{"id":"https://openalex.org/W2144600979","doi":"https://doi.org/10.1016/j.jalz.2008.05.349","title":"O2\u201006\u201301: A powerful, genome\u2010wide association scan for susceptibility genes for late\u2010onset Alzheimer's disease","display_name":"O2\u201006\u201301: A powerful, genome\u2010wide association scan for susceptibility genes for late\u2010onset Alzheimer's disease","publication_year":2008,"publication_date":"2008-07-01","ids":{"openalex":"https://openalex.org/W2144600979","doi":"https://doi.org/10.1016/j.jalz.2008.05.349","mag":"2144600979"},"language":"en","primary_location":{"id":"doi:10.1016/j.jalz.2008.05.349","doi":"https://doi.org/10.1016/j.jalz.2008.05.349","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jalz.2008.05.349","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.jalz.2008.05.349","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.jalz.2008.05.349","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049840252","display_name":"Julie H. Williams","orcid":"https://orcid.org/0000-0002-4069-0259","observed_orcids":["https://orcid.org/0000-0002-4069-0259"]},"institutions":[{"id":"https://openalex.org/I79510175","display_name":"Cardiff University","ror":"https://ror.org/03kk7td41","country_code":"GB","type":"education","lineage":["https://openalex.org/I79510175"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Julie Williams","raw_affiliation_strings":["Cardiff University, Cardiff, UNITED KINGDOM"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiff University, Cardiff, UNITED KINGDOM","institution_ids":["https://openalex.org/I79510175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003164142","display_name":"Richard Abraham","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79510175","display_name":"Cardiff University","ror":"https://ror.org/03kk7td41","country_code":"GB","type":"education","lineage":["https://openalex.org/I79510175"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Richard Abraham","raw_affiliation_strings":["Cardiff University, Cardiff, UNITED KINGDOM"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiff University, Cardiff, UNITED KINGDOM","institution_ids":["https://openalex.org/I79510175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076728928","display_name":"Angharad R. Morgan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79510175","display_name":"Cardiff University","ror":"https://ror.org/03kk7td41","country_code":"GB","type":"education","lineage":["https://openalex.org/I79510175"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Angharad Morgan","raw_affiliation_strings":["Cardiff University, Cardiff, UNITED KINGDOM"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiff University, Cardiff, UNITED KINGDOM","institution_ids":["https://openalex.org/I79510175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040508278","display_name":"Rebecca Sims","orcid":"https://orcid.org/0000-0002-3885-1199","observed_orcids":["https://orcid.org/0000-0002-3885-1199"]},"institutions":[{"id":"https://openalex.org/I79510175","display_name":"Cardiff University","ror":"https://ror.org/03kk7td41","country_code":"GB","type":"education","lineage":["https://openalex.org/I79510175"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Rebecca Sims","raw_affiliation_strings":["Cardiff University, Cardiff, UNITED KINGDOM"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiff University, Cardiff, UNITED KINGDOM","institution_ids":["https://openalex.org/I79510175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036497300","display_name":"Paul Hollingworth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79510175","display_name":"Cardiff University","ror":"https://ror.org/03kk7td41","country_code":"GB","type":"education","lineage":["https://openalex.org/I79510175"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Paul Hollingworth","raw_affiliation_strings":["Cardiff University, Cardiff, UNITED KINGDOM"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiff University, Cardiff, UNITED KINGDOM","institution_ids":["https://openalex.org/I79510175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059458620","display_name":"Michael C. O\u2019Donovan","orcid":"https://orcid.org/0000-0001-7073-2379","observed_orcids":["https://orcid.org/0000-0001-7073-2379"]},"institutions":[{"id":"https://openalex.org/I79510175","display_name":"Cardiff University","ror":"https://ror.org/03kk7td41","country_code":"GB","type":"education","lineage":["https://openalex.org/I79510175"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Michael O'Donovan","raw_affiliation_strings":["Cardiff University, Cardiff, UNITED KINGDOM"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiff University, Cardiff, UNITED KINGDOM","institution_ids":["https://openalex.org/I79510175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026352442","display_name":"Michael John Owen","orcid":"https://orcid.org/0000-0003-4798-0862","observed_orcids":["https://orcid.org/0000-0003-4798-0862"]},"institutions":[{"id":"https://openalex.org/I79510175","display_name":"Cardiff University","ror":"https://ror.org/03kk7td41","country_code":"GB","type":"education","lineage":["https://openalex.org/I79510175"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Michael Owen","raw_affiliation_strings":["Cardiff University, Cardiff, UNITED KINGDOM"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiff University, Cardiff, UNITED KINGDOM","institution_ids":["https://openalex.org/I79510175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028228908","display_name":"Peter Holmans","orcid":"https://orcid.org/0000-0003-0870-9412","observed_orcids":["https://orcid.org/0000-0003-0870-9412"]},"institutions":[{"id":"https://openalex.org/I79510175","display_name":"Cardiff University","ror":"https://ror.org/03kk7td41","country_code":"GB","type":"education","lineage":["https://openalex.org/I79510175"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Peter Holmans","raw_affiliation_strings":["Cardiff University, Cardiff, UNITED KINGDOM"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiff University, Cardiff, UNITED KINGDOM","institution_ids":["https://openalex.org/I79510175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109850283","display_name":"Ivan Nikolov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79510175","display_name":"Cardiff University","ror":"https://ror.org/03kk7td41","country_code":"GB","type":"education","lineage":["https://openalex.org/I79510175"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ivan Nikolov","raw_affiliation_strings":["Cardiff University, Cardiff, UNITED KINGDOM"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiff University, Cardiff, UNITED KINGDOM","institution_ids":["https://openalex.org/I79510175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107834048","display_name":"Valentina Moskvina","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79510175","display_name":"Cardiff University","ror":"https://ror.org/03kk7td41","country_code":"GB","type":"education","lineage":["https://openalex.org/I79510175"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Valentina Moskvina","raw_affiliation_strings":["Cardiff University, Cardiff, UNITED KINGDOM"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiff University, Cardiff, UNITED KINGDOM","institution_ids":["https://openalex.org/I79510175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002493210","display_name":"Simon Lovestone","orcid":"https://orcid.org/0000-0003-0473-4565","observed_orcids":["https://orcid.org/0000-0003-0473-4565"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Simon Lovestone","raw_affiliation_strings":["Institute of Psychiatry, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Psychiatry, London, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008236816","display_name":"David Chaim Rubinsztein","orcid":"https://orcid.org/0000-0001-5002-5263","observed_orcids":["https://orcid.org/0000-0001-5002-5263"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David Rubinsztein","raw_affiliation_strings":["University of Cambridge Cambridge United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Cambridge Cambridge United Kingdom","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085651175","display_name":"Carol Brayne","orcid":"https://orcid.org/0000-0001-5307-663X","observed_orcids":["https://orcid.org/0000-0001-5307-663X"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Carol Brayne","raw_affiliation_strings":["University of Cambridge Cambridge United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Cambridge Cambridge United Kingdom","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Mike Gill","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Mike Gill","raw_affiliation_strings":["University of Dublin Dublin Ireland","Univ. of Dublin, Dublin, Ireland#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Dublin Dublin Ireland","institution_ids":["https://openalex.org/I205274468"]},{"raw_affiliation_string":"Univ. of Dublin, Dublin, Ireland#TAB#","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071373873","display_name":"BRIAN A. LAWLOR","orcid":"https://orcid.org/0000-0002-5012-2116","observed_orcids":["https://orcid.org/0000-0002-5012-2116"]},"institutions":[{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Brian Lawlor","raw_affiliation_strings":["University of Dublin Dublin Ireland","Univ. of Dublin, Dublin, Ireland#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Dublin Dublin Ireland","institution_ids":["https://openalex.org/I205274468"]},{"raw_affiliation_string":"Univ. of Dublin, Dublin, Ireland#TAB#","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047373823","display_name":"Kevin Morgan","orcid":"https://orcid.org/0000-0002-8217-2396","observed_orcids":["https://orcid.org/0000-0002-8217-2396"]},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kevin Morgan","raw_affiliation_strings":["The University of Nottingham, Nottingham, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Nottingham, Nottingham, United Kingdom","institution_ids":["https://openalex.org/I142263535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058572359","display_name":"Peter Passmore","orcid":"https://orcid.org/0000-0003-2858-5509","observed_orcids":["https://orcid.org/0000-0003-2858-5509"]},"institutions":[{"id":"https://openalex.org/I126231945","display_name":"Queen's University Belfast","ror":"https://ror.org/00hswnk62","country_code":"GB","type":"education","lineage":["https://openalex.org/I126231945"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Peter Passmore","raw_affiliation_strings":["The Queen's University of Belfast, Belfast, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Queen's University of Belfast, Belfast, United Kingdom","institution_ids":["https://openalex.org/I126231945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027119794","display_name":"Patrick G. Kehoe","orcid":"https://orcid.org/0000-0002-7542-1139","observed_orcids":["https://orcid.org/0000-0002-7542-1139"]},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Patrick Kehoe","raw_affiliation_strings":["University of Bristol Bristol United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Bristol Bristol United Kingdom","institution_ids":["https://openalex.org/I36234482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064532444","display_name":"Clive Holmes","orcid":"https://orcid.org/0000-0003-1999-6912","observed_orcids":["https://orcid.org/0000-0003-1999-6912"]},"institutions":[{"id":"https://openalex.org/I2802213945","display_name":"Moorgreen Hospital","ror":"https://ror.org/02jb7ng92","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802073232","https://openalex.org/I2802213945"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Clive Holmes","raw_affiliation_strings":["Moorgreen Hospital, Southampton, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Moorgreen Hospital, Southampton, United Kingdom","institution_ids":["https://openalex.org/I2802213945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069768586","display_name":"David Aitchison Smith","orcid":"https://orcid.org/0000-0002-9845-5913","observed_orcids":["https://orcid.org/0000-0002-9845-5913"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David Smith","raw_affiliation_strings":["University of Oxford, Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007631989","display_name":"David M. A. Mann","orcid":"https://orcid.org/0000-0002-3960-9863","observed_orcids":["https://orcid.org/0000-0002-3960-9863","https://orcid.org/0000-0002-2099-0852","https://orcid.org/0000-0003-0522-6802"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David Mann","raw_affiliation_strings":["The University of Manchester, Manchester United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Manchester, Manchester United Kingdom","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020514779","display_name":"John Hardy","orcid":"https://orcid.org/0000-0002-3122-0423","observed_orcids":["https://orcid.org/0000-0002-3122-0423"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"John Hardy","raw_affiliation_strings":["University College London London United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University College London London United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032450718","display_name":"Martin N. Rossor","orcid":"https://orcid.org/0000-0001-8215-3120","observed_orcids":["https://orcid.org/0000-0001-8215-3120"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Martin Rossor","raw_affiliation_strings":["Imperial College London London United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imperial College London London United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018836358","display_name":"Nick C. Fox","orcid":"https://orcid.org/0000-0002-6660-657X","observed_orcids":["https://orcid.org/0000-0002-6660-657X"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nick Fox","raw_affiliation_strings":["University College London London United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University College London London United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085975040","display_name":"Simon Mead","orcid":"https://orcid.org/0000-0002-4326-1468","observed_orcids":["https://orcid.org/0000-0002-4326-1468"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Simon Mead","raw_affiliation_strings":["University College London London United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University College London London United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5049840252"],"corresponding_institution_ids":["https://openalex.org/I79510175"],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.25384027,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"4","issue":"4S_Part_4","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.7271000146865845,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.7271000146865845,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.1639000028371811,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.09920000284910202,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/late-onset-alzheimer-s-disease","display_name":"late-onset Alzheimer's disease","score":0.9769999980926514},{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"genome-wide association study","score":0.8140000104904175}],"concepts":[{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.7144344449043274},{"id":"https://openalex.org/C31467283","wikidata":"https://www.wikidata.org/wiki/Q912147","display_name":"Genotyping","level":4,"score":0.7023372650146484},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.6124758124351501},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.578941822052002},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5736060738563538},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.5567516684532166},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.5360145568847656},{"id":"https://openalex.org/C76818968","wikidata":"https://www.wikidata.org/wiki/Q181940","display_name":"Sanger sequencing","level":4,"score":0.5357884764671326},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5259186029434204},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.455584853887558},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.43656808137893677},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3749493956565857},{"id":"https://openalex.org/C51679486","wikidata":"https://www.wikidata.org/wiki/Q380546","display_name":"DNA sequencing","level":3,"score":0.31223809719085693},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.30777397751808167},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22127032279968262},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12470105290412903}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jalz.2008.05.349","doi":"https://doi.org/10.1016/j.jalz.2008.05.349","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jalz.2008.05.349","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.jalz.2008.05.349","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.jalz.2008.05.349","doi":"https://doi.org/10.1016/j.jalz.2008.05.349","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jalz.2008.05.349","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.jalz.2008.05.349","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2144600979.pdf","grobid_xml":"https://content.openalex.org/works/W2144600979.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2080506082","https://openalex.org/W2097792759","https://openalex.org/W2161718120","https://openalex.org/W2083230478","https://openalex.org/W2158128633","https://openalex.org/W2097838704","https://openalex.org/W2087440627","https://openalex.org/W4312087804","https://openalex.org/W2017581860","https://openalex.org/W4388185574"],"abstract_inverted_index":{"The":[0,184],"generation":[1],"of":[2,10,14,42,60,115,142,162,253,288,301],"dense":[3],"SNP":[4,22],"marker":[5],"maps":[6],"and":[7,44,66,118,146,153,197,203,225,262,293,295],"the":[8,11,15,30,40,58,72,140,163,174,179,201,212,270,296],"decoding":[9],"LD":[12],"architecture":[13],"human":[16],"genome,":[17],"together":[18],"with":[19],"developments":[20],"in":[21,35,76,84,194,211,232,276],"genotyping":[23,129],"platforms":[24],"have":[25,109,125],"allowed":[26],"researchers":[27],"to":[28,90,112,278,285],"capture":[29],"entire":[31],"genome's":[32],"common":[33],"variation":[34],"a":[36,53,80,127,136],"single":[37],"experiment,":[38],"testing":[39],"majority":[41],"genes":[43,87,114,287],"inter-genic":[45],"regions.":[46],"Such":[47],"genome-wide":[48],"association":[49,274],"(GWA)":[50],"studies":[51,231],"provide":[52],"hypothesis-free":[54],"design":[55],"that":[56],"permits":[57],"identification":[59],"novel":[61,291],"genetic":[62,273],"risk":[63,93],"factors,":[64],"pathways":[65,292],"gene":[67],"interactions.":[68],"We":[69,124,215,240,267],"are":[70,88,170,268],"conducting":[71],"largest":[73],"GWA":[74,230],"study":[75,224,275,281],"Alzheimer's":[77],"Disease":[78],"(AD),":[79],"genetically":[81],"complex":[82],"disease":[83,95],"which":[85],"multiple":[86],"thought":[89],"confer":[91],"modest":[92,116],"for":[94,304],"development.":[96],"By":[97],"using":[98,173,220],"large,":[99],"well-characterised":[100],"case-control":[101],"samples,":[102],"collectively":[103],"totalling":[104],"over":[105,147,237,246],"16,000":[106],"individuals,":[107],"we":[108],"sufficient":[110,283],"power":[111,284],"identify":[113],"effect":[117],"reduce":[119],"spurious":[120],"false":[121],"positive":[122],"findings.":[123],"adopted":[126],"tiered":[128],"strategy.":[130],"In":[131],"Stage":[132,189,251],"1":[133,190,252],"DNA":[134],"from":[135,139,188,200,222,228,236,250],"multi-centre":[137],"collaboration":[138],"UK,":[141],"3984":[143],"AD":[144,277,306],"cases":[145,196],"6000":[148],"controls":[149,158,199,208],"(1,229":[150],"age":[151],"matched":[152],"4\u20135000":[154],"additional":[155],"unscreened":[156],"population":[157],"genotyped":[159,172,193],"as":[160],"part":[161],"UK":[164,205,248],"based":[165,244],"1958":[166],"Birth":[167],"Cohort":[168],"study)":[169],"being":[171],"Illumina":[175],"HumanHap550":[176],"platform":[177],"at":[178],"Sanger":[180],"centre":[181],"(Cambridge,":[182],"UK).":[183],"most":[185,259,271],"significant":[186],"SNPs":[187],"will":[191,216,241,299],"be":[192,300],"2,131":[195],"2,845":[198],"USA":[202],"1,057":[204],"age-matched,":[206],"screened":[207],"not":[209],"included":[210],"first":[213],"stage.":[214],"also":[217],"conduct":[218],"meta-analyses":[219],"data":[221,297],"our":[223,258],"those":[226],"available":[227],"other":[229],"AD,":[233],"merging":[234],"information":[235],"20,000":[238],"individuals.":[239],"present":[242],"results":[243],"on":[245,257],"10,000":[247],"samples":[249],"this":[254],"study,":[255],"focusing":[256],"promising":[260],"associations":[261],"discuss":[263],"future":[264,305],"research":[265],"directions.":[266],"undertaking":[269],"powerful":[272],"date.":[279],"Our":[280],"has":[282],"detect":[286],"small":[289],"effect,":[290],"interactions":[294],"generated":[298],"considerable":[302],"importance":[303],"research.":[307]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}