{"id":"https://openalex.org/W2144604752","doi":"https://doi.org/10.1186/2001-1326-1-29","title":"Rapamycin and mTOR: a serendipitous discovery and implications for breast cancer","display_name":"Rapamycin and mTOR: a serendipitous discovery and implications for breast cancer","publication_year":2012,"publication_date":"2012-11-15","ids":{"openalex":"https://openalex.org/W2144604752","doi":"https://doi.org/10.1186/2001-1326-1-29","mag":"2144604752","pmid":"https://pubmed.ncbi.nlm.nih.gov/23369283","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3561035"},"language":"en","primary_location":{"id":"doi:10.1186/2001-1326-1-29","doi":"https://doi.org/10.1186/2001-1326-1-29","is_oa":true,"landing_page_url":"https://doi.org/10.1186/2001-1326-1-29","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1186/2001-1326-1-29","source":{"id":"https://openalex.org/S2765071679","display_name":"Clinical and Translational Medicine","issn_l":"2001-1326","issn":["2001-1326"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Translational Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1186/2001-1326-1-29","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113502616","display_name":"Belinda Seto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210088243","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210088243"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Belinda Seto","raw_affiliation_strings":["National Institutes of Health National Institute of Biomedical Imaging and Bioengineering 9000 Rockville Pike, Building 31, Room 1C14 20892 Bethesda MD USA","National Institutes of Health, National Institute of Biomedical Imaging and Bioengineering, 9000 Rockville Pike, Building 31, Room 1C14, Bethesda, MD 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes of Health National Institute of Biomedical Imaging and Bioengineering 9000 Rockville Pike, Building 31, Room 1C14 20892 Bethesda MD USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210088243"]},{"raw_affiliation_string":"National Institutes of Health, National Institute of Biomedical Imaging and Bioengineering, 9000 Rockville Pike, Building 31, Room 1C14, Bethesda, MD 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210088243"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5113502616"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210088243"],"apc_list":{"value":3470,"currency":"USD","value_usd":3470},"apc_paid":{"value":3470,"currency":"USD","value_usd":3470},"fwci":2.5197,"has_fulltext":false,"cited_by_count":155,"citation_normalized_percentile":{"value":0.90917165,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"1","issue":"1","first_page":"29","last_page":"29"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rapamycin","display_name":"rapamycin","score":1.0},{"id":"https://openalex.org/keywords/mtor-signaling","display_name":"mTOR signaling","score":0.875},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9959999918937683},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.7049999833106995},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.7990000247955322},{"id":"https://openalex.org/keywords/antifungal-activity","display_name":"antifungal activity","score":0.8059999942779541},{"id":"https://openalex.org/keywords/p70-s6-kinase","display_name":"p70 S6 kinase","score":0.8379999995231628},{"id":"https://openalex.org/keywords/rapamycin-analogues","display_name":"rapamycin analogs","score":0.9240000247955322},{"id":"https://openalex.org/keywords/targeted-cancer-therapy","display_name":"targeted cancer therapy","score":0.7250000238418579},{"id":"https://openalex.org/keywords/streptomyces-hygroscopicus","display_name":"Streptomyces hygroscopicus","score":0.8899999856948853}],"concepts":[{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.8534471988677979},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6227855682373047},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5600442290306091},{"id":"https://openalex.org/C183713625","wikidata":"https://www.wikidata.org/wiki/Q5282002","display_name":"Discovery and development of mTOR inhibitors","level":4,"score":0.547844409942627},{"id":"https://openalex.org/C2777949483","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"Mechanistic target of rapamycin","level":4,"score":0.5446233153343201},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.535380482673645},{"id":"https://openalex.org/C2777921159","wikidata":"https://www.wikidata.org/wiki/Q32089","display_name":"Sirolimus","level":2,"score":0.5323190093040466},{"id":"https://openalex.org/C43060935","wikidata":"https://www.wikidata.org/wiki/Q18043110","display_name":"RPTOR","level":4,"score":0.5256327986717224},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4661601483821869},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.4562060534954071},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4442909061908722},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.44098830223083496},{"id":"https://openalex.org/C98490376","wikidata":"https://www.wikidata.org/wiki/Q14876060","display_name":"mTORC1","level":4,"score":0.41222280263900757},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.41205114126205444},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3347930908203125},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.32715022563934326},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17495721578598022},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.057294219732284546}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1186/2001-1326-1-29","doi":"https://doi.org/10.1186/2001-1326-1-29","is_oa":true,"landing_page_url":"https://doi.org/10.1186/2001-1326-1-29","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1186/2001-1326-1-29","source":{"id":"https://openalex.org/S2765071679","display_name":"Clinical and Translational Medicine","issn_l":"2001-1326","issn":["2001-1326"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Translational Medicine","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2564858","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3561035","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3561035","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3561035","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Transl Med","raw_type":"Text"},{"id":"pmid:23369283","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23369283","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and translational medicine","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:2e6c7df5de7b4723bf498207725027fa","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/2e6c7df5de7b4723bf498207725027fa","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clinical and Translational Medicine, Vol 1, Iss 1, Pp n/a-n/a (2012)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/2001-1326-1-29","doi":"https://doi.org/10.1186/2001-1326-1-29","is_oa":true,"landing_page_url":"https://doi.org/10.1186/2001-1326-1-29","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1186/2001-1326-1-29","source":{"id":"https://openalex.org/S2765071679","display_name":"Clinical and Translational Medicine","issn_l":"2001-1326","issn":["2001-1326"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Translational Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332163","display_name":"U.S. Food and Drug Administration","ror":"https://ror.org/034xvzb47"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2144604752.pdf"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W1210193786","https://openalex.org/W1605833010","https://openalex.org/W1811665544","https://openalex.org/W1973299943","https://openalex.org/W1984736455","https://openalex.org/W1985046929","https://openalex.org/W1987961957","https://openalex.org/W1988976358","https://openalex.org/W2001639563","https://openalex.org/W2002199578","https://openalex.org/W2005245900","https://openalex.org/W2011859278","https://openalex.org/W2013956549","https://openalex.org/W2015174638","https://openalex.org/W2017605860","https://openalex.org/W2026842712","https://openalex.org/W2038884210","https://openalex.org/W2041928869","https://openalex.org/W2047057570","https://openalex.org/W2055248589","https://openalex.org/W2058452670","https://openalex.org/W2058829665","https://openalex.org/W2063013559","https://openalex.org/W2073885879","https://openalex.org/W2075639584","https://openalex.org/W2092615292","https://openalex.org/W2099389441","https://openalex.org/W2100506877","https://openalex.org/W2108478376","https://openalex.org/W2110604215","https://openalex.org/W2113458582","https://openalex.org/W2118120822","https://openalex.org/W2119060677","https://openalex.org/W2126493366","https://openalex.org/W2127152525","https://openalex.org/W2129585918","https://openalex.org/W2134138119","https://openalex.org/W2141161352","https://openalex.org/W2146414563","https://openalex.org/W2152365295","https://openalex.org/W2153607816","https://openalex.org/W2163583831","https://openalex.org/W2172159375","https://openalex.org/W2466906265","https://openalex.org/W2517054293","https://openalex.org/W2626632314"],"related_works":["https://openalex.org/W4251022521","https://openalex.org/W2046898223","https://openalex.org/W2089668045","https://openalex.org/W2764507256","https://openalex.org/W7096739644","https://openalex.org/W2003100469","https://openalex.org/W2143645520","https://openalex.org/W2088363975","https://openalex.org/W2377266765","https://openalex.org/W1481792333"],"abstract_inverted_index":{"Rapamycin":[0,52,110],"was":[1,19],"discovered":[2],"more":[3],"than":[4],"thirty":[5],"years":[6],"ago":[7],"from":[8,12,21],"a":[9,57],"soil":[10],"sample":[11],"the":[13,94,106,156,165],"island":[14],"of":[15,97,109,130,133,146,158,161],"Rapa":[16],"Nui.":[17],"It":[18],"isolated":[20],"Streptomyces":[22],"hygroscopicus":[23],"and":[24,40,68,122,124,152,179],"initial":[25],"characterization":[26,33],"focused":[27],"on":[28],"its":[29],"antifungal":[30],"activities.":[31,99],"Subsequent":[32],"showed":[34],"that":[35,79],"it":[36],"has":[37,41,53],"immunosuppressive":[38],"properties":[39],"been":[42],"used":[43],"successfully":[44],"to":[45,55,92,105,118,143],"reduce":[46],"organ":[47],"rejection":[48],"with":[49,60],"kidney":[50],"transplantation.":[51],"proven":[54],"be":[56],"versatile":[58],"compound":[59],"several":[61,173],"seemingly":[62],"unrelated":[63],"properties,":[64],"including":[65,172],"antifungal,":[66],"immunosuppressive,":[67],"anticancer.":[69],"The":[70,112],"National":[71],"Cancer":[72],"Institute":[73],"(NCI)":[74],"Developmental":[75],"Therapeutics":[76],"Program":[77],"demonstrated":[78],"rapamycin":[80,125,174],"inhibited":[81],"cell":[82,86,119],"growth":[83,101,134],"in":[84,140,155],"tumor":[85],"lines.":[87],"These":[88],"observations":[89],"stimulated":[90],"research":[91],"explore":[93],"underlying":[95],"mechanism":[96],"anti-tumor":[98],"Cell":[100],"inhibition":[102],"involves":[103],"binding":[104],"mammalian":[107],"Target":[108],"(mTOR).":[111],"mTOR":[113,137,162],"signaling":[114,163],"pathway":[115],"is":[116],"critical":[117],"growth,":[120],"proliferation,":[121],"survival":[123],"inhibits":[126],"these":[127],"hallmark":[128],"processes":[129],"cancer.":[131],"Binding":[132],"factors":[135],"activates":[136],"signaling,":[138],"which":[139],"turn":[141],"leads":[142],"downstream":[144],"phosphorylation":[145,157],"protein":[147],"kinases,":[148],"e.g.,":[149],"p70S6":[150],"kinase":[151],"lipid":[153],"kinases":[154],"phosphoinositides.":[159],"Understanding":[160],"provided":[164],"biological":[166],"basis":[167],"for":[168,176],"targeted":[169],"chemotherapeutics":[170],"development,":[171],"analogues":[175],"treating":[177],"breast":[178],"other":[180],"cancers.":[181]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":15},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":15},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}