{"id":"https://openalex.org/W2144756579","doi":null,"title":"Multi-institutional validation study of carboplatin dosing formula using adjusted serum creatinine level.","display_name":"Multi-institutional validation study of carboplatin dosing formula using adjusted serum creatinine level.","publication_year":2000,"publication_date":"2000-12-01","ids":{"openalex":"https://openalex.org/W2144756579","mag":"2144756579","pmid":"https://pubmed.ncbi.nlm.nih.gov/11156227"},"language":"en","primary_location":{"id":"pmid:11156227","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11156227","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016128746","display_name":"Maki Ando","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210132181","display_name":"Japanese Red Cross Nagoya Daiichi Hospital","ror":"https://ror.org/03f918r09","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I2799517759","https://openalex.org/I4210132181"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M Ando","raw_affiliation_strings":["Japanese Red Cross Nagoya First Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Japanese Red Cross Nagoya First Hospital","institution_ids":["https://openalex.org/I4210132181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089137663","display_name":"Hironobu Minami","orcid":"https://orcid.org/0000-0001-8630-9145","observed_orcids":["https://orcid.org/0000-0001-8630-9145"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Minami","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048279225","display_name":"Yukio Ando","orcid":"https://orcid.org/0000-0001-7115-9105","observed_orcids":["https://orcid.org/0000-0001-7115-9105"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Ando","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101709104","display_name":"Hideo Saka","orcid":"https://orcid.org/0000-0001-7364-5115","observed_orcids":["https://orcid.org/0000-0001-7364-5115"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Saka","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013144704","display_name":"Sh\u016bz\u014d Sakai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Sakai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058411000","display_name":"Masashi Yamamoto","orcid":"https://orcid.org/0000-0002-1107-6858","observed_orcids":["https://orcid.org/0000-0002-1107-6858"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Yamamoto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103187201","display_name":"Yasutsuna Sasaki","orcid":"https://orcid.org/0000-0002-6712-7116","observed_orcids":["https://orcid.org/0000-0002-6712-7116"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Sasaki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010928312","display_name":"Kaoru Shimokata","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Shimokata","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5091654483","display_name":"Yoshinao Hasegawa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Hasegawa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.722,"has_fulltext":false,"cited_by_count":47,"citation_normalized_percentile":{"value":0.7506535,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"6","issue":"12","first_page":"4733","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.23849999904632568,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.23849999904632568,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.09160000085830688,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.08449999988079071,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/carboplatin","display_name":"carboplatin","score":0.847000002861023},{"id":"https://openalex.org/keywords/dose-adjustment","display_name":"dose adjustment","score":0.4569999873638153},{"id":"https://openalex.org/keywords/creatinine-clearance","display_name":"creatinine clearance","score":0.8109999895095825},{"id":"https://openalex.org/keywords/serum-creatinine","display_name":"serum creatinine","score":0.8159999847412109},{"id":"https://openalex.org/keywords/calvert-formula","display_name":"Calvert formula","score":0.9309999942779541},{"id":"https://openalex.org/keywords/glomerular-filtration-rate","display_name":"glomerular filtration rate","score":0.7269999980926514},{"id":"https://openalex.org/keywords/pharmacokinetic-prediction","display_name":"pharmacokinetic prediction","score":0.4740000069141388},{"id":"https://openalex.org/keywords/multi-institutional-validation","display_name":"multi-institutional validation","score":0.7390000224113464}],"concepts":[{"id":"https://openalex.org/C2781451048","wikidata":"https://www.wikidata.org/wiki/Q415588","display_name":"Carboplatin","level":4,"score":0.8886187076568604},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.6941690444946289},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.6552998423576355},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.6356680393218994},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.6050547361373901},{"id":"https://openalex.org/C139945424","wikidata":"https://www.wikidata.org/wiki/Q1940696","display_name":"Mean squared error","level":2,"score":0.5662293434143066},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47806409001350403},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.4088457524776459},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40615931153297424},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2820306420326233},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.20707488059997559},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.1686713695526123},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.09876340627670288}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003404","descriptor_name":"Creatinine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D003404","descriptor_name":"Creatinine","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009195","descriptor_name":"Peroxidase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015982","descriptor_name":"Bias","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016190","descriptor_name":"Carboplatin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D016190","descriptor_name":"Carboplatin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:11156227","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11156227","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"},{"id":"mag:2144756579","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11156227","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W38278793","https://openalex.org/W120083905","https://openalex.org/W258826308","https://openalex.org/W1550111394","https://openalex.org/W1751540033","https://openalex.org/W1907795058","https://openalex.org/W1941410407","https://openalex.org/W1946067910","https://openalex.org/W1948603161","https://openalex.org/W1957837469","https://openalex.org/W1962731536","https://openalex.org/W1967807825","https://openalex.org/W1968336421","https://openalex.org/W1971946835","https://openalex.org/W1996215485","https://openalex.org/W2003143162","https://openalex.org/W2013093345","https://openalex.org/W2026909448","https://openalex.org/W2036789134","https://openalex.org/W2037545204","https://openalex.org/W2042094741","https://openalex.org/W2059547417","https://openalex.org/W2073825589","https://openalex.org/W2076064453","https://openalex.org/W2077488688","https://openalex.org/W2091457603","https://openalex.org/W2116996913","https://openalex.org/W2131322929","https://openalex.org/W2140435453","https://openalex.org/W2141348928","https://openalex.org/W2147869809","https://openalex.org/W2162924104","https://openalex.org/W2404799624","https://openalex.org/W2412840888","https://openalex.org/W3192605322"],"related_works":["https://openalex.org/W2042094741","https://openalex.org/W2091457603","https://openalex.org/W2122049093","https://openalex.org/W1971946835","https://openalex.org/W2096413704","https://openalex.org/W1968336421","https://openalex.org/W4376872941","https://openalex.org/W2119107859","https://openalex.org/W2554784441","https://openalex.org/W2094498995"],"abstract_inverted_index":{"Creatinine":[0],"clearance":[1,132,168,221],"(Ccr)":[2],"is":[3],"widely":[4],"used":[5],"as":[6,199],"a":[7,232],"practical":[8],"substitute":[9],"for":[10,211],"glomerular":[11],"filtration":[12],"rate":[13],"(GFR)":[14],"in":[15,105,183,193,203,234,239,253],"the":[16,26,47,85,134,160,184,189,196,204,227,246,250],"Calvert":[17,161],"formula:":[18],"carboplatin":[19,69,131,167,220,254],"dose":[20,70],"(mg)":[21,71],"=":[22,72,145,157,173,179],"target":[23],"area":[24],"under":[25],"concentration":[27],"versus":[28],"time":[29],"curve":[30],"(AUC,":[31],"mg":[32,118],"ml(-1)":[33,75,119],"min)":[34,76],"x":[35,77],"[GFR":[36],"(ml":[37,80],"min(-1))":[38,81],"+":[39,82],"25].":[40],"However,":[41],"it":[42],"causes":[43],"systematic":[44],"overdosing":[45],"when":[46,222],"creatinine":[48],"levels":[49],"are":[50],"measured":[51,124],"by":[52,89,125,201,236,241],"an":[53,61],"enzymatic":[54],"peroxidase-antiperoxidase":[55],"method":[56],"(PAP-Cr).":[57],"We":[58],"previously":[59],"suggested":[60],"amended":[62,135],"dosing":[63,255],"formula":[64,104,136,162,216],"to":[65,94,116],"adjust":[66],"this":[67,98,103],"overdosing:":[68],"AUC":[73,112],"(mg":[74,92],"[adjusted":[78],"Ccr":[79,86,122,165],"25],":[83],"where":[84],"was":[87,123,137,191,224],"adjusted":[88],"adding":[90],"0.2":[91],"dl(-1))":[93],"serum":[95,251],"PAP-Cr.":[96],"In":[97],"study,":[99],"we":[100],"prospectively":[101],"validated":[102],"55":[106],"patients":[107],"from":[108,114],"six":[109],"institutions.":[110],"Target":[111],"ranged":[113],"3":[115],"7":[117],"min,":[120],"and":[121,149,177,186,209,238],"24-h":[126],"urine":[127],"collection.":[128],"Estimation":[129],"of":[130,188,195,207,229,248],"with":[133],"unbiased":[138],"[mean":[139],"prediction":[140],"error":[141],"(MPE)":[142],"+/-":[143,147,171,175],"SE":[144,172],"2.9":[146],"3.4%]":[148],"acceptably":[150],"precise":[151],"[root":[152],"mean":[153],"squared":[154],"error,":[155],"(RMSE)":[156],"24.7%],":[158],"whereas":[159],"using":[163],"non-adjusted":[164],"overpredicted":[166],"systematically":[169],"(MPE":[170],"24.9":[174],"4.9%":[176],"RMSE":[178,210,240],"36.1%).":[180],"The":[181,214],"improvement":[182],"bias":[185],"precision":[187],"estimation":[190],"seen":[192],"all":[194],"participating":[197],"institutions":[198],"shown":[200],"decrease":[202,233],"absolute":[205],"value":[206],"MPE":[208,235],"each":[212],"institution.":[213],"Chatelut":[215],"also":[217],"highly":[218],"overestimated":[219],"PAP-Cr":[223,230,252],"used,":[225],"but":[226],"adjustment":[228],"yielded":[231],"30.4%":[237],"21.3%.":[242],"These":[243],"results":[244],"confirmed":[245],"necessity":[247],"adjusting":[249],"formulas.":[256]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
