{"id":"https://openalex.org/W2144459904","doi":null,"title":"Antinociceptive effect of clavulanic acid and its preventive activity against development of morphine tolerance and dependence in animal models.","display_name":"Antinociceptive effect of clavulanic acid and its preventive activity against development of morphine tolerance and dependence in animal models.","publication_year":2014,"publication_date":"2014-09-01","ids":{"openalex":"https://openalex.org/W2144459904","mag":"2144459904","pmid":"https://pubmed.ncbi.nlm.nih.gov/25657803","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4317999"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:3285432","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4317999","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4317999","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020250038","display_name":"Valiollah Hajhashemi","orcid":"https://orcid.org/0000-0001-5783-2324","observed_orcids":["https://orcid.org/0000-0001-5783-2324"]},"institutions":[{"id":"https://openalex.org/I114982161","display_name":"Isfahan University of Medical Sciences","ror":"https://ror.org/04waqzz56","country_code":"IR","type":"education","lineage":["https://openalex.org/I114982161"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"V Hajhashemi","raw_affiliation_strings":["Department of Pharmacology and Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, I.R. Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, I.R. Iran","institution_ids":["https://openalex.org/I114982161"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028415441","display_name":"Kh Dehdashti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114982161","display_name":"Isfahan University of Medical Sciences","ror":"https://ror.org/04waqzz56","country_code":"IR","type":"education","lineage":["https://openalex.org/I114982161"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Kh Dehdashti","raw_affiliation_strings":["Department of Pharmacology and Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, I.R. Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, I.R. Iran","institution_ids":["https://openalex.org/I114982161"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I114982161"],"apc_list":null,"apc_paid":null,"fwci":1.4865,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.79232088,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"9","issue":"5","first_page":"315","last_page":"21"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11199","display_name":"Pain Management and Opioid Use","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clavulanic-acid","display_name":"clavulanic acid","score":1.0},{"id":"https://openalex.org/keywords/antinociception","display_name":"antinociception","score":0.8840000033378601},{"id":"https://openalex.org/keywords/morphine-tolerance","display_name":"morphine tolerance","score":0.9900000095367432},{"id":"https://openalex.org/keywords/morphine-dependence","display_name":"morphine dependence","score":0.9750000238418579},{"id":"https://openalex.org/keywords/opioid-withdrawal","display_name":"opioid withdrawal","score":0.640999972820282},{"id":"https://openalex.org/keywords/glutamate-transporters","display_name":"glutamate transporters","score":0.7070000171661377},{"id":"https://openalex.org/keywords/glutamatergic-neurotransmission","display_name":"glutamatergic neurotransmission","score":0.9789999723434448},{"id":"https://openalex.org/keywords/acetic-acid-writhing-test","display_name":"acetic acid-induced writhing","score":0.8500000238418579},{"id":"https://openalex.org/keywords/formalin-test","display_name":"formalin test","score":0.9639999866485596},{"id":"https://openalex.org/keywords/naloxone-precipitated-withdrawal","display_name":"naloxone-precipitated withdrawal","score":0.6890000104904175}],"concepts":[{"id":"https://openalex.org/C2777389121","wikidata":"https://www.wikidata.org/wiki/Q81225","display_name":"Morphine","level":2,"score":0.8039535284042358},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.655205488204956},{"id":"https://openalex.org/C15490471","wikidata":"https://www.wikidata.org/wiki/Q2734305","display_name":"Nociception","level":3,"score":0.6447728872299194},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5734495520591736},{"id":"https://openalex.org/C2779454058","wikidata":"https://www.wikidata.org/wiki/Q415709","display_name":"Clavulanic acid","level":4,"score":0.5192371010780334},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.5046988725662231},{"id":"https://openalex.org/C2780820201","wikidata":"https://www.wikidata.org/wiki/Q173235","display_name":"Analgesic","level":2,"score":0.4664895534515381},{"id":"https://openalex.org/C2776673659","wikidata":"https://www.wikidata.org/wiki/Q47512","display_name":"Acetic acid","level":2,"score":0.46054336428642273},{"id":"https://openalex.org/C2779245659","wikidata":"https://www.wikidata.org/wiki/Q1633866","display_name":"Hyperalgesia","level":4,"score":0.44139552116394043},{"id":"https://openalex.org/C2780648746","wikidata":"https://www.wikidata.org/wiki/Q28208871","display_name":"Glutamatergic","level":4,"score":0.4224490225315094},{"id":"https://openalex.org/C2780723003","wikidata":"https://www.wikidata.org/wiki/Q2917928","display_name":"Licking","level":2,"score":0.41514357924461365},{"id":"https://openalex.org/C2779985140","wikidata":"https://www.wikidata.org/wiki/Q1425425","display_name":"Drug tolerance","level":2,"score":0.41327089071273804},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3362395465373993},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30614137649536133},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.26036542654037476},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1751033067703247},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0980721116065979},{"id":"https://openalex.org/C2779708577","wikidata":"https://www.wikidata.org/wiki/Q201928","display_name":"Amoxicillin","level":3,"score":0.07221594452857971},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:3285432","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4317999","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:25657803","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25657803","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research in pharmaceutical sciences","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4317999","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4317999/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Res Pharm Sci","raw_type":"Text"},{"id":"mag:2144459904","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25657803","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3285432","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4317999","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W18100118","https://openalex.org/W233025038","https://openalex.org/W1516221483","https://openalex.org/W1526412808","https://openalex.org/W1965262046","https://openalex.org/W1966425023","https://openalex.org/W1973640730","https://openalex.org/W1974574229","https://openalex.org/W1978922105","https://openalex.org/W1987464387","https://openalex.org/W1991066275","https://openalex.org/W1993215757","https://openalex.org/W1997912746","https://openalex.org/W2003410399","https://openalex.org/W2007393557","https://openalex.org/W2009345240","https://openalex.org/W2013445851","https://openalex.org/W2015237651","https://openalex.org/W2016575029","https://openalex.org/W2019623109","https://openalex.org/W2030952232","https://openalex.org/W2033525233","https://openalex.org/W2034348223","https://openalex.org/W2035893848","https://openalex.org/W2043649737","https://openalex.org/W2052778402","https://openalex.org/W2073541816","https://openalex.org/W2077923208","https://openalex.org/W2083204774","https://openalex.org/W2090734244","https://openalex.org/W2096296582","https://openalex.org/W2130742288","https://openalex.org/W2137801699","https://openalex.org/W2165422418","https://openalex.org/W2168339235","https://openalex.org/W2191577851","https://openalex.org/W2278365557","https://openalex.org/W2284695162","https://openalex.org/W2322444147","https://openalex.org/W2791114118"],"related_works":["https://openalex.org/W7155163611","https://openalex.org/W2895247956","https://openalex.org/W1997394823","https://openalex.org/W2005415366","https://openalex.org/W2941603543","https://openalex.org/W2170158125","https://openalex.org/W4392654618","https://openalex.org/W4231699383","https://openalex.org/W2073675839","https://openalex.org/W1997805689"],"abstract_inverted_index":{"Glutamate":[0],"has":[1,18,224],"a":[2,101],"key":[3],"role":[4],"in":[5,58,68,111,207],"pain":[6,196],"perception":[7],"and":[8,13,47,56,76,105,124,131,134,138,154,159,166,170,182,188,194,211,218,228],"also":[9],"development":[10,52,215],"of":[11,29,44,53,87,157,161,179,191,216],"tolerance":[12,55,217],"dependence":[14,57,219],"to":[15,38,82,96,113,149,203,220,233],"morphine.":[16,221],"It":[17],"been":[19],"reported":[20],"that":[21],"clavulanic":[22,45,88],"acid":[23,46,176,193,199,223],"affects":[24],"glutamatergic":[25],"transmission":[26],"via":[27],"activation":[28],"glutamate":[30],"transporter.":[31],"Therefore":[32],"the":[33,40,84,97,155],"present":[34],"study":[35],"was":[36,94,127,147,200],"aimed":[37],"evaluate":[39],"possible":[41],"antinociceptive":[42,85,226],"effect":[43,86],"its":[48,235],"preventive":[49],"activity":[50,227],"against":[51],"morphine":[54,118,120,151],"animal":[59],"models.":[60],"Male":[61],"Swiss":[62],"mice":[63,98],"(25-30":[64],"g)":[65],"were":[66,80,168],"used":[67,81,148],"this":[69],"study.":[70],"Acetic":[71],"acid-induced":[72],"writhing,":[73],"formalin":[74],"test":[75],"hot":[77,208],"plate":[78,209],"method":[79],"assess":[83],"acid.":[89],"Morphine":[90],"(30":[91],"mg/kg,":[92,145],"s.c.)":[93],"administered":[95],"two":[99],"times":[100],"day":[102],"(8":[103],"AM":[104,133],"4":[106],"PM)":[107],"for":[108,139],"3":[109,140],"days":[110],"order":[112],"produce":[114],"tolerance.":[115],"To":[116],"develop":[117],"dependence,":[119],"sulfate":[121],"(50,":[122],"50":[123],"75":[125],"mg/kg)":[126],"injected":[128],"at":[129,177],"8":[130],"12":[132],"16":[135],"PM":[136],"respectively":[137],"consecutive":[141],"days.":[142],"Naloxone":[143],"(5":[144],"i.p)":[146],"induce":[150],"withdrawal":[152],"syndrome":[153],"number":[156],"jumps":[158],"presence":[160],"ptosis,":[162],"piloerection,":[163],"tremor,":[164],"sniffing":[165],"diarrhea":[167],"recorded":[169],"compared":[171],"with":[172],"control":[173],"group.":[174],"Clavulanic":[175,198,222],"doses":[178],"10,":[180],"20":[181],"40":[183],"mg/kg":[184],"inhibited":[185],"abdominal":[186],"constriction":[187],"licking":[189],"behavior":[190],"acetic":[192],"formalin-induced":[195],"respectively.":[197],"not":[201,213],"able":[202],"show":[204],"any":[205],"antinociception":[206],"model":[210],"could":[212],"prevent":[214],"considerable":[225],"further":[229],"studies":[230],"are":[231],"needed":[232],"clarify":[234],"exact":[236],"mechanism.":[237]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}