{"id":"https://openalex.org/W2145001877","doi":null,"title":"Cancer stem cell and stromal microenvironment.","display_name":"Cancer stem cell and stromal microenvironment.","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2145001877","mag":"2145001877","pmid":"https://pubmed.ncbi.nlm.nih.gov/23531695","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3603173"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:2603975","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3603173","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3603173","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100361348","display_name":"Li Li","orcid":"https://orcid.org/0000-0003-2342-3658","observed_orcids":["https://orcid.org/0000-0003-2342-3658","https://orcid.org/0009-0002-6853-3631"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Li Li","raw_affiliation_strings":["Institute for Translational Research, Laboratory of Translational Cancer Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Translational Research, Laboratory of Translational Cancer Research","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103495455","display_name":"JOHN TOTTERDALE COLE","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I2799767083","display_name":"Ochsner Medical Center","ror":"https://ror.org/0290qyp66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336053918","https://openalex.org/I2799767083"]}],"countries":["AU","US"],"is_corresponding":false,"raw_author_name":"John Cole","raw_affiliation_strings":["The University of Queensland School of Medicine, Ochsner Clinical School, New Orleans, LA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Queensland School of Medicine, Ochsner Clinical School, New Orleans, LA","institution_ids":["https://openalex.org/I165143802","https://openalex.org/I2799767083"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109988530","display_name":"David A. Margolin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I2799767083","display_name":"Ochsner Medical Center","ror":"https://ror.org/0290qyp66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336053918","https://openalex.org/I2799767083"]}],"countries":["AU","US"],"is_corresponding":false,"raw_author_name":"David A Margolin","raw_affiliation_strings":["The University of Queensland School of Medicine, Ochsner Clinical School, New Orleans, LA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Queensland School of Medicine, Ochsner Clinical School, New Orleans, LA","institution_ids":["https://openalex.org/I165143802","https://openalex.org/I2799767083"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.1427,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.92583065,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"13","issue":"1","first_page":"109","last_page":"18"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.9340000152587891},{"id":"https://openalex.org/keywords/lymph-node-stroma","display_name":"lymph node stroma","score":0.8299999833106995},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.859000027179718},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.8840000033378601},{"id":"https://openalex.org/keywords/tumor-recurrence","display_name":"tumor recurrence","score":0.796999990940094},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9980000257492065},{"id":"https://openalex.org/keywords/follicular-lymphoma","display_name":"follicular lymphoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.7350000143051147},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.6359999775886536},{"id":"https://openalex.org/keywords/stromal-signaling","display_name":"stromal signaling","score":0.9150000214576721}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8385839462280273},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.7091951966285706},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.6825253963470459},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.6269658803939819},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5709962844848633},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5668274760246277},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.5315563082695007},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5315354466438293},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.48831769824028015},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4806453287601471},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4548909366130829},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36936020851135254},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0878136157989502},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:2603975","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3603173","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:23531695","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23531695","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ochsner journal","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3603173","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3603173/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ochsner J","raw_type":"Text"},{"id":"mag:2145001877","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23531695","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2603975","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3603173","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9789000153541565,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8532724777","display_name":"Stromal Cell Molecules Required for Lymphoma Generation","funder_award_id":"R01CA089057","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":104,"referenced_works":["https://openalex.org/W12805001","https://openalex.org/W1480706413","https://openalex.org/W1495724837","https://openalex.org/W1516231415","https://openalex.org/W1534577564","https://openalex.org/W1927423808","https://openalex.org/W1943633942","https://openalex.org/W1967090278","https://openalex.org/W1967192670","https://openalex.org/W1967580470","https://openalex.org/W1972932862","https://openalex.org/W1973172185","https://openalex.org/W1976609425","https://openalex.org/W1978747495","https://openalex.org/W1982297389","https://openalex.org/W1983357205","https://openalex.org/W1985698425","https://openalex.org/W1987673721","https://openalex.org/W1988515290","https://openalex.org/W1989805762","https://openalex.org/W1990049304","https://openalex.org/W1990589849","https://openalex.org/W1996349127","https://openalex.org/W1999356404","https://openalex.org/W2001402386","https://openalex.org/W2001634461","https://openalex.org/W2005609755","https://openalex.org/W2009213090","https://openalex.org/W2010450664","https://openalex.org/W2013833543","https://openalex.org/W2014562331","https://openalex.org/W2015795638","https://openalex.org/W2016714482","https://openalex.org/W2020131167","https://openalex.org/W2022861295","https://openalex.org/W2027505310","https://openalex.org/W2028663226","https://openalex.org/W2032314331","https://openalex.org/W2033809978","https://openalex.org/W2036487194","https://openalex.org/W2036705097","https://openalex.org/W2037796411","https://openalex.org/W2045926135","https://openalex.org/W2046079960","https://openalex.org/W2046248396","https://openalex.org/W2048769231","https://openalex.org/W2051055358","https://openalex.org/W2056502071","https://openalex.org/W2058554403","https://openalex.org/W2062205986","https://openalex.org/W2066616821","https://openalex.org/W2066897404","https://openalex.org/W2067243578","https://openalex.org/W2068366699","https://openalex.org/W2071949698","https://openalex.org/W2072194461","https://openalex.org/W2073406151","https://openalex.org/W2078757557","https://openalex.org/W2081447858","https://openalex.org/W2082057023","https://openalex.org/W2083364356","https://openalex.org/W2094572856","https://openalex.org/W2094974693","https://openalex.org/W2096042605","https://openalex.org/W2096065464","https://openalex.org/W2097563123","https://openalex.org/W2102085111","https://openalex.org/W2103709809","https://openalex.org/W2103970768","https://openalex.org/W2110108339","https://openalex.org/W2110576880","https://openalex.org/W2113995806","https://openalex.org/W2115588189","https://openalex.org/W2116490042","https://openalex.org/W2118960457","https://openalex.org/W2126002765","https://openalex.org/W2126369996","https://openalex.org/W2129644533","https://openalex.org/W2131170195","https://openalex.org/W2133851039","https://openalex.org/W2134068241","https://openalex.org/W2134987819","https://openalex.org/W2135231064","https://openalex.org/W2135536911","https://openalex.org/W2138842322","https://openalex.org/W2139942643","https://openalex.org/W2141110984","https://openalex.org/W2141419529","https://openalex.org/W2145742835","https://openalex.org/W2147650118","https://openalex.org/W2152310279","https://openalex.org/W2154992334","https://openalex.org/W2156365913","https://openalex.org/W2156522119","https://openalex.org/W2157195219","https://openalex.org/W2157910818","https://openalex.org/W2160138651","https://openalex.org/W2163572306","https://openalex.org/W2165477362","https://openalex.org/W2165948908","https://openalex.org/W2167715370","https://openalex.org/W2312293427","https://openalex.org/W2332701617","https://openalex.org/W2436530364"],"related_works":["https://openalex.org/W4378175487","https://openalex.org/W2888354232","https://openalex.org/W3029334151","https://openalex.org/W4404574795","https://openalex.org/W3185870033","https://openalex.org/W4301393861","https://openalex.org/W4384831124","https://openalex.org/W3029402451","https://openalex.org/W2464918474","https://openalex.org/W3123190114"],"abstract_inverted_index":{"BACKGROUND:":[0],"Chemotherapeutic":[1],"resistance":[2],"and":[3,36,50,58],"local":[4],"recurrence":[5,51],"or":[6],"distant":[7],"organ":[8],"metastasis":[9],"are":[10],"the":[11,29,37,40],"major":[12],"causes":[13],"of":[14],"cancer":[15,18,24,33,57,85],"mortality.":[16],"Conventional":[17],"treatments":[19],"do":[20],"not":[21],"consistently":[22],"prevent":[23],"recurrence.":[25,86],"METHODS:":[26],"We":[27,62],"illustrate":[28],"key":[30],"roles":[31],"that":[32,64],"stem":[34,78],"cells":[35],"tumor":[38,46],"microenvironment-particularly":[39],"lymph":[41],"node":[42],"stromal":[43],"microenvironment-play":[44],"in":[45,52,70],"drug":[47],"resistance,":[48],"metastasis,":[49],"2":[53],"representative":[54],"cancers:":[55],"colorectal":[56],"follicular":[59],"lymphoma.":[60],"CONCLUSION:":[61],"believe":[63],"combination":[65],"treatment":[66],"with":[67,72],"chemotherapeutic":[68],"agents":[69],"conjunction":[71],"targeted":[73],"therapies,":[74],"such":[75],"as":[76],"stromal/cancer":[77],"cell":[79],"signaling-targeted":[80],"therapy,":[81],"may":[82],"effectively":[83],"minimize":[84]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}