{"id":"https://openalex.org/W2144486320","doi":null,"title":"Drug resistance & virulence determinants in clinical isolates of Enterococcus species.","display_name":"Drug resistance & virulence determinants in clinical isolates of Enterococcus species.","publication_year":2013,"publication_date":"2013-05-01","ids":{"openalex":"https://openalex.org/W2144486320","mag":"2144486320","pmid":"https://pubmed.ncbi.nlm.nih.gov/23760387","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3734693"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:2729744","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3734693","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3734693","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060587416","display_name":"Sanal C Fernandes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I164861460","display_name":"Manipal Academy of Higher Education","ror":"https://ror.org/02xzytt36","country_code":"IN","type":"education","lineage":["https://openalex.org/I164861460"]},{"id":"https://openalex.org/I4387153400","display_name":"Kasturba Medical College, Mangalore","ror":"https://ror.org/048vk1h54","country_code":"IN","type":"education","lineage":["https://openalex.org/I164861460","https://openalex.org/I4387153400"]},{"id":"https://openalex.org/I76414455","display_name":"Kasturba Medical College, Manipal","ror":"https://ror.org/05hg48t65","country_code":"IN","type":"education","lineage":["https://openalex.org/I164861460","https://openalex.org/I76414455"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sanal C Fernandes","raw_affiliation_strings":["Department of Microbiology, Kasturba Medical College, Manipal University, Mangalore, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Kasturba Medical College, Manipal University, Mangalore, India","institution_ids":["https://openalex.org/I164861460","https://openalex.org/I4387153400","https://openalex.org/I76414455"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012733010","display_name":"Biranthabail Dhanashree","orcid":"https://orcid.org/0000-0002-5370-0663","observed_orcids":["https://orcid.org/0000-0002-5370-0663"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Dhanashree","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.2015,"has_fulltext":false,"cited_by_count":56,"citation_normalized_percentile":{"value":0.94418239,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"137","issue":"5","first_page":"981","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12167","display_name":"Bacterial Identification and Susceptibility Testing","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/enterococcus","display_name":"Enterococcus","score":0.9980000257492065},{"id":"https://openalex.org/keywords/antibiotic-resistance","display_name":"antibiotic resistance","score":0.8619999885559082},{"id":"https://openalex.org/keywords/virulence-factors","display_name":"virulence factors","score":0.9829999804496765},{"id":"https://openalex.org/keywords/vancomycin-resistance","display_name":"vancomycin resistance","score":0.890999972820282},{"id":"https://openalex.org/keywords/vancomycin-resistant-enterococci","display_name":"vancomycin-resistant enterococci","score":0.949999988079071},{"id":"https://openalex.org/keywords/high-level-aminoglycoside-resistance","display_name":"high-level aminoglycoside resistance","score":0.9679999947547913},{"id":"https://openalex.org/keywords/hemolysin","display_name":"hemolysin","score":0.8999999761581421},{"id":"https://openalex.org/keywords/gelatinase","display_name":"gelatinase","score":0.9929999709129333},{"id":"https://openalex.org/keywords/enterococcus-faecalis","display_name":"Enterococcus faecalis","score":0.9769999980926514},{"id":"https://openalex.org/keywords/enterococcus-faecium","display_name":"Enterococcus faecium","score":1.0},{"id":"https://openalex.org/keywords/nosocomial-infections","display_name":"nosocomial infections","score":0.9229999780654907},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.8999999761581421},{"id":"https://openalex.org/keywords/clinical-isolates","display_name":"clinical isolates","score":0.8790000081062317}],"concepts":[{"id":"https://openalex.org/C2780585763","wikidata":"https://www.wikidata.org/wiki/Q517258","display_name":"Enterococcus","level":3,"score":0.7781764268875122},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.7260357141494751},{"id":"https://openalex.org/C2778980435","wikidata":"https://www.wikidata.org/wiki/Q424027","display_name":"Vancomycin","level":4,"score":0.6894409656524658},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.6612107753753662},{"id":"https://openalex.org/C2779895986","wikidata":"https://www.wikidata.org/wiki/Q140014","display_name":"Enterococcus faecalis","level":4,"score":0.6263014078140259},{"id":"https://openalex.org/C2778660310","wikidata":"https://www.wikidata.org/wiki/Q177998","display_name":"Agar","level":3,"score":0.5371246337890625},{"id":"https://openalex.org/C2777677444","wikidata":"https://www.wikidata.org/wiki/Q140010","display_name":"Enterococcus faecium","level":3,"score":0.5076738595962524},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4767756760120392},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.4607788920402527},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.4283786416053772},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3403749167919159},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.24650058150291443},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.09926897287368774},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000617","descriptor_name":"Aminoglycosides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003428","descriptor_name":"Cross Infection","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003428","descriptor_name":"Cross Infection","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003428","descriptor_name":"Cross Infection","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D004352","descriptor_name":"Drug Resistance, Microbial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014640","descriptor_name":"Vancomycin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D014774","descriptor_name":"Virulence","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014774","descriptor_name":"Virulence","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016983","descriptor_name":"Enterococcus","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D016983","descriptor_name":"Enterococcus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016983","descriptor_name":"Enterococcus","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D020713","descriptor_name":"Vancomycin Resistance","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:2729744","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3734693","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3734693","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3734693","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian J Med Res","raw_type":"Text"},{"id":"pmid:23760387","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23760387","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Indian journal of medical research","raw_type":"Journal Article"},{"id":"mag:2144486320","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23760387","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2729744","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3734693","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W611976593","https://openalex.org/W1484819781","https://openalex.org/W1510985733","https://openalex.org/W1976667730","https://openalex.org/W1996345883","https://openalex.org/W2040377269","https://openalex.org/W2058133520","https://openalex.org/W2070418581","https://openalex.org/W2126524876","https://openalex.org/W2133842224","https://openalex.org/W2136931384","https://openalex.org/W2146193543","https://openalex.org/W2147853980","https://openalex.org/W2151921983","https://openalex.org/W2154008825","https://openalex.org/W2160913100","https://openalex.org/W2184295436","https://openalex.org/W2185371335","https://openalex.org/W2188490285","https://openalex.org/W2341381399","https://openalex.org/W2412271593","https://openalex.org/W2743041357","https://openalex.org/W4322578595"],"related_works":["https://openalex.org/W4291298331","https://openalex.org/W2556935659","https://openalex.org/W2941400666","https://openalex.org/W2734749684","https://openalex.org/W2715190236","https://openalex.org/W4381571079","https://openalex.org/W4292294936","https://openalex.org/W2195876193","https://openalex.org/W1537881893","https://openalex.org/W1623402627"],"abstract_inverted_index":{"BACKGROUND":[0],"&":[1,158],"OBJECTIVES:":[2],"Enterococci":[3],"are":[4,12],"the":[5,25,29,94,132,169,210],"leading":[6],"cause":[7],"of":[8,131,142,149,161,174,183,197,214],"nosocomial":[9],"infections,":[10],"and":[11,28,39,51,73,85,106,187,193,199,212],"thus":[13],"a":[14],"persisting":[15],"clinical":[16,34,46],"problem":[17],"globally.":[18],"We":[19],"undertook":[20],"this":[21],"study":[22],"to":[23,53,63,165,189],"determine":[24],"virulence":[26,204],"factors":[27],"antibiotic":[30,54],"resistance":[31,138,185],"in":[32,208],"Enterococcus":[33,41,96,111,217],"isolates.":[35],"METHODS:":[36],"One":[37],"hundred":[38],"fifty":[40],"isolates":[42,120,124,133,145,170],"obtained":[43],"from":[44],"various":[45],"specimens":[47],"were":[48,76,100,109],"speciated":[49],"biochemically":[50],"subjected":[52],"susceptibility":[55],"testing":[56],"using":[57,68,78],"Kirby-Bauer":[58],"disk":[59],"diffusion":[60],"method.":[61,71],"Resistance":[62],"vancomycin":[64,147,184],"was":[65,115,163],"determined":[66],"by":[67],"agar":[69,84],"screen":[70],"Haemolysin":[72,113],"gelatinase":[74],"productions":[75],"detected":[77],"5":[79],"per":[80,87,129],"cent":[81,88,130],"sheep":[82],"blood":[83],"12":[86],"gelatin":[89],"agar,":[90],"respectively.":[91],"RESULTS:":[92],"Among":[93],"150":[95],"isolates,":[97],"84":[98],"(56%)":[99],"E.":[101,104],"faecalis.":[102],"51(34%)":[103],"faecium,":[105],"15":[107],"(10%)":[108],"other":[110],"spp.":[112],"production":[114],"seen":[116],"among":[117,168],"123":[118],"(82%)":[119],"while":[121],"61":[122],"(40.6%)":[123],"produced":[125],"gelatinase.":[126],"Nearly":[127],"50":[128],"showed":[134,146],"high":[135],"level":[136],"aminoglycoside":[137],"(HLAR).":[139],"A":[140],"total":[141],"13":[143],"(8.6%)":[144],"resistance,":[148],"which":[150],"11(7.3%)":[151],"had":[152],"an":[153],"MIC":[154],">8":[155],"\u03bcg/ml.":[156],"INTERPRETATION":[157],"CONCLUSIONS:":[159],"Presence":[160],"VRE":[162,175,191,198],"found":[164],"be":[166],"low":[167],"studied.":[171],"However,":[172],"occurrence":[173],"along":[176,201],"with":[177,202],"HLAR":[178,200],"calls":[179],"for":[180],"regular":[181],"detection":[182,196],"promptly":[186],"accurately":[188],"recognize":[190],"colonization":[192],"infection.":[194],"Early":[195],"their":[203],"trait":[205],"will":[206],"help":[207],"preventing":[209],"establishment":[211],"spread":[213],"multidrug":[215],"resistant":[216],"species.":[218]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}