{"id":"https://openalex.org/W2144308301","doi":null,"title":"Development of siRNA against the CYP1A1 gene for trap of endogenous Ah-receptor ligand","display_name":"Development of siRNA against the CYP1A1 gene for trap of endogenous Ah-receptor ligand","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W2144308301","mag":"2144308301"},"language":"en","primary_location":{"id":"pmh:oai:DiVA.org:sh-878","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-878","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/bachelorThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-878","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Sara Pettersson","orcid":"https://orcid.org/0009-0004-2175-1943","observed_orcids":["https://orcid.org/0009-0004-2175-1943"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Sara Pettersson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0004-2175-1943","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9463000297546387,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9463000297546387,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.04259999841451645,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aryl-hydrocarbon-receptor","display_name":"aryl hydrocarbon receptor","score":0.9980000257492065},{"id":"https://openalex.org/keywords/ficz","display_name":"FICZ","score":0.9409999847412109},{"id":"https://openalex.org/keywords/cyp1a1","display_name":"CYP1A1","score":0.9190000295639038},{"id":"https://openalex.org/keywords/cyp1a2","display_name":"CYP1A2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/aldehyde-oxidase","display_name":"aldehyde oxidase","score":0.9269999861717224},{"id":"https://openalex.org/keywords/tungstate","display_name":"tungstate","score":0.953000009059906},{"id":"https://openalex.org/keywords/sirna-knockdown","display_name":"siRNA knockdown","score":0.8709999918937683},{"id":"https://openalex.org/keywords/hepg2-cells","display_name":"HepG2 cells","score":0.7620000243186951},{"id":"https://openalex.org/keywords/xenobiotic-metabolism","display_name":"xenobiotic metabolism","score":0.7730000019073486},{"id":"https://openalex.org/keywords/bhlh-pas-transcription-factors","display_name":"bHLH-PAS transcription factors","score":0.7559999823570251}],"concepts":[{"id":"https://openalex.org/C17971392","wikidata":"https://www.wikidata.org/wiki/Q18027445","display_name":"5-HT5A receptor","level":3,"score":0.6771721839904785},{"id":"https://openalex.org/C33594762","wikidata":"https://www.wikidata.org/wiki/Q155750","display_name":"Aryl hydrocarbon receptor","level":4,"score":0.5937502980232239},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5877013802528381},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5244203805923462},{"id":"https://openalex.org/C116016267","wikidata":"https://www.wikidata.org/wiki/Q18039826","display_name":"Interleukin-21 receptor","level":3,"score":0.50063157081604},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4878990352153778},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.45705389976501465},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.45672518014907837},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4456920921802521},{"id":"https://openalex.org/C75184817","wikidata":"https://www.wikidata.org/wiki/Q5381540","display_name":"Enzyme-linked receptor","level":3,"score":0.433085173368454},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.37091606855392456},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3675469160079956},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.27324116230010986}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:DiVA.org:sh-878","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-878","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/bachelorThesis"},{"id":"mag:2144308301","doi":null,"is_oa":false,"landing_page_url":"http://sh.diva-portal.org/smash/get/diva2:16600/FULLTEXT01.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:DiVA.org:sh-878","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-878","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/bachelorThesis"},"sustainable_development_goals":[{"score":0.46810001134872437,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":62,"referenced_works":["https://openalex.org/W197396423","https://openalex.org/W1485553398","https://openalex.org/W1546766816","https://openalex.org/W1551348338","https://openalex.org/W1622053312","https://openalex.org/W1666105298","https://openalex.org/W1757381995","https://openalex.org/W1852941485","https://openalex.org/W1928012741","https://openalex.org/W1935479846","https://openalex.org/W1935728713","https://openalex.org/W1954721684","https://openalex.org/W1968334101","https://openalex.org/W1969120382","https://openalex.org/W1970118403","https://openalex.org/W1974993420","https://openalex.org/W1975124499","https://openalex.org/W1981594612","https://openalex.org/W1982944995","https://openalex.org/W1983635854","https://openalex.org/W1984490307","https://openalex.org/W1985754063","https://openalex.org/W1986333080","https://openalex.org/W1988376244","https://openalex.org/W1995023151","https://openalex.org/W2002062079","https://openalex.org/W2009078371","https://openalex.org/W2027487946","https://openalex.org/W2030607204","https://openalex.org/W2030975106","https://openalex.org/W2033042205","https://openalex.org/W2037482981","https://openalex.org/W2037664183","https://openalex.org/W2038764863","https://openalex.org/W2047778256","https://openalex.org/W2049480378","https://openalex.org/W2051843093","https://openalex.org/W2054518364","https://openalex.org/W2059565720","https://openalex.org/W2088285810","https://openalex.org/W2095942531","https://openalex.org/W2096666806","https://openalex.org/W2097893055","https://openalex.org/W2106195907","https://openalex.org/W2106400422","https://openalex.org/W2107235611","https://openalex.org/W2114629114","https://openalex.org/W2122575917","https://openalex.org/W2124739658","https://openalex.org/W2129185784","https://openalex.org/W2138429533","https://openalex.org/W2138913971","https://openalex.org/W2141306531","https://openalex.org/W2141617279","https://openalex.org/W2144062280","https://openalex.org/W2146909058","https://openalex.org/W2149538815","https://openalex.org/W2149540498","https://openalex.org/W2166802510","https://openalex.org/W2170264506","https://openalex.org/W2171885946","https://openalex.org/W2522837470"],"related_works":["https://openalex.org/W2149540498","https://openalex.org/W2031200148","https://openalex.org/W2336304637","https://openalex.org/W7033642222","https://openalex.org/W2020873521","https://openalex.org/W2112701873","https://openalex.org/W2093177850","https://openalex.org/W2036436070","https://openalex.org/W2552659228","https://openalex.org/W2551295145"],"abstract_inverted_index":{"The":[0,13,37,155,188],"aryl":[1],"hydrocarbon":[2],"receptor":[3],"(Ah-receptor)":[4],"is":[5,15,43,59,71,178,182],"a":[6,16,23,64,183,196],"member":[7],"of":[8,26,40,106,137,158,190,198,212,221],"the":[9,30,41,68,91,165,186,219],"bHLH-PAS":[10],"protein":[11],"family.":[12],"Ah-receptor":[14,42,57,69,89,131,173,229],"ligand":[17,49,58,184],"dependent":[18,132],"transcription":[19],"factor,":[20],"which":[21,147],"activates":[22],"wide":[24],"range":[25],"genes,":[27,33],"most":[28],"notably":[29],"xenobiotica":[31],"metabolising":[32,92],"CYP1A1":[34,107,119,159,191,199,222],"and":[35,46,70,77,96,108,112,120,160,223],"CYP1A2.":[36,121],"biological":[38],"function":[39],"still":[44],"unknown":[45],"an":[47,128],"endogenous":[48,88],"has":[50,63],"yet":[51],"not":[52,142,170,216],"been":[53],"identified.":[54],"A":[55],"possible":[56,87,179],"6-formylindolo[3,2-b]carbazole":[60],"(FICZ).":[61],"FICZ":[62,84],"high":[65],"affinity":[66],"for":[67,185],"rapidly":[72],"metabolised":[73],"by":[74,110,192,201],"CYP1A1,":[75,94],"CYP1A2":[76,95,109,161,224],"aldehydeoxidase":[78],"(AOX).":[79],"To":[80],"try":[81],"to":[82,210,227],"trap":[83,228],"or":[85],"other":[86],"ligands,":[90],"enzymes":[93],"AOX":[97,138],"were":[98],"blocked.":[99],"This":[100],"was":[101,194,206,215,225],"achieved":[102],"through":[103,113],"chemical":[104,156],"blockage":[105,123,136,157,189,220],"ellepticin":[111,163,181],"silencing":[114,197],"with":[115,139,162],"siRNA":[116,193],"directed":[117],"against":[118],"Successful":[122],"would":[124],"be":[125],"seen":[126],"as":[127],"increase":[129],"in":[130],"XRE-luciferase":[133,145,166],"activity.":[134],"Chemical":[135],"tungstate":[140],"did":[141,169],"affect":[143],"FICZ-dependent":[144],"activation":[146],"could":[148],"indicate":[149],"that":[150,180],"HepG2":[151],"cells":[152],"lack":[153,211],"AOX.":[154],"modified":[164],"response,":[167],"but":[168],"completely":[171],"block":[172],"activation.":[174],"In":[175],"addition":[176],"it":[177,214],"Ah-receptor.":[187],"successful;":[195],"mRNA":[200],"at":[202],"least":[203],"50":[204],"percent":[205],"detected.":[207],"However":[208],"due":[209],"time":[213],"tested":[217],"if":[218],"sufficient":[226],"ligands.":[230]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}