{"id":"https://openalex.org/W2145161383","doi":"https://doi.org/10.1080/09553009314551531","title":"Detection of DNA Double-strand Breaks through the Cell Cycle after Exposure to X-rays, Bleomycin, Etoposide and 125 IdUrd","display_name":"Detection of DNA Double-strand Breaks through the Cell Cycle after Exposure to X-rays, Bleomycin, Etoposide and 125 IdUrd","publication_year":1993,"publication_date":"1993-01-01","ids":{"openalex":"https://openalex.org/W2145161383","doi":"https://doi.org/10.1080/09553009314551531","mag":"2145161383","pmid":"https://pubmed.ncbi.nlm.nih.gov/7693837"},"language":"en","primary_location":{"id":"doi:10.1080/09553009314551531","doi":"https://doi.org/10.1080/09553009314551531","is_oa":false,"landing_page_url":"https://doi.org/10.1080/09553009314551531","pdf_url":null,"source":{"id":"https://openalex.org/S44383424","display_name":"International Journal of Radiation Biology","issn_l":"0955-3002","issn":["0955-3002","1362-3095"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Radiation Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111889006","display_name":"Peggy L. Olive","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289530486","display_name":"BC Cancer Agency","ror":"https://ror.org/03sfybe47","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"P.L. Olive","raw_affiliation_strings":["Medical Biophysics Department, British Columbia Cancer Research Centre, 601 W. 10th Avenue, Vancouver, BC, V5Z 1L3, Canada","Medical Biophysics Department, British Columbia Cancer Research Centre, Vancouver, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Biophysics Department, British Columbia Cancer Research Centre, 601 W. 10th Avenue, Vancouver, BC, V5Z 1L3, Canada","institution_ids":[]},{"raw_affiliation_string":"Medical Biophysics Department, British Columbia Cancer Research Centre, Vancouver, Canada","institution_ids":["https://openalex.org/I1289530486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054306473","display_name":"Judit P. Ban\u00e1th","orcid":"https://orcid.org/0009-0003-5788-4679","observed_orcids":["https://orcid.org/0009-0003-5788-4679"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J.P. Ban\u00e1th","raw_affiliation_strings":["Medical Biophysics Department, British Columbia Cancer Research Centre, 601 W. 10th Avenue, Vancouver, BC, V5Z 1L3, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Biophysics Department, British Columbia Cancer Research Centre, 601 W. 10th Avenue, Vancouver, BC, V5Z 1L3, Canada","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9848,"has_fulltext":false,"cited_by_count":117,"citation_normalized_percentile":{"value":0.74703892,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"64","issue":"4","first_page":"349","last_page":"358"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.48190000653266907,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.48190000653266907,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.26980000734329224,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.20190000534057617,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-double-strand-breaks","display_name":"DNA double-strand breaks","score":1.0},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"cell cycle","score":0.5910000205039978},{"id":"https://openalex.org/keywords/s-phase","display_name":"S phase","score":0.8659999966621399},{"id":"https://openalex.org/keywords/x-rays","display_name":"X-rays","score":0.6510000228881836},{"id":"https://openalex.org/keywords/bleomycin","display_name":"bleomycin","score":0.9890000224113464},{"id":"https://openalex.org/keywords/etoposide","display_name":"etoposide","score":1.0},{"id":"https://openalex.org/keywords/ionizing-radiation","display_name":"ionizing radiation","score":0.6970000267028809},{"id":"https://openalex.org/keywords/dna-damage-detection","display_name":"DNA damage detection","score":0.6740000247955322},{"id":"https://openalex.org/keywords/v79-cells","display_name":"V79 cells","score":0.8479999899864197},{"id":"https://openalex.org/keywords/dna-structure","display_name":"DNA structure","score":0.5960000157356262},{"id":"https://openalex.org/keywords/residual-protein","display_name":"residual protein","score":0.43700000643730164},{"id":"https://openalex.org/keywords/comet-assay","display_name":"comet assay","score":0.4959999918937683}],"concepts":[{"id":"https://openalex.org/C2776253266","wikidata":"https://www.wikidata.org/wiki/Q414000","display_name":"Aphidicolin","level":4,"score":0.6787190437316895},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.6550253033638},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.6496829986572266},{"id":"https://openalex.org/C2776232574","wikidata":"https://www.wikidata.org/wiki/Q415571","display_name":"Bleomycin","level":3,"score":0.6445142030715942},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.6405291557312012},{"id":"https://openalex.org/C2778119113","wikidata":"https://www.wikidata.org/wiki/Q418817","display_name":"Etoposide","level":3,"score":0.6108847260475159},{"id":"https://openalex.org/C2780358455","wikidata":"https://www.wikidata.org/wiki/Q903780","display_name":"Comet assay","level":4,"score":0.5867124795913696},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5531451106071472},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5194737315177917},{"id":"https://openalex.org/C57409179","wikidata":"https://www.wikidata.org/wiki/Q1218293","display_name":"Lysis","level":2,"score":0.5009331703186035},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4260713458061218},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.4245317578315735},{"id":"https://openalex.org/C18231593","wikidata":"https://www.wikidata.org/wiki/Q186161","display_name":"Ionizing radiation","level":3,"score":0.4175224304199219},{"id":"https://openalex.org/C2777755551","wikidata":"https://www.wikidata.org/wiki/Q2539773","display_name":"Chinese hamster","level":3,"score":0.41052502393722534},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38260382413864136},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.34591054916381836},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3280531167984009},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23282024264335632},{"id":"https://openalex.org/C111337013","wikidata":"https://www.wikidata.org/wiki/Q2737837","display_name":"Irradiation","level":2,"score":0.22126984596252441},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17917540669441223},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.07386109232902527},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.0},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001761","descriptor_name":"Bleomycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003412","descriptor_name":"Cricetulus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005047","descriptor_name":"Etoposide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007065","descriptor_name":"Idoxuridine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1080/09553009314551531","doi":"https://doi.org/10.1080/09553009314551531","is_oa":false,"landing_page_url":"https://doi.org/10.1080/09553009314551531","pdf_url":null,"source":{"id":"https://openalex.org/S44383424","display_name":"International Journal of Radiation Biology","issn_l":"0955-3002","issn":["0955-3002","1362-3095"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Radiation Biology","raw_type":"journal-article"},{"id":"pmid:7693837","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7693837","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of radiation biology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.579.8878","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.579.8878","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://cometassay.com/Olive and Banath 1993.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W130386237","https://openalex.org/W376676552","https://openalex.org/W587543992","https://openalex.org/W1491951542","https://openalex.org/W1521920054","https://openalex.org/W1559647740","https://openalex.org/W1749073943","https://openalex.org/W1780177435","https://openalex.org/W1959740129","https://openalex.org/W1968352315","https://openalex.org/W1971045116","https://openalex.org/W1978764891","https://openalex.org/W1979230039","https://openalex.org/W1981934855","https://openalex.org/W1984858135","https://openalex.org/W1997462031","https://openalex.org/W2003279154","https://openalex.org/W2012083162","https://openalex.org/W2012861895","https://openalex.org/W2033516066","https://openalex.org/W2037902796","https://openalex.org/W2038845073","https://openalex.org/W2040235808","https://openalex.org/W2044142379","https://openalex.org/W2051576487","https://openalex.org/W2052810045","https://openalex.org/W2069914850","https://openalex.org/W2074257914","https://openalex.org/W2082616271","https://openalex.org/W2084462556","https://openalex.org/W2084554663","https://openalex.org/W2110479470","https://openalex.org/W2134812307","https://openalex.org/W2137741723","https://openalex.org/W2141853256","https://openalex.org/W2149901880","https://openalex.org/W2157767060","https://openalex.org/W2206536388","https://openalex.org/W2319895613","https://openalex.org/W2323236725","https://openalex.org/W2324723148","https://openalex.org/W2406093174","https://openalex.org/W2604338383","https://openalex.org/W4249107824","https://openalex.org/W4255244349"],"related_works":["https://openalex.org/W7099350831","https://openalex.org/W2137741723","https://openalex.org/W7097048638","https://openalex.org/W7096207631","https://openalex.org/W2068489270","https://openalex.org/W2022915148","https://openalex.org/W2032390484","https://openalex.org/W2035714015","https://openalex.org/W121972703","https://openalex.org/W2161776046"],"abstract_inverted_index":{"Ionizing":[0],"radiation-induced":[1],"DNA":[2,80,97,163],"double-strand":[3,33],"breaks":[4],"(DSBs)":[5],"are":[6,165],"generally":[7],"more":[8],"difficult":[9],"to":[10,127,154],"detect":[11],"in":[12,16,47,50,109,162,173],"S-phase":[13,79,106,174],"cells":[14,17,49,77,92,107],"than":[15,91],"from":[18,115],"other":[19,32],"phases":[20],"of":[21,55,66,71,105,119,124,137,142,148],"the":[22,27,61,67,72,116,139,143,146],"cell":[23,56],"cycle.":[24],"To":[25],"explore":[26],"basis":[28],"for":[29,167,170],"this":[30],"observation,":[31],"breaking":[34],"agents":[35,46,90],"were":[36,58],"examined:":[37],"etoposide,":[38],"bleomycin":[39],"and":[40,122],"125IdUrd.":[41],"DSBs":[42,172],"induced":[43],"by":[44,88],"these":[45],"single":[48],"S,":[51],"G1":[52,94],"or":[53,69,95,145],"G2/M-phases":[54],"cycle":[57],"measured":[59,102],"using":[60],"neutral":[62],"comet":[63],"assay.":[64],"Regardless":[65],"nature":[68,141],"location":[70],"DSBs,":[73,138],"Chinese":[74],"hamster":[75],"V79":[76],"with":[78,93],"content":[81,101,118],"showed":[82],"about":[83],"2-3":[84],"times":[85],"less":[86],"damage":[87],"all":[89],"G2/M-phase":[96],"content.":[98],"Residual":[99],"protein":[100,117],"after":[103],"lysis":[104],"embedded":[108],"agarose":[110],"did":[111,129,151],"not":[112,130,152],"differ":[113],"significantly":[114],"asynchronous":[120],"cells,":[121],"removal":[123],"proteins":[125],"prior":[126],"irradiation":[128],"enhance":[131],"S":[132],"phase":[133],"migration.":[134,156],"The":[135],"number":[136],"physical":[140],"DSB,":[144],"presence":[147],"residual":[149],"proteins,":[150],"appear":[153],"influence":[155],"Therefore,":[157],"we":[158],"conclude":[159],"that":[160],"differences":[161],"structure":[164],"responsible":[166],"reduced":[168],"sensitivity":[169],"detecting":[171],"cells.":[175]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
