{"id":"https://openalex.org/W2145013117","doi":"https://doi.org/10.1530/joe-12-0260","title":"Myostatin inhibits myosatellite cell proliferation and consequently activates differentiation: evidence for endocrine-regulated transcript processing","display_name":"Myostatin inhibits myosatellite cell proliferation and consequently activates differentiation: evidence for endocrine-regulated transcript processing","publication_year":2012,"publication_date":"2012-08-07","ids":{"openalex":"https://openalex.org/W2145013117","doi":"https://doi.org/10.1530/joe-12-0260","mag":"2145013117","pmid":"https://pubmed.ncbi.nlm.nih.gov/22872758"},"language":"en","primary_location":{"id":"doi:10.1530/joe-12-0260","doi":"https://doi.org/10.1530/joe-12-0260","is_oa":true,"landing_page_url":"https://doi.org/10.1530/joe-12-0260","pdf_url":"https://joe.bioscientifica.com/downloadpdf/journals/joe/215/1/177.pdf","source":{"id":"https://openalex.org/S34842069","display_name":"Journal of Endocrinology","issn_l":"0022-0795","issn":["0022-0795","1479-6805"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://joe.bioscientifica.com/downloadpdf/journals/joe/215/1/177.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037570676","display_name":"Dilip K. Garikipati","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I72951846","display_name":"Washington State University","ror":"https://ror.org/05dk0ce17","country_code":"US","type":"education","lineage":["https://openalex.org/I72951846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dilip K Garikipati","raw_affiliation_strings":["Department of Animal Sciences, 124 ASLB, School of Molecular Biosciences, Washington Center for Muscle Biology, Washington State University, Pullman, Washington 99164, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal Sciences, 124 ASLB, School of Molecular Biosciences, Washington Center for Muscle Biology, Washington State University, Pullman, Washington 99164, USA","institution_ids":["https://openalex.org/I72951846"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042062669","display_name":"Buel D. Rodgers","orcid":"https://orcid.org/0000-0003-0751-1105","observed_orcids":["https://orcid.org/0000-0003-0751-1105"]},"institutions":[{"id":"https://openalex.org/I72951846","display_name":"Washington State University","ror":"https://ror.org/05dk0ce17","country_code":"US","type":"education","lineage":["https://openalex.org/I72951846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Buel D Rodgers","raw_affiliation_strings":["Department of Animal Sciences , 124 ASLB ,","School of Molecular Biosciences , Washington Center for Muscle Biology , Washington State University , Pullman , Washington 99164 , USA","Department of Animal Sciences124 ASLB, School of Molecular Biosciences, Washington Center for Muscle Biology, Washington State University, Pullman, Washington 99164, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal Sciences , 124 ASLB ,","institution_ids":[]},{"raw_affiliation_string":"School of Molecular Biosciences , Washington Center for Muscle Biology , Washington State University , Pullman , Washington 99164 , USA","institution_ids":["https://openalex.org/I72951846"]},{"raw_affiliation_string":"Department of Animal Sciences124 ASLB, School of Molecular Biosciences, Washington Center for Muscle Biology, Washington State University, Pullman, Washington 99164, USA","institution_ids":["https://openalex.org/I72951846"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I72951846"],"apc_list":null,"apc_paid":null,"fwci":3.2114,"has_fulltext":true,"cited_by_count":77,"citation_normalized_percentile":{"value":0.93244674,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"215","issue":"1","first_page":"177","last_page":"187"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myostatin","display_name":"myostatin","score":1.0},{"id":"https://openalex.org/keywords/satellite-cells","display_name":"satellite cells","score":0.953000009059906},{"id":"https://openalex.org/keywords/satellite-cell-proliferation","display_name":"satellite cell proliferation","score":0.8159999847412109},{"id":"https://openalex.org/keywords/myogenesis","display_name":"myogenesis","score":0.7039999961853027},{"id":"https://openalex.org/keywords/transcript-processing","display_name":"transcript processing","score":0.5130000114440918},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.9390000104904175},{"id":"https://openalex.org/keywords/rainbow-trout","display_name":"rainbow trout","score":0.8809999823570251},{"id":"https://openalex.org/keywords/subfunctionalization","display_name":"subfunctionalization","score":0.8859999775886536},{"id":"https://openalex.org/keywords/myokines","display_name":"myokines","score":0.4300000071525574},{"id":"https://openalex.org/keywords/myf5","display_name":"Myf5","score":0.7490000128746033},{"id":"https://openalex.org/keywords/myod","display_name":"MyoD","score":0.9670000076293945},{"id":"https://openalex.org/keywords/myosin-light-chain","display_name":"myosin light chain","score":0.8029999732971191},{"id":"https://openalex.org/keywords/muscle-growth-regulation","display_name":"muscle growth regulation","score":0.5830000042915344}],"concepts":[{"id":"https://openalex.org/C2777488582","wikidata":"https://www.wikidata.org/wiki/Q29630","display_name":"Myostatin","level":3,"score":0.9625622034072876},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7971612215042114},{"id":"https://openalex.org/C97816823","wikidata":"https://www.wikidata.org/wiki/Q166726","display_name":"Myogenin","level":4,"score":0.5282776951789856},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5245490074157715},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5125584602355957},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.505057156085968},{"id":"https://openalex.org/C2778831791","wikidata":"https://www.wikidata.org/wiki/Q408122","display_name":"Follistatin","level":2,"score":0.48601967096328735},{"id":"https://openalex.org/C146539212","wikidata":"https://www.wikidata.org/wiki/Q5611740","display_name":"Growth differentiation factor","level":4,"score":0.4774235486984253},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.47282421588897705},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4625062346458435},{"id":"https://openalex.org/C6997183","wikidata":"https://www.wikidata.org/wiki/Q271727","display_name":"Myosin","level":2,"score":0.454592764377594},{"id":"https://openalex.org/C117365660","wikidata":"https://www.wikidata.org/wiki/Q962589","display_name":"Myokine","level":3,"score":0.4433459937572479},{"id":"https://openalex.org/C2778463287","wikidata":"https://www.wikidata.org/wiki/Q18029725","display_name":"MYF5","level":5,"score":0.4316997826099396},{"id":"https://openalex.org/C167414201","wikidata":"https://www.wikidata.org/wiki/Q1955391","display_name":"Muscle hypertrophy","level":2,"score":0.29287251830101013},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2853550314903259},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23852524161338806},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.17832884192466736},{"id":"https://openalex.org/C31507581","wikidata":"https://www.wikidata.org/wiki/Q425383","display_name":"Bone morphogenetic protein","level":3,"score":0.06408628821372986},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004703","descriptor_name":"Endocrine System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004703","descriptor_name":"Endocrine System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006728","descriptor_name":"Hormones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007334","descriptor_name":"Insulin-Like Growth Factor I","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012323","descriptor_name":"RNA Processing, Post-Transcriptional","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017686","descriptor_name":"Oncorhynchus mykiss","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D032496","descriptor_name":"Satellite Cells, Skeletal Muscle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D032496","descriptor_name":"Satellite Cells, Skeletal Muscle","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D055435","descriptor_name":"Myostatin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055435","descriptor_name":"Myostatin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055435","descriptor_name":"Myostatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D055435","descriptor_name":"Myostatin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1530/joe-12-0260","doi":"https://doi.org/10.1530/joe-12-0260","is_oa":true,"landing_page_url":"https://doi.org/10.1530/joe-12-0260","pdf_url":"https://joe.bioscientifica.com/downloadpdf/journals/joe/215/1/177.pdf","source":{"id":"https://openalex.org/S34842069","display_name":"Journal of Endocrinology","issn_l":"0022-0795","issn":["0022-0795","1479-6805"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Endocrinology","raw_type":"journal-article"},{"id":"pmid:22872758","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22872758","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of endocrinology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.985.5061","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.985.5061","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://joe.endocrinology-journals.org/content/early/2012/08/07/JOE-12-0260.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1530/joe-12-0260","doi":"https://doi.org/10.1530/joe-12-0260","is_oa":true,"landing_page_url":"https://doi.org/10.1530/joe-12-0260","pdf_url":"https://joe.bioscientifica.com/downloadpdf/journals/joe/215/1/177.pdf","source":{"id":"https://openalex.org/S34842069","display_name":"Journal of Endocrinology","issn_l":"0022-0795","issn":["0022-0795","1479-6805"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Endocrinology","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"display_name":"Life below water","id":"https://metadata.un.org/sdg/14","score":0.4099999964237213},{"display_name":"Life on land","id":"https://metadata.un.org/sdg/15","score":0.4099999964237213}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8761997328","display_name":"Physiological Mechanisms of Myostatin Functional Divergence","funder_award_id":"0840644","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2145013117.pdf","grobid_xml":"https://content.openalex.org/works/W2145013117.grobid-xml"},"referenced_works_count":79,"referenced_works":["https://openalex.org/W80922074","https://openalex.org/W162490457","https://openalex.org/W1505206366","https://openalex.org/W1563659068","https://openalex.org/W1972668070","https://openalex.org/W1976775787","https://openalex.org/W1977858070","https://openalex.org/W1980068920","https://openalex.org/W1980689906","https://openalex.org/W1982013501","https://openalex.org/W1986749116","https://openalex.org/W1987388422","https://openalex.org/W1996339633","https://openalex.org/W1999631078","https://openalex.org/W2002501178","https://openalex.org/W2004621059","https://openalex.org/W2004751759","https://openalex.org/W2005053484","https://openalex.org/W2005366749","https://openalex.org/W2009571461","https://openalex.org/W2011163066","https://openalex.org/W2012284260","https://openalex.org/W2012628315","https://openalex.org/W2017429680","https://openalex.org/W2022410320","https://openalex.org/W2022905237","https://openalex.org/W2024057452","https://openalex.org/W2027507903","https://openalex.org/W2033924360","https://openalex.org/W2035450796","https://openalex.org/W2039744083","https://openalex.org/W2039906099","https://openalex.org/W2041168550","https://openalex.org/W2043875204","https://openalex.org/W2045557931","https://openalex.org/W2046194164","https://openalex.org/W2048134135","https://openalex.org/W2049586866","https://openalex.org/W2051094259","https://openalex.org/W2051437976","https://openalex.org/W2055789788","https://openalex.org/W2056359233","https://openalex.org/W2057162008","https://openalex.org/W2059281708","https://openalex.org/W2059328349","https://openalex.org/W2060011023","https://openalex.org/W2062867597","https://openalex.org/W2064813976","https://openalex.org/W2064895186","https://openalex.org/W2066056709","https://openalex.org/W2068756636","https://openalex.org/W2069740469","https://openalex.org/W2071861150","https://openalex.org/W2078149211","https://openalex.org/W2085014866","https://openalex.org/W2085569401","https://openalex.org/W2092051076","https://openalex.org/W2100345592","https://openalex.org/W2101825220","https://openalex.org/W2104717998","https://openalex.org/W2106840901","https://openalex.org/W2106999078","https://openalex.org/W2111274663","https://openalex.org/W2114468352","https://openalex.org/W2118392869","https://openalex.org/W2120960764","https://openalex.org/W2128303661","https://openalex.org/W2134971385","https://openalex.org/W2153289066","https://openalex.org/W2155685150","https://openalex.org/W2159189766","https://openalex.org/W2160999627","https://openalex.org/W2161256277","https://openalex.org/W2164928197","https://openalex.org/W2165519158","https://openalex.org/W2165578387","https://openalex.org/W2166596195","https://openalex.org/W2167467376","https://openalex.org/W2225799406"],"related_works":["https://openalex.org/W2118392869","https://openalex.org/W1980068920","https://openalex.org/W2026450541","https://openalex.org/W1994922641","https://openalex.org/W2054532151","https://openalex.org/W1518100107","https://openalex.org/W2100345592","https://openalex.org/W2176865116","https://openalex.org/W2068698102","https://openalex.org/W3095049430"],"abstract_inverted_index":{"Myostatin":[0,178],"is":[1,20,24,175,202,206,236],"a":[2,53],"potent":[3],"negative":[4],"regulator":[5],"of":[6,33,56,104,124,171,199,208],"muscle":[7,62],"growth":[8,63,138],"in":[9,17,38,43,66,91,100,187,193],"mammals.":[10],"Despite":[11],"high":[12],"structural":[13],"conservation,":[14],"functional":[15],"conservation":[16],"nonmammalian":[18],"species":[19,40],"only":[21],"assumed.":[22],"This":[23,190],"particularly":[25],"true":[26],"for":[27],"fish":[28],"due":[29],"to":[30,74,181],"the":[31,111,122,169,196,211,219,232],"presence":[32],"several":[34,107],"myostatin":[35,94],"paralogs:":[36],"two":[37],"most":[39],"and":[41,48,114,131,151,156,168,205,230],"four":[42],"salmonids":[44],"(MSTN-1a,":[45],"-1b,":[46],"-2a,":[47],"-2b).":[49],"Rainbow":[50],"trout":[51],"are":[52,228],"rich":[54],"source":[55],"primary":[57],"myosatellite":[58,185],"cells":[59,70],"as":[60],"hyperplastic":[61],"occurs":[64,192],"even":[65],"adult":[67],"fish.":[68],"These":[69,214],"were":[71,159],"therefore":[72,179],"used":[73],"determine":[75],"myostatin's":[76],"effects":[77,86,153],"on":[78,87,154],"proliferation":[79,96,147],"whereas":[80],"our":[81],"earlier":[82],"studies":[83,215],"reported":[84],"its":[85,157,172,223],"quiescent":[88],"cells.":[89],"As":[90],"mammals,":[92,194],"recombinant":[93],"suppressed":[95,160],"with":[97,226],"no":[98],"changes":[99],"cell":[101],"morphology.":[102],"Expression":[103],"MSTN-1a":[105],"was":[106,115],"fold":[108],"higher":[109],"than":[110,142],"other":[112],"paralogs":[113],"autoregulated":[116],"by":[117,161],"myostatin,":[118],"which":[119,174],"also":[120,191,216],"upregulated":[121,165],"expression":[123,167],"key":[125],"differentiation":[126,155,186],"markers:":[127],"Myf5,":[128],"MyoD1,":[129],"myogenin,":[130],"myosin":[132],"light":[133],"chain.":[134],"Thus,":[135],"myostatin-stimulated":[136],"cellular":[137],"inhibition":[139],"activates":[140],"rather":[141],"represses":[143],"differentiation.":[144],"IGF-1":[145,164],"stimulated":[146],"but":[148],"had":[149],"minimal":[150],"delayed":[152],"actions":[158],"myostatin.":[162],"However,":[163],"MSTN-2a":[166,200],"processing":[170,198],"transcript,":[173],"normally":[176],"unprocessed.":[177],"appears":[180],"partly":[182],"mediate":[183],"IGF-stimulated":[184,197],"rainbow":[188],"trout.":[189],"although":[195],"transcripts":[201],"highly":[203],"unique":[204],"indicative":[207],"subfunctionalization":[209],"within":[210],"gene":[212,234],"family.":[213],"suggest":[217],"that":[218,231],"myokine's":[220],"actions,":[221],"including":[222],"antagonistic":[224],"relationship":[225],"IGF-1,":[227],"conserved":[229],"salmonid":[233],"family":[235],"functionally":[237],"diverging.":[238]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}