{"id":"https://openalex.org/W2144872069","doi":"https://doi.org/10.1093/neuonc/nos329","title":"Prognostic significance of telomerase-associated parameters in glioblastoma: effect of patient age","display_name":"Prognostic significance of telomerase-associated parameters in glioblastoma: effect of patient age","publication_year":2013,"publication_date":"2013-02-07","ids":{"openalex":"https://openalex.org/W2144872069","doi":"https://doi.org/10.1093/neuonc/nos329","mag":"2144872069","pmid":"https://pubmed.ncbi.nlm.nih.gov/23393205","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3607268"},"language":"en","primary_location":{"id":"doi:10.1093/neuonc/nos329","doi":"https://doi.org/10.1093/neuonc/nos329","is_oa":false,"landing_page_url":"https://doi.org/10.1093/neuonc/nos329","pdf_url":null,"source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/articles/PMC3607268","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112245679","display_name":"Daniela L\u00f6tsch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Daniela L\u00f6tsch","raw_affiliation_strings":["Institute of Cancer Research, Department of Medicine I, Medical University Vienna, Borschkegasse 8a, 1090 Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cancer Research, Department of Medicine I, Medical University Vienna, Borschkegasse 8a, 1090 Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010453061","display_name":"Bahil Ghanim","orcid":"https://orcid.org/0000-0002-6563-5643","observed_orcids":["https://orcid.org/0000-0002-6563-5643"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bahil Ghanim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070339748","display_name":"Magdalena Laaber","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Magdalena Laaber","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010536571","display_name":"Gabriele Wurm","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gabriele Wurm","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032775594","display_name":"Serge Weis","orcid":"https://orcid.org/0000-0001-6750-2599","observed_orcids":["https://orcid.org/0000-0001-6750-2599"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Serge Weis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060533947","display_name":"Stefan Lenz","orcid":"https://orcid.org/0000-0001-9135-1743","observed_orcids":["https://orcid.org/0000-0001-9135-1743","https://orcid.org/0000-0002-4179-6784"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stefan Lenz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022408812","display_name":"Gerald Webersinke","orcid":"https://orcid.org/0000-0001-5654-6190","observed_orcids":["https://orcid.org/0000-0001-5654-6190"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gerald Webersinke","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055193081","display_name":"Josef Pichler","orcid":"https://orcid.org/0000-0003-4847-7994","observed_orcids":["https://orcid.org/0000-0003-4847-7994"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Josef Pichler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043913136","display_name":"Walter Berger","orcid":"https://orcid.org/0000-0003-0014-1658","observed_orcids":["https://orcid.org/0000-0003-0014-1658"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Walter Berger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5059704501","display_name":"Sabine Spiegl\u2010Kreinecker","orcid":"https://orcid.org/0000-0002-0553-834X","observed_orcids":["https://orcid.org/0000-0002-0553-834X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sabine Spiegl-Kreinecker","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5132,"currency":"USD","value_usd":5132},"apc_paid":null,"fwci":3.3926,"has_fulltext":false,"cited_by_count":68,"citation_normalized_percentile":{"value":0.93422435,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"15","issue":"4","first_page":"423","last_page":"432"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.7670999765396118,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.7670999765396118,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.22339999675750732,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9779999852180481},{"id":"https://openalex.org/keywords/telomerase","display_name":"telomerase","score":0.8600000143051147},{"id":"https://openalex.org/keywords/htert","display_name":"hTERT","score":0.8059999942779541},{"id":"https://openalex.org/keywords/telomere-length","display_name":"telomere length","score":0.9480000138282776},{"id":"https://openalex.org/keywords/telomerase-activity","display_name":"telomerase activity","score":0.9079999923706055},{"id":"https://openalex.org/keywords/patient-age","display_name":"patient age","score":0.7490000128746033},{"id":"https://openalex.org/keywords/idh1-mutation","display_name":"IDH1 mutation","score":0.8640000224113464},{"id":"https://openalex.org/keywords/mgmt-promoter-methylation","display_name":"MGMT promoter methylation","score":0.996999979019165},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.7789999842643738},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9350000023841858},{"id":"https://openalex.org/keywords/tumor-aggressiveness","display_name":"tumor aggressiveness","score":0.906000018119812}],"concepts":[{"id":"https://openalex.org/C94581717","wikidata":"https://www.wikidata.org/wiki/Q331839","display_name":"Telomerase","level":3,"score":0.9337007403373718},{"id":"https://openalex.org/C125593758","wikidata":"https://www.wikidata.org/wiki/Q15315135","display_name":"Telomerase reverse transcriptase","level":4,"score":0.9193559288978577},{"id":"https://openalex.org/C177336024","wikidata":"https://www.wikidata.org/wiki/Q14872779","display_name":"Telomere","level":3,"score":0.8474762439727783},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.5297409296035767},{"id":"https://openalex.org/C127848430","wikidata":"https://www.wikidata.org/wiki/Q18027543","display_name":"IDH1","level":4,"score":0.49828314781188965},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4878127872943878},{"id":"https://openalex.org/C156719811","wikidata":"https://www.wikidata.org/wiki/Q28774","display_name":"Reverse transcriptase","level":4,"score":0.46570947766304016},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4527270793914795},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.37513959407806396},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3275981545448303},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32017290592193604},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.26643314957618713},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.26316511631011963},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19717863202095032},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13388526439666748}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007521","descriptor_name":"Isocitrate Dehydrogenase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015254","descriptor_name":"DNA Modification Methylases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016615","descriptor_name":"Telomere","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019098","descriptor_name":"Telomerase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019098","descriptor_name":"Telomerase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D045643","descriptor_name":"DNA Repair Enzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060888","descriptor_name":"Real-Time Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/neuonc/nos329","doi":"https://doi.org/10.1093/neuonc/nos329","is_oa":false,"landing_page_url":"https://doi.org/10.1093/neuonc/nos329","pdf_url":null,"source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2948072","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3607268","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3607268","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3607268","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro Oncol","raw_type":"Text"},{"id":"pmid:23393205","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23393205","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-oncology","raw_type":"Clinical Trial"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2948072","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3607268","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320323437","display_name":"Medizinische Universit\u00e4t Wien","ror":"https://ror.org/05n3x4p02"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W1603021672","https://openalex.org/W1621602741","https://openalex.org/W1965845401","https://openalex.org/W1970878541","https://openalex.org/W1979708010","https://openalex.org/W1989113088","https://openalex.org/W1990441744","https://openalex.org/W1998785914","https://openalex.org/W2000971601","https://openalex.org/W2001545865","https://openalex.org/W2007888447","https://openalex.org/W2010947710","https://openalex.org/W2015752274","https://openalex.org/W2017109401","https://openalex.org/W2023874237","https://openalex.org/W2024922359","https://openalex.org/W2030976397","https://openalex.org/W2031396267","https://openalex.org/W2031847583","https://openalex.org/W2033494613","https://openalex.org/W2054007578","https://openalex.org/W2062395030","https://openalex.org/W2063723780","https://openalex.org/W2065193283","https://openalex.org/W2069973575","https://openalex.org/W2074095225","https://openalex.org/W2077631046","https://openalex.org/W2098771215","https://openalex.org/W2103453025","https://openalex.org/W2105100844","https://openalex.org/W2107097909","https://openalex.org/W2120872266","https://openalex.org/W2126224474","https://openalex.org/W2126581491","https://openalex.org/W2127901599","https://openalex.org/W2129558754","https://openalex.org/W2152778958","https://openalex.org/W2158681922","https://openalex.org/W2160621707","https://openalex.org/W2161289668","https://openalex.org/W2161948433","https://openalex.org/W2163261748","https://openalex.org/W2166169003","https://openalex.org/W2168784615","https://openalex.org/W2175722093","https://openalex.org/W2441087424","https://openalex.org/W6683762786"],"related_works":["https://openalex.org/W2330579147","https://openalex.org/W2322570649","https://openalex.org/W2891199295","https://openalex.org/W4377839648","https://openalex.org/W7025296649","https://openalex.org/W2514238202","https://openalex.org/W2512715753","https://openalex.org/W2014923959","https://openalex.org/W2287245553","https://openalex.org/W3199210289"],"abstract_inverted_index":{"BACKGROUND:":[0],"Glioblastoma":[1],"multiforme":[2],"(GBM)":[3],"is":[4,244],"a":[5,114,130,211,259],"heterogeneous,":[6],"highly":[7,115],"aggressive":[8,254],"primary":[9],"brain":[10],"tumor":[11,255],"with":[12,45,113,139,179,187,205],"strongly":[13],"variable":[14],"patient":[15,229,261],"survival.":[16,50],"Because":[17],"reliable":[18],"prognostic":[19,248],"biomarkers":[20],"are":[21],"lacking,":[22],"we":[23],"investigated":[24],"the":[25,31,134,144,227],"relation":[26],"between":[27,118,133],"telomerase-associated":[28],"parameters":[29,36,120,178],"and":[30,43,48,58,74,89,111,136,197,199],"disease":[32],"course.":[33],"METHODS:":[34],"Telomerase-associated":[35],"were":[37,64,105,157,191],"determined":[38,85],"in":[39,143,159,250,258],"100":[40,101],"GBM":[41,102,160,251],"tissues":[42,161],"associated":[44],"clinical":[46],"characteristics":[47],"overall":[49],"Expressions":[51],"of":[52,80,176],"telomere":[53,177],"length,":[54],"telomerase":[55,60],"activity":[56],"(TA),":[57],"human":[59],"reverse":[61,75],"transcriptase":[62],"(hTERT)":[63],"analyzed":[65],"by":[66,86,96],"quantitative":[67],"PCR,":[68],"telomeric":[69],"repeat":[70],"amplification":[71],"protocol":[72],"assay,":[73],"transcriptase-PCR,":[76],"respectively.":[77],"Mutation":[78],"status":[79,182],"isocitrate":[81],"dehydrogenase":[82],"(IDH)1":[83],"was":[84,183,223],"direct":[87],"sequencing,":[88],"O(6)-methylguanine":[90],"DNA":[91],"methyltransferase":[92],"(MGMT)":[93],"promoter":[94,181],"methylation":[95],"methylation-specific":[97],"PCR.":[98],"RESULTS:":[99],"Of":[100],"tissues,":[103],"61":[104],"positive":[106],"for":[107,193],"both":[108,119,194,217,233,239],"hTERT":[109,195,208],"mRNA":[110],"TA,":[112],"significant":[116,131,212],"correlation":[117],"(linear":[121],"regression,":[122],"P":[123,150,170,218,234],"<":[124,171,219,235],".0001).":[125,152,172],"Telomere":[126],"length":[127],"determination":[128],"revealed":[129],"difference":[132],"hTERT/TA-positive":[135],"-negative":[137],"subgroups,":[138],"markedly":[140],"longer":[141,202],"telomeres":[142,156],"hTERT/TA-negative":[145],"cohort":[146],"(unpaired":[147],"Student's":[148],"t-test,":[149],"=":[151],"Accordingly,":[153],"significantly":[154,201],"shorter":[155],"detected":[158],"derived":[162],"from":[163],"older":[164],"patients":[165],"(>60":[166],"y":[167],"at":[168],"diagnosis,":[169],"While":[173],"no":[174],"association":[175],"MGMT":[180],"found,":[184],"all":[185],"tumors":[186,206],"IDH1":[188],"mutation":[189],"(6/100)":[190],"negative":[192],"expression":[196],"TA":[198],"harbored":[200],"telomeres.":[203],"Patients":[204],"lacking":[207],"expression/TA":[209],"showed":[210],"survival":[213],"benefit":[214],"(Kaplan-Meier":[215],"test,":[216],".01),":[220],"which,":[221],"however,":[222],"based":[224],"exclusively":[225],"on":[226],"younger":[228,260],"subgroup":[230],"(\u226460":[231],"y,":[232,238],".005;":[236],">60":[237],"ns).":[240],"CONCLUSIONS:":[241],"Telomerase":[242],"activation":[243],"not":[245],"an":[246],"independent":[247],"parameter":[249],"but":[252],"predicts":[253],"behavior":[256],"solely":[257],"cohort.":[262]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}