{"id":"https://openalex.org/W2144690385","doi":"https://doi.org/10.1128/aac.14.2.234","title":"Ascitic Fluid Cephalosporin Concentrations: Influence of Protein Binding and Serum Pharmacokinetics","display_name":"Ascitic Fluid Cephalosporin Concentrations: Influence of Protein Binding and Serum Pharmacokinetics","publication_year":1978,"publication_date":"1978-08-01","ids":{"openalex":"https://openalex.org/W2144690385","doi":"https://doi.org/10.1128/aac.14.2.234","mag":"2144690385","pmid":"https://pubmed.ncbi.nlm.nih.gov/697350","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/352439"},"language":"en","primary_location":{"id":"doi:10.1128/aac.14.2.234","doi":"https://doi.org/10.1128/aac.14.2.234","is_oa":false,"landing_page_url":"https://doi.org/10.1128/aac.14.2.234","pdf_url":null,"source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/352439","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002008542","display_name":"Dale N. Gerding","orcid":"https://orcid.org/0000-0003-4409-1605","observed_orcids":["https://orcid.org/0000-0003-4409-1605"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]},{"id":"https://openalex.org/I4210140408","display_name":"Minneapolis VA Medical Center","ror":"https://ror.org/032b8d361","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210117246","https://openalex.org/I4210117924","https://openalex.org/I4210140408"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dale N. Gerding","raw_affiliation_strings":["Infectious Disease Section, Department of Medicine, Veterans Administration Hospital, Minneapolis, Minnesota 55417","University of Minnesota Medical School, Minneapolis, Minnesota 55455"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Disease Section, Department of Medicine, Veterans Administration Hospital, Minneapolis, Minnesota 55417","institution_ids":["https://openalex.org/I2799886695","https://openalex.org/I4210140408"]},{"raw_affiliation_string":"University of Minnesota Medical School, Minneapolis, Minnesota 55455","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026183066","display_name":"Lance R. Peterson","orcid":"https://orcid.org/0000-0001-5279-4752","observed_orcids":["https://orcid.org/0000-0001-5279-4752"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]},{"id":"https://openalex.org/I4210140408","display_name":"Minneapolis VA Medical Center","ror":"https://ror.org/032b8d361","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210117246","https://openalex.org/I4210117924","https://openalex.org/I4210140408"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lance R. Peterson","raw_affiliation_strings":["Infectious Disease Section, Department of Medicine, Veterans Administration Hospital, Minneapolis, Minnesota 55417","University of Minnesota Medical School, Minneapolis, Minnesota 55455"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Disease Section, Department of Medicine, Veterans Administration Hospital, Minneapolis, Minnesota 55417","institution_ids":["https://openalex.org/I2799886695","https://openalex.org/I4210140408"]},{"raw_affiliation_string":"University of Minnesota Medical School, Minneapolis, Minnesota 55455","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058711349","display_name":"Dwight C. Legler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]},{"id":"https://openalex.org/I4210140408","display_name":"Minneapolis VA Medical Center","ror":"https://ror.org/032b8d361","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210117246","https://openalex.org/I4210117924","https://openalex.org/I4210140408"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dwight C. Legler","raw_affiliation_strings":["Infectious Disease Section, Department of Medicine, Veterans Administration Hospital, Minneapolis, Minnesota 55417","University of Minnesota Medical School, Minneapolis, Minnesota 55455"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Disease Section, Department of Medicine, Veterans Administration Hospital, Minneapolis, Minnesota 55417","institution_ids":["https://openalex.org/I2799886695","https://openalex.org/I4210140408"]},{"raw_affiliation_string":"University of Minnesota Medical School, Minneapolis, Minnesota 55455","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040303394","display_name":"Wendell H. Hall","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]},{"id":"https://openalex.org/I4210140408","display_name":"Minneapolis VA Medical Center","ror":"https://ror.org/032b8d361","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210117246","https://openalex.org/I4210117924","https://openalex.org/I4210140408"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wendell H. Hall","raw_affiliation_strings":["Infectious Disease Section, Department of Medicine, Veterans Administration Hospital, Minneapolis, Minnesota 55417","University of Minnesota Medical School, Minneapolis, Minnesota 55455"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Disease Section, Department of Medicine, Veterans Administration Hospital, Minneapolis, Minnesota 55417","institution_ids":["https://openalex.org/I2799886695","https://openalex.org/I4210140408"]},{"raw_affiliation_string":"University of Minnesota Medical School, Minneapolis, Minnesota 55455","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040691110","display_name":"Elizabeth A. Schierl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]},{"id":"https://openalex.org/I4210140408","display_name":"Minneapolis VA Medical Center","ror":"https://ror.org/032b8d361","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210117246","https://openalex.org/I4210117924","https://openalex.org/I4210140408"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth A. Schierl","raw_affiliation_strings":["Infectious Disease Section, Department of Medicine, Veterans Administration Hospital, Minneapolis, Minnesota 55417","University of Minnesota Medical School, Minneapolis, Minnesota 55455"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Disease Section, Department of Medicine, Veterans Administration Hospital, Minneapolis, Minnesota 55417","institution_ids":["https://openalex.org/I2799886695","https://openalex.org/I4210140408"]},{"raw_affiliation_string":"University of Minnesota Medical School, Minneapolis, Minnesota 55455","institution_ids":["https://openalex.org/I130238516"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.8967,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.8620438,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"14","issue":"2","first_page":"234","last_page":"239"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ascitic-fluid","display_name":"ascitic fluid","score":0.7749999761581421},{"id":"https://openalex.org/keywords/cephalosporins","display_name":"cephalosporins","score":0.9850000143051147},{"id":"https://openalex.org/keywords/cephalothin","display_name":"cephalothin","score":0.8009999990463257},{"id":"https://openalex.org/keywords/cephaloridine","display_name":"cephaloridine","score":0.9909999966621399},{"id":"https://openalex.org/keywords/cefazolin","display_name":"cefazolin","score":1.0},{"id":"https://openalex.org/keywords/cefamandole","display_name":"cefamandole","score":0.9990000128746033},{"id":"https://openalex.org/keywords/protein-binding","display_name":"protein binding","score":0.9079999923706055},{"id":"https://openalex.org/keywords/serum-pharmacokinetics","display_name":"serum pharmacokinetics","score":0.9819999933242798},{"id":"https://openalex.org/keywords/drug-distribution","display_name":"drug distribution","score":0.7450000047683716},{"id":"https://openalex.org/keywords/ascites","display_name":"ascites","score":0.6370000243186951},{"id":"https://openalex.org/keywords/drug-penetration","display_name":"drug penetration","score":0.42500001192092896},{"id":"https://openalex.org/keywords/dogs","display_name":"dogs","score":0.5080000162124634}],"concepts":[{"id":"https://openalex.org/C2777085960","wikidata":"https://www.wikidata.org/wiki/Q5063323","display_name":"Cephaloridine","level":4,"score":0.9630100727081299},{"id":"https://openalex.org/C2778353156","wikidata":"https://www.wikidata.org/wiki/Q415739","display_name":"Cefazolin","level":3,"score":0.924970805644989},{"id":"https://openalex.org/C2780463255","wikidata":"https://www.wikidata.org/wiki/Q2601530","display_name":"Cefamandole","level":4,"score":0.8197206258773804},{"id":"https://openalex.org/C64778159","wikidata":"https://www.wikidata.org/wiki/Q271021","display_name":"Cephalosporin","level":3,"score":0.760746955871582},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.5745306611061096},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5433046221733093},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.5262919068336487},{"id":"https://openalex.org/C2779233340","wikidata":"https://www.wikidata.org/wiki/Q2736126","display_name":"Cefalotin","level":4,"score":0.47926709055900574},{"id":"https://openalex.org/C146543888","wikidata":"https://www.wikidata.org/wiki/Q425056","display_name":"Blood proteins","level":2,"score":0.4689868092536926},{"id":"https://openalex.org/C2776368647","wikidata":"https://www.wikidata.org/wiki/Q3010262","display_name":"Cephem","level":3,"score":0.4548918902873993},{"id":"https://openalex.org/C2910308651","wikidata":"https://www.wikidata.org/wiki/Q271021","display_name":"Cephalosporin Antibiotic","level":4,"score":0.41384655237197876},{"id":"https://openalex.org/C2780496750","wikidata":"https://www.wikidata.org/wiki/Q193889","display_name":"Ascites","level":2,"score":0.413754940032959},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3688143491744995},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2879948019981384},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.267448365688324},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12478110194206238},{"id":"https://openalex.org/C2779074116","wikidata":"https://www.wikidata.org/wiki/Q134856","display_name":"Carboxylic acid","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001202","descriptor_name":"Ascitic Fluid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002511","descriptor_name":"Cephalosporins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002511","descriptor_name":"Cephalosporins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1128/aac.14.2.234","doi":"https://doi.org/10.1128/aac.14.2.234","is_oa":false,"landing_page_url":"https://doi.org/10.1128/aac.14.2.234","pdf_url":null,"source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:352439","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/352439","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrob Agents Chemother","raw_type":"Text"},{"id":"pmid:697350","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/697350","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial agents and chemotherapy","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:352439","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/352439","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrob Agents Chemother","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.4300000071525574,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1971094693","https://openalex.org/W1981560519","https://openalex.org/W1985179011","https://openalex.org/W1997107396","https://openalex.org/W2008967946","https://openalex.org/W2021585557","https://openalex.org/W2038779441","https://openalex.org/W2050720060","https://openalex.org/W2055186771","https://openalex.org/W2062452713","https://openalex.org/W2076712917","https://openalex.org/W2084655721","https://openalex.org/W2119704169","https://openalex.org/W2171780477","https://openalex.org/W2317789093","https://openalex.org/W2415382338","https://openalex.org/W2464218943"],"related_works":["https://openalex.org/W2005688614","https://openalex.org/W1981560519","https://openalex.org/W1985179011","https://openalex.org/W2011192331","https://openalex.org/W2062360058","https://openalex.org/W2026280376","https://openalex.org/W1988093421","https://openalex.org/W1993367868","https://openalex.org/W2316754203","https://openalex.org/W2121269750"],"abstract_inverted_index":{"Mongrel":[0],"dogs":[1],"with":[2],"ascites":[3,144],"created":[4],"by":[5,60],"inferior":[6],"vena":[7],"cava":[8],"ligation":[9],"were":[10,36,114,129],"given":[11,37],"cephalothin,":[12,77,86],"cephaloridine,":[13,135],"cefazolin,":[14,85],"and":[15,24,55,87,119,124,134,136,185,189],"cefamandole":[16],"to":[17,52,66,74,91,100,111,143,160,187,195],"evaluate":[18],"the":[19,28,64,153,170,180],"effect":[20],"of":[21,30,47,63,140,157],"protein":[22,163,192],"binding":[23,51,83,90,186],"serum":[25,54,68,82,127,141,183,188],"pharmacokinetics":[26],"on":[27],"distribution":[29],"cephalosporins":[31,65,159],"into":[32],"ascitic":[33,56,92,172,198],"fluid.":[34],"Antibiotics":[35],"intramuscularly":[38],"(15":[39],"mg/kg)":[40],"every":[41],"4":[42],"h":[43],"for":[44,72,76,84,117,122,132],"a":[45],"total":[46,171],"eight":[48],"doses.":[49],"Antibiotic":[50,89],"dog":[53,67],"fluid":[57,93,103,162,173,191,199],"was":[58,94,148,164,193],"measured":[59],"ultracentrifugation.":[61],"Binding":[62,156],"ranged":[69],"from":[70],"31%":[71],"cephaloridine":[73,120],"46%":[75],"considerably":[78],"lower":[79,97],"than":[80,98,121],"human":[81],"cefamandole.":[88,125],"only":[95],"slightly":[96],"that":[99,168],"serum.":[101],"Ascitic":[102],"antibiotic":[104,174],"concentrations,":[105],"which":[106],"approached":[107],"equilibrium":[108],"at":[109,202],"16":[110],"28":[112],"h,":[113],"significantly":[115],"higher":[116,131],"cefazolin":[118,133],"cephalothin":[123],"However,":[126],"concentrations":[128],"also":[130],"percent":[137],"penetration":[138],"(ratio":[139],"peak":[142,145],"x":[146],"100)":[147],"not":[149],"statistically":[150],"different":[151],"among":[152],"four":[154],"drugs.":[155],"these":[158],"extravascular":[161,190],"an":[165],"important":[166],"factor":[167],"determined":[169],"level":[175,184],"achieved.":[176],"A":[177],"formula":[178],"utilizing":[179],"log":[181],"mean":[182],"used":[194],"accurately":[196],"predict":[197],"drug":[200],"levels":[201],"equilibrium.":[203]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
