{"id":"https://openalex.org/W2144881986","doi":"https://doi.org/10.1371/journal.pone.0057179","title":"Late Infusion of Cloned Marrow Fibroblasts Stimulates Endogenous Recovery from Radiation-Induced Lung Injury","display_name":"Late Infusion of Cloned Marrow Fibroblasts Stimulates Endogenous Recovery from Radiation-Induced Lung Injury","publication_year":2013,"publication_date":"2013-03-08","ids":{"openalex":"https://openalex.org/W2144881986","doi":"https://doi.org/10.1371/journal.pone.0057179","mag":"2144881986","pmid":"https://pubmed.ncbi.nlm.nih.gov/23520463","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3592849"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0057179","doi":"https://doi.org/10.1371/journal.pone.0057179","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0057179","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0057179&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0057179&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110051987","display_name":"Mineo Iwata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mineo Iwata","raw_affiliation_strings":["Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037474143","display_name":"David K. Madtes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David K. Madtes","raw_affiliation_strings":["Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America","Department of Medicine, University of Washington, Seattle, Washington, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I4210089486"]},{"raw_affiliation_string":"Department of Medicine, University of Washington, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024539015","display_name":"Kraig Abrams","orcid":"https://orcid.org/0000-0002-4997-0222","observed_orcids":["https://orcid.org/0000-0002-4997-0222"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kraig Abrams","raw_affiliation_strings":["Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108402936","display_name":"W. J. Lamm","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wayne J. E. Lamm","raw_affiliation_strings":["Department of Medicine, University of Washington, Seattle, Washington, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Washington, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086220514","display_name":"Robb W. Glenny","orcid":"https://orcid.org/0000-0003-0545-6691","observed_orcids":["https://orcid.org/0000-0003-0545-6691"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robb W. Glenny","raw_affiliation_strings":["Department of Medicine, University of Washington, Seattle, Washington, United States of America","Department of Physiology and Biophysics, University of Washington, Seattle, Washington, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Washington, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Physiology and Biophysics, University of Washington, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065409070","display_name":"Richard A. Nash","orcid":"https://orcid.org/0009-0005-2683-5182","observed_orcids":["https://orcid.org/0009-0005-2683-5182"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard A. Nash","raw_affiliation_strings":["Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America","Department of Medicine, University of Washington, Seattle, Washington, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I4210089486"]},{"raw_affiliation_string":"Department of Medicine, University of Washington, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022803134","display_name":"Aravind Ramakrishnan","orcid":"https://orcid.org/0000-0001-6827-5615","observed_orcids":["https://orcid.org/0000-0001-6827-5615"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aravind Ramakrishnan","raw_affiliation_strings":["Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America","Department of Medicine, University of Washington, Seattle, Washington, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I4210089486"]},{"raw_affiliation_string":"Department of Medicine, University of Washington, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063850995","display_name":"Beverly Torok\u2010Storb","orcid":"https://orcid.org/0000-0001-9393-1290","observed_orcids":["https://orcid.org/0000-0001-9393-1290"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Beverly Torok-Storb","raw_affiliation_strings":["Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I4210089486"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5063850995"],"corresponding_institution_ids":["https://openalex.org/I4210089486"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":0.0,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.17131594,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"8","issue":"3","first_page":"e57179","last_page":"e57179"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/radiation-induced-lung-injury","display_name":"radiation-induced lung injury","score":0.9919999837875366},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.8420000076293945},{"id":"https://openalex.org/keywords/cell-therapy","display_name":"cell therapy","score":0.6010000109672546},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.7770000100135803},{"id":"https://openalex.org/keywords/lung-repair","display_name":"lung repair","score":0.7889999747276306},{"id":"https://openalex.org/keywords/lung-function","display_name":"lung function","score":0.7170000076293945},{"id":"https://openalex.org/keywords/pneumonitis","display_name":"pneumonitis","score":0.949999988079071},{"id":"https://openalex.org/keywords/ttf-1","display_name":"TTF-1","score":0.8410000205039978},{"id":"https://openalex.org/keywords/canine-model","display_name":"canine model","score":0.5759999752044678}],"concepts":[{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.6556911468505859},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.6381548643112183},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.5479956269264221},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5407971739768982},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5128427147865295},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5122970342636108},{"id":"https://openalex.org/C16020263","wikidata":"https://www.wikidata.org/wiki/Q1778553","display_name":"DLCO","level":5,"score":0.49724629521369934},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.4726247787475586},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.4442843198776245},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.37933549284935},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28665614128112793},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25776487588882446},{"id":"https://openalex.org/C165637977","wikidata":"https://www.wikidata.org/wiki/Q11067835","display_name":"Diffusing capacity","level":4,"score":0.17608749866485596},{"id":"https://openalex.org/C3018587741","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung function","level":3,"score":0.09540686011314392},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002461","descriptor_name":"Cell Line, Transformed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002461","descriptor_name":"Cell Line, Transformed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002461","descriptor_name":"Cell Line, Transformed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":false},{"descriptor_ui":"D008171","descriptor_name":"Lung Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D008171","descriptor_name":"Lung Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D008171","descriptor_name":"Lung Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D008171","descriptor_name":"Lung Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008171","descriptor_name":"Lung Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008171","descriptor_name":"Lung Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008171","descriptor_name":"Lung Diseases","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D008171","descriptor_name":"Lung Diseases","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D008171","descriptor_name":"Lung Diseases","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011650","descriptor_name":"Pulmonary Alveoli","qualifier_ui":"Q000293","qualifier_name":"injuries","is_major_topic":false},{"descriptor_ui":"D011650","descriptor_name":"Pulmonary Alveoli","qualifier_ui":"Q000293","qualifier_name":"injuries","is_major_topic":false},{"descriptor_ui":"D011650","descriptor_name":"Pulmonary Alveoli","qualifier_ui":"Q000293","qualifier_name":"injuries","is_major_topic":false},{"descriptor_ui":"D011650","descriptor_name":"Pulmonary Alveoli","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011650","descriptor_name":"Pulmonary Alveoli","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011650","descriptor_name":"Pulmonary Alveoli","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011833","descriptor_name":"Radiation Injuries, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011833","descriptor_name":"Radiation Injuries, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011833","descriptor_name":"Radiation Injuries, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011833","descriptor_name":"Radiation Injuries, Experimental","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D011833","descriptor_name":"Radiation Injuries, Experimental","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D011833","descriptor_name":"Radiation Injuries, Experimental","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017154","descriptor_name":"Stromal Cells","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":false},{"descriptor_ui":"D017154","descriptor_name":"Stromal Cells","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":false},{"descriptor_ui":"D017154","descriptor_name":"Stromal Cells","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":false},{"descriptor_ui":"D017690","descriptor_name":"Cell Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017690","descriptor_name":"Cell Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017690","descriptor_name":"Cell Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055745","descriptor_name":"Bronchioles","qualifier_ui":"Q000293","qualifier_name":"injuries","is_major_topic":false},{"descriptor_ui":"D055745","descriptor_name":"Bronchioles","qualifier_ui":"Q000293","qualifier_name":"injuries","is_major_topic":false},{"descriptor_ui":"D055745","descriptor_name":"Bronchioles","qualifier_ui":"Q000293","qualifier_name":"injuries","is_major_topic":false},{"descriptor_ui":"D055745","descriptor_name":"Bronchioles","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D055745","descriptor_name":"Bronchioles","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D055745","descriptor_name":"Bronchioles","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0057179","doi":"https://doi.org/10.1371/journal.pone.0057179","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0057179","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0057179&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2601468","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3592849","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3592849","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3592849","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:23520463","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23520463","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:659c5b4ed0974033b75308977e2dd6c6","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/659c5b4ed0974033b75308977e2dd6c6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 8, Iss 3, p e57179 (2013)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/648838","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/Late_Infusion_of_Cloned_Marrow_Fibroblasts_Stimulates_Endogenous_Recovery_from_Radiation_Induced_Lung_Injury__/648838","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0057179","doi":"https://doi.org/10.1371/journal.pone.0057179","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0057179","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0057179&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9789000153541565,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.7699999809265137,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2567390826","display_name":"Controlling Hematopoietic Lineage Commitment from ESC to Platelets","funder_award_id":"U01HL099993","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2780658106","display_name":"Mitigation of Radiation-Induced Lung Injury in the Dog Model","funder_award_id":"RC1AI081298","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G3757055246","display_name":"Core Center of Excellence in Hematology","funder_award_id":"P30DK056465","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G938461115","display_name":null,"funder_award_id":"P01HL094374","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320308793","display_name":"Fred Hutchinson Cancer Research Center","ror":"https://ror.org/007ps6h72"},{"id":"https://openalex.org/F4320310094","display_name":"University of Washington","ror":"https://ror.org/00cvxb145"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2144881986.pdf","grobid_xml":"https://content.openalex.org/works/W2144881986.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1658545","https://openalex.org/W1967586814","https://openalex.org/W1974911818","https://openalex.org/W1977532338","https://openalex.org/W1978154805","https://openalex.org/W1978393588","https://openalex.org/W1979103623","https://openalex.org/W1983311716","https://openalex.org/W1985977074","https://openalex.org/W1987361539","https://openalex.org/W1988022060","https://openalex.org/W1988126593","https://openalex.org/W1988224129","https://openalex.org/W1992752163","https://openalex.org/W1993175314","https://openalex.org/W2005433255","https://openalex.org/W2006464386","https://openalex.org/W2008062232","https://openalex.org/W2008188840","https://openalex.org/W2016596484","https://openalex.org/W2026089703","https://openalex.org/W2029844302","https://openalex.org/W2043161346","https://openalex.org/W2051377548","https://openalex.org/W2060074461","https://openalex.org/W2069905905","https://openalex.org/W2077319771","https://openalex.org/W2105902643","https://openalex.org/W2108356931","https://openalex.org/W2109773324","https://openalex.org/W2111727066","https://openalex.org/W2121449552","https://openalex.org/W2147156629","https://openalex.org/W2147497952","https://openalex.org/W2150103989","https://openalex.org/W2151420887","https://openalex.org/W2166019746","https://openalex.org/W2241784197","https://openalex.org/W2339555669","https://openalex.org/W2411653119","https://openalex.org/W2411694251","https://openalex.org/W2598987449","https://openalex.org/W2931878287"],"related_works":["https://openalex.org/W1543079524","https://openalex.org/W2373300262","https://openalex.org/W7100175817","https://openalex.org/W3029975160","https://openalex.org/W2054667169","https://openalex.org/W2807671294","https://openalex.org/W1980419256","https://openalex.org/W1981654793","https://openalex.org/W2464527747","https://openalex.org/W3030466191"],"abstract_inverted_index":{"In":[0],"the":[1,15,28,37,119,125,131,180],"current":[2],"study,":[3],"we":[4,85],"used":[5],"a":[6,18,46,54,238],"canine":[7],"model":[8],"of":[9,17,22,24,30,49,57,90,105,170,192,227,232],"radiation-induced":[10,243],"lung":[11,70,133,244,265],"injury":[12],"to":[13,36,102,185,259],"test":[14],"effect":[16],"single":[19,120],"i.v.":[20],"infusion":[21,226],"10\u00d710(6)/kg":[23],"marrow":[25,58,228],"fibroblasts":[26,229],"on":[27],"progression":[29],"damage":[31,71],"following":[32],"15":[33],"Gy":[34],"exposure":[35],"right":[38],"lung.":[39],"The":[40,155],"fibroblasts,":[41],"designated":[42],"DS1":[43,61,94,205],"cells,":[44],"are":[45,252],"cloned":[47],"population":[48],"immortalized":[50],"cells":[51,62,95,178,190],"isolated":[52],"from":[53],"primary":[55],"culture":[56],"stromal":[59],"cells.":[60],"were":[63,199,216],"infused":[64],"at":[65],"week":[66],"5":[67,91,106],"post-irradiation":[68,84],"when":[69],"was":[72,116],"evident":[73],"by":[74,163,196,219],"imaging":[75,165],"with":[76,237],"high-resolution":[77],"computed":[78],"tomography":[79],"(CT).":[80],"At":[81],"13":[82],"weeks":[83],"found":[86,200],"that":[87,225,248,255],"4":[88],"out":[89,104],"dogs":[92,108,157],"receiving":[93],"had":[96,159],"significantly":[97,138],"improved":[98],"pulmonary":[99],"function":[100,115],"compared":[101,184],"0":[103],"control":[107,140,186],"(p":[109],"=":[110,145,148,152],"0.047,":[111],"Fisher's":[112],"Exact).":[113],"Pulmonary":[114],"measured":[117],"as":[118],"breath":[121],"diffusion":[122],"capacity-hematocrit":[123],"(DLCO-Hct),":[124],"total":[126,132],"inspiratory":[127],"capacity":[128,134],"(IC),":[129],"and":[130,141,150,166,182,215],"(TLC),":[135],"which":[136,234,262],"differed":[137],"between":[139],"DS1-treated":[142,156],"dogs;":[143],"p":[144,147,151],"0.002,":[146],"0.005,":[149],"0.004,":[153],"respectively.":[154],"also":[158],"less":[160],"pneumonitis":[161],"detected":[162,195],"CT":[164],"an":[167],"increased":[168,260],"number":[169],"TTF-1":[171],"(thyroid":[172],"transcription":[173],"factor":[174],"1,":[175],"NKX2-1)":[176],"positive":[177],"in":[179,201,240],"bronchioli":[181],"alveoli":[183],"dogs.":[187],"Endothelial-like":[188],"progenitor":[189],"(ELC)":[191],"host":[193],"origin,":[194],"colony":[197],"assays,":[198],"peripheral":[202],"blood":[203],"after":[204,213],"cell":[206],"infusion.":[207],"ELC":[208,257],"numbers":[209],"peaked":[210],"one":[211],"day":[212],"infusion,":[214],"not":[217],"detectable":[218],"7":[220],"days.":[221],"These":[222],"data":[223],"suggest":[224],"stimulates":[230],"mobilization":[231],"ELC,":[233],"is":[235],"associated":[236],"reduction":[239],"otherwise":[241],"progressive":[242],"injury.":[245],"We":[246],"hypothesize":[247],"these":[249],"two":[250],"observations":[251],"related,":[253],"specifically":[254],"circulating":[256],"contribute":[258],"angiogenesis,":[261],"facilitates":[263],"endogenous":[264],"repair.":[266]},"counts_by_year":[{"year":2017,"cited_by_count":3}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}