{"id":"https://openalex.org/W2144437705","doi":"https://doi.org/10.1002/jlb.58.5.616","title":"Nitric oxide synthase in circulating vs. extravasated polymorphonuclear leukocytes","display_name":"Nitric oxide synthase in circulating vs. extravasated polymorphonuclear leukocytes","publication_year":1995,"publication_date":"1995-11-01","ids":{"openalex":"https://openalex.org/W2144437705","doi":"https://doi.org/10.1002/jlb.58.5.616","mag":"2144437705","pmid":"https://pubmed.ncbi.nlm.nih.gov/7595064"},"language":"en","primary_location":{"id":"doi:10.1002/jlb.58.5.616","doi":"https://doi.org/10.1002/jlb.58.5.616","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jlb.58.5.616","pdf_url":null,"source":{"id":"https://openalex.org/S199011235","display_name":"Journal of Leukocyte Biology","issn_l":"0741-5400","issn":["0741-5400","1938-3673"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Leukocyte Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052532148","display_name":"Allen M. Miles","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Allen M Miles","raw_affiliation_strings":["Department of Physiology and Biophysics, Louisiana State University Medical Center , Shreveport, Louisiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, Louisiana State University Medical Center , Shreveport, Louisiana","institution_ids":["https://openalex.org/I121820613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070297078","display_name":"Michael W. Owens","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]},{"id":"https://openalex.org/I81020160","display_name":"Louisiana State University Health Sciences Center Shreveport","ror":"https://ror.org/03151rh82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I81020160"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael W Owens","raw_affiliation_strings":["Department of Medicine, Louisiana State University Medical Center, Shreveport, Louisiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Louisiana State University Medical Center, Shreveport, Louisiana","institution_ids":["https://openalex.org/I121820613","https://openalex.org/I81020160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040159703","display_name":"Shawn A. Milligan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]},{"id":"https://openalex.org/I81020160","display_name":"Louisiana State University Health Sciences Center Shreveport","ror":"https://ror.org/03151rh82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I81020160"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shawn Milligan","raw_affiliation_strings":["Department of Medicine, Louisiana State University Medical Center, Shreveport, Louisiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Louisiana State University Medical Center, Shreveport, Louisiana","institution_ids":["https://openalex.org/I121820613","https://openalex.org/I81020160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113492208","display_name":"Glenda G. Johnson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Glenda G Johnson","raw_affiliation_strings":["Department of Physiology and Biophysics, Louisiana State University Medical Center , Shreveport, Louisiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, Louisiana State University Medical Center , Shreveport, Louisiana","institution_ids":["https://openalex.org/I121820613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113977400","display_name":"Jeremy Z. Fields","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1304196042","display_name":"Loyola University Medical Center","ror":"https://ror.org/05xcyt367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1304196042","https://openalex.org/I1304269903"]},{"id":"https://openalex.org/I1925986","display_name":"Loyola University Chicago","ror":"https://ror.org/04b6x2g63","country_code":"US","type":"education","lineage":["https://openalex.org/I1925986"]},{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]},{"id":"https://openalex.org/I2802230104","display_name":"Edward Hines, Jr. VA Hospital","ror":"https://ror.org/02223wv31","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2802230104","https://openalex.org/I4210115976"]},{"id":"https://openalex.org/I4210159390","display_name":"Loyola Medicine","ror":"https://ror.org/04azs9g49","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210159390"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeremy Z Fields","raw_affiliation_strings":["GI Division, Department of Medicine, Loyola University Medical School , Maywood","Medical and Research Services, Hines Veterans Administration Hospital , Hines, Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GI Division, Department of Medicine, Loyola University Medical School , Maywood","institution_ids":["https://openalex.org/I1304196042","https://openalex.org/I1925986","https://openalex.org/I4210159390"]},{"raw_affiliation_string":"Medical and Research Services, Hines Veterans Administration Hospital , Hines, Illinois","institution_ids":["https://openalex.org/I2799886695","https://openalex.org/I2802230104"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048913438","display_name":"Todd S. Ing","orcid":"https://orcid.org/0000-0002-6804-9260","observed_orcids":["https://orcid.org/0000-0002-6804-9260"]},"institutions":[{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]},{"id":"https://openalex.org/I2802230104","display_name":"Edward Hines, Jr. VA Hospital","ror":"https://ror.org/02223wv31","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2802230104","https://openalex.org/I4210115976"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Todd S Ing","raw_affiliation_strings":["Medical and Research Services, Hines Veterans Administration Hospital , Hines, Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical and Research Services, Hines Veterans Administration Hospital , Hines, Illinois","institution_ids":["https://openalex.org/I2799886695","https://openalex.org/I2802230104"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072666037","display_name":"Venkata Kottapalli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1304196042","display_name":"Loyola University Medical Center","ror":"https://ror.org/05xcyt367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1304196042","https://openalex.org/I1304269903"]},{"id":"https://openalex.org/I1925986","display_name":"Loyola University Chicago","ror":"https://ror.org/04b6x2g63","country_code":"US","type":"education","lineage":["https://openalex.org/I1925986"]},{"id":"https://openalex.org/I4210159390","display_name":"Loyola Medicine","ror":"https://ror.org/04azs9g49","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210159390"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Venkata Kottapalli","raw_affiliation_strings":["GI Division, Department of Medicine, Loyola University Medical School , Maywood"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GI Division, Department of Medicine, Loyola University Medical School , Maywood","institution_ids":["https://openalex.org/I1304196042","https://openalex.org/I1925986","https://openalex.org/I4210159390"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002619544","display_name":"Ali Keshavarzian","orcid":"https://orcid.org/0000-0002-7969-3369","observed_orcids":["https://orcid.org/0000-0002-7969-3369"]},"institutions":[{"id":"https://openalex.org/I1304196042","display_name":"Loyola University Medical Center","ror":"https://ror.org/05xcyt367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1304196042","https://openalex.org/I1304269903"]},{"id":"https://openalex.org/I1925986","display_name":"Loyola University Chicago","ror":"https://ror.org/04b6x2g63","country_code":"US","type":"education","lineage":["https://openalex.org/I1925986"]},{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]},{"id":"https://openalex.org/I2802230104","display_name":"Edward Hines, Jr. VA Hospital","ror":"https://ror.org/02223wv31","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2802230104","https://openalex.org/I4210115976"]},{"id":"https://openalex.org/I4210159390","display_name":"Loyola Medicine","ror":"https://ror.org/04azs9g49","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210159390"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ali Keshavarzian","raw_affiliation_strings":["GI Division, Department of Medicine, Loyola University Medical School , Maywood","Medical and Research Services, Hines Veterans Administration Hospital , Hines, Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GI Division, Department of Medicine, Loyola University Medical School , Maywood","institution_ids":["https://openalex.org/I1304196042","https://openalex.org/I1925986","https://openalex.org/I4210159390"]},{"raw_affiliation_string":"Medical and Research Services, Hines Veterans Administration Hospital , Hines, Illinois","institution_ids":["https://openalex.org/I2799886695","https://openalex.org/I2802230104"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014512255","display_name":"Matthew B. Grisham","orcid":"https://orcid.org/0000-0001-9090-721X","observed_orcids":["https://orcid.org/0000-0001-9090-721X"]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Matthew B Grisham","raw_affiliation_strings":["Department of Physiology and Biophysics, Louisiana State University Medical Center , Shreveport, Louisiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, Louisiana State University Medical Center , Shreveport, Louisiana","institution_ids":["https://openalex.org/I121820613"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5014512255"],"corresponding_institution_ids":["https://openalex.org/I121820613"],"apc_list":{"value":3800,"currency":"USD","value_usd":3800},"apc_paid":null,"fwci":5.0702,"has_fulltext":false,"cited_by_count":93,"citation_normalized_percentile":{"value":0.95787564,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"58","issue":"5","first_page":"616","last_page":"622"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.7207000255584717,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.7207000255584717,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.2694999873638153,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":0.9729999899864197},{"id":"https://openalex.org/keywords/polymorphonuclear-leukocytes","display_name":"polymorphonuclear leukocytes","score":0.9150000214576721},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.9110000133514404},{"id":"https://openalex.org/keywords/extravasation","display_name":"extravasation","score":0.7699999809265137},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.46700000762939453},{"id":"https://openalex.org/keywords/inos-mrna-expression","display_name":"iNOS mRNA expression","score":0.6949999928474426},{"id":"https://openalex.org/keywords/nitric-oxide-production","display_name":"nitric oxide production","score":0.7059999704360962},{"id":"https://openalex.org/keywords/nitrite-production","display_name":"nitrite production","score":0.5609999895095825},{"id":"https://openalex.org/keywords/peritoneal-dialysis","display_name":"peritoneal dialysis","score":0.6800000071525574},{"id":"https://openalex.org/keywords/peritonitis","display_name":"peritonitis","score":0.9459999799728394},{"id":"https://openalex.org/keywords/oyster-glycogen","display_name":"oyster glycogen","score":0.7429999709129333},{"id":"https://openalex.org/keywords/leukocyte-migration","display_name":"leukocyte migration","score":0.3790000081062317},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.4399999976158142},{"id":"https://openalex.org/keywords/human","display_name":"human","score":0.9940000176429749}],"concepts":[{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.8058903217315674},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6512935757637024},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.6304525136947632},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.49846529960632324},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4774813652038574},{"id":"https://openalex.org/C160448771","wikidata":"https://www.wikidata.org/wiki/Q184726","display_name":"Phagocytosis","level":2,"score":0.45830491185188293},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.43478071689605713},{"id":"https://openalex.org/C2908937200","wikidata":"https://www.wikidata.org/wiki/Q6823955","display_name":"Omega-N-Methylarginine","level":4,"score":0.42668595910072327},{"id":"https://openalex.org/C91415057","wikidata":"https://www.wikidata.org/wiki/Q18030177","display_name":"NOS1","level":4,"score":0.41945844888687134},{"id":"https://openalex.org/C2779129087","wikidata":"https://www.wikidata.org/wiki/Q408641","display_name":"Citrulline","level":4,"score":0.4162635803222656},{"id":"https://openalex.org/C2777468819","wikidata":"https://www.wikidata.org/wiki/Q173670","display_name":"Arginine","level":3,"score":0.4155653119087219},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.415188729763031},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3545563817024231},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3491728901863098},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.23454567790031433},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D009573","descriptor_name":"Nitrites","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019001","descriptor_name":"Nitric Oxide Synthase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019001","descriptor_name":"Nitric Oxide Synthase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jlb.58.5.616","doi":"https://doi.org/10.1002/jlb.58.5.616","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jlb.58.5.616","pdf_url":null,"source":{"id":"https://openalex.org/S199011235","display_name":"Journal of Leukocyte Biology","issn_l":"0741-5400","issn":["0741-5400","1938-3673"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Leukocyte Biology","raw_type":"journal-article"},{"id":"pmid:7595064","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7595064","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of leukocyte biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3002899775","display_name":null,"funder_award_id":"DK-47663","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G4733363870","display_name":"Role of the Microcirculation in Intestinal Inflammation","funder_award_id":"P01DK043785","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G663048502","display_name":null,"funder_award_id":"DK-43785","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G732592782","display_name":"ADHESION MOLECULE EXPRESSION IN CHRONIC GUT INFLAMMATION","funder_award_id":"5r01dk047663-06","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W122947453","https://openalex.org/W1486448888","https://openalex.org/W1611751935","https://openalex.org/W1649485503","https://openalex.org/W1801230418","https://openalex.org/W1861977709","https://openalex.org/W1964688175","https://openalex.org/W1965077361","https://openalex.org/W1972672472","https://openalex.org/W1973610790","https://openalex.org/W1990283000","https://openalex.org/W1992317118","https://openalex.org/W1995862463","https://openalex.org/W2002150254","https://openalex.org/W2004940500","https://openalex.org/W2011233979","https://openalex.org/W2011347602","https://openalex.org/W2012536557","https://openalex.org/W2012936255","https://openalex.org/W2013911376","https://openalex.org/W2016687652","https://openalex.org/W2023170094","https://openalex.org/W2026779790","https://openalex.org/W2032837160","https://openalex.org/W2034966948","https://openalex.org/W2061143361","https://openalex.org/W2062936676","https://openalex.org/W2064270790","https://openalex.org/W2072284181","https://openalex.org/W2073030710","https://openalex.org/W2084654400","https://openalex.org/W2088584829","https://openalex.org/W2093195099","https://openalex.org/W2109893157","https://openalex.org/W2114298357","https://openalex.org/W2120005533","https://openalex.org/W2137838799","https://openalex.org/W2141120654","https://openalex.org/W2150882549","https://openalex.org/W2187771220","https://openalex.org/W2313326603","https://openalex.org/W2396986556"],"related_works":["https://openalex.org/W2074521679","https://openalex.org/W1985889676","https://openalex.org/W2036984165","https://openalex.org/W1482666884","https://openalex.org/W2156916241","https://openalex.org/W1519876579","https://openalex.org/W124081177","https://openalex.org/W2064525153","https://openalex.org/W2066204045","https://openalex.org/W2434936261"],"abstract_inverted_index":{"It":[0],"is":[1,39,394,420,426],"becoming":[2],"increasingly":[3],"apparent":[4],"that":[5,202,369,387,414],"certain":[6],"forms":[7],"of":[8,18,31,47,58,69,103,113,158,167,181,195,232,269,306,322,352,372,380,389],"acute":[9],"and":[10,44,66,80,85,93,122,147,178,190,248,255,277,292,298,337,344,378,386],"chronic":[11],"inflammation":[12],"are":[13],"associated":[14],"with":[15,115,132,260],"enhanced":[16],"production":[17,197],"nitric":[19],"oxide":[20],"(NO).":[21],"Although":[22],"substantial":[23],"information":[24,38],"has":[25],"been":[26],"obtained":[27],"describing":[28],"the":[29,42,64,70,154,179,186,267,273,296,307,320,342,376,390,415,427],"regulation":[30,424],"NO":[32,72,196],"synthase":[33,73],"(NOS)":[34],"in":[35,49,75,98,108,185,198,239,246,272,286,319,382],"macrophages,":[36],"little":[37],"available":[40],"regarding":[41],"biochemistry":[43],"molecular":[45,65],"biology":[46],"NOS":[48,118,148,393],"circulating":[50,76,121,169,203,217,261,287,332,399],"vs.":[51,77],"extravasated":[52,78,94,171,353,401],"polymorphonuclear":[53],"leukocytes":[54],"(PMNs).":[55],"The":[56],"objective":[57],"this":[59],"study":[60],"was":[61,125,141,150,188,311],"to":[62,161,228,290,334],"characterize":[63],"biochemical":[67],"properties":[68],"inducible":[71,392],"(iNOS)":[74],"rat":[79,84,218,251,275,288,301,317,373,428],"human":[81,86,220,354,402,416],"PMNs.":[82],"Circulating":[83],"PMNs":[87,95,124,172,204,221,252,276,289,318,333,355,374,403],"were":[88,96,173,226],"purified":[89],"from":[90,120,282,327],"peripheral":[91],"blood":[92],"elicited":[97,123,250,274,300,316,346],"rats":[99],"by":[100,110,152,315],"intraperitoneal":[101],"injection":[102],"1%":[104],"oyster":[105],"glycogen":[106],"or":[107,170,206,213,219,408],"humans":[109],"peritoneal":[111],"dialysis":[112],"patients":[114],"peritonitis.":[116],"Inducible":[117],"mRNA":[119,244],"quantified":[126,151],"using":[127,143],"slot":[128],"blot":[129,264],"hybridization":[130],"analysis":[131,265],"a":[133,164,193,383],"cDNA":[134],"probe":[135],"specific":[136],"for":[137,175,236,295,331,341],"iNOS.":[138],"iNOS":[139,210,243,270,278,309,361,381,405,418],"protein":[140,271,359],"identified":[142],"Western":[144,263],"immunoblot":[145],"analysis,":[146],"activity":[149,280,310],"measuring":[153],"NG-monomethyl-L-arginine":[155],"(L-NMMA)-inhibitable":[156],"conversion":[157],"14C-labeled":[159],"L-arginine":[160],"L-[14C]citrulline.":[162],"In":[163,241,396],"separate":[165],"series":[166],"experiments,":[168],"cultured":[174,235],"4":[176,237],"h":[177,238],"accumulation":[180],"L-NMMA-inhibitable":[182],"nitrite":[183],"(NO2-)":[184],"supernatant":[187],"determined":[189],"used":[191],"as":[192],"measure":[194],"vitro.":[199,240],"We":[200],"found":[201],"(rat":[205],"human)":[207],"contained":[208,356,404],"no":[209],"mRNA,":[211],"protein,":[212,407],"enzymatic":[214,279,362,409],"activity.":[215,363,410],"Furthermore,":[216],"(2":[222],"x":[223],"10(6)":[224],"cells/well)":[225],"unable":[227],"generate":[229],"significant":[230],"amounts":[231,330],"NO2-":[233],"when":[234,258],"contrast,":[242,397],"levels":[245,285],"4-":[247,297,343],"6-h":[249,299,345],"increased":[253,281,326],"21-":[254],"42-fold,":[256],"respectively,":[257],"compared":[259],"cells.":[262],"revealed":[266],"presence":[268],"normally":[283,328],"undetectable":[284,329],"81":[291],"285":[293],"pmol/min/mg":[294],"PMNs,":[302,347],"respectively.":[303,348],"Approximately":[304],"20-30%":[305,388],"total":[308,391],"Ca(2+)-dependent.":[312,395],"Nitrite":[313],"formation":[314],"absence":[321],"any":[323],"exogenous":[324],"stimuli":[325],"approximately":[335],"8":[336],"11":[338],"microM/10(6)":[339],"cells":[340],"Highly":[349],"enriched":[350],"preparations":[351],"neither":[357,398],"message,":[358,406],"nor":[360,400],"Taken":[364],"together":[365],"our":[366],"data":[367,412],"demonstrate":[368],"inflammation-induced":[370],"extravasation":[371],"upregulates":[375],"transcription":[377],"translation":[379],"time-dependent":[384],"fashion":[385],"These":[411],"suggest":[413],"PMN":[417],"gene":[419],"under":[421],"very":[422],"different":[423],"than":[425],"gene.":[429]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}