{"id":"https://openalex.org/W2145199121","doi":"https://doi.org/10.4162/nrp.2007.1.3.195","title":"Apoptotic effect of IP6was not enhanced by co-treatment with myo-inositol in prostate carcinoma PC3 cells","display_name":"Apoptotic effect of IP6was not enhanced by co-treatment with myo-inositol in prostate carcinoma PC3 cells","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W2145199121","doi":"https://doi.org/10.4162/nrp.2007.1.3.195","mag":"2145199121","pmid":"https://pubmed.ncbi.nlm.nih.gov/20368938","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2849022"},"language":"en","primary_location":{"id":"doi:10.4162/nrp.2007.1.3.195","doi":"https://doi.org/10.4162/nrp.2007.1.3.195","is_oa":true,"landing_page_url":"https://doi.org/10.4162/nrp.2007.1.3.195","pdf_url":"http://e-nrp.org/Synapse/Data/PDFData/0161NRP/nrp-1-195.pdf","source":{"id":"https://openalex.org/S34455620","display_name":"Nutrition Research and Practice","issn_l":"1976-1457","issn":["1976-1457","2005-6168"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","kci-registered","ki-jl-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrition Research and Practice","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://e-nrp.org/Synapse/Data/PDFData/0161NRP/nrp-1-195.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Hyun-Jung Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyun-Jung Kim","raw_affiliation_strings":["Department of Food and Nutrition, Seoul National University, Seoul 151-742, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food and Nutrition, Seoul National University, Seoul 151-742, Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054825454","display_name":"Yumi Jang","orcid":"https://orcid.org/0000-0002-0626-0458","observed_orcids":["https://orcid.org/0000-0002-0626-0458","https://orcid.org/0009-0000-4804-0528"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yu-mi Jang","raw_affiliation_strings":["Department of Food and Nutrition, Seoul National University, Seoul 151-742, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food and Nutrition, Seoul National University, Seoul 151-742, Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083533957","display_name":"Harriet Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Harriet Kim","raw_affiliation_strings":["Department of Food and Nutrition, Seoul National University, Seoul 151-742, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food and Nutrition, Seoul National University, Seoul 151-742, Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012776022","display_name":"Young Hye Kwon","orcid":"https://orcid.org/0000-0002-7152-4085","observed_orcids":["https://orcid.org/0000-0002-7152-4085"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Young Hye Kwon","raw_affiliation_strings":["Research Institute of Human Ecology, Seoul National University, Seoul 151-742, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute of Human Ecology, Seoul National University, Seoul 151-742, Korea","institution_ids":["https://openalex.org/I139264467"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5012776022"],"corresponding_institution_ids":["https://openalex.org/I139264467"],"apc_list":null,"apc_paid":null,"fwci":0.4114,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.68256629,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"1","issue":"3","first_page":"195","last_page":"195"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12991","display_name":"Phytase and its Applications","score":0.37790000438690186,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12991","display_name":"Phytase and its Applications","score":0.37790000438690186,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.2888000011444092,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.04780000075697899,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phytic-acid","display_name":"phytic acid","score":0.9629999995231628},{"id":"https://openalex.org/keywords/myo-inositol","display_name":"myo-inositol","score":0.9729999899864197},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.7360000014305115},{"id":"https://openalex.org/keywords/pc-3-cells","display_name":"PC-3 cells","score":0.9900000095367432},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.9110000133514404},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.9440000057220459},{"id":"https://openalex.org/keywords/p21","display_name":"p21","score":0.9169999957084656},{"id":"https://openalex.org/keywords/synergistic-antitumor-effect","display_name":"synergistic antitumor effect","score":0.8029999732971191},{"id":"https://openalex.org/keywords/cell-growth-inhibition","display_name":"cell growth inhibition","score":0.8090000152587891}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.707484245300293},{"id":"https://openalex.org/C2777427919","wikidata":"https://www.wikidata.org/wiki/Q407997","display_name":"Inositol","level":3,"score":0.7038626670837402},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.5726109743118286},{"id":"https://openalex.org/C105696609","wikidata":"https://www.wikidata.org/wiki/Q1068809","display_name":"Cell cycle checkpoint","level":4,"score":0.5680409669876099},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.505828857421875},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.470051646232605},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.45384660363197327},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4485701620578766},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3359520435333252},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.32148414850234985},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2986433804035187},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.29663458466529846},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15641120076179504}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.4162/nrp.2007.1.3.195","doi":"https://doi.org/10.4162/nrp.2007.1.3.195","is_oa":true,"landing_page_url":"https://doi.org/10.4162/nrp.2007.1.3.195","pdf_url":"http://e-nrp.org/Synapse/Data/PDFData/0161NRP/nrp-1-195.pdf","source":{"id":"https://openalex.org/S34455620","display_name":"Nutrition Research and Practice","issn_l":"1976-1457","issn":["1976-1457","2005-6168"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","kci-registered","ki-jl-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrition Research and Practice","raw_type":"journal-article"},{"id":"pmid:20368938","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20368938","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrition research and practice","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2849022","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2849022/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutr Res Pract","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.4162/nrp.2007.1.3.195","doi":"https://doi.org/10.4162/nrp.2007.1.3.195","is_oa":true,"landing_page_url":"https://doi.org/10.4162/nrp.2007.1.3.195","pdf_url":"http://e-nrp.org/Synapse/Data/PDFData/0161NRP/nrp-1-195.pdf","source":{"id":"https://openalex.org/S34455620","display_name":"Nutrition Research and Practice","issn_l":"1976-1457","issn":["1976-1457","2005-6168"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","kci-registered","ki-jl-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrition Research and Practice","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2145199121.pdf","grobid_xml":"https://content.openalex.org/works/W2145199121.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W43957442","https://openalex.org/W66405674","https://openalex.org/W203115101","https://openalex.org/W1593954725","https://openalex.org/W1779463793","https://openalex.org/W1895967479","https://openalex.org/W1938459893","https://openalex.org/W1974545813","https://openalex.org/W1998881600","https://openalex.org/W1999118553","https://openalex.org/W2005238632","https://openalex.org/W2011485328","https://openalex.org/W2015177602","https://openalex.org/W2019234769","https://openalex.org/W2054354013","https://openalex.org/W2055632695","https://openalex.org/W2065171941","https://openalex.org/W2077815748","https://openalex.org/W2082768010","https://openalex.org/W2085593164","https://openalex.org/W2125639857","https://openalex.org/W2133506204","https://openalex.org/W2138123431","https://openalex.org/W2473017794"],"related_works":["https://openalex.org/W7135831502","https://openalex.org/W2980321711","https://openalex.org/W1604729496","https://openalex.org/W2125639857","https://openalex.org/W2034183628","https://openalex.org/W2130983457","https://openalex.org/W1968474020","https://openalex.org/W2024115343","https://openalex.org/W3022840054","https://openalex.org/W1999118553"],"abstract_inverted_index":{"Inositol":[0],"hexaphosphate":[1],"(IP(6))":[2],"is":[3],"a":[4],"major":[5],"constituent":[6],"of":[7,22,28,36,42,51,72,99,115,123,156,160,209,223,238,242],"most":[8],"cereals,":[9],"legumes,":[10],"nuts,":[11],"oil":[12],"seeds":[13],"and":[14,24,53,55,74,81,95,117,144,158,172,188,240,254],"soybean.":[15],"Previous":[16],"studies":[17],"reported":[18],"the":[19,39,48,65,70,97,113,121,154,207,221],"anticancer":[20,34,40,234],"effect":[21,35,41,50,71,114,155,199,247],"IP(6)":[23,29,43,52,73,94,109,116,139,143,157,187,204,214,232],"suggested":[25],"that":[26,107,231],"co-treatment":[27,185,201],"with":[30,93,137,146,186],"inositol":[31,54],"may":[32],"enhance":[33],"IP(6).":[37,180],"Although":[38],"has":[44,233],"been":[45],"intensively":[46],"studied,":[47],"combinational":[49],"involved":[56],"mechanisms":[57],"are":[58],"not":[59,191,257],"well":[60],"understood":[61],"so":[62],"far.":[63],"In":[64,193],"present":[66],"study,":[67],"we":[68,164],"investigated":[69],"myo-inositol":[75],"(MI)":[76],"on":[77,119,206,250],"cell":[78,87,100,161,210,217,243,251],"cycle":[79,162,211,218,252],"regulation":[80,183,208,241,253],"apoptosis":[82,239,255],"using":[83],"PC3":[84,170,260],"prostate":[85,261],"cancer":[86,262],"lines.":[88],"When":[89],"cells":[90,134,171],"were":[91,135],"co-treated":[92],"MI,":[96,145],"extent":[98],"growth":[101],"inhibition":[102],"was":[103,125,130,190,196,256],"significantly":[104,131,215],"increased":[105,132],"than":[106],"by":[108,150,179,184,200,236,248],"alone.":[110],"To":[111,152],"identify":[112],"MI":[118,159,189,224,249],"apoptosis,":[120],"activity":[122,129],"caspase-3":[124,128],"measured.":[126],"The":[127],"when":[133],"treated":[136],"either":[138],"alone":[140],"or":[141,225],"both":[142],"no":[147,197],"significant":[148,174,198],"enhancement":[149],"co-treatment.":[151],"investigate":[153],"arrest,":[163],"measured":[165],"p21":[166,177],"mRNA":[167,178],"expression":[168],"in":[169,176,220,259],"observed":[173,258],"increase":[175],"But":[181],"synergistic":[182,246],"observed.":[192],"addition,":[194],"there":[195],"compared":[202],"to":[203],"treatment":[205],"progression":[212],"although":[213],"changed":[216],"distribution":[219],"presence":[222],"not.":[226],"Therefore,":[227],"these":[228],"findings":[229],"support":[230],"function":[235],"induction":[237],"cycle.":[244],"However,":[245],"cells.":[263]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
