{"id":"https://openalex.org/W2145130031","doi":"https://doi.org/10.5603/4609","title":"Expression of natural antimicrobial peptide beta-defensin-2 and Langerhans cell accumulation in epidermis from human non-healing leg ulcers.","display_name":"Expression of natural antimicrobial peptide beta-defensin-2 and Langerhans cell accumulation in epidermis from human non-healing leg ulcers.","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W2145130031","doi":"https://doi.org/10.5603/4609","mag":"2145130031","pmid":"https://pubmed.ncbi.nlm.nih.gov/16201312"},"language":"en","primary_location":{"id":"pmid:16201312","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16201312","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Folia histochemica et cytobiologica","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://journals.viamedica.pl/folia_histochemica_cytobiologica/article/view/4609","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020223977","display_name":"Hanna Ga\u0142kowska","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99542240","display_name":"Polish Academy of Sciences","ror":"https://ror.org/01dr6c206","country_code":"PL","type":"government","lineage":["https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Hanna Galkowska","raw_affiliation_strings":["Department of Surgery and Transplantation, Medical Research Center, Polish Academy of Sciences, Warsaw, Poland. hgalk@cmdik.pan.pl"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery and Transplantation, Medical Research Center, Polish Academy of Sciences, Warsaw, Poland. hgalk@cmdik.pan.pl","institution_ids":["https://openalex.org/I99542240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029625361","display_name":"Waldemar Lech Olszewski","orcid":"https://orcid.org/0000-0002-7153-8532","observed_orcids":["https://orcid.org/0000-0002-7153-8532"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Waldemar L Olszewski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5007286336","display_name":"Urszula Wojew\u00f3dzka","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Urszula Wojewodzka","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3446,"has_fulltext":true,"cited_by_count":38,"citation_normalized_percentile":{"value":0.62006183,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"43","issue":"3","first_page":"133","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.7465999722480774,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.7465999722480774,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.186599999666214,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11227","display_name":"Diabetic Foot Ulcer Assessment and Management","score":0.023600000888109207,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-beta-defensin-2","display_name":"human beta-defensin 2","score":0.9980000257492065},{"id":"https://openalex.org/keywords/langerhans-cells","display_name":"Langerhans cells","score":0.9509999752044678},{"id":"https://openalex.org/keywords/chronic-wounds","display_name":"chronic wounds","score":0.6439999938011169},{"id":"https://openalex.org/keywords/diabetic-foot-ulcer","display_name":"diabetic foot ulcer","score":0.9340000152587891},{"id":"https://openalex.org/keywords/venous-leg-ulcers","display_name":"venous leg ulcers","score":0.9110000133514404},{"id":"https://openalex.org/keywords/epidermis","display_name":"epidermis","score":0.902999997138977},{"id":"https://openalex.org/keywords/gm-csf","display_name":"GM-CSF","score":0.8040000200271606},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.9940000176429749},{"id":"https://openalex.org/keywords/cd1a","display_name":"CD1a","score":0.7620000243186951},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.7429999709129333},{"id":"https://openalex.org/keywords/bacterial-colonization","display_name":"bacterial colonization","score":0.7210000157356262},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.5049999952316284}],"concepts":[{"id":"https://openalex.org/C2776458125","wikidata":"https://www.wikidata.org/wiki/Q1827343","display_name":"Epidermis (zoology)","level":2,"score":0.8132660388946533},{"id":"https://openalex.org/C2778379841","wikidata":"https://www.wikidata.org/wiki/Q1623344","display_name":"Langerhans cell","level":3,"score":0.6056409478187561},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.596504271030426},{"id":"https://openalex.org/C129437159","wikidata":"https://www.wikidata.org/wiki/Q4897294","display_name":"Beta defensin","level":4,"score":0.5679136514663696},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5628012418746948},{"id":"https://openalex.org/C2780439664","wikidata":"https://www.wikidata.org/wiki/Q7535376","display_name":"Skin biopsy","level":3,"score":0.5480806827545166},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5462363362312317},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.48544174432754517},{"id":"https://openalex.org/C2777074287","wikidata":"https://www.wikidata.org/wiki/Q1473931","display_name":"Keratinocyte","level":3,"score":0.4201769232749939},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.39168107509613037},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.29858583211898804},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2714606523513794},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.23288634419441223},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.18337887525558472},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1501055359840393},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.12625765800476074},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004817","descriptor_name":"Epidermis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004817","descriptor_name":"Epidermis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004817","descriptor_name":"Epidermis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007801","descriptor_name":"Langerhans Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007871","descriptor_name":"Leg Ulcer","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015603","descriptor_name":"Keratinocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016178","descriptor_name":"Granulocyte-Macrophage Colony-Stimulating Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017719","descriptor_name":"Diabetic Foot","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D023083","descriptor_name":"beta-Defensins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:16201312","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16201312","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Folia histochemica et cytobiologica","raw_type":"Journal Article"},{"id":"pmh:oai:czasopisma.viamedica.pl:article/4609","doi":null,"is_oa":true,"landing_page_url":"https://journals.viamedica.pl/folia_histochemica_cytobiologica/article/view/4609","pdf_url":"https://journals.viamedica.pl/folia_histochemica_cytobiologica/article/view/4609","source":{"id":"https://openalex.org/S4377196119","display_name":"Via Medica Journals","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Folia Histochemica et Cytobiologica; Vol 43, No 3 (2005); 133-136","raw_type":null},{"id":"pmh:oai:doaj.org/article:4f648890b97d4990a135e8841da21e1c","doi":"https://doi.org/10.5603/4609","is_oa":false,"landing_page_url":"https://doaj.org/article/4f648890b97d4990a135e8841da21e1c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Folia Histochemica et Cytobiologica, Vol 43, Iss 3, Pp 133-136 (2011)","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:czasopisma.viamedica.pl:article/4609","doi":null,"is_oa":true,"landing_page_url":"https://journals.viamedica.pl/folia_histochemica_cytobiologica/article/view/4609","pdf_url":"https://journals.viamedica.pl/folia_histochemica_cytobiologica/article/view/4609","source":{"id":"https://openalex.org/S4377196119","display_name":"Via Medica Journals","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Folia Histochemica et Cytobiologica; Vol 43, No 3 (2005); 133-136","raw_type":null},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2145130031.pdf","grobid_xml":"https://content.openalex.org/works/W2145130031.grobid-xml"},"referenced_works_count":15,"referenced_works":["https://openalex.org/W1571292455","https://openalex.org/W1954606945","https://openalex.org/W1964758221","https://openalex.org/W1965432550","https://openalex.org/W1975904765","https://openalex.org/W2013621172","https://openalex.org/W2013767004","https://openalex.org/W2023606718","https://openalex.org/W2035931280","https://openalex.org/W2104159258","https://openalex.org/W2118178754","https://openalex.org/W2125985831","https://openalex.org/W2139605495","https://openalex.org/W2275872217","https://openalex.org/W2288913919"],"related_works":["https://openalex.org/W6950307710","https://openalex.org/W7100137646","https://openalex.org/W2013767004","https://openalex.org/W2084190406","https://openalex.org/W1974985657","https://openalex.org/W2109367940","https://openalex.org/W3153566731","https://openalex.org/W1801159412","https://openalex.org/W2322054807","https://openalex.org/W2948100181"],"abstract_inverted_index":{"Chronic":[0,168],"wounds":[1],"like":[2],"venous":[3,224,270],"calf":[4,101,160,197,225,237,271],"and":[5,12,16,27,60,73,102,127,151,163,204,215,238,255,269],"diabetic":[6,92,212,267],"foot":[7,155,191,213,268],"ulcers":[8,72,98,169,272],"are":[9],"frequently":[10],"contaminated":[11],"colonized":[13],"by":[14,250],"bacteria":[15],"it":[17,76],"remains":[18],"unclear":[19],"whether":[20],"there":[21],"is":[22],"sufficient":[23],"expression":[24,52,173],"of":[25,29,36,44,53,62,99,140,146,174,184,201,211,217,223,246,263,278,284],"defensins":[26],"recruitment":[28],"epidermal":[30],"Langerhans":[31,64],"cells":[32,65],"in":[33,67,88,148,187,243,265,281],"the":[34,51,81,100,171,208,221,244,251,275,282],"margin":[35,222],"ulcer":[37,214,226],"compared":[38,158,194,227],"to":[39,48,74,77,159,195,228],"normal":[40,78,150,177,188,196,229,236],"skin.":[41,178],"The":[42],"aim":[43],"this":[45,279],"study":[46],"was":[47,180],"examine":[49],"immunohistochemically":[50],"beta-defensin-2":[54],"(hBD2),":[55],"GM-CSF,":[56],"VEGF":[57],"growth":[58],"factors":[59],"accumulation":[61,183],"CD1a+":[63,185,202],"(LC)":[66],"epidermis":[68,153,189,240],"from":[69,80,154,190],"chronic":[70],"skin":[71,79,109,157,161,193,198,230],"compare":[75],"corresponding":[82],"areas.":[83],"Studies":[84],"were":[85,114,131,231],"carried":[86],"out":[87],"10":[89,94,103],"patients":[90,95,104],"with":[91,96],"foot,":[93],"varicous":[97],"undergoing":[105],"orthopedic":[106],"surgery":[107],"(normal":[108,162],"for":[110],"control).":[111],"Biopsy":[112],"specimens":[113],"immunostained":[115],"using":[116],"specific":[117],"primary":[118],"antibodies,":[119],"LSAB+":[120],"kit":[121],"based":[122],"on":[123],"biotin-avidin-peroxidase":[124],"complex":[125],"technique":[126],"DAB":[128],"chromogen.":[129],"Results":[130],"expressed":[132],"as":[133,176],"a":[134],"mean":[135],"staining":[136,141,145],"intensity.":[137],"Statistical":[138],"analysis":[139],"showed":[142,170],"significantly":[143,181],"higher":[144],"hBD2":[147,175,264],"both":[149,266],"ulcerated":[152],"sole":[156,192,239],"ulcerated,":[164],"p":[165],"<":[166],"0.05).":[167],"same":[172],"There":[179],"lower":[182],"LC":[186,203,218],"(p<0.05).":[199],"Accumulation":[200],"GM-CSF":[205],"upregulation":[206,262],"at":[207,220],"border":[209],"area":[210],"reduction":[216],"concentration":[219],"observed.":[232],"It":[233],"seems":[234],"that":[235],"is,":[241],"unlike":[242],"mechanisms":[245],"innate":[247],"immunity,":[248],"influenced":[249],"different":[252],"keratinocyte":[253],"turnover":[254],"bacterial":[256],"flora":[257],"colonizing":[258],"these":[259],"regions.":[260],"Insufficient":[261],"may":[273],"suggest":[274],"pathological":[276],"role":[277],"protein":[280],"chronicity":[283],"ulcers.":[285]},"counts_by_year":[{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
