{"id":"https://openalex.org/W2144284338","doi":null,"title":"Amplification of c-myc but not of c-erbB-2 is associated with high proliferative capacity in breast cancer.","display_name":"Amplification of c-myc but not of c-erbB-2 is associated with high proliferative capacity in breast cancer.","publication_year":1993,"publication_date":"1993-04-15","ids":{"openalex":"https://openalex.org/W2144284338","mag":"2144284338","pmid":"https://pubmed.ncbi.nlm.nih.gov/8096798"},"language":"en","primary_location":{"id":"pmid:8096798","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8096798","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044665296","display_name":"Hans Heinrich Kreipe","orcid":"https://orcid.org/0000-0003-0708-1790","observed_orcids":["https://orcid.org/0000-0003-0708-1790"]},"institutions":[{"id":"https://openalex.org/I32021983","display_name":"Christian-Albrechts-Universit\u00e4t zu Kiel","ror":"https://ror.org/04v76ef78","country_code":"DE","type":"education","lineage":["https://openalex.org/I32021983"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"H Kreipe","raw_affiliation_strings":["Department of Gynecology, University of Kiel, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology, University of Kiel, Germany","institution_ids":["https://openalex.org/I32021983"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056683916","display_name":"Henning Feist","orcid":"https://orcid.org/0000-0001-5202-4555","observed_orcids":["https://orcid.org/0000-0001-5202-4555"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Feist","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"L Fischer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Fischer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113137035","display_name":"J. Felgner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Felgner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091059192","display_name":"Klaus Heidorn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Heidorn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051502735","display_name":"Liselotte Mettler","orcid":"https://orcid.org/0000-0001-6333-5527","observed_orcids":["https://orcid.org/0000-0001-6333-5527"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Mettler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5112903941","display_name":"Reza M. Parwaresch","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Parwaresch","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.0788,"has_fulltext":false,"cited_by_count":73,"citation_normalized_percentile":{"value":0.92175004,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":95},"biblio":{"volume":"53","issue":"8","first_page":"1956","last_page":"61"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.6187000274658203,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.6187000274658203,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.31929999589920044,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11134","display_name":"Breast Lesions and Carcinomas","score":0.04899999871850014,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.8700000047683716},{"id":"https://openalex.org/keywords/c-erbb-2","display_name":"c-erbB-2","score":0.9900000095367432},{"id":"https://openalex.org/keywords/gene-amplification","display_name":"gene amplification","score":0.9020000100135803},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8100000023841858},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.8159999847412109},{"id":"https://openalex.org/keywords/copy-number","display_name":"copy number","score":0.6970000267028809},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8050000071525574},{"id":"https://openalex.org/keywords/invasive-lobular-carcinoma","display_name":"invasive lobular carcinoma","score":0.8429999947547913}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5969655513763428},{"id":"https://openalex.org/C2778001805","wikidata":"https://www.wikidata.org/wiki/Q189961","display_name":"Mammary gland","level":4,"score":0.5826656818389893},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5698984861373901},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5082080364227295},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.47220689058303833},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.46569618582725525},{"id":"https://openalex.org/C7602840","wikidata":"https://www.wikidata.org/wiki/Q746284","display_name":"Gene duplication","level":3,"score":0.4495009481906891},{"id":"https://openalex.org/C3018521938","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast carcinoma","level":4,"score":0.44884970784187317},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.4485100209712982},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.4351480007171631},{"id":"https://openalex.org/C2910938049","wikidata":"https://www.wikidata.org/wiki/Q7249605","display_name":"Proliferation index","level":3,"score":0.4269801676273346},{"id":"https://openalex.org/C2779251935","wikidata":"https://www.wikidata.org/wiki/Q5385089","display_name":"ErbB","level":3,"score":0.4158557653427124},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3690492510795593},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.31198054552078247},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1936269998550415},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17894425988197327},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.17807608842849731},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1221550703048706}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005784","descriptor_name":"Gene Amplification","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011519","descriptor_name":"Proto-Oncogenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016259","descriptor_name":"Genes, myc","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:8096798","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8096798","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.328.4931","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.328.4931","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://cancerres.aacrjournals.org/content/53/8/1956.full.pdf","raw_type":"text"},{"id":"mag:2144284338","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8096798","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W161464813","https://openalex.org/W1507475205","https://openalex.org/W1599112898","https://openalex.org/W1665239406","https://openalex.org/W1665778615","https://openalex.org/W1706459762","https://openalex.org/W1845163208","https://openalex.org/W1847864430","https://openalex.org/W1918416431","https://openalex.org/W1971074898","https://openalex.org/W1973188134","https://openalex.org/W1983673751","https://openalex.org/W1987905586","https://openalex.org/W1990015440","https://openalex.org/W1993132416","https://openalex.org/W1997514744","https://openalex.org/W2003327103","https://openalex.org/W2006285921","https://openalex.org/W2014669590","https://openalex.org/W2024247791","https://openalex.org/W2027830190","https://openalex.org/W2028387622","https://openalex.org/W2029581665","https://openalex.org/W2043471865","https://openalex.org/W2045808986","https://openalex.org/W2045937693","https://openalex.org/W2048632014","https://openalex.org/W2072140252","https://openalex.org/W2073101093","https://openalex.org/W2079816467","https://openalex.org/W2095156669","https://openalex.org/W2098567881","https://openalex.org/W2103734662","https://openalex.org/W2113584052","https://openalex.org/W2123679993","https://openalex.org/W2126486896","https://openalex.org/W2139995230","https://openalex.org/W2141393790","https://openalex.org/W2144634347","https://openalex.org/W2171904018","https://openalex.org/W2186150092","https://openalex.org/W2298415113","https://openalex.org/W2323254708","https://openalex.org/W2328364787","https://openalex.org/W2341230536","https://openalex.org/W3034290355"],"related_works":["https://openalex.org/W2090465837","https://openalex.org/W7026423684","https://openalex.org/W2014048009","https://openalex.org/W1975479986","https://openalex.org/W2418347202","https://openalex.org/W2098664842","https://openalex.org/W2045937693","https://openalex.org/W53637493","https://openalex.org/W1665239406","https://openalex.org/W2167251253"],"abstract_inverted_index":{"Proliferative":[0],"capacity":[1],"provides":[2],"an":[3,118,194],"independent":[4],"prognostic":[5],"marker":[6],"of":[7,36,52,73,90,105,122,146,177,186],"progression":[8],"in":[9,24,49,56,109,112,156],"breast":[10],"cancer.":[11],"Little":[12],"is":[13,79],"known":[14,189],"about":[15],"the":[16,20,33,63,74,82,113,157,178,182],"molecular":[17,179],"mechanisms":[18],"influencing":[19],"cell":[21],"division":[22],"rate":[23],"mammary":[25,58,187],"carcinomas.":[26],"In":[27,101],"order":[28],"to":[29,46,62,134,190],"address":[30],"this":[31,102],"issue,":[32],"copy":[34,120,154],"numbers":[35,155],"c-erbB-2":[37,129],"(HER/neu)":[38],"and":[39,60],"c-myc":[40,106,123,172],"protooncogenes":[41,151],"that":[42,171],"have":[43],"been":[44],"shown":[45],"be":[47,135,175,191],"amplified":[48],"aggressive":[50],"types":[51],"cancers":[53],"were":[54],"determined":[55,70],"60":[57],"carcinomas":[59],"related":[61],"proliferation":[64,140,159],"rate.":[65],"The":[66],"proliferative":[67],"activity":[68],"was":[69,107,131],"by":[71,81],"labeling":[72,97],"proliferation-associated":[75],"nuclear":[76],"antigen":[77],"which":[78],"defined":[80],"recently":[83],"described":[84],"monoclonal":[85],"antibody":[86],"Ki-S1.":[87],"Approximately":[88],"one-third":[89],"samples":[91],"under":[92],"investigation":[93],"displayed":[94],"a":[95,138],"Ki-S1":[96],"index":[98],"exceeding":[99],"30%.":[100],"subgroup,":[103],"amplification":[104,130,173],"found":[108,133],"52.6%,":[110],"whereas":[111],"remaining":[114],"cases,":[115],"26.1%":[116],"exhibited":[117,152],"enhanced":[119],"number":[121],"(P":[124],"<":[125,164],"0.025).":[126],"By":[127],"contrast,":[128],"not":[132],"associated":[136,192],"with":[137,193],"higher":[139],"index.":[141],"Except":[142],"for":[143],"one":[144,176],"case":[145],"invasive":[147],"lobular":[148],"carcinoma,":[149,188],"both":[150],"regular":[153],"low":[158],"subgroup":[160],"(<":[161],"20%;":[162],"P":[163],"0.03).":[165],"We":[166],"conclude":[167],"from":[168],"our":[169],"findings":[170],"may":[174],"causes":[180],"underlying":[181],"highly":[183],"proliferating":[184],"phenotype":[185],"unfavorable":[195],"clinical":[196],"course.":[197]},"counts_by_year":[{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
