{"id":"https://openalex.org/W2144550641","doi":"https://doi.org/10.1210/jc.2010-1587","title":"Effects of a Growth Hormone-Releasing Hormone Analog on Endogenous GH Pulsatility and Insulin Sensitivity in Healthy Men","display_name":"Effects of a Growth Hormone-Releasing Hormone Analog on Endogenous GH Pulsatility and Insulin Sensitivity in Healthy Men","publication_year":2010,"publication_date":"2010-10-14","ids":{"openalex":"https://openalex.org/W2144550641","doi":"https://doi.org/10.1210/jc.2010-1587","mag":"2144550641","pmid":"https://pubmed.ncbi.nlm.nih.gov/20943777","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3038486"},"language":"en","primary_location":{"id":"doi:10.1210/jc.2010-1587","doi":"https://doi.org/10.1210/jc.2010-1587","is_oa":true,"landing_page_url":"https://doi.org/10.1210/jc.2010-1587","pdf_url":"https://academic.oup.com/jcem/article-pdf/96/1/150/10745507/jcem0150.pdf","source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology &amp; Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/jcem/article-pdf/96/1/150/10745507/jcem0150.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034813577","display_name":"Takara Leah Stanley","orcid":"https://orcid.org/0000-0002-2336-2958","observed_orcids":["https://orcid.org/0000-0002-2336-2958"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Takara L. Stanley","raw_affiliation_strings":["Massachusetts General Hospital Program in Nutritional Metabolism, Harvard Medical School, Boston, Massachusetts 02114, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital Program in Nutritional Metabolism, Harvard Medical School, Boston, Massachusetts 02114, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102238717","display_name":"Cindy Y. Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cindy Y. Chen","raw_affiliation_strings":["Program in Nutritional Metabolism and Neuroendocrine Unit (T.L.S., C.Y.C., H.M., S.K.G.), Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Nutritional Metabolism and Neuroendocrine Unit (T.L.S., C.Y.C., H.M., S.K.G.), Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000996728","display_name":"Karen L. Branch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karen L. Branch","raw_affiliation_strings":["Clinical Research Center (K.L.B.), Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research Center (K.L.B.), Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053884502","display_name":"Hideo Makimura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hideo Makimura","raw_affiliation_strings":["Program in Nutritional Metabolism and Neuroendocrine Unit (T.L.S., C.Y.C., H.M., S.K.G.), Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Nutritional Metabolism and Neuroendocrine Unit (T.L.S., C.Y.C., H.M., S.K.G.), Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063043469","display_name":"Steven Kyle Grinspoon","orcid":"https://orcid.org/0000-0002-6338-000X","observed_orcids":["https://orcid.org/0000-0002-6338-000X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Steven K. Grinspoon","raw_affiliation_strings":["Program in Nutritional Metabolism and Neuroendocrine Unit (T.L.S., C.Y.C., H.M., S.K.G.), Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Nutritional Metabolism and Neuroendocrine Unit (T.L.S., C.Y.C., H.M., S.K.G.), Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5063043469"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":32.4097,"has_fulltext":true,"cited_by_count":163,"citation_normalized_percentile":{"value":0.99823795,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"96","issue":"1","first_page":"150","last_page":"158"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tesamorelin","display_name":"tesamorelin","score":1.0},{"id":"https://openalex.org/keywords/growth-hormone-pulsatility","display_name":"growth hormone pulsatility","score":0.7940000295639038},{"id":"https://openalex.org/keywords/growth-hormone-secretion","display_name":"growth hormone secretion","score":0.8299999833106995},{"id":"https://openalex.org/keywords/insulin-sensitivity","display_name":"insulin sensitivity","score":0.9660000205039978},{"id":"https://openalex.org/keywords/insulin-stimulated-glucose-uptake","display_name":"insulin-stimulated glucose uptake","score":0.9789999723434448},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.9919999837875366},{"id":"https://openalex.org/keywords/visceral-fat","display_name":"visceral fat","score":0.9139999747276306},{"id":"https://openalex.org/keywords/healthy-men","display_name":"healthy men","score":0.7099999785423279}],"concepts":[{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.7437793016433716},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7149760723114014},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7053279876708984},{"id":"https://openalex.org/C3017594256","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin sensitivity","level":4,"score":0.6175137758255005},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.5778701901435852},{"id":"https://openalex.org/C2984496839","wikidata":"https://www.wikidata.org/wiki/Q29956617","display_name":"Growth hormone","level":3,"score":0.5253416895866394},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5111971497535706},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4195803701877594},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38520345091819763},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.12788492441177368}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007334","descriptor_name":"Insulin-Like Growth Factor I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010902","descriptor_name":"Pituitary Gland","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013007","descriptor_name":"Growth Hormone-Releasing Hormone","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D013007","descriptor_name":"Growth Hormone-Releasing Hormone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015309","descriptor_name":"Glucose Clamp Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019382","descriptor_name":"Human Growth Hormone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1210/jc.2010-1587","doi":"https://doi.org/10.1210/jc.2010-1587","is_oa":true,"landing_page_url":"https://doi.org/10.1210/jc.2010-1587","pdf_url":"https://academic.oup.com/jcem/article-pdf/96/1/150/10745507/jcem0150.pdf","source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology &amp; Metabolism","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2254993","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3038486","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3038486","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3038486","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Endocrinol Metab","raw_type":"Text"},{"id":"pmid:20943777","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20943777","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical endocrinology and metabolism","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1210/jc.2010-1587","doi":"https://doi.org/10.1210/jc.2010-1587","is_oa":true,"landing_page_url":"https://doi.org/10.1210/jc.2010-1587","pdf_url":"https://academic.oup.com/jcem/article-pdf/96/1/150/10745507/jcem0150.pdf","source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology &amp; Metabolism","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[{"id":"https://openalex.org/G1024134251","display_name":null,"funder_award_id":"1UL1RR025758","funder_id":"https://openalex.org/F4320309673","funder_display_name":"Harvard Catalyst"},{"id":"https://openalex.org/G1121993805","display_name":"Augmenting Pulsatile Growth Hormone: Metabolic Effects in HIV-Infection","funder_award_id":"K23DK089910","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G1817153103","display_name":"Training Program in Nutrition and Metabolism","funder_award_id":"T32HD052961","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G2496518617","display_name":null,"funder_award_id":"UL1-RR025758","funder_id":"https://openalex.org/F4320309673","funder_display_name":"Harvard Catalyst"},{"id":"https://openalex.org/G2523096557","display_name":"Growth Hormone Releasing Hormone in Patients with HIV Lipodystrophy","funder_award_id":"F32DK080642","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3447108572","display_name":"Harvard Clinical and Translational Science Center (UL1)","funder_award_id":"UL1RR025758","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G3493866547","display_name":"General Clinical Research Center","funder_award_id":"M01RR001066","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G3740841103","display_name":null,"funder_award_id":"RR025758","funder_id":"https://openalex.org/F4320309673","funder_display_name":"Harvard Catalyst"},{"id":"https://openalex.org/G3981800229","display_name":null,"funder_award_id":"M01RR01066","funder_id":"https://openalex.org/F4320309673","funder_display_name":"Harvard Catalyst"},{"id":"https://openalex.org/G518405130","display_name":"Growth Hormone, Mitochondria, and Cardio-metabolic Complications of Obesity","funder_award_id":"K23DK087857","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G7495689722","display_name":"Strategies to Improve CAD Risk In HIV Disease","funder_award_id":"K24DK064545","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G758595025","display_name":"Metabolic, and Cardiovascular Effects of GHRH in HIV Infected Patients","funder_award_id":"R01DK063639","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000907652","display_name":"Boston Area Nutrition Obesity Research Center (NORC)","funder_award_id":"P30DK040561","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320308349","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78"},{"id":"https://openalex.org/F4320309673","display_name":"Harvard Catalyst","ror":null},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332200","display_name":"EMD Serono","ror":"https://ror.org/027zrs220"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2144550641.pdf","grobid_xml":"https://content.openalex.org/works/W2144550641.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W165592964","https://openalex.org/W1935313559","https://openalex.org/W1987910229","https://openalex.org/W2003188803","https://openalex.org/W2009614797","https://openalex.org/W2014672870","https://openalex.org/W2018336983","https://openalex.org/W2024901198","https://openalex.org/W2025089542","https://openalex.org/W2027844527","https://openalex.org/W2031980352","https://openalex.org/W2032080493","https://openalex.org/W2032366308","https://openalex.org/W2048331100","https://openalex.org/W2049144714","https://openalex.org/W2049167103","https://openalex.org/W2049552245","https://openalex.org/W2058588784","https://openalex.org/W2061911279","https://openalex.org/W2063287755","https://openalex.org/W2063701256","https://openalex.org/W2074107669","https://openalex.org/W2079868428","https://openalex.org/W2084608105","https://openalex.org/W2086269626","https://openalex.org/W2087447921","https://openalex.org/W2091239171","https://openalex.org/W2092157623","https://openalex.org/W2100818058","https://openalex.org/W2103115713","https://openalex.org/W2104769193","https://openalex.org/W2105912552","https://openalex.org/W2106375220","https://openalex.org/W2107532860","https://openalex.org/W2117457454","https://openalex.org/W2122200062","https://openalex.org/W2124632379","https://openalex.org/W2124966147","https://openalex.org/W2134702438","https://openalex.org/W2156435407","https://openalex.org/W2161754063","https://openalex.org/W2315987042","https://openalex.org/W2416445356","https://openalex.org/W4239320088","https://openalex.org/W4240922836","https://openalex.org/W4250426666"],"related_works":["https://openalex.org/W2024528536","https://openalex.org/W2070657614","https://openalex.org/W2117138448","https://openalex.org/W2003166537","https://openalex.org/W1970805105","https://openalex.org/W2028608010","https://openalex.org/W2134127282","https://openalex.org/W1987978661","https://openalex.org/W2005150551","https://openalex.org/W2078978796"],"abstract_inverted_index":{"CONTEXT":[0],"AND":[1,52],"OBJECTIVE:":[2],"Strategies":[3],"to":[4,29,237],"augment":[5],"pulsatile":[6,223],"GH":[7,19,42,107,129,146,157,171,224],"may":[8],"be":[9,238],"beneficial":[10],"in":[11,17,47,104],"patients":[12],"with":[13,80,215],"excess":[14],"visceral":[15],"adiposity,":[16],"whom":[18],"secretion":[20,130,172],"is":[21],"reduced.":[22],"The":[23,98],"objective":[24],"of":[25,33,88,94],"this":[26],"study":[27],"was":[28,102,206],"determine":[30],"the":[31],"effects":[32],"a":[34,216],"novel":[35],"GHRH":[36],"(GHRH(1-44))":[37],"analog,":[38,218],"tesamorelin,":[39,219],"on":[40],"endogenous":[41],"pulsatility":[43],"and":[44,62,90,128,137,169,222],"insulin":[45],"sensitivity":[46],"healthy":[48],"men.":[49],"DESIGN,":[50],"PARTICIPANTS,":[51],"INTERVENTION:":[53],"Thirteen":[54],"males":[55],"(mean":[56],"age":[57],"45":[58],"\u00b1":[59,67,149,162,175,187],"3":[60],"yr":[61],"body":[63],"mass":[64],"index":[65],"27.3":[66],"1.2":[68],"kg/m(2))":[69],"received":[70],"tesamorelin":[71,228],"2":[72,78,86,92],"mg":[73],"sc":[74],"once":[75],"daily":[76],"for":[77],"wk,":[79],"assessment":[81],"made":[82],"at":[83],"baseline,":[84],"after":[85,91],"wk":[87,93],"treatment,":[89],"withdrawal.":[95],"OUTCOME":[96],"MEASURES:":[97],"primary":[99],"end":[100,115],"point":[101],"change":[103],"mean":[105,144],"overnight":[106,111,145],"as":[108,121],"determined":[109],"by":[110,123,185,209],"frequent":[112],"sampling.":[113],"Secondary":[114],"points":[116],"included":[117],"insulin-stimulated":[118,200,233],"glucose":[119,195,201,234],"uptake":[120,202,235],"measured":[122],"euglycemic":[124],"hyperinsulinemic":[125],"clamp;":[126],"IGF-I;":[127],"parameters,":[131],"including":[132],"pulse":[133,135],"area,":[134],"frequency,":[136],"basal":[138,170,221],"secretion.":[139,225],"RESULTS:":[140],"Tesamorelin":[141],"treatment":[142,214],"increased":[143,184],"(change":[147,160,173],"+0.5":[148],"0.1":[150,163],"\u03bcg/liter,":[151,165],"P":[152,166,180],"=":[153,167,181,197,204],"0.004),":[154],"average":[155],"log(10)":[156,164],"peak":[158],"area":[159],"+0.4":[161],"0.001),":[168],"+0.008":[174],"0.003":[176],"\u03bcg/liter":[177,189],"\u00b7":[178],"min,":[179],"0.008).":[182],"IGF-I":[183],"181":[186],"22":[188],"(P":[190,196,203],"<":[191],"0.0001).":[192],"Neither":[193],"fasting":[194],"0.93)":[198],"nor":[199],"0.61)":[205],"significantly":[207,229],"affected":[208],"tesamorelin.":[210],"CONCLUSIONS:":[211],"Once-daily":[212],"short-term":[213],"GHRH(1-44)":[217],"augments":[220],"Moreover,":[226],"although":[227],"increases":[230],"IGF-I,":[231],"peripheral":[232],"appears":[236],"preserved.":[239]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}