{"id":"https://openalex.org/W2144347018","doi":"https://doi.org/10.1128/aac.38.2.385","title":"Bactericidal activities of peptide antibiotics against multidrug-resistant Enterococcus faecium","display_name":"Bactericidal activities of peptide antibiotics against multidrug-resistant Enterococcus faecium","publication_year":1994,"publication_date":"1994-02-01","ids":{"openalex":"https://openalex.org/W2144347018","doi":"https://doi.org/10.1128/aac.38.2.385","mag":"2144347018","pmid":"https://pubmed.ncbi.nlm.nih.gov/8192473","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/284464"},"language":"en","primary_location":{"id":"doi:10.1128/aac.38.2.385","doi":"https://doi.org/10.1128/aac.38.2.385","is_oa":false,"landing_page_url":"https://doi.org/10.1128/aac.38.2.385","pdf_url":null,"source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC284464","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024199227","display_name":"Neville K. Mobarakai","orcid":"https://orcid.org/0000-0002-8652-5849","observed_orcids":["https://orcid.org/0000-0002-8652-5849"]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N Mobarakai","raw_affiliation_strings":["Department of Medicine, Department of Veterans Affairs, Brooklyn, New York 11209"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Department of Veterans Affairs, Brooklyn, New York 11209","institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024228283","display_name":"John M. Quale","orcid":"https://orcid.org/0000-0001-6043-4298","observed_orcids":["https://orcid.org/0000-0001-6043-4298"]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J M Quale","raw_affiliation_strings":["Department of Medicine, Department of Veterans Affairs, Brooklyn, New York 11209"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Department of Veterans Affairs, Brooklyn, New York 11209","institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039985590","display_name":"David Landman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D Landman","raw_affiliation_strings":["Department of Medicine, Department of Veterans Affairs, Brooklyn, New York 11209"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Department of Veterans Affairs, Brooklyn, New York 11209","institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.9216,"has_fulltext":false,"cited_by_count":44,"citation_normalized_percentile":{"value":0.92941533,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"38","issue":"2","first_page":"385","last_page":"387"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.6478999853134155,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.6478999853134155,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.2728999853134155,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12526","display_name":"Antimicrobial agents and applications","score":0.02239999920129776,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/enterococcus-faecium","display_name":"Enterococcus faecium","score":0.9169999957084656},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.9940000176429749},{"id":"https://openalex.org/keywords/peptide-antibiotics","display_name":"peptide antibiotics","score":0.8640000224113464},{"id":"https://openalex.org/keywords/ramoplanin","display_name":"ramoplanin","score":0.9869999885559082},{"id":"https://openalex.org/keywords/daptomycin","display_name":"daptomycin","score":1.0},{"id":"https://openalex.org/keywords/bactericidal-activity","display_name":"bactericidal activity","score":0.968999981880188},{"id":"https://openalex.org/keywords/vancomycin-resistance","display_name":"vancomycin resistance","score":0.7870000004768372},{"id":"https://openalex.org/keywords/ampicillin-resistance","display_name":"ampicillin resistance","score":0.8840000033378601},{"id":"https://openalex.org/keywords/aminoglycoside-resistance","display_name":"aminoglycoside resistance","score":0.9929999709129333},{"id":"https://openalex.org/keywords/time-kill-kinetics","display_name":"time-kill kinetics","score":0.8759999871253967}],"concepts":[{"id":"https://openalex.org/C2778651397","wikidata":"https://www.wikidata.org/wiki/Q418747","display_name":"Daptomycin","level":5,"score":0.9558004140853882},{"id":"https://openalex.org/C2777677444","wikidata":"https://www.wikidata.org/wiki/Q140010","display_name":"Enterococcus faecium","level":3,"score":0.8815732002258301},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.7662084102630615},{"id":"https://openalex.org/C2776021129","wikidata":"https://www.wikidata.org/wiki/Q244150","display_name":"Ampicillin","level":3,"score":0.7605966329574585},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.7290505766868591},{"id":"https://openalex.org/C2780585763","wikidata":"https://www.wikidata.org/wiki/Q517258","display_name":"Enterococcus","level":3,"score":0.5751932859420776},{"id":"https://openalex.org/C133936738","wikidata":"https://www.wikidata.org/wiki/Q643839","display_name":"Multiple drug resistance","level":3,"score":0.4763515293598175},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4131247401237488},{"id":"https://openalex.org/C2778980435","wikidata":"https://www.wikidata.org/wiki/Q424027","display_name":"Vancomycin","level":4,"score":0.41005682945251465},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.2165210247039795},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.08226808905601501},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000667","descriptor_name":"Ampicillin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002939","descriptor_name":"Ciprofloxacin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004352","descriptor_name":"Drug Resistance, Microbial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010456","descriptor_name":"Peptides, Cyclic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013293","descriptor_name":"Enterococcus faecalis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D014640","descriptor_name":"Vancomycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017576","descriptor_name":"Daptomycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D047630","descriptor_name":"Depsipeptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1128/aac.38.2.385","doi":"https://doi.org/10.1128/aac.38.2.385","is_oa":false,"landing_page_url":"https://doi.org/10.1128/aac.38.2.385","pdf_url":null,"source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:30744","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC284464","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:284464","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/284464","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrob Agents Chemother","raw_type":"Text"},{"id":"pmid:8192473","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8192473","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial agents and chemotherapy","raw_type":"Comparative Study"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:30744","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC284464","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W193074756","https://openalex.org/W1928483520","https://openalex.org/W1997811421","https://openalex.org/W1998724080","https://openalex.org/W2002500891","https://openalex.org/W2005167939","https://openalex.org/W2040119817","https://openalex.org/W2062398891","https://openalex.org/W2072749218","https://openalex.org/W2084775001","https://openalex.org/W2096056987","https://openalex.org/W2097638025","https://openalex.org/W2136167568","https://openalex.org/W2142330123","https://openalex.org/W2145919740","https://openalex.org/W2161963100","https://openalex.org/W2164257572","https://openalex.org/W2167985903","https://openalex.org/W2325812089"],"related_works":["https://openalex.org/W7099065090","https://openalex.org/W2141011536","https://openalex.org/W2030775317","https://openalex.org/W3119494106","https://openalex.org/W2161963100","https://openalex.org/W2145919740","https://openalex.org/W2011360272","https://openalex.org/W1970747983","https://openalex.org/W2037091330","https://openalex.org/W1984321267"],"abstract_inverted_index":{"Multidrug-resistant":[0],"Enterococcus":[1],"faecium":[2,36],"has":[3,14,92],"emerged":[4],"as":[5],"a":[6],"serious":[7],"pathogen":[8],"for":[9,99],"which":[10],"no":[11],"effective":[12],"therapy":[13,101],"been":[15,93],"established.":[16],"In":[17],"this":[18,76],"report,":[19],"we":[20],"describe":[21],"the":[22,56,88,100],"activities":[23],"of":[24,34,58,67,90,102],"two":[25],"peptide":[26,79],"antibiotics,":[27],"ramoplanin":[28,71,95],"and":[29,41],"daptomycin,":[30],"against":[31,84],"15":[32],"isolates":[33],"E.":[35,104],"resistant":[37],"to":[38],"vancomycin,":[39],"ampicillin,":[40],"aminoglycosides":[42],"using":[43],"time-kill":[44],"experiments.":[45],"Both":[46],"antibiotics":[47,80],"were":[48],"rapidly":[49],"bactericidal":[50],"when":[51,107],"tested":[52],"in":[53,62],"broth;":[54],"however,":[55],"addition":[57],"50%":[59],"serum":[60],"resulted":[61],"significant":[63],"regrowth.":[64,77],"The":[65],"combination":[66],"ampicillin":[68],"with":[69,109],"either":[70],"or":[72],"daptomycin":[73,91],"largely":[74],"prevented":[75],"These":[78],"showed":[81],"good":[82],"activity":[83],"these":[85],"pathogens.":[86],"While":[87],"development":[89],"halted,":[94],"may":[96],"hold":[97],"promise":[98],"multidrug-resistant":[103],"faecium,":[105],"especially":[106],"combined":[108],"ampicillin.":[110]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}