{"id":"https://openalex.org/W2144321027","doi":"https://doi.org/10.1161/01.cir.29.5s4.iv-3","title":"Idiopathic Hypertrophic Subaortic Stenosis: I. A Description of the Disease Based Upon an Analysis of 64 Patients","display_name":"Idiopathic Hypertrophic Subaortic Stenosis: I. A Description of the Disease Based Upon an Analysis of 64 Patients","publication_year":1964,"publication_date":"1964-11-01","ids":{"openalex":"https://openalex.org/W2144321027","doi":"https://doi.org/10.1161/01.cir.29.5s4.iv-3","mag":"2144321027","pmid":"https://pubmed.ncbi.nlm.nih.gov/14227306"},"language":"en","primary_location":{"id":"doi:10.1161/01.cir.29.5s4.iv-3","doi":"https://doi.org/10.1161/01.cir.29.5s4.iv-3","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.cir.29.5s4.iv-3","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2144321027"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022267024","display_name":"Eugene Braunwald","orcid":"https://orcid.org/0000-0002-3472-626X","observed_orcids":["https://orcid.org/0000-0002-3472-626X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210155647","display_name":"National Institutes of Health Clinical Center","ror":"https://ror.org/04vfsmv21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210155647"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"EUGENE BRAUNWALD","raw_affiliation_strings":["From the Cardiology Branch and the Clinic of Surgery, National Heart Institute, and the Diagnostic X-ray Department, Clinical Center, National Institutes of Health, Bethesda, Maryland","EUGENE BRAUNWALD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Cardiology Branch and the Clinic of Surgery, National Heart Institute, and the Diagnostic X-ray Department, Clinical Center, National Institutes of Health, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210155647"]},{"raw_affiliation_string":"EUGENE BRAUNWALD","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109148095","display_name":"Costas T. Lambrew","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210155647","display_name":"National Institutes of Health Clinical Center","ror":"https://ror.org/04vfsmv21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210155647"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"COSTAS T. LAMBREW","raw_affiliation_strings":["From the Cardiology Branch and the Clinic of Surgery, National Heart Institute, and the Diagnostic X-ray Department, Clinical Center, National Institutes of Health, Bethesda, Maryland","COSTAS T. LAMBREW"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Cardiology Branch and the Clinic of Surgery, National Heart Institute, and the Diagnostic X-ray Department, Clinical Center, National Institutes of Health, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210155647"]},{"raw_affiliation_string":"COSTAS T. LAMBREW","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111621100","display_name":"S. David Rockoff","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. DAVID ROCKOFF","raw_affiliation_strings":["S. DAVID ROCKOFF"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"S. DAVID ROCKOFF","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102343559","display_name":"John Ross","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210155647","display_name":"National Institutes of Health Clinical Center","ror":"https://ror.org/04vfsmv21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210155647"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"JOHN ROSS","raw_affiliation_strings":["From the Cardiology Branch and the Clinic of Surgery, National Heart Institute, and the Diagnostic X-ray Department, Clinical Center, National Institutes of Health, Bethesda, Maryland","JOHN ROSSJR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Cardiology Branch and the Clinic of Surgery, National Heart Institute, and the Diagnostic X-ray Department, Clinical Center, National Institutes of Health, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210155647"]},{"raw_affiliation_string":"JOHN ROSSJR","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111866176","display_name":"Andrew G. Morrow","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210155647","display_name":"National Institutes of Health Clinical Center","ror":"https://ror.org/04vfsmv21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210155647"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"ANDREW G. MORROW","raw_affiliation_strings":["From the Cardiology Branch and the Clinic of Surgery, National Heart Institute, and the Diagnostic X-ray Department, Clinical Center, National Institutes of Health, Bethesda, Maryland","ANDREW G. MORROW"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Cardiology Branch and the Clinic of Surgery, National Heart Institute, and the Diagnostic X-ray Department, Clinical Center, National Institutes of Health, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210155647"]},{"raw_affiliation_string":"ANDREW G. MORROW","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":22.0028,"has_fulltext":false,"cited_by_count":775,"citation_normalized_percentile":{"value":0.99675598,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"29","issue":"5s4","first_page":"SUPPL 4:3","last_page":"119"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11922","display_name":"Cardiovascular Effects of Exercise","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypertrophic-obstructive-cardiomyopathy","display_name":"hypertrophic obstructive cardiomyopathy","score":0.9959999918937683},{"id":"https://openalex.org/keywords/left-ventricular-hypertrophy","display_name":"left ventricular hypertrophy","score":0.9409999847412109},{"id":"https://openalex.org/keywords/left-ventricular-outflow-tract-obstruction","display_name":"left ventricular outflow tract obstruction","score":0.9369999766349792},{"id":"https://openalex.org/keywords/interventricular-septum","display_name":"interventricular septum","score":0.6269999742507935},{"id":"https://openalex.org/keywords/norepinephrine","display_name":"norepinephrine","score":0.7390000224113464},{"id":"https://openalex.org/keywords/sex-distribution","display_name":"sex distribution","score":0.6790000200271606},{"id":"https://openalex.org/keywords/familial-inheritance","display_name":"familial inheritance","score":0.4740000069141388},{"id":"https://openalex.org/keywords/congenital-heart-disease","display_name":"congenital heart disease","score":0.8619999885559082},{"id":"https://openalex.org/keywords/heart-murmurs","display_name":"heart murmurs","score":0.7120000123977661},{"id":"https://openalex.org/keywords/clinical-characteristics","display_name":"clinical features","score":0.4269999861717224},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.3869999945163727}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9677706956863403},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6558973789215088},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6117992401123047},{"id":"https://openalex.org/C2780007028","wikidata":"https://www.wikidata.org/wiki/Q2343082","display_name":"Stenosis","level":2,"score":0.5038980841636658}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000680","descriptor_name":"Amyl Nitrite","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000790","descriptor_name":"Angiocardiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001024","descriptor_name":"Aortic Valve Stenosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002312","descriptor_name":"Cardiomyopathy, Hypertrophic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003251","descriptor_name":"Constriction, Pathologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004071","descriptor_name":"Digitalis Glycosides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004358","descriptor_name":"Drug Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004562","descriptor_name":"Electrocardiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005080","descriptor_name":"Exercise Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005826","descriptor_name":"Genetics, Medical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005996","descriptor_name":"Nitroglycerin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006328","descriptor_name":"Cardiac Catheterization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007545","descriptor_name":"Isoproterenol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008729","descriptor_name":"Methoxamine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010042","descriptor_name":"Ouabain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010701","descriptor_name":"Phonocardiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013565","descriptor_name":"Sympatholytics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013902","descriptor_name":"Radiography, Thoracic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1161/01.cir.29.5s4.iv-3","doi":"https://doi.org/10.1161/01.cir.29.5s4.iv-3","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.cir.29.5s4.iv-3","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},{"id":"pmid:14227306","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14227306","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2076537391","https://openalex.org/W4206189678","https://openalex.org/W2312526853","https://openalex.org/W2021978839","https://openalex.org/W191170624","https://openalex.org/W393112603","https://openalex.org/W2003474515","https://openalex.org/W2014156702","https://openalex.org/W7116965963","https://openalex.org/W1909441754"],"abstract_inverted_index":{"Idiopathic":[0],"hypertrophic":[1],"subaortic":[2],"stenosis":[3,971],"(IHSS)":[4],"is":[5,90,95,104,203,238,328,820,944,975,1149],"a":[6,175,272,301,314,348,368,420,502,524,602,739,749,754,758,957,1028,1204,1240,1276,1373],"disease":[7,77,255,392,444],"characterized":[8],"by":[9,106,127,181,725],"marked":[10,954],"hypertrophy":[11,89,832,844],"of":[12,52,55,100,113,118,123,134,211,218,253,300,310,316,347,353,358,365,380,407,419,428,439,442,448,473,477,483,490,534,556,595,611,714,741,810,859,865,874,894,909,915,922,939,953,984,988,995,1013,1031,1035,1064,1105,1120,1130,1138,1157,1172,1189,1244,1259,1294,1331,1408,1427,1431,1506,1515],"the":[13,19,23,30,34,50,76,80,98,101,107,114,119,124,128,135,145,150,159,164,168,188,207,216,224,228,235,250,254,261,265,269,289,296,306,311,325,351,359,363,378,388,391,402,408,425,429,440,443,449,456,471,474,496,535,557,562,573,596,612,636,642,652,656,668,672,775,783,807,816,838,846,857,863,872,875,880,895,898,910,913,916,920,923,931,936,940,951,985,989,993,996,1007,1011,1033,1036,1065,1081,1103,1106,1113,1121,1128,1136,1139,1144,1155,1158,1164,1180,1190,1219,1224,1228,1260,1267,1295,1329,1350,1361,1376,1381,1409,1418,1424,1432,1445,1489,1497,1504,1512,1516],"left":[14,24,46,87,169,189,503,637,678,715,765,842,899,924,962,990,997,1023,1037,1049,1066,1082,1107,1122,1165,1206,1288,1384,1400,1419,1438,1485,1517],"ventricle,":[15],"involving":[16],"in":[17,33,58,167,174,206,215,223,268,324,342,356,367,372,396,405,432,488,531,544,549,567,571,581,592,598,628,651,654,662,671,683,691,734,738,774,782,804,813,845,891,906,948,956,1006,1027,1045,1052,1072,1079,1091,1127,1186,1227,1236,1253,1257,1266,1271,1305,1311,1316,1328,1342,1357,1369,1380,1388,1406,1412,1429,1444,1452,1462,1472,1488,1501],"particular":[18,70],"interventricular":[20,1161],"septum":[21,147,1162],"and":[22,54,97,117,132,178,209,214,243,278,362,371,431,464,537,570,631,737,757,794,868,871,897,919,950,992,1026,1078,1112,1196,1203,1265,1307,1360,1383,1458,1465,1468,1503],"ventricular":[25,47,88,130,152,504,766,843,925,963,998,1024,1038,1083,1108,1123,1166,1207,1289,1352,1363,1420,1439,1486,1518],"outflow":[26,35,102,153,767,964,1353,1440,1487],"tract.":[27],"During":[28],"systole,":[29],"hypertrophied":[31,109,146,1160],"muscle":[32,165,184],"tract":[36,103,154,1354],"often":[37,172,192,511,803],"narrows":[38],"this":[39,59,584,787,1152,1213],"region":[40],"sufficiently":[41],"to":[42,45,75,197,424,539,764,769,829,903,961,1087,1176,1198,1239,1281,1287,1300,1484],"produce":[43],"obstruction":[44,763,960,1286,1483],"ejection.":[48],"Although":[49,466,667,837],"reports":[51,364],"Schmincke":[53],"Bernheim":[56],"early":[57,343,616],"century":[60],"indicate":[61],"that":[62,330,390,437,822,966,1043,1151],"IHSS":[63,232,366,381,453,811,949,974,1018,1218,1314,1502],"has":[64,72],"been":[65,73],"recognized":[66],"for":[67,841,1179],"many":[68,143,438],"years,":[69],"attention":[71],"directed":[74],"only":[78,279,1275],"during":[79,561,1110],"last":[81],"7":[82],"years.":[83],"In":[84,142,1215],"most":[85,457,633,1145,1377,1498],"instances":[86],"asymmetric,":[91],"but":[92,195,693,709,912],"occasionally":[93],"it":[94,327,434,1414],"diffuse":[96],"lumen":[99],"reduced":[105],"concentrically":[108],"muscle.":[110,226],"Marked":[111],"enlargement":[112,720,926],"papillary":[115],"muscles":[116],"trabeculae":[120],"carneae,":[121],"deformation":[122],"mitral":[125,137],"valve":[126],"thickened":[129],"septum,":[131],"thickening":[133],"anterior":[136],"leaflet":[138],"are":[139,171,179,191,827],"commonly":[140,1174],"noted.":[141,981],"hearts":[144],"bulges":[148],"into":[149,158,1163],"right":[151,1140,1351,1362,1382],"as":[155,157,319,321,375,377],"well":[156,320,376],"left.":[160],"On":[161,264,401,493,879],"microscopic":[162],"examination,":[163],"bundles":[166],"ventricle":[170,190,900,991,1067],"arranged":[173],"bizarre":[176],"fashion":[177],"separated":[180],"clefts.":[182],"Individual":[183],"fibers":[185],"obtained":[186],"from":[187,1154],"greatly":[193,1159],"thickened,":[194],"tend":[196],"be":[198,337,399,540,770,904,1088,1177,1282,1301],"shorter":[199],"than":[200,295,548,580,661,781,812,834,973,1042,1070,1090,1210,1303,1315],"normal.":[201],"There":[202],"an":[204,517,743,884,945,1020,1132],"increase":[205],"size":[208],"number":[210,740,1030],"nerve":[212],"fibrils":[213],"quantity":[217],"fluorescent":[219],"material,":[220],"presumably":[221],"norepinephrine,":[222],"affected":[225],"Of":[227],"64":[229,360,409,450,613,1433],"patients":[230,248,270,291,410,451,536,545,597,614,653,701,710,777,785,790,805,1032,1046,1216,1262,1270,1312,1359,1411,1464,1478],"with":[231,249,382,452,501,546,551,664,702,711,748,778,806,815,930,959,1017,1047,1054,1076,1094,1217,1250,1263,1313,1318],"on":[233,1002,1511],"which":[234],"present":[236,338,487,541,566,690,733,1185],"report":[237],"based,":[239],"67%":[240],"were":[241,245,256,276,281,292,445,454,577,648,658,706,721,849,1000,1193],"males":[242,277],"33%":[244],"females.":[246,282],"The":[247,283,298,345,644,700,728,762,982,1061,1118,1291,1322,1333,1372,1392,1398,1435,1475],"familial":[251,808],"form":[252,745,809],"distributed":[257],"approximately":[258,532,892],"equally":[259],"between":[260,856,1102,1456,1466,1496],"2":[262,694,735],"sexes.":[263],"other":[266,403,1268,1476],"hand,":[267,404],"without":[271,583,786,1212],"family":[273],"history,":[274],"78%":[275],"22%":[280],"average":[284,1242],"age":[285,352],"was":[286,304,486,498,510,529,565,590,606,626,632,675,681,689,732,746,853,889,901,979,1040,1068,1085,1099,1125,1184,1255,1274,1308,1326,1355,1366,1375,1403,1415,1494],"25.7":[287],"years;":[288],"female":[290],"significantly":[293,578,649,771,801,1194],"older":[294],"males.":[297],"discovery":[299,427],"heart":[302,421,479,497,559,588,604,624],"murmur":[303,349,422,625],"usually":[305,499,515,676,722,850],"first":[307,1292],"clinical":[308,331,475,1201],"manifestation":[309],"disease.":[312,727],"From":[313],"consideration":[315],"our":[317,491],"patients,":[318,361,569,630,695,736,896,911,1191,1454],"those":[322,550,582,663,814,1053,1211,1317],"reported":[323],"literature,":[326],"evident":[329],"findings":[332,476,713],"may":[333,335],"or":[334,341,640,717,862,935,968,1051,1056],"not":[336,928,1480],"at":[339,394,411,641,1010,1135],"birth":[340],"childhood.":[344],"finding":[346,799,947],"before":[350],"1":[354,413,870],"year":[355],"9":[357],"stillborn":[369],"baby":[370],"several":[373],"infants,":[374],"association":[379],"congenital":[383],"cardiac":[384,484,1394],"malformations,":[385],"all":[386,594,629,692,908],"support":[387],"concept":[389],"may,":[393],"least":[395,412],"some":[397,1080],"instances,":[398],"congenital.":[400],"20":[406],"detailed":[414],"examination":[415,495],"revealed":[416],"no":[417,854,1100],"evidence":[418,482],"prior":[423],"eventual":[426],"murmur,":[430],"them":[433,572],"appears":[435],"likely":[436,821],"manifestations":[441],"acquired.":[446],"Forty-eight":[447],"symptomatic,":[455],"common":[458,1146,1499],"symptoms":[459,1500],"being":[460,1143],"dyspnea,":[461],"angina,":[462],"dizziness":[463],"syncope.":[465],"others":[467,742],"have":[468,1199],"commented":[469],"upon":[470],"absence":[472],"congestive":[478],"failure,":[480],"clear":[481],"decompensation":[485],"14":[489,684,1453,1477],"patients.":[492,685,1332,1344,1371,1434,1474],"physical":[494],"enlarged,":[500],"lift.":[505],"A":[506,526,586,1168,1247,1345,1508],"double":[507],"apical":[508],"impulse":[509],"palpable.":[512],"Apex":[513],"cardiograms":[514],"showed":[516],"abnormally":[518,792,885,1021,1367,1404],"tall":[519],"presystolic":[520],"expansion":[521],"wave":[522,756,1374,1379],"(":[523],"wave).":[525],"systolic":[527,574,617,623,645,876,932,1115,1336,1346,1437],"thrill":[528],"palpable":[530],"one-half":[533,893,1188],"tended":[538,768,1197,1280,1299],"more":[542,772,802,1200],"frequently":[543],"severe":[547,773],"mild":[552],"obstruction.":[553,1096,1181,1507],"Paradoxical":[554],"splitting":[555],"second":[558],"sound":[560,589,605],"respiratory":[563],"cycle":[564],"22":[568],"pressure":[575,646,877,933,1116,1209,1297,1325,1337,1347,1365,1386,1402,1422,1441,1519],"gradients":[576,647],"higher":[579,1205,1310],"finding.":[585,788,1147,1214],"fourth":[587],"audible":[591],"almost":[593,907,1073,1389],"sinus":[599,687],"rhythm":[600,688],"while":[601,1417],"third":[603],"heard":[607,627],"less":[608,1041],"frequently.":[609],"Seven":[610],"had":[615,697],"ejection":[618,621],"sounds.":[619],"An":[620],"type":[622],"prominent":[634,1378],"along":[635],"sternal":[638],"border":[639],"apex.":[643],"lower":[650],"whom":[655,1272,1413],"murmurs":[657],"relatively":[659],"soft":[660],"louder":[665],"murmurs.":[666],"electrical":[669],"axis":[670,679],"frontal":[673,1008],"plane":[674],"normal,":[677],"deviation":[680],"noted":[682,890],"Normal":[686],"who":[696,1192],"atrial":[698,716,719,1385,1401],"fibrillation.":[699],"normal":[703,759,1048,1071,1241,1304,1327,1428],"P":[704],"waves":[705,780,826],"generally":[707],"asymptomatic,":[708],"electrocardiographic":[712],"combined":[718],"markedly":[723],"disabled":[724],"their":[726],"classical":[729],"WPW":[730],"pattern":[731],"incomplete":[744],"seen":[747],"shortened":[750],"P-R":[751],"interval":[752],"and/or":[753],"delta":[755,779],"QRS":[760],"duration.":[761],"27":[776],"37":[784],"Sixteen":[789],"exhibited":[791,1019],"deep":[793],"broad":[795],"Q":[796,825],"waves.":[797],"This":[798],"occurred":[800],"nonfamilial":[817],"form.":[818],"It":[819,1148],"these":[823],"abnormal":[824,1126],"related":[828],"gross":[830],"septal":[831],"rather":[833,972],"myocardial":[835],"infarction.":[836],"voltage":[839],"criteria":[840],"precordial":[847],"leads":[848],"satisfied,":[851],"there":[852,1098,1273,1279],"correlation":[855,1101,1493],"height":[858],"RV":[860,866],"5":[861,867],"sum":[864],"SV":[869],"magnitude":[873,914],"gradient.":[878,1117],"conventional":[881],"chest":[882],"roentgenograms":[883],"large":[886],"cardiothoracic":[887,917],"ratio":[888,918],"considered":[902],"enlarged":[905],"extent":[921],"did":[927,1479],"correlate":[929],"gradient":[934,1348],"functional":[937],"classification":[938],"patient.":[941,1391],"Aortic":[942],"dilatation":[943,955],"uncommon":[946],"presence":[952],"patient":[958,1016,1075,1093],"suggests":[965],"valvular":[967,1055,1319],"discrete":[969,1057,1095],"subvalvular":[970,1058,1170],"present.":[976],"Intracardiac":[977],"calcification":[978],"never":[980],"thickness":[983,1104],"free":[986,1062],"wall":[987,1063,1084],"width":[994,1034],"cavity":[999,1039,1124],"measured":[1001,1443],"angiographic":[1003],"films":[1004],"exposed":[1005],"projection":[1009],"end":[1012],"diastole.":[1014],"No":[1015,1492],"wide":[1022],"cavity,":[1025],"significant":[1029,1482],"observed":[1044],"ventricles":[1050],"aortic":[1059,1320],"stenosis.":[1060,1321],"thicker":[1069,1089],"every":[1074,1390],"IHSS,":[1077,1237,1264,1306],"found":[1086,1495],"any":[1092,1285],"However,":[1097],"myocardium":[1109],"diastole":[1111],"peak":[1114,1278,1436],"shape":[1119],"majority":[1129,1330],"patients;":[1131],"inward":[1133],"concavity":[1134],"midportion":[1137],"inferior":[1141],"margin":[1142],"presumed":[1150],"results":[1153],"bulging":[1156],"cavity.":[1167],"long":[1169],"area":[1171],"narrowing":[1173],"appeared":[1175],"responsible":[1178],"Mitral":[1182],"regurgitation":[1183],"nearly":[1187],"older,":[1195],"disability":[1202],"end-diastolic":[1208,1364],"arterial":[1220,1231,1296,1324],"pulse":[1221,1249,1298,1520],"rises":[1222],"sharply,":[1223],"upstroke":[1225],"times":[1226],"indirect":[1229],"carotid":[1230,1248],"pulses":[1232,1387],"averaging":[1233],"0.062":[1234],"sec.":[1235,1246],"compared":[1238],"value":[1243],"0.088":[1245],"two":[1251],"peaks":[1252],"systole":[1254],"recorded":[1256,1356],"35":[1258],"47":[1261,1430],"12":[1269],"single":[1277],"little":[1283],"if":[1284],"outflow.":[1290],"derivative":[1293],"greater":[1302],"always":[1309],"systemic":[1323],"pulmonary":[1334],"artery":[1335],"exceeded":[1338,1423,1448],"30":[1339],"mm.":[1340,1450,1460,1470],"Hg":[1341,1451,1461,1471],"16":[1343],"within":[1349],"10":[1358,1467],"elevated":[1368,1405],"21":[1370,1463],"resting":[1393],"index":[1395],"varied":[1396],"widely.":[1397],"mean":[1399],"18":[1407],"42":[1410],"measured,":[1416],"enddiastolic":[1421],"upper":[1425],"limit":[1426],"gradient,":[1442],"basal":[1446,1490],"state,":[1447],"100":[1449,1459],"ranged":[1455],"50":[1457,1469],"15":[1473],"exhibit":[1481],"state.":[1491],"severity":[1505],"distinct":[1509],"notch":[1510],"ascending":[1513],"limb":[1514]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":22},{"year":2023,"cited_by_count":25},{"year":2022,"cited_by_count":18},{"year":2021,"cited_by_count":17},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":15},{"year":2016,"cited_by_count":23},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":21},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":14}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}