"https://orcid.org/0000-0002-0219-6495","observed_orcids":["https://orcid.org/0000-0002-0219-6495"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210157861","display_name":"Harvard Stem Cell Institute","ror":"https://ror.org/04kj1hn59","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210157861"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ke Xu","raw_affiliation_strings":["Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA","Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210157861"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005109479","display_name":"Vatsal Oza","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210157861","display_name":"Harvard Stem Cell Institute","ror":"https://ror.org/04kj1hn59","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210157861"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vatsal Oza","raw_affiliation_strings":["Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA","Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210157861"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110611089","display_name":"Jin Woo Yoo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jin\u00a0Woo Yoo","raw_affiliation_strings":["Harvard College, Harvard University, Cambridge, MA 02138, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard College, Harvard University, Cambridge, MA 02138, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026136378","display_name":"Jessica M.Y. Ng","orcid":"https://orcid.org/0000-0002-6887-7488","observed_orcids":["https://orcid.org/0000-0002-6887-7488"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica\u00a0M.Y. Ng","raw_affiliation_strings":["Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006841058","display_name":"Tom Curran","orcid":"https://orcid.org/0000-0003-1444-7551","observed_orcids":["https://orcid.org/0000-0003-1444-7551"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tom Curran","raw_affiliation_strings":["Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I1335321130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056524310","display_name":"Lee L. Rubin","orcid":"https://orcid.org/0000-0002-8658-841X","observed_orcids":["https://orcid.org/0000-0002-8658-841X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210157861","display_name":"Harvard Stem Cell Institute","ror":"https://ror.org/04kj1hn59","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210157861"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lee\u00a0L. Rubin","raw_affiliation_strings":["Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA","Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210157861"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003394161","display_name":"Andrew P. McMahon","orcid":"https://orcid.org/0000-0002-3779-1729","observed_orcids":["https://orcid.org/0000-0002-3779-1729"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210157861","display_name":"Harvard Stem Cell Institute","ror":"https://ror.org/04kj1hn59","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210157861"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Andrew\u00a0P. McMahon","raw_affiliation_strings":["Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA","Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA","Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210157861"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5003394161","https://openalex.org/A5056524310"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210157861"],"apc_list":null,"apc_paid":null,"fwci":4.2382,"has_fulltext":true,"cited_by_count":73,"citation_normalized_percentile":{"value":0.9569227,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"19","issue":"8","first_page":"972","last_page":"982"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12009","display_name":"Hedgehog Signaling Pathway Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12009","display_name":"Hedgehog Signaling Pathway Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glucocorticoids","display_name":"glucocorticoids","score":0.8479999899864197},{"id":"https://openalex.org/keywords/smoothened","display_name":"Smoothened","score":0.9639999866485596},{"id":"https://openalex.org/keywords/hedgehog-signaling","display_name":"Hedgehog signaling","score":0.9750000238418579},{"id":"https://openalex.org/keywords/primary-cilia","display_name":"primary cilia","score":0.9350000023841858},{"id":"https://openalex.org/keywords/smom2","display_name":"SmoM2","score":0.7720000147819519},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.5929999947547913},{"id":"https://openalex.org/keywords/high-content-screening","display_name":"high-content screening","score":0.5950000286102295},{"id":"https://openalex.org/keywords/crosstalk","display_name":"crosstalk","score":0.5270000100135803},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.7179999947547913}],"concepts":[{"id":"https://openalex.org/C145837895","wikidata":"https://www.wikidata.org/wiki/Q18031607","display_name":"Smoothened","level":4,"score":0.9884899854660034},{"id":"https://openalex.org/C88498014","wikidata":"https://www.wikidata.org/wiki/Q14859918","display_name":"Hedgehog signaling pathway","level":3,"score":0.8678804636001587},{"id":"https://openalex.org/C2778539099","wikidata":"https://www.wikidata.org/wiki/Q6120","display_name":"Hedgehog","level":3,"score":0.8018920421600342},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6609227061271667},{"id":"https://openalex.org/C2779545874","wikidata":"https://www.wikidata.org/wiki/Q2070286","display_name":"Vismodegib","level":4,"score":0.5588924884796143},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.521305501461029},{"id":"https://openalex.org/C2780841215","wikidata":"https://www.wikidata.org/wiki/Q422549","display_name":"Glucocorticoid","level":2,"score":0.4661121964454651},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4594297409057617},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4128006100654602},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.22440698742866516}],"mesh":[{"descriptor_ui":"D000072079","descriptor_name":"Patched Receptors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072086","descriptor_name":"Smoothened Receptor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000813","descriptor_name":"Anilides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002522","descriptor_name":"Chlorocebus aethiops","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005446","descriptor_name":"Fluocinolone Acetonide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019556","descriptor_name":"COS Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D041681","descriptor_name":"NIH 3T3 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053823","descriptor_name":"Hedgehog Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1016/j.chembiol.2012.06.012","doi":"https://doi.org/10.1016/j.chembiol.2012.06.012","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.chembiol.2012.06.012","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1074552112002207/pdf","source":{"id":"https://openalex.org/S85134406","display_name":"Chemistry & Biology","issn_l":"1074-5521","issn":["1074-5521","1879-1301"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry & Biology","raw_type":"journal-article"},{"id":"pmid:22921064","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22921064","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry & biology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2740865","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3724998","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3724998","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3724998","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Chem Biol","raw_type":"Text"},{"id":"pmh:oai:dash.harvard.edu:1/9555244","doi":null,"is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:9555244","pdf_url":null,"source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.chembiol.2012.06.012","doi":"https://doi.org/10.1016/j.chembiol.2012.06.012","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.chembiol.2012.06.012","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1074552112002207/pdf","source":{"id":"https://openalex.org/S85134406","display_name":"Chemistry & Biology","issn_l":"1074-5521","issn":["1074-5521","1879-1301"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry & Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8560000061988831,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1903033493","display_name":"Regulation of polarity by Sonic hedgehog morphogen signaling","funder_award_id":"R01NS033642","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G4313676554","display_name":null,"funder_award_id":"U48 DP000033","funder_id":"https://openalex.org/F4320337383","funder_display_name":"National Center for Chronic Disease Prevention and Health Promotion"},{"id":"https://openalex.org/G7867750073","display_name":"Regulation of CNS and Limb Polarity by Sonic Hedgehog","funder_award_id":"R37NS033642","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G9000256801","display_name":null,"funder_award_id":"NS-033642","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000884403","display_name":"NORMAL & NEOPLASTIC GROWTH IN THE BRAIN","funder_award_id":"P01CA096832","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332616","display_name":"Harvard Stem Cell Institute","ror":"https://ror.org/04kj1hn59"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337383","display_name":"National Center for Chronic Disease Prevention and Health Promotion","ror":"https://ror.org/021rths28"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2145203496.pdf","grobid_xml":"https://content.openalex.org/works/W2145203496.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W122407444","https://openalex.org/W1529396499","https://openalex.org/W1594815607","https://openalex.org/W1963493384","https://openalex.org/W1972207998","https://openalex.org/W1980405010","https://openalex.org/W1982448212","https://openalex.org/W1990567821","https://openalex.org/W1991001144","https://openalex.org/W1997862931","https://openalex.org/W1998796212","https://openalex.org/W2001173847","https://openalex.org/W2010237337","https://openalex.org/W2012535690","https://openalex.org/W2020443955","https://openalex.org/W2023040415","https://openalex.org/W2027034464","https://openalex.org/W2027102742","https://openalex.org/W2030013561","https://openalex.org/W2030199762","https://openalex.org/W2031182850","https://openalex.org/W2032856965","https://openalex.org/W2040182956","https://openalex.org/W2056774387","https://openalex.org/W2057671045","https://openalex.org/W2059921810","https://openalex.org/W2066480724","https://openalex.org/W2069347490","https://openalex.org/W2070073434","https://openalex.org/W2070184849","https://openalex.org/W2078025797","https://openalex.org/W2079380806","https://openalex.org/W2086345909","https://openalex.org/W2088811912","https://openalex.org/W2090455515","https://openalex.org/W2100868792","https://openalex.org/W2101266961","https://openalex.org/W2101859789","https://openalex.org/W2106586740","https://openalex.org/W2110321605","https://openalex.org/W2123105952","https://openalex.org/W2123999563","https://openalex.org/W2128801071","https://openalex.org/W2132910786","https://openalex.org/W2137700247","https://openalex.org/W2141640690","https://openalex.org/W2146298285","https://openalex.org/W2149573520","https://openalex.org/W2159970646","https://openalex.org/W2160084509","https://openalex.org/W2171910249","https://openalex.org/W2474599166"],"related_works":["https://openalex.org/W2001173847","https://openalex.org/W2149573520","https://openalex.org/W2040182956","https://openalex.org/W2892407418","https://openalex.org/W2312772969","https://openalex.org/W3123996621","https://openalex.org/W2803955894","https://openalex.org/W2053385369","https://openalex.org/W7116347412","https://openalex.org/W4231468846"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}