{"id":"https://openalex.org/W2144396366","doi":"https://doi.org/10.1586/14737159.4.2.219","title":"Diagnostic value of real-time capillary thermal cycler in virus detection","display_name":"Diagnostic value of real-time capillary thermal cycler in virus detection","publication_year":2004,"publication_date":"2004-03-01","ids":{"openalex":"https://openalex.org/W2144396366","doi":"https://doi.org/10.1586/14737159.4.2.219","mag":"2144396366","pmid":"https://pubmed.ncbi.nlm.nih.gov/14995908"},"language":"en","primary_location":{"id":"doi:10.1586/14737159.4.2.219","doi":"https://doi.org/10.1586/14737159.4.2.219","is_oa":false,"landing_page_url":"https://doi.org/10.1586/14737159.4.2.219","pdf_url":null,"source":{"id":"https://openalex.org/S124386304","display_name":"Expert Review of Molecular Diagnostics","issn_l":"1473-7159","issn":["1473-7159","1744-8352"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Review of Molecular Diagnostics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081307107","display_name":"Boon Huan Tan","orcid":"https://orcid.org/0000-0002-4976-7988","observed_orcids":["https://orcid.org/0000-0002-4976-7988"]},"institutions":[{"id":"https://openalex.org/I28490864","display_name":"DSO National Laboratories","ror":"https://ror.org/03e05fb06","country_code":"SG","type":"nonprofit","lineage":["https://openalex.org/I28490864"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Boon-Huan Tan","raw_affiliation_strings":["Virology Group, Defence Medical and Environmental Research Institute, DMERI@DSO(KENT RIDGE), 27 Medical Drive 13-00, Singapore 117510. tboonhua@dso.org.sg","Defence Medical and Environmental Research Institute, DMERI@DSO(KENT RIDGE), 27 Medical Drive 13-00, Singapore 117510. tboonhua@dso.org.sg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Virology Group, Defence Medical and Environmental Research Institute, DMERI@DSO(KENT RIDGE), 27 Medical Drive 13-00, Singapore 117510. tboonhua@dso.org.sg","institution_ids":["https://openalex.org/I28490864"]},{"raw_affiliation_string":"Defence Medical and Environmental Research Institute, DMERI@DSO(KENT RIDGE), 27 Medical Drive 13-00, Singapore 117510. tboonhua@dso.org.sg","institution_ids":["https://openalex.org/I28490864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113564889","display_name":"Elizabeth Ai\u2010Sim Lim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28490864","display_name":"DSO National Laboratories","ror":"https://ror.org/03e05fb06","country_code":"SG","type":"nonprofit","lineage":["https://openalex.org/I28490864"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Elizabeth Ai-Sim Lim","raw_affiliation_strings":["Defence Medical and Environmental Research Institute, DMERI@DSO(KENT RIDGE), 27 Medical Drive 13-00, Singapore 117510. laisim@dso.org.sg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Defence Medical and Environmental Research Institute, DMERI@DSO(KENT RIDGE), 27 Medical Drive 13-00, Singapore 117510. laisim@dso.org.sg","institution_ids":["https://openalex.org/I28490864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037802078","display_name":"Jasper Chin\u2010Wen Liaw","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28490864","display_name":"DSO National Laboratories","ror":"https://ror.org/03e05fb06","country_code":"SG","type":"nonprofit","lineage":["https://openalex.org/I28490864"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Jasper Chin-Wen Liaw","raw_affiliation_strings":["Defence Medical and Environmental Research Institute, DMERI@DSO(KENT RIDGE), 27 Medical Drive 13-00, Singapore 117510. lchinwen@dso.org.sg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Defence Medical and Environmental Research Institute, DMERI@DSO(KENT RIDGE), 27 Medical Drive 13-00, Singapore 117510. lchinwen@dso.org.sg","institution_ids":["https://openalex.org/I28490864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108206845","display_name":"Shirley G. K. Seah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28490864","display_name":"DSO National Laboratories","ror":"https://ror.org/03e05fb06","country_code":"SG","type":"nonprofit","lineage":["https://openalex.org/I28490864"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Shirley Gek-Kheng Seah","raw_affiliation_strings":["Defence Medical and Environmental Research Institute, DMERI@DSO(KENT RIDGE), 27 Medical Drive 13-00, Singapore 117510. sgekkhen@dso.org.sg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Defence Medical and Environmental Research Institute, DMERI@DSO(KENT RIDGE), 27 Medical Drive 13-00, Singapore 117510. sgekkhen@dso.org.sg","institution_ids":["https://openalex.org/I28490864"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113434992","display_name":"Eric P.H. Yap","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28490864","display_name":"DSO National Laboratories","ror":"https://ror.org/03e05fb06","country_code":"SG","type":"nonprofit","lineage":["https://openalex.org/I28490864"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Eric Peng-Huat Yap","raw_affiliation_strings":["Defence Medical and Environmental Research Institute, DMERI@DSO(KENT RIDGE), 27 Medical Drive 13-00, Singapore 117510. ericyap@dso.org.sg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Defence Medical and Environmental Research Institute, DMERI@DSO(KENT RIDGE), 27 Medical Drive 13-00, Singapore 117510. ericyap@dso.org.sg","institution_ids":["https://openalex.org/I28490864"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I28490864"],"apc_list":null,"apc_paid":null,"fwci":0.9469,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.71506764,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"4","issue":"2","first_page":"219","last_page":"230"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11970","display_name":"Molecular Biology Techniques and Applications","score":0.9115999937057495,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11970","display_name":"Molecular Biology Techniques and Applications","score":0.9115999937057495,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11393","display_name":"Biosensors and Analytical Detection","score":0.04780000075697899,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11754","display_name":"SARS-CoV-2 detection and testing","score":0.02419999986886978,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/real-time-pcr","display_name":"real-time PCR","score":0.9459999799728394},{"id":"https://openalex.org/keywords/virus-detection","display_name":"virus detection","score":0.6700000166893005},{"id":"https://openalex.org/keywords/diagnostic-virology","display_name":"diagnostic virology","score":0.906000018119812},{"id":"https://openalex.org/keywords/sybr-green-i","display_name":"SYBR Green I","score":0.9390000104904175},{"id":"https://openalex.org/keywords/hybridization-probes","display_name":"hybridization probes","score":0.628000020980835},{"id":"https://openalex.org/keywords/viral-outbreak","display_name":"viral outbreak","score":0.6140000224113464},{"id":"https://openalex.org/keywords/early-disease-detection","display_name":"early disease detection","score":0.652999997138977}],"concepts":[{"id":"https://openalex.org/C48023723","wikidata":"https://www.wikidata.org/wiki/Q856198","display_name":"Real-time polymerase chain reaction","level":3,"score":0.6312857866287231},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6008788347244263},{"id":"https://openalex.org/C176553487","wikidata":"https://www.wikidata.org/wiki/Q7855819","display_name":"Turnaround time","level":2,"score":0.5728693008422852},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49607881903648376},{"id":"https://openalex.org/C2780968160","wikidata":"https://www.wikidata.org/wiki/Q423692","display_name":"SYBR Green I","level":4,"score":0.45812779664993286},{"id":"https://openalex.org/C179786068","wikidata":"https://www.wikidata.org/wiki/Q16257937","display_name":"Molecular diagnostics","level":2,"score":0.4289761185646057},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13104739785194397},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.12981390953063965},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.10567352175712585},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07100072503089905},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003959","descriptor_name":"Diamines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004279","descriptor_name":"DNA, Viral","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004279","descriptor_name":"DNA, Viral","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009691","descriptor_name":"Nucleic Acid Denaturation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009930","descriptor_name":"Organic Chemicals","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011804","descriptor_name":"Quinolines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014777","descriptor_name":"Virus Diseases","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D014777","descriptor_name":"Virus Diseases","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D015342","descriptor_name":"DNA Probes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":true},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D025202","descriptor_name":"Molecular Diagnostic Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D031541","descriptor_name":"Fluorescence Resonance Energy Transfer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052160","descriptor_name":"Benzothiazoles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1586/14737159.4.2.219","doi":"https://doi.org/10.1586/14737159.4.2.219","is_oa":false,"landing_page_url":"https://doi.org/10.1586/14737159.4.2.219","pdf_url":null,"source":{"id":"https://openalex.org/S124386304","display_name":"Expert Review of Molecular Diagnostics","issn_l":"1473-7159","issn":["1473-7159","1744-8352"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Review of Molecular Diagnostics","raw_type":"journal-article"},{"id":"pmid:14995908","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14995908","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert review of molecular diagnostics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W114174565","https://openalex.org/W1517480469","https://openalex.org/W1569947224","https://openalex.org/W1594653092","https://openalex.org/W1986561264","https://openalex.org/W2005934517","https://openalex.org/W2031138358","https://openalex.org/W2050717506","https://openalex.org/W2063016208","https://openalex.org/W2100187217","https://openalex.org/W2108842440","https://openalex.org/W2130304561","https://openalex.org/W2131589770","https://openalex.org/W2134343377","https://openalex.org/W2150705960","https://openalex.org/W2164204487","https://openalex.org/W2167312953","https://openalex.org/W2170881661","https://openalex.org/W2412944388","https://openalex.org/W4254533614"],"related_works":["https://openalex.org/W2800591602","https://openalex.org/W2064918842","https://openalex.org/W7100206936","https://openalex.org/W2100187217","https://openalex.org/W108733969","https://openalex.org/W7168696883","https://openalex.org/W2112542927","https://openalex.org/W2066985281","https://openalex.org/W2015251349","https://openalex.org/W2141613431"],"abstract_inverted_index":{"Molecular-based":[0],"detection":[1,48,59],"methods":[2],"such":[3],"as":[4],"PCR":[5,34],"techniques":[6],"have":[7],"had":[8],"a":[9],"significant":[10],"impact":[11],"on":[12,35],"the":[13,30,36,40,56,58,86,89],"diagnosis":[14],"of":[15,19,32,54,85,91],"viral":[16,81,94],"infections":[17],"because":[18],"their":[20],"superior":[21],"sensitivity":[22],"and":[23,65],"rapid":[24],"turnaround":[25],"time.":[26],"This":[27],"review":[28],"describes":[29],"use":[31,84],"real-time":[33],"capillary":[37],"thermal":[38],"cycler,":[39],"Roche":[41],"LightCycler":[42,87],"trade":[43],"mark,":[44],"for":[45,88],"early":[46],"disease":[47],"in":[49,72,96],"diagnostic":[50],"virology.":[51],"The":[52,83],"advantages":[53],"using":[55,61],"LightCycler,":[57],"processes":[60],"SYBR":[62],"Green":[63],"I":[64],"different":[66],"hybridization":[67],"strategies":[68],"will":[69,98],"be":[70,100],"discussed":[71],"detail,":[73],"with":[74],"specific":[75],"examples":[76],"drawn":[77],"from":[78],"our":[79],"in-house":[80],"assays.":[82],"investigation":[90],"two":[92],"recent":[93],"outbreaks":[95],"Singapore":[97],"also":[99],"briefly":[101],"described.":[102]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
