{"id":"https://openalex.org/W2145199690","doi":"https://doi.org/10.1681/asn.v7112371","title":"Cultured rat mesothelial cells generate hydrogen peroxide","display_name":"Cultured rat mesothelial cells generate hydrogen peroxide","publication_year":1996,"publication_date":"1996-11-01","ids":{"openalex":"https://openalex.org/W2145199690","doi":"https://doi.org/10.1681/asn.v7112371","mag":"2145199690","pmid":"https://pubmed.ncbi.nlm.nih.gov/8959627"},"language":"en","primary_location":{"id":"doi:10.1681/asn.v7112371","doi":"https://doi.org/10.1681/asn.v7112371","is_oa":false,"landing_page_url":"https://doi.org/10.1681/asn.v7112371","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111857183","display_name":"Avshalom Shostak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799294462","display_name":"Emek Medical Center","ror":"https://ror.org/02b988t02","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799294462","https://openalex.org/I64767286"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"A Shostak","raw_affiliation_strings":["Department of Nephrology and Hypertension, Central Emek Hospital, Afula, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology and Hypertension, Central Emek Hospital, Afula, Israel","institution_ids":["https://openalex.org/I2799294462"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029891312","display_name":"E Pivnik","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799294462","display_name":"Emek Medical Center","ror":"https://ror.org/02b988t02","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799294462","https://openalex.org/I64767286"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"E Pivnik","raw_affiliation_strings":["Department of Nephrology and Hypertension, Central Emek Hospital, Afula, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology and Hypertension, Central Emek Hospital, Afula, Israel","institution_ids":["https://openalex.org/I2799294462"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113914080","display_name":"L. Gotloib","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799294462","display_name":"Emek Medical Center","ror":"https://ror.org/02b988t02","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799294462","https://openalex.org/I64767286"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"L Gotloib","raw_affiliation_strings":["Department of Nephrology and Hypertension, Central Emek Hospital, Afula, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology and Hypertension, Central Emek Hospital, Afula, Israel","institution_ids":["https://openalex.org/I2799294462"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2799294462"],"apc_list":null,"apc_paid":null,"fwci":0.6311,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.66978216,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"7","issue":"11","first_page":"2371","last_page":"2378"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.6509000062942505,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.6509000062942505,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10291","display_name":"Dialysis and Renal Disease Management","score":0.19120000302791595,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.11729999631643295,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/peritoneal-mesothelial-cells","display_name":"peritoneal mesothelial cells","score":0.9039999842643738},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":0.9350000023841858},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9039999842643738},{"id":"https://openalex.org/keywords/phorbol-myristate-acetate","display_name":"phorbol myristate acetate","score":0.9480000138282776},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":0.9860000014305115},{"id":"https://openalex.org/keywords/catalase","display_name":"catalase","score":0.9929999709129333},{"id":"https://openalex.org/keywords/glucose","display_name":"glucose","score":0.7390000224113464},{"id":"https://openalex.org/keywords/peritoneal-dialysis","display_name":"peritoneal dialysis","score":0.8709999918937683},{"id":"https://openalex.org/keywords/peritoneal-injury","display_name":"peritoneal injury","score":0.7080000042915344}],"concepts":[{"id":"https://openalex.org/C2909640154","wikidata":"https://www.wikidata.org/wiki/Q35970","display_name":"Mesothelial Cell","level":2,"score":0.9628341197967529},{"id":"https://openalex.org/C533411734","wikidata":"https://www.wikidata.org/wiki/Q171877","display_name":"Hydrogen peroxide","level":2,"score":0.8964300751686096},{"id":"https://openalex.org/C2909406889","wikidata":"https://www.wikidata.org/wiki/Q1756474","display_name":"Continuous ambulatory peritoneal dialysis","level":3,"score":0.7002954483032227},{"id":"https://openalex.org/C2778979269","wikidata":"https://www.wikidata.org/wiki/Q106951292","display_name":"Catalase","level":3,"score":0.6958709359169006},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.6747249960899353},{"id":"https://openalex.org/C2779747549","wikidata":"https://www.wikidata.org/wiki/Q35970","display_name":"Mesothelium","level":3,"score":0.6647084355354309},{"id":"https://openalex.org/C2779056158","wikidata":"https://www.wikidata.org/wiki/Q1756474","display_name":"Peritoneal dialysis","level":2,"score":0.6299555897712708},{"id":"https://openalex.org/C2780043322","wikidata":"https://www.wikidata.org/wiki/Q2705359","display_name":"Phorbol","level":4,"score":0.6210373640060425},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.5134257078170776},{"id":"https://openalex.org/C2776001837","wikidata":"https://www.wikidata.org/wiki/Q9629","display_name":"Peritoneum","level":2,"score":0.512360692024231},{"id":"https://openalex.org/C2780795997","wikidata":"https://www.wikidata.org/wiki/Q413283","display_name":"Superoxide","level":3,"score":0.4885324239730835},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.48817282915115356},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4587753713130951},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3643604516983032},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.35534441471099854},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30913329124450684},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.26267096400260925},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2608945071697235},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.18103179335594177},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.11048153042793274},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.06586703658103943}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002273","descriptor_name":"Carcinogens","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010530","descriptor_name":"Peritoneal Dialysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010537","descriptor_name":"Peritoneum","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D010537","descriptor_name":"Peritoneum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010537","descriptor_name":"Peritoneum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013755","descriptor_name":"Tetradecanoylphorbol Acetate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016897","descriptor_name":"Respiratory Burst","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1681/asn.v7112371","doi":"https://doi.org/10.1681/asn.v7112371","is_oa":false,"landing_page_url":"https://doi.org/10.1681/asn.v7112371","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"},{"id":"pmid:8959627","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8959627","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology : JASN","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.979200005531311,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W7121946","https://openalex.org/W118276485","https://openalex.org/W164441968","https://openalex.org/W168596621","https://openalex.org/W1480967651","https://openalex.org/W1547153486","https://openalex.org/W1592252967","https://openalex.org/W1752786746","https://openalex.org/W1965340455","https://openalex.org/W1966423289","https://openalex.org/W1971221852","https://openalex.org/W1976911231","https://openalex.org/W1978016588","https://openalex.org/W1996708870","https://openalex.org/W2000405107","https://openalex.org/W2005984152","https://openalex.org/W2011383364","https://openalex.org/W2011558362","https://openalex.org/W2014829681","https://openalex.org/W2015883559","https://openalex.org/W2021213106","https://openalex.org/W2022840093","https://openalex.org/W2034156415","https://openalex.org/W2048062311","https://openalex.org/W2049131840","https://openalex.org/W2049750186","https://openalex.org/W2049856962","https://openalex.org/W2056620406","https://openalex.org/W2065350540","https://openalex.org/W2074387820","https://openalex.org/W2080482903","https://openalex.org/W2085921508","https://openalex.org/W2089046319","https://openalex.org/W2095380692","https://openalex.org/W2098621632","https://openalex.org/W2113710155","https://openalex.org/W2114918609","https://openalex.org/W2115381431","https://openalex.org/W2156060851","https://openalex.org/W2170182659","https://openalex.org/W2174934515","https://openalex.org/W2181615208","https://openalex.org/W2407276337","https://openalex.org/W2410826065","https://openalex.org/W2419416533","https://openalex.org/W4300629861"],"related_works":["https://openalex.org/W2074786983","https://openalex.org/W2464034055","https://openalex.org/W2094338406","https://openalex.org/W2579729739","https://openalex.org/W1994678068","https://openalex.org/W4298374901","https://openalex.org/W2369970337","https://openalex.org/W310744155","https://openalex.org/W2767042196","https://openalex.org/W2080442169"],"abstract_inverted_index":{"This":[0,30,182],"study":[1],"was":[2,32,52,108,116],"designed":[3],"to":[4,47,61,75,98,168,175,212],"examine":[5],"whether":[6],"rat":[7],"peritoneal":[8,69,102,146,197,221],"mesothelial":[9,59,96,147,189,210],"cells":[10,60,97,148,190,211],"in":[11,17,24,105,149,171,178,195,217],"culture":[12,150],"could":[13],"generate":[14],"hydrogen":[15,28,83,112,160,240],"peroxide":[16,113,241],"different":[18],"experimental":[19],"conditions.":[20],"Mesothelial":[21],"cells,":[22],"incubated":[23],"M-199,":[25,107],"spontaneously":[26],"released":[27],"peroxide.":[29],"process":[31,232],"significantly":[33,117],"increased":[34,111,239],"by":[35,55,89],"addition":[36],"of":[37,44,58,82,95,158,199,209,230,233],"phorbol":[38,90,130],"myristate":[39,91,131],"acetate,":[40],"as":[41,43,215],"well":[42,224],"superoxide":[45,134],"dismutase":[46],"the":[48,79,99,120,156,196,204,228],"medium,":[49],"whereas":[50],"it":[51,138],"substantially":[53],"inhibited":[54],"catalase.":[56],"Exposure":[57],"modified":[62],"M-199":[63],"medium":[64],"with":[65,78,86,110,129,155],"1.5%":[66],"glucose":[67,100],"concentration-lactated":[68],"dialysis":[70,103],"solution":[71,104],"did":[72],"not":[73,124,152],"seem":[74],"interfere":[76],"either":[77],"spontaneous":[80,121],"release":[81],"peroxide,":[84,161],"or":[85],"that":[87,127,145,176,188],"induced":[88],"acetate.":[92],"Furthermore,":[93],"exposure":[94,208],"(4.25%)":[101],"Medium":[106],"coincident":[109],"generation,":[114],"which":[115],"higher":[118],"than":[119],"release,":[122],"and":[123,133,180],"far":[125],"from":[126,142,237],"observed":[128,177],"acetate":[132],"dismutase.":[135],"So":[136],"far,":[137],"can":[139,164],"be":[140,166,226],"inferred":[141],"this":[143],"evidence":[144],"are":[151],"only":[153],"endowed":[154],"capability":[157],"producing":[159],"but":[162],"they":[163],"also":[165,225],"activated":[167],"do":[169],"so":[170],"a":[172,192,231],"way":[173],"comparable":[174],"neutrophils":[179],"macrophages.":[181],"attribute":[183],"is":[184],"one":[185],"more":[186],"indication":[187],"play":[191],"relevant":[193],"role":[194],"mechanism":[198],"defense":[200],"against":[201],"infection.":[202],"On":[203],"other":[205],"hand,":[206],"continuous":[207,219,234],"glucose-enriched":[213],"fluids,":[214],"occurs":[216],"clinical":[218],"ambulatory":[220],"dialysis,":[222],"may":[223],"at":[227],"origin":[229],"injury,":[235],"resulting":[236],"an":[238],"generation.":[242]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
