{"id":"https://openalex.org/W2144392901","doi":"https://doi.org/10.1111/j.1538-7836.2005.01562.x","title":"LETTERS TO THE EDITOR: Characterization of a novel prothrombin variant, Prothrombin C20209T, as a modifier of thrombotic risk among African-Americans","display_name":"LETTERS TO THE EDITOR: Characterization of a novel prothrombin variant, Prothrombin C20209T, as a modifier of thrombotic risk among African-Americans","publication_year":2005,"publication_date":"2005-09-29","ids":{"openalex":"https://openalex.org/W2144392901","doi":"https://doi.org/10.1111/j.1538-7836.2005.01562.x","mag":"2144392901","pmid":"https://pubmed.ncbi.nlm.nih.gov/16194213"},"language":"en","primary_location":{"id":"doi:10.1111/j.1538-7836.2005.01562.x","doi":"https://doi.org/10.1111/j.1538-7836.2005.01562.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1538-7836.2005.01562.x","pdf_url":null,"source":{"id":"https://openalex.org/S164469042","display_name":"Journal of Thrombosis and Haemostasis","issn_l":"1538-7836","issn":["1538-7836","1538-7933"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Thrombosis and Haemostasis","raw_type":"journal-article"},"volume":null,"type":"letter","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1111/j.1538-7836.2005.01562.x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070505607","display_name":"Haruka Itakura","orcid":"https://orcid.org/0000-0003-4382-0183","observed_orcids":["https://orcid.org/0000-0003-4382-0183"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I4390039303","display_name":"Stanford Cancer Institute","ror":"https://ror.org/014qe3j22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I4390039303","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"H. ITAKURA","raw_affiliation_strings":["Division of Hematology, Department of Medicine, Stanford University School of Medicine, Stanford Cancer Center, Stanford, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Medicine, Stanford University School of Medicine, Stanford Cancer Center, Stanford, CA, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I4390039303","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061155508","display_name":"Marilyn J. Telen","orcid":"https://orcid.org/0000-0003-3809-1780","observed_orcids":["https://orcid.org/0000-0003-3809-1780"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M.J. TELEN","raw_affiliation_strings":["Duke-UNC Comprehensive Sickle Cell Center, Duke University Medical Center, Durham, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke-UNC Comprehensive Sickle Cell Center, Duke University Medical Center, Durham, NC, USA","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001812366","display_name":"Carolyn C. Hoppe","orcid":"https://orcid.org/0000-0001-9213-0547","observed_orcids":["https://orcid.org/0000-0001-9213-0547"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C.C. HOPPE","raw_affiliation_strings":["Department of Hematology and Oncology, Children's Hospital Oakland, Oakland, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Oncology, Children's Hospital Oakland, Oakland, CA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006392514","display_name":"Douglas A.E. White","orcid":"https://orcid.org/0000-0002-5979-8008","observed_orcids":["https://orcid.org/0000-0002-5979-8008"]},"institutions":[{"id":"https://openalex.org/I2800769186","display_name":"Alameda Health System","ror":"https://ror.org/04hcg0q34","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800769186"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D.A.E. WHITE","raw_affiliation_strings":["Department of Emergency Medicine, Alameda County Medical Center \u2013 Highland Campus, Oakland, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Medicine, Alameda County Medical Center \u2013 Highland Campus, Oakland, CA, USA","institution_ids":["https://openalex.org/I2800769186"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014659823","display_name":"James L. Zehnder","orcid":"https://orcid.org/0000-0002-5380-303X","observed_orcids":["https://orcid.org/0000-0002-5380-303X"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J.L. ZEHNDER","raw_affiliation_strings":["Division of Hematology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5070505607"],"corresponding_institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I4390039303","https://openalex.org/I97018004"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"3","issue":"10","first_page":"2357","last_page":"2359"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10285","display_name":"Venous Thromboembolism Diagnosis and Management","score":0.03680000081658363,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/venous-thromboembolism","display_name":"venous thromboembolism","score":0.9290000200271606},{"id":"https://openalex.org/keywords/thrombophilia","display_name":"thrombophilia","score":0.8690000176429749},{"id":"https://openalex.org/keywords/african-americans","display_name":"African Americans","score":0.890999972820282},{"id":"https://openalex.org/keywords/thrombotic-risk","display_name":"thrombosis risk","score":0.847000002861023},{"id":"https://openalex.org/keywords/genetic-risk-factors","display_name":"genetic risk factors","score":0.6340000033378601},{"id":"https://openalex.org/keywords/thrombosis-prevalence","display_name":"thrombosis prevalence","score":0.4620000123977661},{"id":"https://openalex.org/keywords/obstetrical-complications","display_name":"obstetrical complications","score":0.9419999718666077}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7815358638763428},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.6291704773902893},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.6080966591835022},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.52955561876297},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.5070886611938477},{"id":"https://openalex.org/C2780842393","wikidata":"https://www.wikidata.org/wiki/Q1570013","display_name":"Thrombophilia","level":3,"score":0.4199322760105133},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4124820828437805},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.3682776689529419},{"id":"https://openalex.org/C2780868729","wikidata":"https://www.wikidata.org/wiki/Q261327","display_name":"Thrombosis","level":2,"score":0.2767535448074341},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.11294436454772949},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D001741","descriptor_name":"Black or African American","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011516","descriptor_name":"Prothrombin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000208","qualifier_name":"ethnology","is_major_topic":false},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1538-7836.2005.01562.x","doi":"https://doi.org/10.1111/j.1538-7836.2005.01562.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1538-7836.2005.01562.x","pdf_url":null,"source":{"id":"https://openalex.org/S164469042","display_name":"Journal of Thrombosis and Haemostasis","issn_l":"1538-7836","issn":["1538-7836","1538-7933"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Thrombosis and Haemostasis","raw_type":"journal-article"},{"id":"pmid:16194213","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16194213","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of thrombosis and haemostasis : JTH","raw_type":"Letter"}],"best_oa_location":{"id":"doi:10.1111/j.1538-7836.2005.01562.x","doi":"https://doi.org/10.1111/j.1538-7836.2005.01562.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1538-7836.2005.01562.x","pdf_url":null,"source":{"id":"https://openalex.org/S164469042","display_name":"Journal of Thrombosis and Haemostasis","issn_l":"1538-7836","issn":["1538-7836","1538-7933"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Thrombosis and Haemostasis","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1531281563","https://openalex.org/W1652638233","https://openalex.org/W1862054033","https://openalex.org/W1969182008","https://openalex.org/W1971486500","https://openalex.org/W1985935781","https://openalex.org/W2000893933","https://openalex.org/W2043306284","https://openalex.org/W2047493725","https://openalex.org/W2049731767","https://openalex.org/W2050604269","https://openalex.org/W2061715720","https://openalex.org/W2062457520","https://openalex.org/W2063570477","https://openalex.org/W2068860975","https://openalex.org/W2089566432","https://openalex.org/W2092398210","https://openalex.org/W2104062454","https://openalex.org/W2104645411","https://openalex.org/W2142076534","https://openalex.org/W2157876594","https://openalex.org/W2320704925","https://openalex.org/W2411439128"],"related_works":["https://openalex.org/W2121162360","https://openalex.org/W2017386186","https://openalex.org/W1652638233","https://openalex.org/W2336021817","https://openalex.org/W1933996892","https://openalex.org/W2275359850","https://openalex.org/W2160654498","https://openalex.org/W2468331795","https://openalex.org/W2062287060","https://openalex.org/W4400416597"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}