{"id":"https://openalex.org/W2144489169","doi":null,"title":"Paracrine factors from aggregates of fibroblasts or bone marrow stromal cells enhance skin wound healing","display_name":"Paracrine factors from aggregates of fibroblasts or bone marrow stromal cells enhance skin wound healing","publication_year":2012,"publication_date":"2012-06-15","ids":{"openalex":"https://openalex.org/W2144489169","mag":"2144489169"},"language":"en","primary_location":{"id":"pmh:oai:helda.helsinki.fi:10138/33699","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/33699","pdf_url":null,"source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10138/33699","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065753385","display_name":"Matti Peura","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Matti Peura","raw_affiliation_strings":["Clinicum"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinicum","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5065753385"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cutaneous-wound-healing","display_name":"skin wound healing","score":0.8569999933242798},{"id":"https://openalex.org/keywords/paracrine-factors","display_name":"paracrine factors","score":0.7720000147819519},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.996999979019165},{"id":"https://openalex.org/keywords/keratinocyte-migration","display_name":"keratinocyte migration","score":0.968999981880188},{"id":"https://openalex.org/keywords/keratinocyte-proliferation","display_name":"keratinocyte proliferation","score":0.8949999809265137},{"id":"https://openalex.org/keywords/c-met","display_name":"c-Met","score":0.7429999709129333},{"id":"https://openalex.org/keywords/hepatocyte-growth-factor","display_name":"hepatocyte growth factor","score":0.9950000047683716},{"id":"https://openalex.org/keywords/growth-factor-delivery","display_name":"growth factor delivery","score":0.6669999957084656},{"id":"https://openalex.org/keywords/fibrin-matrix","display_name":"fibrin matrix","score":0.9800000190734863},{"id":"https://openalex.org/keywords/keratinocyte-transplantation","display_name":"keratinocyte transplantation","score":0.9559999704360962},{"id":"https://openalex.org/keywords/partial-thickness-wounds","display_name":"partial-thickness wounds","score":0.8159999847412109},{"id":"https://openalex.org/keywords/full-thickness-wounds","display_name":"full-thickness wounds","score":0.9089999794960022},{"id":"https://openalex.org/keywords/granulation-tissue","display_name":"granulation tissue","score":0.8849999904632568},{"id":"https://openalex.org/keywords/chronic-non-healing-wounds","display_name":"chronic non-healing wounds","score":0.722000002861023}],"concepts":[{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.7839986085891724},{"id":"https://openalex.org/C7876069","wikidata":"https://www.wikidata.org/wiki/Q14873666","display_name":"Paracrine signalling","level":3,"score":0.7634091377258301},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.7545278072357178},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.5918759703636169},{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.4645260274410248},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4640120267868042},{"id":"https://openalex.org/C190567982","wikidata":"https://www.wikidata.org/wiki/Q7535422","display_name":"Skin repair","level":3,"score":0.43376970291137695},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.34732913970947266},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.24552515149116516},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18760430812835693},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16772061586380005},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.12918248772621155},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:helda.helsinki.fi:10138/33699","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/33699","pdf_url":null,"source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoralThesis"},{"id":"mag:2144489169","doi":null,"is_oa":false,"landing_page_url":"https://helda.helsinki.fi/bitstream/handle/10138/33699/Paracrin.pdf?sequence=1","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:helda.helsinki.fi:10138/33699","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/33699","pdf_url":null,"source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":258,"referenced_works":["https://openalex.org/W22120313","https://openalex.org/W79668981","https://openalex.org/W104918950","https://openalex.org/W140314759","https://openalex.org/W148753544","https://openalex.org/W149810482","https://openalex.org/W152502414","https://openalex.org/W204511859","https://openalex.org/W639401131","https://openalex.org/W1487373628","https://openalex.org/W1502904746","https://openalex.org/W1505584712","https://openalex.org/W1529396499","https://openalex.org/W1545694669","https://openalex.org/W1563542893","https://openalex.org/W1581155767","https://openalex.org/W1581614391","https://openalex.org/W1607351680","https://openalex.org/W1639755981","https://openalex.org/W1812245576","https://openalex.org/W1815558303","https://openalex.org/W1818313483","https://openalex.org/W1901969375","https://openalex.org/W1920480608","https://openalex.org/W1927300791","https://openalex.org/W1931315964","https://openalex.org/W1949832432","https://openalex.org/W1955795615","https://openalex.org/W1965490606","https://openalex.org/W1967058955","https://openalex.org/W1967376453","https://openalex.org/W1967823590","https://openalex.org/W1969690763","https://openalex.org/W1969703263","https://openalex.org/W1971182101","https://openalex.org/W1971543939","https://openalex.org/W1971562341","https://openalex.org/W1971934781","https://openalex.org/W1971996334","https://openalex.org/W1972036696","https://openalex.org/W1972141220","https://openalex.org/W1972241298","https://openalex.org/W1974487824","https://openalex.org/W1976162098","https://openalex.org/W1976393051","https://openalex.org/W1978133294","https://openalex.org/W1978339849","https://openalex.org/W1978862186","https://openalex.org/W1981110839","https://openalex.org/W1982105288","https://openalex.org/W1982186359","https://openalex.org/W1982343754","https://openalex.org/W1982771591","https://openalex.org/W1983201136","https://openalex.org/W1983836639","https://openalex.org/W1984707646","https://openalex.org/W1984783970","https://openalex.org/W1986514032","https://openalex.org/W1988207497","https://openalex.org/W1988566133","https://openalex.org/W1988691104","https://openalex.org/W1989021197","https://openalex.org/W1990065094","https://openalex.org/W1990160715","https://openalex.org/W1990669035","https://openalex.org/W1990875443","https://openalex.org/W1990922681","https://openalex.org/W1994437329","https://openalex.org/W1995276955","https://openalex.org/W1996789266","https://openalex.org/W1997830990","https://openalex.org/W1998598793","https://openalex.org/W1998868529","https://openalex.org/W2000649145","https://openalex.org/W2001675896","https://openalex.org/W2001779049","https://openalex.org/W2001860584","https://openalex.org/W2004127276","https://openalex.org/W2004418591","https://openalex.org/W2005291085","https://openalex.org/W2006027198","https://openalex.org/W2006086550","https://openalex.org/W2006729028","https://openalex.org/W2006875835","https://openalex.org/W2007285318","https://openalex.org/W2008153386","https://openalex.org/W2009085438","https://openalex.org/W2009852602","https://openalex.org/W2009969959","https://openalex.org/W2011202983","https://openalex.org/W2011642803","https://openalex.org/W2011847072","https://openalex.org/W2012792646","https://openalex.org/W2013322971","https://openalex.org/W2013497532","https://openalex.org/W2015865696","https://openalex.org/W2016193552","https://openalex.org/W2016278203","https://openalex.org/W2016715128","https://openalex.org/W2020787417","https://openalex.org/W2020901140","https://openalex.org/W2021081081","https://openalex.org/W2021785318","https://openalex.org/W2021855690","https://openalex.org/W2022406746","https://openalex.org/W2022582979","https://openalex.org/W2022604327","https://openalex.org/W2022658482","https://openalex.org/W2025209544","https://openalex.org/W2025780832","https://openalex.org/W2026813843","https://openalex.org/W2027000474","https://openalex.org/W2027155227","https://openalex.org/W2028358547","https://openalex.org/W2029542498","https://openalex.org/W2030281917","https://openalex.org/W2030776545","https://openalex.org/W2031768006","https://openalex.org/W2032666845","https://openalex.org/W2032731042","https://openalex.org/W2034305619","https://openalex.org/W2034381586","https://openalex.org/W2035055796","https://openalex.org/W2035643457","https://openalex.org/W2037059879","https://openalex.org/W2037298358","https://openalex.org/W2037509685","https://openalex.org/W2038086562","https://openalex.org/W2038153134","https://openalex.org/W2038689279","https://openalex.org/W2040108044","https://openalex.org/W2042186200","https://openalex.org/W2042202567","https://openalex.org/W2042396998","https://openalex.org/W2042629233","https://openalex.org/W2043442238","https://openalex.org/W2048227994","https://openalex.org/W2049043712","https://openalex.org/W2049252866","https://openalex.org/W2049920231","https://openalex.org/W2052038646","https://openalex.org/W2054012934","https://openalex.org/W2055423598","https://openalex.org/W2056072605","https://openalex.org/W2056438352","https://openalex.org/W2057514048","https://openalex.org/W2058087004","https://openalex.org/W2058312109","https://openalex.org/W2059032249","https://openalex.org/W2059727529","https://openalex.org/W2060049869","https://openalex.org/W2061581470","https://openalex.org/W2062352917","https://openalex.org/W2065173834","https://openalex.org/W2065465240","https://openalex.org/W2065942568","https://openalex.org/W2068397002","https://openalex.org/W2068765932","https://openalex.org/W2069145789","https://openalex.org/W2070618750","https://openalex.org/W2071062350","https://openalex.org/W2071972670","https://openalex.org/W2073092341","https://openalex.org/W2075112237","https://openalex.org/W2077766337","https://openalex.org/W2078132464","https://openalex.org/W2078919314","https://openalex.org/W2079238808","https://openalex.org/W2079457579","https://openalex.org/W2080036786","https://openalex.org/W2080166457","https://openalex.org/W2080318490","https://openalex.org/W2082224498","https://openalex.org/W2082405430","https://openalex.org/W2082416335","https://openalex.org/W2082723727","https://openalex.org/W2084099797","https://openalex.org/W2084599179","https://openalex.org/W2086377126","https://openalex.org/W2086474709","https://openalex.org/W2087018283","https://openalex.org/W2087874571","https://openalex.org/W2090345406","https://openalex.org/W2090787883","https://openalex.org/W2091611973","https://openalex.org/W2092066675","https://openalex.org/W2092800759","https://openalex.org/W2093096778","https://openalex.org/W2098610498","https://openalex.org/W2098799479","https://openalex.org/W2100742787","https://openalex.org/W2104058491","https://openalex.org/W2104606637","https://openalex.org/W2105106090","https://openalex.org/W2106059813","https://openalex.org/W2110504545","https://openalex.org/W2110542271","https://openalex.org/W2111572095","https://openalex.org/W2111893100","https://openalex.org/W2112006376","https://openalex.org/W2112604656","https://openalex.org/W2112787985","https://openalex.org/W2115465396","https://openalex.org/W2115757150","https://openalex.org/W2116358704","https://openalex.org/W2117852040","https://openalex.org/W2125280450","https://openalex.org/W2125366323","https://openalex.org/W2125685597","https://openalex.org/W2131281032","https://openalex.org/W2133632488","https://openalex.org/W2134150152","https://openalex.org/W2134782683","https://openalex.org/W2137273526","https://openalex.org/W2137545824","https://openalex.org/W2138178479","https://openalex.org/W2138309116","https://openalex.org/W2140273413","https://openalex.org/W2143464311","https://openalex.org/W2143845455","https://openalex.org/W2144314842","https://openalex.org/W2145116085","https://openalex.org/W2145796127","https://openalex.org/W2147834652","https://openalex.org/W2148835676","https://openalex.org/W2149423925","https://openalex.org/W2149438471","https://openalex.org/W2150275873","https://openalex.org/W2151607513","https://openalex.org/W2154263946","https://openalex.org/W2159193579","https://openalex.org/W2159752830","https://openalex.org/W2159999899","https://openalex.org/W2160233674","https://openalex.org/W2161191354","https://openalex.org/W2162562455","https://openalex.org/W2164020827","https://openalex.org/W2165638615","https://openalex.org/W2166817851","https://openalex.org/W2168539583","https://openalex.org/W2171609261","https://openalex.org/W2184743351","https://openalex.org/W2185333371","https://openalex.org/W2186509953","https://openalex.org/W2189233644","https://openalex.org/W2205931255","https://openalex.org/W2317184793","https://openalex.org/W2323310581","https://openalex.org/W2325727928","https://openalex.org/W2326276889","https://openalex.org/W2405763369","https://openalex.org/W2413737812","https://openalex.org/W2416895886","https://openalex.org/W2416975341","https://openalex.org/W2418611766","https://openalex.org/W2491699159","https://openalex.org/W3023110197","https://openalex.org/W4293632152"],"related_works":["https://openalex.org/W2072082901","https://openalex.org/W2012124754","https://openalex.org/W2418627967","https://openalex.org/W2065633193","https://openalex.org/W2015865696","https://openalex.org/W1985925525","https://openalex.org/W4318428575","https://openalex.org/W2009085438","https://openalex.org/W7095147892","https://openalex.org/W2005943573"],"abstract_inverted_index":{"The":[0,217,310],"skin":[1,160],"is":[2,54,76,365],"the":[3,7,23,28,49,122,139,173,189,240,259,269,346],"largest":[4],"organ":[5],"of":[6,33,59,107,116,141,144,159,166,176,223,273,342,360,373],"human":[8,184,236,305,333],"body.":[9],"It":[10],"maintains":[11],"body":[12],"homeostasis":[13],"and":[14,72,85,129,197,248,271,275],"provides":[15],"an":[16,209,266],"essential":[17],"barrier":[18],"that":[19,315,367],"protects":[20],"us":[21],"from":[22],"environment.":[24],"After":[25],"injury":[26],"to":[27,39,57,171,188,220,243,345],"skin,":[29],"a":[30,104,142,152,179,245,303],"complex":[31],"series":[32],"tightly":[34],"controlled":[35],"responses":[36],"are":[37,355],"initiated":[38],"restore":[40],"its":[41],"integrity.":[42],"In":[43,279],"large-scale":[44],"wounds,":[45,363],"such":[46,68,96,231],"as":[47,69,81,83,90,92,97,155,206,208,232,338],"burns,":[48],"intrinsic":[50],"capacity":[51],"for":[52,157,340,358],"healing":[53,226,359],"compromised":[55],"due":[56],"lack":[58],"dermal":[60],"support.":[61],"Dermal":[62],"fibroblasts":[63,318],"guide":[64],"crucial":[65,357],"re-epithelialization":[66],"events":[67],"keratinocyte":[70,180,325],"migration":[71,272],"proliferation.":[73],"Fibroblast-keratinocyte":[74],"interaction":[75],"directed":[77],"by":[78,114,148,227],"paracrine":[79,328],"factors":[80,109,146,242,354],"well":[82,91,207],"cell-cell":[84,316],"cell-extracellular":[86],"matrix":[87,118],"contacts.":[88],"Fibroblasts":[89],"other":[93],"mesenchyme-derived":[94],"cells":[95,101,123,323],"bone":[98,320],"marrow":[99,321],"stromal":[100,322],"can":[102,336],"produce":[103],"vast":[105],"array":[106],"growth":[108,131,145,211,241,249,260],"in":[110,268,295,349,375],"vitro.":[111],"When":[112,252],"activated":[113],"deprivation":[115],"extracellular":[117],"cell":[119,150],"adhesion":[120],"sites,":[121],"prefer":[124],"cell-to-cell":[125],"contacts,":[126],"form":[127],"clusters,":[128],"release":[130],"factors.":[132,329],"This":[133],"present":[134],"work":[135],"focused":[136],"on":[137,290],"characterizing":[138],"use":[140],"combination":[143],"released":[147],"mesenchymal":[149],"aggregates,":[151],"process":[153],"designated":[154],"nemosis,":[156],"treatment":[158],"wound":[161,225],"healing.":[162],"We":[163],"used":[164],"inhibitors":[165],"several":[167],"intracellular":[168],"signaling":[169],"pathways":[170],"define":[172],"migration-inducing":[174],"mechanisms":[175],"nemosis":[177],"using":[178],"wound-healing":[181],"assay.":[182],"Model":[183],"keratinocytes":[185],"HaCaT-cells":[186],"responded":[187],"nemosis-derived":[190],"conditioned":[191],"medium":[192],"with":[193,239,258,288,302,327],"enhanced":[194,285],"migration,":[195],"proliferation,":[196],"viability.":[198],"A":[199],"c-Met-specific":[200],"small":[201],"molecule":[202],"tyrosine":[203],"kinase":[204],"inhibitor":[205],"anti-hepatocyte":[210],"factor":[212],"antibody":[213],"inhibited":[214],"these":[215,343,353],"responses.":[216],"study":[218],"aimed":[219],"characterize":[221],"means":[222],"improving":[224],"combining":[228],"biological":[229],"materials,":[230],"fibrin":[233,262],"or":[234,319,331],"recombinant":[235,304,332],"collagen":[237,306,334],"III":[238,308,335],"construct":[244],"transplantable":[246],"cell-":[247],"factor-containing":[250,261],"matrix.":[251,309],"we":[253,264],"treated":[254],"porcine":[255,296],"partial-thickness":[256],"wounds":[257,299],"matrix,":[263],"observed":[265],"increase":[267],"proliferation":[270],"hair-follicle":[274],"lateral":[276],"wound-edge":[277],"keratinocytes.":[278],"addition,":[280],"granulation":[281],"tissue":[282],"formation":[283,289],"was":[284,300],"when":[286],"compared":[287],"saline-treated":[291],"wounds.":[292,351],"Keratinocyte":[293],"transplantation":[294,326],"full":[297],"thickness":[298],"feasible":[301],"type":[307],"results":[311],"presented":[312],"here":[313],"indicate":[314],"contact-activated":[317],"improve":[324],"Fibrin":[330],"serve":[337],"vehicles":[339],"delivery":[341],"signals":[344],"target":[347],"site":[348],"acute":[350],"Since":[352],"also":[356],"chronic":[361],"non-healing":[362],"it":[364],"likely":[366],"our":[368],"therapeutic":[369],"approach":[370],"will":[371],"be":[372],"benefit":[374],"their":[376],"treatment,":[377],"too.":[378]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}