{"id":"https://openalex.org/W2145072012","doi":"https://doi.org/10.2174/157488611798280933","title":"Zopiclone as Positive Control in Studies Examining the Residual Effects of Hypnotic Drugs on Driving Ability","display_name":"Zopiclone as Positive Control in Studies Examining the Residual Effects of Hypnotic Drugs on Driving Ability","publication_year":2011,"publication_date":"2011-09-01","ids":{"openalex":"https://openalex.org/W2145072012","doi":"https://doi.org/10.2174/157488611798280933","mag":"2145072012","pmid":"https://pubmed.ncbi.nlm.nih.gov/22129315"},"language":"en","primary_location":{"id":"doi:10.2174/157488611798280933","doi":"https://doi.org/10.2174/157488611798280933","is_oa":false,"landing_page_url":"https://doi.org/10.2174/157488611798280933","pdf_url":null,"source":{"id":"https://openalex.org/S18096204","display_name":"Current Drug Safety","issn_l":"1574-8863","issn":["1574-8863","2212-3911"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Drug Safety","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028155072","display_name":"Joris C. Verster","orcid":"https://orcid.org/0000-0002-6455-2096","observed_orcids":["https://orcid.org/0000-0002-6455-2096"]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Joris C. Verster","raw_affiliation_strings":["Utrecht University, Utrecht Institute for Pharmaceutical Sciences, Division of Pharmacology, Universiteitsweg 99, 3584 CG Utrecht, The Netherlands. j.c.verster@uu.nl"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Utrecht University, Utrecht Institute for Pharmaceutical Sciences, Division of Pharmacology, Universiteitsweg 99, 3584 CG Utrecht, The Netherlands. j.c.verster@uu.nl","institution_ids":["https://openalex.org/I193662353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053353211","display_name":"D. Warren Spence","orcid":"https://orcid.org/0000-0002-1664-6960","observed_orcids":["https://orcid.org/0000-0002-1664-6960"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. Warren Spence","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109953385","display_name":"Azmeh Shahid","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Azmeh Shahid","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071016733","display_name":"Seithikurippu Ratnas Pandi-Perumal","orcid":"https://orcid.org/0000-0002-8686-7259","observed_orcids":["https://orcid.org/0000-0002-8686-7259"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Seithikurippu R. Pandi-Perumal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5011832419","display_name":"Thomas G. Roth","orcid":"https://orcid.org/0000-0001-8309-4134","observed_orcids":["https://orcid.org/0000-0001-8309-4134"]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Thomas Roth","raw_affiliation_strings":["Utrecht Institute for Pharmaceutical Sciences, Division of Pharmacology, Utrecht University, Universiteitsweg 99, 3584 CG, Utrecht, The Netherlands.,Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Utrecht Institute for Pharmaceutical Sciences, Division of Pharmacology, Utrecht University, Universiteitsweg 99, 3584 CG, Utrecht, The Netherlands.,Netherlands","institution_ids":["https://openalex.org/I193662353"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5011832419"],"corresponding_institution_ids":["https://openalex.org/I193662353"],"apc_list":null,"apc_paid":null,"fwci":9.1049,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.97045606,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"6","issue":"4","first_page":"209","last_page":"218"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10370","display_name":"Traffic and Road Safety","score":0.5922999978065491,"subfield":{"id":"https://openalex.org/subfields/2213","display_name":"Safety, Risk, Reliability and Quality"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10370","display_name":"Traffic and Road Safety","score":0.5922999978065491,"subfield":{"id":"https://openalex.org/subfields/2213","display_name":"Safety, Risk, Reliability and Quality"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11373","display_name":"Sleep and Work-Related Fatigue","score":0.3278999924659729,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10316","display_name":"Sleep and related disorders","score":0.035100001841783524,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/zopiclone","display_name":"zopiclone","score":1.0},{"id":"https://openalex.org/keywords/hypnotics","display_name":"hypnotics","score":0.7670000195503235},{"id":"https://openalex.org/keywords/residual-drug-effects","display_name":"residual drug effects","score":0.7540000081062317},{"id":"https://openalex.org/keywords/driving-performance","display_name":"driving performance","score":0.7200000286102295},{"id":"https://openalex.org/keywords/driving-simulator","display_name":"driving simulator","score":0.5830000042915344},{"id":"https://openalex.org/keywords/blood-alcohol-concentration","display_name":"blood alcohol concentration","score":0.6230000257492065},{"id":"https://openalex.org/keywords/older-drivers","display_name":"older drivers","score":0.7450000047683716}],"concepts":[{"id":"https://openalex.org/C2777810057","wikidata":"https://www.wikidata.org/wiki/Q220426","display_name":"Zopiclone","level":3,"score":0.9975581765174866},{"id":"https://openalex.org/C2780930544","wikidata":"https://www.wikidata.org/wiki/Q62962","display_name":"Hypnotic","level":2,"score":0.7641923427581787},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7204477787017822},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.6819204092025757},{"id":"https://openalex.org/C2778537899","wikidata":"https://www.wikidata.org/wiki/Q254034","display_name":"Bedtime","level":2,"score":0.4665035605430603},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.4605717957019806},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4303149878978729},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.21648898720741272},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2094232738018036},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001334","descriptor_name":"Automobile Driving","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006993","descriptor_name":"Hypnotics and Sedatives","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D011597","descriptor_name":"Psychomotor Performance","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011597","descriptor_name":"Psychomotor Performance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018592","descriptor_name":"Cross-Over Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018849","descriptor_name":"Controlled Clinical Trials as Topic","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D053961","descriptor_name":"Azabicyclo Compounds","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.2174/157488611798280933","doi":"https://doi.org/10.2174/157488611798280933","is_oa":false,"landing_page_url":"https://doi.org/10.2174/157488611798280933","pdf_url":null,"source":{"id":"https://openalex.org/S18096204","display_name":"Current Drug Safety","issn_l":"1574-8863","issn":["1574-8863","2212-3911"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Drug Safety","raw_type":"journal-article"},{"id":"pmid:22129315","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22129315","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current drug safety","raw_type":"Journal Article"},{"id":"pmh:oai:researchbank.swinburne.edu.au:d01efc41-d074-4a8f-8e9e-35638d986cd5/1","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1959.3/439226","pdf_url":null,"source":{"id":"https://openalex.org/S4306401157","display_name":"Swinburne figshare (Swinburne University of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I57093077","host_organization_name":"Swinburne University of Technology","host_organization_lineage":["https://openalex.org/I57093077"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Current Drug Safety, Vol. 6, no. 4 (2011), pp. 209-218","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"},{"display_name":"Meta-Analysis","id":"https://openalex.org/study-designs/meta-analysis"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4410908505","https://openalex.org/W4210537434","https://openalex.org/W2160202884","https://openalex.org/W2171230255","https://openalex.org/W2050678883","https://openalex.org/W1531560013","https://openalex.org/W2126523529","https://openalex.org/W1982880881","https://openalex.org/W105174322","https://openalex.org/W1999898642"],"abstract_inverted_index":{"Zopiclone":[0],"(7.5":[1,93,111,124,171,212],"mg)":[2,94,125,213],"is":[3,214],"frequently":[4],"used":[5],"as":[6,39],"a":[7,40,186,215],"positive":[8,217],"control":[9],"in":[10,86,119,158,180],"studies":[11,29,62,76],"that":[12,63,85,219],"examine":[13],"the":[14,31,78,87,178,204,227],"residual":[15,46],"effects":[16,32,47],"of":[17,33,45,48,101,155,161,190],"hypnotic":[18],"drugs":[19],"on":[20,66,226],"driving":[21,81,97,120,196,206,229],"ability":[22],"and":[23,35,56,109,128,137,198,223],"related":[24],"skills.":[25],"This":[26,173],"review":[27,54],"summarizes":[28],"examining":[30],"zopiclone,":[34],"discusses":[36],"its":[37],"usefulness":[38],"comparator":[41],"drug":[42],"for":[43,61,72,142,183],"investigations":[44],"novel":[49],"sleep":[50],"medication.":[51],"A":[52,99],"literature":[53],"(Pubmed":[55],"Embase)":[57],"was":[58,145,165,175],"conducted":[59],"searching":[60],"tested":[64,106],"zopiclone":[65,92,110,123,170,211],"driving.":[67],"Cross":[68],"references":[69],"were":[70,105],"checked":[71],"additional":[73],"papers.":[74],"Eight":[75],"utilizing":[77],"standardized":[79],"on-the-road":[80,228],"test":[82,207],"consistently":[83,220],"showed":[84,115],"morning":[88],"following":[89],"bedtime":[90],"administration":[91],"significantly":[95],"impaired":[96],"performance.":[98],"total":[100],"191":[102],"healthy":[103,130,143],"volunteers":[104,144],"after":[107,122],"placebo":[108],"mg).":[112,172],"Meta":[113],"analyses":[114],"no":[116],"significant":[117,222],"differences":[118],"performance":[121],"between":[126],"adult":[127],"elderly":[129],"volunteers.":[131],"The":[132],"combined":[133],"effect":[134],"size":[135],"(ES)":[136],"95%":[138],"confidence":[139],"interval":[140],"(95%CI)":[141],"0.782":[146],"(0.620,":[147],"0.944).":[148],"Relative":[149],"to":[150],"placebo,":[151],"an":[152],"average":[153],"increment":[154,179],"3.0":[156],"cm":[157],"Standard":[159],"Deviation":[160],"Lateral":[162],"Position":[163],"(SDLP)":[164],"observed":[166],"when":[167],"treated":[168],"with":[169,185,203],"deviation":[174],"higher":[176],"than":[177],"SDLP":[181],"reported":[182],"drivers":[184],"blood":[187],"alcohol":[188],"concentration":[189],"0.05%":[191],"(+2.4":[192],"cm).":[193],"Results":[194],"from":[195],"simulators":[197],"psychometric":[199],"tests":[200],"are":[201],"consistent":[202],"on-road":[205],"results.":[208],"In":[209],"conclusion,":[210],"reliable":[216],"control,":[218],"shows":[221],"meaningful":[224],"impairment":[225],"test.":[230]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
