{"id":"https://openalex.org/W2144658500","doi":"https://doi.org/10.1152/japplphysiol.01051.2006","title":"8-Oxoguanosine and uracil repair of nuclear and mitochondrial DNA in red and white skeletal muscle of exercise-trained old rats","display_name":"8-Oxoguanosine and uracil repair of nuclear and mitochondrial DNA in red and white skeletal muscle of exercise-trained old rats","publication_year":2007,"publication_date":"2007-01-04","ids":{"openalex":"https://openalex.org/W2144658500","doi":"https://doi.org/10.1152/japplphysiol.01051.2006","mag":"2144658500","pmid":"https://pubmed.ncbi.nlm.nih.gov/17204574"},"language":"en","primary_location":{"id":"doi:10.1152/japplphysiol.01051.2006","doi":"https://doi.org/10.1152/japplphysiol.01051.2006","is_oa":false,"landing_page_url":"https://doi.org/10.1152/japplphysiol.01051.2006","pdf_url":null,"source":{"id":"https://openalex.org/S140889577","display_name":"Journal of Applied Physiology","issn_l":"0161-7567","issn":["0161-7567","1522-1601","8750-7587"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040707618","display_name":"Zsolt O. Radak","orcid":"https://orcid.org/0000-0003-1297-6804","observed_orcids":["https://orcid.org/0000-0003-1297-6804"]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Zsolt Radak","raw_affiliation_strings":["Institute of Sport Science, Faculty of Physical Education and Sport Science, Semmelweis University, Budapest, Hungary. radak@mail.hupe.hu","Semmelweis University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Sport Science, Faculty of Physical Education and Sport Science, Semmelweis University, Budapest, Hungary. radak@mail.hupe.hu","institution_ids":["https://openalex.org/I101202996"]},{"raw_affiliation_string":"Semmelweis University","institution_ids":["https://openalex.org/I101202996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045350012","display_name":"Shuzo Kumagai","orcid":"https://orcid.org/0000-0002-4098-3385","observed_orcids":["https://orcid.org/0000-0002-4098-3385"]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Shuzo Kumagai","raw_affiliation_strings":["","Semmelweis University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Semmelweis University","institution_ids":["https://openalex.org/I101202996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057804376","display_name":"Hideko Nakamoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129634264","display_name":"Toho University","ror":"https://ror.org/02hcx7n63","country_code":"JP","type":"education","lineage":["https://openalex.org/I129634264"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideko Nakamoto","raw_affiliation_strings":["","Toho University,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Toho University,","institution_ids":["https://openalex.org/I129634264"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048939598","display_name":"Sataro Goto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129634264","display_name":"Toho University","ror":"https://ror.org/02hcx7n63","country_code":"JP","type":"education","lineage":["https://openalex.org/I129634264"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Sataro Goto","raw_affiliation_strings":["","Toho University,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Toho University,","institution_ids":["https://openalex.org/I129634264"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.2849,"has_fulltext":false,"cited_by_count":74,"citation_normalized_percentile":{"value":0.88922361,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"102","issue":"4","first_page":"1696","last_page":"1701"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.8125,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.8125,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11585","display_name":"Exercise and Physiological Responses","score":0.14139999449253082,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.012400000356137753,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/8-oxoguanosine","display_name":"8-oxoguanosine","score":0.9549999833106995},{"id":"https://openalex.org/keywords/uracil","display_name":"uracil","score":0.8320000171661377},{"id":"https://openalex.org/keywords/base-excision-repair","display_name":"base excision repair","score":0.800000011920929},{"id":"https://openalex.org/keywords/ogg1","display_name":"OGG1","score":0.7559999823570251},{"id":"https://openalex.org/keywords/uracil-dna-glycosylase","display_name":"uracil-DNA glycosylase","score":0.9710000157356262},{"id":"https://openalex.org/keywords/oxidative-dna-damage","display_name":"oxidative DNA damage","score":0.7979999780654907},{"id":"https://openalex.org/keywords/mitochondrial-dna","display_name":"mitochondrial DNA","score":0.6200000047683716},{"id":"https://openalex.org/keywords/nuclear-dna","display_name":"nuclear DNA","score":0.8399999737739563},{"id":"https://openalex.org/keywords/skeletal-muscle-fibers","display_name":"skeletal muscle fibers","score":0.75},{"id":"https://openalex.org/keywords/red-muscle","display_name":"red muscle","score":0.7519999742507935},{"id":"https://openalex.org/keywords/white-muscle-fibers","display_name":"white muscle","score":0.9950000047683716},{"id":"https://openalex.org/keywords/exercise-training","display_name":"exercise training","score":0.9729999899864197},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.9919999837875366},{"id":"https://openalex.org/keywords/antioxidant-enzymes","display_name":"antioxidant enzymes","score":0.6190000176429749},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.675000011920929},{"id":"https://openalex.org/keywords/enzyme-regulation","display_name":"enzyme regulation","score":0.6050000190734863}],"concepts":[{"id":"https://openalex.org/C2778711568","wikidata":"https://www.wikidata.org/wiki/Q11788286","display_name":"Uracil-DNA glycosylase","level":5,"score":0.7872858643531799},{"id":"https://openalex.org/C192396546","wikidata":"https://www.wikidata.org/wiki/Q413156","display_name":"DNA glycosylase","level":4,"score":0.761978805065155},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.6950571537017822},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.619947075843811},{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.5777403712272644},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.5232712030410767},{"id":"https://openalex.org/C187206112","wikidata":"https://www.wikidata.org/wiki/Q3113091","display_name":"Base excision repair","level":4,"score":0.5155527591705322},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.4973309338092804},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.48867157101631165},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.4613300561904907},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.45719093084335327},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.44906795024871826},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43061283230781555},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.42579060792922974},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34807252883911133},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.1771889328956604},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09489893913269043}],"mesh":[{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004272","descriptor_name":"DNA, Mitochondrial","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006151","descriptor_name":"Guanosine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D006151","descriptor_name":"Guanosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010805","descriptor_name":"Physical Conditioning, Animal","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D011916","descriptor_name":"Rats, Inbred F344","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014498","descriptor_name":"Uracil","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018485","descriptor_name":"Muscle Fibers, Skeletal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018656","descriptor_name":"Muscle Fibers, Fast-Twitch","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018657","descriptor_name":"Muscle Fibers, Slow-Twitch","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1152/japplphysiol.01051.2006","doi":"https://doi.org/10.1152/japplphysiol.01051.2006","is_oa":false,"landing_page_url":"https://doi.org/10.1152/japplphysiol.01051.2006","pdf_url":null,"source":{"id":"https://openalex.org/S140889577","display_name":"Journal of Applied Physiology","issn_l":"0161-7567","issn":["0161-7567","1522-1601","8750-7587"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Physiology","raw_type":"journal-article"},{"id":"pmid:17204574","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17204574","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of applied physiology (Bethesda, Md. : 1985)","raw_type":"Comparative Study"},{"id":"mag:2185483821","doi":null,"is_oa":false,"landing_page_url":"http://tf.hu/wp-content/uploads/2009/08/Rad\u00e1k-Zsolt-NTK-47.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1601027696","https://openalex.org/W1969643746","https://openalex.org/W1974748827","https://openalex.org/W1978946171","https://openalex.org/W1980979756","https://openalex.org/W1984290310","https://openalex.org/W1992091136","https://openalex.org/W1996366132","https://openalex.org/W2021506091","https://openalex.org/W2026625396","https://openalex.org/W2032224311","https://openalex.org/W2033926195","https://openalex.org/W2036462832","https://openalex.org/W2037349364","https://openalex.org/W2042684962","https://openalex.org/W2046875213","https://openalex.org/W2048623885","https://openalex.org/W2050588921","https://openalex.org/W2051727071","https://openalex.org/W2063741431","https://openalex.org/W2064502414","https://openalex.org/W2064899405","https://openalex.org/W2090389306","https://openalex.org/W2099961264","https://openalex.org/W2103405153","https://openalex.org/W2111001861","https://openalex.org/W2113007696","https://openalex.org/W2115647865","https://openalex.org/W2122677203","https://openalex.org/W2126464410","https://openalex.org/W2136799979","https://openalex.org/W2138475885","https://openalex.org/W2162808674","https://openalex.org/W2169911836","https://openalex.org/W2218000086","https://openalex.org/W2306259730","https://openalex.org/W2397847279"],"related_works":["https://openalex.org/W2150245656","https://openalex.org/W2185483821","https://openalex.org/W2138475885","https://openalex.org/W2125187897","https://openalex.org/W2099961264","https://openalex.org/W2162808674","https://openalex.org/W2620186132","https://openalex.org/W6958597222","https://openalex.org/W1978946171","https://openalex.org/W4320912590"],"abstract_inverted_index":{"Oxoguanine":[0],"DNA":[1,6,187],"glycosylase":[2,7],"(OGG1)":[3],"and":[4,38,49,94,102,109,121,137,149,166,181],"uracil":[5],"(UDG)":[8],"are":[9,18],"two":[10],"of":[11,62,71,91,99,106,114,132,145,155,169,179,186],"the":[12,21,60,68,89,104,130,135,143,156],"most":[13],"important":[14],"repair":[15,24],"enzymes":[16],"that":[17,59],"involved":[19],"in":[20,67,84,88,97,103,118,134,147,164,183,188],"base":[22],"excision":[23],"processes":[25],"to":[26,51,128],"eliminate":[27],"oxidative":[28,52],"damage":[29],"from":[30,78],"mammalian":[31],"DNA,":[32],"which":[33],"accumulates":[34],"with":[35,75],"aging.":[36],"Red":[37],"white":[39,76,100,110,122],"skeletal":[40,72],"muscle":[41,73,123],"fibers":[42,77,93,101],"have":[43],"very":[44],"different":[45,153],"antioxidant":[46],"enzyme":[47],"activities":[48,113,163],"resistance":[50],"stress.":[53],"In":[54,158],"this":[55],"paper,":[56],"we":[57],"demonstrate":[58],"activity":[61,87,96,131,144],"OGG1":[63,86,146,182],"is":[64],"significantly":[65],"higher":[66],"red":[69,92,108,120],"type":[70],"compared":[74],"old":[79],"rats.":[80],"Exercise":[81,125],"training":[82,126,141],"resulted":[83],"increased":[85],"nuclei":[90,98,136,148,165],"decreased":[95],"mitochondria":[105,150],"both":[107,119],"fibers.":[111,124],"The":[112],"UDG":[115,133,160,180],"were":[116],"similar":[117,162],"appears":[127],"increase":[129],"mitochondria.":[138],"However,":[139],"exercise":[140],"affects":[142],"differently,":[151],"suggesting":[152],"regulation":[154,178],"enzymes.":[157],"contrast,":[159],"showed":[161],"mitochondrial":[167],"extracts":[168],"exercise-trained":[170],"animals.":[171],"These":[172],"data":[173],"provide":[174],"evidence":[175],"for":[176],"differential":[177],"maintaining":[184],"fidelity":[185],"oxidatively":[189],"stressed":[190],"cells.":[191]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}