{"id":"https://openalex.org/W2144426640","doi":null,"title":"Acute endotoxemia during gestation induces organ dysfunction and tissue damage in mouse offspring.","display_name":"Acute endotoxemia during gestation induces organ dysfunction and tissue damage in mouse offspring.","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2144426640","mag":"2144426640"},"language":"en","primary_location":{"id":"mag:2144426640","doi":null,"is_oa":false,"landing_page_url":"http://agris.fao.org/agris-search/search.do?recordID=PK2013000611","pdf_url":null,"source":{"id":"https://openalex.org/S204491027","display_name":"Pakistan Journal of Zoology","issn_l":"0030-9923","issn":["0030-9923","3049-5709"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4323283803","host_organization_name":"University of Punjab (new Campus)","host_organization_lineage":["https://openalex.org/P4323283803"],"host_organization_lineage_names":["University of Punjab (new Campus)"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Pakistan Journal of Zoology","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067180206","display_name":"Hossam Ebaid","orcid":"https://orcid.org/0000-0003-3318-7820","observed_orcids":["https://orcid.org/0000-0003-3318-7820"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hossam Ebaid","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3318-7820","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027738141","display_name":"Jamaan Said Ajarem","orcid":"https://orcid.org/0000-0003-2151-445X","observed_orcids":["https://orcid.org/0000-0003-2151-445X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jamaan S. Ajarem","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5027668614","display_name":"Gasem Mohammad Abu-Taweel","orcid":"https://orcid.org/0000-0002-5090-8661","observed_orcids":["https://orcid.org/0000-0002-5090-8661"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gasem Mohammad Abu-Taweel","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5090-8661","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5689,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.72070207,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"44","issue":"3","first_page":"765","last_page":"776"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.7939000129699707,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.7939000129699707,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11961","display_name":"Neonatal and Maternal Infections","score":0.10989999771118164,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":0.010300000198185444,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endotoxemia","display_name":"endotoxemia","score":0.8809999823570251},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.984000027179718},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.765999972820282},{"id":"https://openalex.org/keywords/pregnancy","display_name":"pregnancy","score":0.6710000038146973},{"id":"https://openalex.org/keywords/mother-to-child-transmission","display_name":"mother-to-child transmission","score":0.6269999742507935},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8989999890327454},{"id":"https://openalex.org/keywords/malondialdehyde","display_name":"malondialdehyde","score":0.9620000123977661},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.9829999804496765},{"id":"https://openalex.org/keywords/liver-injury","display_name":"liver injury","score":0.515999972820282},{"id":"https://openalex.org/keywords/intestinal-injury","display_name":"intestinal injury","score":0.9300000071525574},{"id":"https://openalex.org/keywords/neutrophil-depletion","display_name":"neutrophil depletion","score":0.8379999995231628},{"id":"https://openalex.org/keywords/learning-and-memory-impairment","display_name":"learning and memory impairment","score":0.746999979019165},{"id":"https://openalex.org/keywords/offspring-development","display_name":"offspring development","score":0.5170000195503235}],"concepts":[{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.7720192670822144},{"id":"https://openalex.org/C112672928","wikidata":"https://www.wikidata.org/wiki/Q239526","display_name":"Offspring","level":3,"score":0.7594723701477051},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.72413569688797},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.7209530472755432},{"id":"https://openalex.org/C2778401633","wikidata":"https://www.wikidata.org/wiki/Q418661","display_name":"Malondialdehyde","level":3,"score":0.6995816230773926},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.6598847508430481},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.6155350208282471},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5794004201889038},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5714164972305298},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5345546007156372},{"id":"https://openalex.org/C153400128","wikidata":"https://www.wikidata.org/wiki/Q3150731","display_name":"Infiltration (HVAC)","level":2,"score":0.45512956380844116},{"id":"https://openalex.org/C2780159080","wikidata":"https://www.wikidata.org/wiki/Q1400536","display_name":"Intraperitoneal injection","level":2,"score":0.4392770230770111},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.42870187759399414},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.4224241375923157},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.327359139919281},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3266497254371643},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25034284591674805},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2144426640","doi":null,"is_oa":false,"landing_page_url":"http://agris.fao.org/agris-search/search.do?recordID=PK2013000611","pdf_url":null,"source":{"id":"https://openalex.org/S204491027","display_name":"Pakistan Journal of Zoology","issn_l":"0030-9923","issn":["0030-9923","3049-5709"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4323283803","host_organization_name":"University of Punjab (new Campus)","host_organization_lineage":["https://openalex.org/P4323283803"],"host_organization_lineage_names":["University of Punjab (new Campus)"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Pakistan Journal of Zoology","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W9009826","https://openalex.org/W1524166508","https://openalex.org/W1546962148","https://openalex.org/W1594485853","https://openalex.org/W1625092822","https://openalex.org/W1923540728","https://openalex.org/W1949673334","https://openalex.org/W1963975982","https://openalex.org/W1966920840","https://openalex.org/W1975862620","https://openalex.org/W1980287292","https://openalex.org/W1983310681","https://openalex.org/W2010094123","https://openalex.org/W2012527845","https://openalex.org/W2014983427","https://openalex.org/W2015737228","https://openalex.org/W2024130943","https://openalex.org/W2028015638","https://openalex.org/W2029619625","https://openalex.org/W2035600065","https://openalex.org/W2052429062","https://openalex.org/W2061360383","https://openalex.org/W2066406354","https://openalex.org/W2066639890","https://openalex.org/W2085143181","https://openalex.org/W2088245795","https://openalex.org/W2111683372","https://openalex.org/W2118784284","https://openalex.org/W2126811697","https://openalex.org/W2130804322","https://openalex.org/W2133943626","https://openalex.org/W2164862750","https://openalex.org/W2258790231","https://openalex.org/W2266929960","https://openalex.org/W2317093305","https://openalex.org/W2328831975","https://openalex.org/W2608799023","https://openalex.org/W2897982828","https://openalex.org/W3035322935"],"related_works":["https://openalex.org/W91487905","https://openalex.org/W2150739801","https://openalex.org/W2118310510","https://openalex.org/W1987843838","https://openalex.org/W2058817255","https://openalex.org/W2372835647","https://openalex.org/W2184338193","https://openalex.org/W2065892697","https://openalex.org/W2044508115","https://openalex.org/W2735237449"],"abstract_inverted_index":{"Sepsis":[0],"complications":[1,22,109,214],"represent":[2],"a":[3,50],"systemic":[4],"inflammatory":[5],"response":[6],"to":[7,114,131,175,190,221],"microbial":[8],"infection":[9],"or":[10],"severe":[11],"injury.":[12],"This":[13],"study":[14],"aimed":[15],"at":[16,49],"determining":[17],"the":[18,28,92,105,111,209,239],"effects":[19],"of":[20,30,45,53,164],"septic":[21,213],"in":[23,66,77,91,110,122,128,150,168,208,242],"pregnant":[24,37],"female":[25],"mice":[26,39],"on":[27],"development":[29],"their":[31,82,96],"pups.":[32,83,97,210,246],"To":[33],"achieve":[34],"this":[35],"aim,":[36],"Swiss":[38],"were":[40,215,238],"given":[41],"an":[42,148],"intraperitoneal":[43],"injection":[44],"endotoxin":[46,62],"(lipopolysaccharide,":[47],"LPS)":[48],"single":[51],"dose":[52],"2.5":[54],"mg/kg":[55],"body":[56,133],"weight.":[57],"Results":[58],"revealed":[59],"that":[60,185,198],"bacterial":[61],"increased":[63],"oxidative":[64,227,230],"stress":[65,103],"both":[67,78,243],"brain":[68],"and":[69,81,95,107,124,136,145,157,205,235,245],"liver":[70],"tissue.":[71],"Malondialdehyde":[72],"(MDA)":[73],"was":[74,88,120,166,201],"significantly":[75,89,179],"elevated":[76],"LPS-treated":[79,93,115,176],"mothers":[80,94,144,177,220,244],"The":[84,193,229],"anti-oxidant":[85],"enzyme":[86],"glutathione":[87],"reduced":[90],"Free":[98],"radicals":[99],"induced":[100],"by":[101,225],"endotoxemic":[102],"mediated":[104,224],"pathological":[106],"behavioral":[108],"pups":[112,146,173,188],"born":[113,174,189],"mothers.":[116,192],"Thus,":[117],"obvious":[118],"damage":[119],"observed":[121],"hepatic":[123],"intestinal":[125],"tissues,":[126],"which":[127],"turn":[129],"led":[130],"decreased":[132],"weight":[134],"gain":[135],"decrease":[137],"general":[138],"activity.":[139],"Spleen":[140],"sections":[141],"from":[142,218],"treated":[143],"showed":[147,178],"increase":[149],"trabeculae,":[151],"high":[152,226],"leukocyte":[153],"infiltration":[154],"(especially":[155],"neutrophils":[156,165],"immature":[158],"megakaryocytes).":[159],"In":[160,171,211],"contrast,":[161],"significant":[162],"depletion":[163],"detected":[167],"peripheral":[169],"blood.":[170],"addition,":[172],"lower":[180],"muscular":[181],"grip":[182],"strength":[183],"than":[184],"recorded":[186],"for":[187],"control":[191],"active":[194],"avoidance":[195],"test":[196],"indicated":[197],"LPS":[199],"exposure":[200],"associated":[202],"with":[203],"learning":[204],"memory":[206],"impairment":[207],"conclusion,":[212],"actively":[216],"transferred":[217],"endotoxin-treated":[219],"developing":[222],"pups,":[223],"stress.":[228],"stress,":[231],"hepatic,":[232],"ileal,":[233],"splenic":[234],"developmental":[236],"changes":[237],"major":[240],"determinants":[241]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}
