{"id":"https://openalex.org/W2144693201","doi":"https://doi.org/10.1099/vir.0.19454-0","title":"Identification of protein kinases responsible for phosphorylation of Epstein\u2013Barr virus nuclear antigen leader protein at serine-35, which regulates its coactivator function","display_name":"Identification of protein kinases responsible for phosphorylation of Epstein\u2013Barr virus nuclear antigen leader protein at serine-35, which regulates its coactivator function","publication_year":2003,"publication_date":"2003-11-26","ids":{"openalex":"https://openalex.org/W2144693201","doi":"https://doi.org/10.1099/vir.0.19454-0","mag":"2144693201","pmid":"https://pubmed.ncbi.nlm.nih.gov/14645919"},"language":"en","primary_location":{"id":"doi:10.1099/vir.0.19454-0","doi":"https://doi.org/10.1099/vir.0.19454-0","is_oa":false,"landing_page_url":"https://doi.org/10.1099/vir.0.19454-0","pdf_url":null,"source":{"id":"https://openalex.org/S103035011","display_name":"Journal of General Virology","issn_l":"0022-1317","issn":["0022-1317","1465-2099"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320497","host_organization_name":"Microbiology Society","host_organization_lineage":["https://openalex.org/P4310320497"],"host_organization_lineage_names":["Microbiology Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of General Virology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089293101","display_name":"Kentaro Kato","orcid":"https://orcid.org/0000-0003-4890-567X","observed_orcids":["https://orcid.org/0000-0003-4890-567X"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kentaro Kato","raw_affiliation_strings":["Department of Cell Regulation, Medical Research Institute, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8510, Japan","Department of Veterinary Microbiology, Graduate School of Agricultural and Life Science, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Regulation, Medical Research Institute, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8510, Japan","institution_ids":["https://openalex.org/I125602781"]},{"raw_affiliation_string":"Department of Veterinary Microbiology, Graduate School of Agricultural and Life Science, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056843690","display_name":"Akihiko Yokoyama","orcid":"https://orcid.org/0000-0002-5639-8068","observed_orcids":["https://orcid.org/0000-0002-5639-8068"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akihiko Yokoyama","raw_affiliation_strings":["Department of Cell Regulation, Medical Research Institute, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8510, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Regulation, Medical Research Institute, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8510, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047758255","display_name":"Yukinobu Tohya","orcid":"https://orcid.org/0000-0002-9385-2274","observed_orcids":["https://orcid.org/0000-0002-9385-2274"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yukinobu Tohya","raw_affiliation_strings":["Department of Veterinary Microbiology, Graduate School of Agricultural and Life Science, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Microbiology, Graduate School of Agricultural and Life Science, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113675332","display_name":"Hiroomi Akashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroomi Akashi","raw_affiliation_strings":["Department of Veterinary Microbiology, Graduate School of Agricultural and Life Science, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Microbiology, Graduate School of Agricultural and Life Science, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110066128","display_name":"Yukihiro Nishiyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yukihiro Nishiyama","raw_affiliation_strings":["Department of Virology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Virology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062366510","display_name":"Yasushi Kawaguchi","orcid":"https://orcid.org/0000-0001-8232-6925","observed_orcids":["https://orcid.org/0000-0001-8232-6925"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]},{"id":"https://openalex.org/I4210086780","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19","country_code":"JP","type":"government","lineage":["https://openalex.org/I1319490839","https://openalex.org/I4210086780"]},{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasushi Kawaguchi","raw_affiliation_strings":["Department of Cell Regulation, Medical Research Institute, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8510, Japan","Department of Virology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan","PRESTO, Japan Science and Technology Corporation, Tachikawa, Tokyo 190-0012, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Regulation, Medical Research Institute, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8510, Japan","institution_ids":["https://openalex.org/I125602781"]},{"raw_affiliation_string":"Department of Virology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan","institution_ids":["https://openalex.org/I60134161"]},{"raw_affiliation_string":"PRESTO, Japan Science and Technology Corporation, Tachikawa, Tokyo 190-0012, Japan","institution_ids":["https://openalex.org/I4210086780"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.6665,"has_fulltext":false,"cited_by_count":70,"citation_normalized_percentile":{"value":0.89621975,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"84","issue":"12","first_page":"3381","last_page":"3392"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.9560999870300293,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.9560999870300293,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.008100000210106373,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.0066999997943639755,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epstein-barr-virus","display_name":"Epstein-Barr virus","score":0.8790000081062317},{"id":"https://openalex.org/keywords/ebna-lp","display_name":"EBNA-LP","score":0.9629999995231628},{"id":"https://openalex.org/keywords/cdc2-kinase","display_name":"cdc2 kinase","score":0.9010000228881836},{"id":"https://openalex.org/keywords/viral-protein-kinase","display_name":"viral protein kinase","score":0.7059999704360962},{"id":"https://openalex.org/keywords/coactivator-function","display_name":"coactivator function","score":0.9259999990463257}],"concepts":[{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.7791107892990112},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7578158974647522},{"id":"https://openalex.org/C120504264","wikidata":"https://www.wikidata.org/wiki/Q1147372","display_name":"Cyclin-dependent kinase 1","level":4,"score":0.708433210849762},{"id":"https://openalex.org/C2777061661","wikidata":"https://www.wikidata.org/wiki/Q423934","display_name":"Phosphoprotein","level":3,"score":0.6855155825614929},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.6467587351799011},{"id":"https://openalex.org/C77445288","wikidata":"https://www.wikidata.org/wiki/Q637488","display_name":"Coactivator","level":4,"score":0.5859843492507935},{"id":"https://openalex.org/C2776414213","wikidata":"https://www.wikidata.org/wiki/Q183290","display_name":"Serine","level":3,"score":0.5246663093566895},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4911000728607178},{"id":"https://openalex.org/C87325107","wikidata":"https://www.wikidata.org/wiki/Q7251493","display_name":"Protein phosphorylation","level":4,"score":0.48321831226348877},{"id":"https://openalex.org/C159479382","wikidata":"https://www.wikidata.org/wiki/Q18030801","display_name":"MAP2K7","level":5,"score":0.47995761036872864},{"id":"https://openalex.org/C171896709","wikidata":"https://www.wikidata.org/wiki/Q18034663","display_name":"Autophagy-related protein 13","level":5,"score":0.4647011160850525},{"id":"https://openalex.org/C99405784","wikidata":"https://www.wikidata.org/wiki/Q410434","display_name":"c-Raf","level":5,"score":0.4373153746128082},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4351210296154022},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.4225085973739624},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3421146273612976},{"id":"https://openalex.org/C82495950","wikidata":"https://www.wikidata.org/wiki/Q14911732","display_name":"Cyclin-dependent kinase 2","level":4,"score":0.31349775195121765},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.07099732756614685},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.0626181960105896},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000409","descriptor_name":"Alanine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002472","descriptor_name":"Cell Transformation, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004854","descriptor_name":"Herpesvirus 4, Human","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004854","descriptor_name":"Herpesvirus 4, Human","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012694","descriptor_name":"Serine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012694","descriptor_name":"Serine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016203","descriptor_name":"CDC2 Protein Kinase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018411","descriptor_name":"Spodoptera","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019943","descriptor_name":"Amino Acid Substitution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1099/vir.0.19454-0","doi":"https://doi.org/10.1099/vir.0.19454-0","is_oa":false,"landing_page_url":"https://doi.org/10.1099/vir.0.19454-0","pdf_url":null,"source":{"id":"https://openalex.org/S103035011","display_name":"Journal of General Virology","issn_l":"0022-1317","issn":["0022-1317","1465-2099"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320497","host_organization_name":"Microbiology Society","host_organization_lineage":["https://openalex.org/P4310320497"],"host_organization_lineage_names":["Microbiology Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of General Virology","raw_type":"journal-article"},{"id":"pmid:14645919","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14645919","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of general virology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":67,"referenced_works":["https://openalex.org/W37844384","https://openalex.org/W1488614375","https://openalex.org/W1495408999","https://openalex.org/W1514074978","https://openalex.org/W1576811559","https://openalex.org/W1599938904","https://openalex.org/W1720083525","https://openalex.org/W1726935597","https://openalex.org/W1854068525","https://openalex.org/W1912140146","https://openalex.org/W1928604815","https://openalex.org/W1964899178","https://openalex.org/W1985082049","https://openalex.org/W1989466826","https://openalex.org/W1995701262","https://openalex.org/W1999007642","https://openalex.org/W2001813004","https://openalex.org/W2005210883","https://openalex.org/W2013028390","https://openalex.org/W2019395700","https://openalex.org/W2020257412","https://openalex.org/W2023530705","https://openalex.org/W2033498634","https://openalex.org/W2035379549","https://openalex.org/W2036997702","https://openalex.org/W2038407368","https://openalex.org/W2043051204","https://openalex.org/W2048235818","https://openalex.org/W2053337195","https://openalex.org/W2055397341","https://openalex.org/W2058746315","https://openalex.org/W2061319065","https://openalex.org/W2072410706","https://openalex.org/W2072945014","https://openalex.org/W2079199354","https://openalex.org/W2082612250","https://openalex.org/W2082678443","https://openalex.org/W2083245342","https://openalex.org/W2086484834","https://openalex.org/W2090685521","https://openalex.org/W2092599452","https://openalex.org/W2096905045","https://openalex.org/W2102929697","https://openalex.org/W2103061497","https://openalex.org/W2103277453","https://openalex.org/W2109840090","https://openalex.org/W2109868696","https://openalex.org/W2114937129","https://openalex.org/W2127911531","https://openalex.org/W2130278093","https://openalex.org/W2133575147","https://openalex.org/W2137701618","https://openalex.org/W2138630631","https://openalex.org/W2140225836","https://openalex.org/W2141616119","https://openalex.org/W2144870469","https://openalex.org/W2145623629","https://openalex.org/W2155046255","https://openalex.org/W2159742314","https://openalex.org/W2164516553","https://openalex.org/W2167561115","https://openalex.org/W2171498528","https://openalex.org/W2226175820","https://openalex.org/W4205204633","https://openalex.org/W4236019121","https://openalex.org/W6669785307","https://openalex.org/W6682112134"],"related_works":["https://openalex.org/W7097755381","https://openalex.org/W2133575147","https://openalex.org/W1975216103","https://openalex.org/W2013753271","https://openalex.org/W2114937129","https://openalex.org/W2002665988","https://openalex.org/W2109840090","https://openalex.org/W2158212099","https://openalex.org/W2140662587","https://openalex.org/W2159742314"],"abstract_inverted_index":{"Epstein-Barr":[0],"virus":[1],"(EBV)":[2],"nuclear":[3],"antigen":[4],"leader":[5],"protein":[6,75,88,168,185,213,244],"(EBNA-LP)":[7],"is":[8,34,48],"a":[9,35,96,117,140],"phosphoprotein":[10],"suggested":[11],"to":[12,73,95,104,116],"play":[13],"important":[14],"roles":[15],"in":[16,111,122,136,143],"EBV-induced":[17],"immortalization.":[18],"Earlier":[19],"studies":[20],"have":[21,71],"shown":[22],"that":[23,43,165,181,227],"the":[24,44,53,67,79,144,166,172,191,210,218,228,237],"major":[25],"site":[26],"of":[27,29,46,52,56,81,90,98,120,134,146,156,174,196,220,231,239],"phosphorylation":[28,45,80,145,151,173,219],"EBNA-LP":[30,57,82,99,121,157,175,221,232],"by":[31,108,188,236],"cellular":[32,167,241],"kinase(s)":[33,76],"serine":[36],"residue":[37,195],"at":[38,83,176,222],"position":[39],"35":[40],"(Ser-35)":[41],"and":[42,183,242],"Ser-35":[47,101,124,155],"critical":[49],"for":[50,78],"regulation":[51],"coactivator":[54,229],"function":[55,230],"(Yokoyama":[58],"et":[59,200],"al.,":[60,201],"J":[61,202],"Virol":[62,203],"75,":[63],"5119-5128,":[64],"2001).":[65],"In":[66,131],"present":[68],"study,":[69],"we":[70,179],"attempted":[72],"identify":[74],"responsible":[77],"Ser-35.":[84,177,223],"A":[85],"purified":[86,109],"chimeric":[87],"consisting":[89],"glutathione":[91],"S-transferase":[92],"(GST)":[93],"fused":[94,115],"domain":[97,119],"containing":[100],"was":[102,125,129,152,158],"found":[103],"be":[105,234],"specifically":[106,216],"phosphorylated":[107],"cdc2":[110,135,170,182],"vitro,":[112],"while":[113,148],"GST":[114],"mutated":[118],"which":[123],"replaced":[126,159],"with":[127,160,208],"alanine":[128],"not.":[130],"addition,":[132],"overexpression":[133],"mammalian":[137],"cells":[138],"caused":[139],"significant":[141],"increase":[142],"EBNA-LP,":[147],"this":[149],"increased":[150],"eliminated":[153],"if":[154],"alanine.":[161],"These":[162,224],"results":[163,225],"indicate":[164,226],"kinase":[169,214],"mediates":[171],"Recently,":[178],"reported":[180],"conserved":[184,212],"kinases":[186],"encoded":[187],"herpesviruses":[189],"phosphorylate":[190],"same":[192],"amino":[193],"acid":[194],"target":[197],"proteins":[198],"(Kawaguchi":[199],"77,":[204],"2359-2368,":[205],"2003).":[206],"Consistent":[207],"this,":[209],"EBV-encoded":[211],"BGLF4":[215],"mediated":[217],"can":[233],"regulated":[235],"activity":[238],"these":[240],"viral":[243],"kinases.":[245]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
