{"id":"https://openalex.org/W2144356569","doi":"https://doi.org/10.1128/jvi.78.18.9987-9997.2004","title":"Effects of the \u039467 Complex of Mutations in Human Immunodeficiency Virus Type 1 Reverse Transcriptase on Nucleoside Analog Excision","display_name":"Effects of the \u039467 Complex of Mutations in Human Immunodeficiency Virus Type 1 Reverse Transcriptase on Nucleoside Analog Excision","publication_year":2004,"publication_date":"2004-08-26","ids":{"openalex":"https://openalex.org/W2144356569","doi":"https://doi.org/10.1128/jvi.78.18.9987-9997.2004","mag":"2144356569","pmid":"https://pubmed.ncbi.nlm.nih.gov/15331732","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/515022"},"language":"en","primary_location":{"id":"doi:10.1128/jvi.78.18.9987-9997.2004","doi":"https://doi.org/10.1128/jvi.78.18.9987-9997.2004","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.78.18.9987-9997.2004","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC515022","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053352871","display_name":"Paul L. Boyer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul L. Boyer","raw_affiliation_strings":["HIV Drug Resistance Program","HIV Drug Resistance Program, National Cancer Institute-FCRDC, P.O. Box B, Building 539, Room 130A, Frederick, MD 21702-1201, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HIV Drug Resistance Program","institution_ids":[]},{"raw_affiliation_string":"HIV Drug Resistance Program, National Cancer Institute-FCRDC, P.O. Box B, Building 539, Room 130A, Frederick, MD 21702-1201, USA","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089434852","display_name":"Tomozumi Imamichi","orcid":"https://orcid.org/0000-0002-1474-1796","observed_orcids":["https://orcid.org/0000-0002-1474-1796","https://orcid.org/0009-0007-0910-5297"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tomozumi Imamichi","raw_affiliation_strings":["SAIC-Frederick, National Cancer Institute at Frederick, Frederick, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SAIC-Frederick, National Cancer Institute at Frederick, Frederick, Maryland","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073716313","display_name":"Stefan G. Sarafianos","orcid":"https://orcid.org/0000-0002-5840-154X","observed_orcids":["https://orcid.org/0000-0002-5840-154X"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stefan G. Sarafianos","raw_affiliation_strings":["Center for Advanced Biotechnology and Medicine and Rutgers University Chemistry Department, Piscataway, New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Advanced Biotechnology and Medicine and Rutgers University Chemistry Department, Piscataway, New Jersey","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076685416","display_name":"Eddy Arnold","orcid":"https://orcid.org/0000-0003-2612-9622","observed_orcids":["https://orcid.org/0000-0003-2612-9622"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward Arnold","raw_affiliation_strings":["Center for Advanced Biotechnology and Medicine and Rutgers University Chemistry Department, Piscataway, New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Advanced Biotechnology and Medicine and Rutgers University Chemistry Department, Piscataway, New Jersey","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063432648","display_name":"Stephen H. Hughes","orcid":"https://orcid.org/0000-0002-9176-4377","observed_orcids":["https://orcid.org/0000-0002-9176-4377"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Stephen H. Hughes","raw_affiliation_strings":["HIV Drug Resistance Program"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HIV Drug Resistance Program","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5063432648"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.1758,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.91406141,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"78","issue":"18","first_page":"9987","last_page":"9997"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1-reverse-transcriptase","display_name":"HIV-1 reverse transcriptase","score":0.9959999918937683},{"id":"https://openalex.org/keywords/azt-resistance","display_name":"AZT resistance","score":0.8669999837875366},{"id":"https://openalex.org/keywords/tenofovir","display_name":"tenofovir","score":0.902999997138977},{"id":"https://openalex.org/keywords/pyrophosphorolysis","display_name":"pyrophosphorolysis","score":0.8389999866485596},{"id":"https://openalex.org/keywords/polymerase-activity","display_name":"polymerase activity","score":0.652999997138977},{"id":"https://openalex.org/keywords/nrti-resistance","display_name":"NRTI resistance","score":0.5899999737739563},{"id":"https://openalex.org/keywords/hiv-drug-resistance","display_name":"HIV drug resistance","score":0.49300000071525574},{"id":"https://openalex.org/keywords/reverse-transcriptase-mutations","display_name":"reverse transcriptase mutations","score":0.4320000112056732}],"concepts":[{"id":"https://openalex.org/C156719811","wikidata":"https://www.wikidata.org/wiki/Q28774","display_name":"Reverse transcriptase","level":4,"score":0.8365945816040039},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8324129581451416},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.7077237367630005},{"id":"https://openalex.org/C2777563447","wikidata":"https://www.wikidata.org/wiki/Q7243397","display_name":"Primer (cosmetics)","level":2,"score":0.6219098567962646},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5475170016288757},{"id":"https://openalex.org/C2777333352","wikidata":"https://www.wikidata.org/wiki/Q2689559","display_name":"Nucleoside analogue","level":3,"score":0.4943413734436035},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4883289039134979},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4658210277557373},{"id":"https://openalex.org/C2780216070","wikidata":"https://www.wikidata.org/wiki/Q198504","display_name":"Zidovudine","level":4,"score":0.4580904245376587},{"id":"https://openalex.org/C153574943","wikidata":"https://www.wikidata.org/wiki/Q408939","display_name":"Nucleotidyltransferase","level":4,"score":0.43507814407348633},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.42939597368240356},{"id":"https://openalex.org/C2776543447","wikidata":"https://www.wikidata.org/wiki/Q28734","display_name":"Nucleoside","level":2,"score":0.3473864197731018},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.24987691640853882},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.231560617685318},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.2211926281452179},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.21559658646583557},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19849911332130432},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.10000735521316528},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.06583923101425171},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004279","descriptor_name":"DNA, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004279","descriptor_name":"DNA, Viral","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009705","descriptor_name":"Nucleosides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015215","descriptor_name":"Zidovudine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018894","descriptor_name":"Reverse Transcriptase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019943","descriptor_name":"Amino Acid Substitution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024882","descriptor_name":"Drug Resistance, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054303","descriptor_name":"HIV Reverse Transcriptase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D054303","descriptor_name":"HIV Reverse Transcriptase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D054303","descriptor_name":"HIV Reverse Transcriptase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1128/jvi.78.18.9987-9997.2004","doi":"https://doi.org/10.1128/jvi.78.18.9987-9997.2004","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.78.18.9987-9997.2004","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:141847","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC515022","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:515022","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/515022","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},{"id":"pmid:15331732","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15331732","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of virology","raw_type":"Journal Article"},{"id":"pmh:oai:alma.01RUT_INST:11663607720004646","doi":null,"is_oa":false,"landing_page_url":"https://scholarship.libraries.rutgers.edu/esploro/outputs/journalArticle/Effects-of-the-\u039467-Complex-of/991031654762504646","pdf_url":null,"source":{"id":"https://openalex.org/S4306401388","display_name":"Rutgers University Community Repository (Rutgers University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I102322142","host_organization_name":"Rutgers, The State University of New Jersey","host_organization_lineage":["https://openalex.org/I102322142"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:141847","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC515022","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8299999833106995,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320308573","display_name":"Gilead Sciences","ror":"https://ror.org/056546b03"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W15370145","https://openalex.org/W1543329660","https://openalex.org/W1829460786","https://openalex.org/W1967936159","https://openalex.org/W1973711348","https://openalex.org/W1974345523","https://openalex.org/W1979033897","https://openalex.org/W1980418635","https://openalex.org/W1996219694","https://openalex.org/W1998230389","https://openalex.org/W2005910303","https://openalex.org/W2015939102","https://openalex.org/W2020014483","https://openalex.org/W2030992672","https://openalex.org/W2033978085","https://openalex.org/W2092890561","https://openalex.org/W2098371287","https://openalex.org/W2099789127","https://openalex.org/W2109587611","https://openalex.org/W2116004666","https://openalex.org/W2130241957","https://openalex.org/W2134308480","https://openalex.org/W2140453283","https://openalex.org/W2141333767","https://openalex.org/W2144598503","https://openalex.org/W2145447211","https://openalex.org/W2146777881","https://openalex.org/W2149782795","https://openalex.org/W2156695548","https://openalex.org/W2165473677","https://openalex.org/W2167201468","https://openalex.org/W2168910994","https://openalex.org/W2169653376","https://openalex.org/W2328285239","https://openalex.org/W2341771132","https://openalex.org/W2411497633","https://openalex.org/W3145257564","https://openalex.org/W3214318063"],"related_works":["https://openalex.org/W7098931595","https://openalex.org/W2150796710","https://openalex.org/W2016502882","https://openalex.org/W2168910994","https://openalex.org/W2114941400","https://openalex.org/W2109587611","https://openalex.org/W2778641769","https://openalex.org/W4254311761","https://openalex.org/W207473052","https://openalex.org/W2169653376"],"abstract_inverted_index":{"Long-term":[0],"use":[1],"of":[2,40,74,80,82,132,142,162,169,183,198,235,246,264,293,306],"combination":[3],"therapy":[4],"against":[5],"human":[6],"immunodeficiency":[7],"virus":[8,288],"type":[9],"(HIV-1)":[10],"provides":[11],"strong":[12],"selective":[13],"pressure":[14],"on":[15],"the":[16,37,47,60,67,78,87,100,139,156,166,175,184,196,207,232,249,290,304],"virus,":[17,106],"and":[18,53,129,147,158,174,191,216,267,275],"HIV-1":[19,30,41,149,229],"variants":[20,31,91,179,186],"that":[21,286],"are":[22,64],"resistant":[23,65],"to":[24,66,171,221,240,258,269,272],"multiple":[25],"inhibitors":[26],"have":[27,92,137,145],"been":[28,94],"isolated.":[29],"containing":[32,56,151,231,289],"amino":[33,126],"acid":[34,127],"substitutions":[35,128],"within":[36],"coding":[38,102],"region":[39],"reverse":[42],"transcriptase":[43],"(RT),":[44],"such":[45,105],"as":[46,242,248],"3'-azido-3'-deoxythymidine":[48],"(AZT)-resistant":[49],"variant":[50,55,208,252],"AZT-R":[51,282],"(M41L/D67N/K70R/T215Y/K219Q)":[52],"a":[54,130,199,244,287],"an":[57,75,163],"insertion":[58,251],"in":[59,77,99,299,303],"fingers":[61,250],"domain":[62],"(S69SGR70/T215Y),":[63],"nucleoside":[68],"RT":[69,101,150,164,173,230],"inhibitor":[70],"(NRTI)":[71],"AZT":[72,83],"because":[73],"increase":[76],"level":[79],"excision":[81],"monophosphate":[84],"(AZTMP)":[85],"from":[86,195],"primer.":[88],"While":[89],"rare,":[90],"also":[93],"isolated":[95],"which":[96,135],"contain":[97],"deletions":[98],"region.":[103],"One":[104],"described":[107,180],"by":[108],"Imamichi":[109],"et":[110],"al.":[111],"(J.":[112],"Virol":[113],"74:10958-10964,":[114],"2000;":[115,119],"J.":[116,120],"Virol.":[117,121],"74:1023-1028,":[118],"75:3988-3992,":[122],"2001),":[123],"contains":[124],"numerous":[125],"deletion":[131],"codon":[133],"67,":[134],"we":[136,187],"designated":[138],"Delta67":[140,167,233,291],"complex":[141,168,234,292],"mutations.":[143,153],"We":[144,154],"expressed":[146],"purified":[148],"these":[152],"compared":[155],"polymerase":[157],"pyrophosphorolysis":[159],"(excision)":[160],"activity":[161],"with":[165,261],"mutations":[170,236,294],"wild-type":[172,204,227],"two":[176],"other":[177],"AZT-resistant":[178,185],"above.":[181],"All":[182],"tested":[188],"excise":[189,222,241,273],"AZTMP":[190,215,274],"9-[2-(R)-(phosphonomethoxy)propyl]adenine":[192],"(PMPA":[193],"[tenofovir])":[194],"end":[197],"primer":[200],"more":[201,224],"efficiently":[202,213,225,260],"than":[203,214,226,281],"RT.":[205,228],"Although":[206],"RTs":[209],"excised":[210],"d4TMP":[211,223],"less":[212],"PMPA,":[217],"they":[218],"were":[219],"able":[220,239,257,271],"was":[237,256],"not":[238],"broad":[243],"range":[245],"NRTIs":[247],"SSGR/T215Y,":[253,284],"but":[254],"it":[255],"polymerize":[259],"low":[262],"concentrations":[263,280],"deoxynucleoside":[265],"triphosphates":[266],"seems":[268],"be":[270],"PMPA":[276],"at":[277],"lower":[278],"ATP":[279],"or":[283],"suggesting":[285],"would":[295],"replicate":[296],"reasonably":[297],"well":[298],"quiescent":[300],"cells,":[301],"even":[302],"presence":[305],"AZT.":[307]},"counts_by_year":[{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}