{"id":"https://openalex.org/W2144269162","doi":"https://doi.org/10.3109/10409239109114070","title":"Enzymology of the Acetyl-CoA Pathway of CO2Fixation","display_name":"Enzymology of the Acetyl-CoA Pathway of CO2Fixation","publication_year":1991,"publication_date":"1991-01-01","ids":{"openalex":"https://openalex.org/W2144269162","doi":"https://doi.org/10.3109/10409239109114070","mag":"2144269162","pmid":"https://pubmed.ncbi.nlm.nih.gov/1935170"},"language":"en","primary_location":{"id":"doi:10.3109/10409239109114070","doi":"https://doi.org/10.3109/10409239109114070","is_oa":false,"landing_page_url":"https://doi.org/10.3109/10409239109114070","pdf_url":null,"source":{"id":"https://openalex.org/S55210418","display_name":"Critical Reviews in Biochemistry and Molecular Biology","issn_l":"0045-6411","issn":["0045-6411","1040-8355","1040-9238","1549-7798"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Reviews in Biochemistry and Molecular Biology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080730574","display_name":"Stephen Wiley Ragsdale","orcid":"https://orcid.org/0000-0003-3938-8906","observed_orcids":["https://orcid.org/0000-0003-3938-8906"]},"institutions":[{"id":"https://openalex.org/I43579087","display_name":"University of Wisconsin\u2013Milwaukee","ror":"https://ror.org/031q21x57","country_code":"US","type":"education","lineage":["https://openalex.org/I43579087"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Stephen W. Ragsdale","raw_affiliation_strings":["Department of Chemistry, University of Wisconsin-Milwaukee","Department of Chemistry, The University of Wisconsin-Milwaukee, Milwaukee, Wisconsin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Wisconsin-Milwaukee","institution_ids":["https://openalex.org/I43579087"]},{"raw_affiliation_string":"Department of Chemistry, The University of Wisconsin-Milwaukee, Milwaukee, Wisconsin","institution_ids":["https://openalex.org/I43579087"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5080730574"],"corresponding_institution_ids":["https://openalex.org/I43579087"],"apc_list":null,"apc_paid":null,"fwci":1.7519,"has_fulltext":false,"cited_by_count":260,"citation_normalized_percentile":{"value":0.85973282,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":99},"biblio":{"volume":"26","issue":"3-4","first_page":"261","last_page":"300"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12688","display_name":"Microbial metabolism and enzyme function","score":0.6636000275611877,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12688","display_name":"Microbial metabolism and enzyme function","score":0.6636000275611877,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11626","display_name":"Metalloenzymes and iron-sulfur proteins","score":0.15330000221729279,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12441","display_name":"Porphyrin Metabolism and Disorders","score":0.028300000354647636,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acetyl-coa-pathway","display_name":"acetyl-CoA pathway","score":0.9459999799728394},{"id":"https://openalex.org/keywords/wood-ljungdahl-pathway","display_name":"Wood-Ljungdahl pathway","score":0.871999979019165},{"id":"https://openalex.org/keywords/co2-fixation","display_name":"CO2 fixation","score":0.9599999785423279},{"id":"https://openalex.org/keywords/methyltetrahydrofolate","display_name":"methyltetrahydrofolate","score":0.9430000185966492},{"id":"https://openalex.org/keywords/enzyme-kinetics","display_name":"enzyme kinetics","score":0.3569999933242798},{"id":"https://openalex.org/keywords/carbon-cycle","display_name":"carbon cycle","score":0.6179999709129333},{"id":"https://openalex.org/keywords/calvin-cycle","display_name":"Calvin cycle","score":0.531000018119812},{"id":"https://openalex.org/keywords/reverse-tca-cycle","display_name":"reverse TCA cycle","score":0.7509999871253967}],"concepts":[{"id":"https://openalex.org/C199873434","wikidata":"https://www.wikidata.org/wiki/Q901921","display_name":"Carbon fixation","level":3,"score":0.8199216723442078},{"id":"https://openalex.org/C2778470496","wikidata":"https://www.wikidata.org/wiki/Q715317","display_name":"Acetyl-CoA","level":3,"score":0.7901015281677246},{"id":"https://openalex.org/C165135838","wikidata":"https://www.wikidata.org/wiki/Q133895","display_name":"Citric acid cycle","level":3,"score":0.7322512865066528},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.690739631652832},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.675954282283783},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6339771747589111},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6233457326889038},{"id":"https://openalex.org/C2776441662","wikidata":"https://www.wikidata.org/wiki/Q2823314","display_name":"Tricarboxylic acid","level":4,"score":0.6210326552391052},{"id":"https://openalex.org/C512735826","wikidata":"https://www.wikidata.org/wiki/Q2025","display_name":"Carbon monoxide","level":3,"score":0.500770092010498},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.4516654312610626},{"id":"https://openalex.org/C36674120","wikidata":"https://www.wikidata.org/wiki/Q370228","display_name":"Isotopic labeling","level":2,"score":0.4278016984462738},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.38915157318115234},{"id":"https://openalex.org/C183688256","wikidata":"https://www.wikidata.org/wiki/Q11982","display_name":"Photosynthesis","level":2,"score":0.25942090153694153},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.17358198761940002},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.16085410118103027}],"mesh":[{"descriptor_ui":"D000105","descriptor_name":"Acetyl Coenzyme A","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D001421","descriptor_name":"Bacteria, Anaerobic","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002245","descriptor_name":"Carbon Dioxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002248","descriptor_name":"Carbon Monoxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003065","descriptor_name":"Coenzyme A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009942","descriptor_name":"Organometallic Compounds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013763","descriptor_name":"Tetrahydrofolates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3109/10409239109114070","doi":"https://doi.org/10.3109/10409239109114070","is_oa":false,"landing_page_url":"https://doi.org/10.3109/10409239109114070","pdf_url":null,"source":{"id":"https://openalex.org/S55210418","display_name":"Critical Reviews in Biochemistry and Molecular Biology","issn_l":"0045-6411","issn":["0045-6411","1040-8355","1040-9238","1549-7798"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Reviews in Biochemistry and Molecular Biology","raw_type":"journal-article"},{"id":"pmid:1935170","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1935170","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical reviews in biochemistry and molecular biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":205,"referenced_works":["https://openalex.org/W79933106","https://openalex.org/W95169307","https://openalex.org/W97003190","https://openalex.org/W135492993","https://openalex.org/W185273197","https://openalex.org/W233832995","https://openalex.org/W273889473","https://openalex.org/W399814894","https://openalex.org/W566531607","https://openalex.org/W959024556","https://openalex.org/W1146692588","https://openalex.org/W1481631643","https://openalex.org/W1489973775","https://openalex.org/W1490730015","https://openalex.org/W1504142642","https://openalex.org/W1506904792","https://openalex.org/W1507572675","https://openalex.org/W1508069339","https://openalex.org/W1508578483","https://openalex.org/W1510574485","https://openalex.org/W1515072523","https://openalex.org/W1516104905","https://openalex.org/W1519541902","https://openalex.org/W1531416894","https://openalex.org/W1532429817","https://openalex.org/W1534622291","https://openalex.org/W1535285273","https://openalex.org/W1536982492","https://openalex.org/W1538778697","https://openalex.org/W1540990666","https://openalex.org/W1543294787","https://openalex.org/W1550092053","https://openalex.org/W1551400471","https://openalex.org/W1556964559","https://openalex.org/W1558499662","https://openalex.org/W1561193389","https://openalex.org/W1562015285","https://openalex.org/W1562902928","https://openalex.org/W1566043215","https://openalex.org/W1566189726","https://openalex.org/W1566514223","https://openalex.org/W1570745070","https://openalex.org/W1572723753","https://openalex.org/W1573383902","https://openalex.org/W1574971132","https://openalex.org/W1576053978","https://openalex.org/W1579446995","https://openalex.org/W1579709565","https://openalex.org/W1580479730","https://openalex.org/W1584316379","https://openalex.org/W1586734181","https://openalex.org/W1589209214","https://openalex.org/W1590115961","https://openalex.org/W1592272590","https://openalex.org/W1593125638","https://openalex.org/W1593839182","https://openalex.org/W1595267158","https://openalex.org/W1600166016","https://openalex.org/W1600883380","https://openalex.org/W1602431495","https://openalex.org/W1608045495","https://openalex.org/W1615293143","https://openalex.org/W1627242721","https://openalex.org/W1633401484","https://openalex.org/W1655366942","https://openalex.org/W1659670715","https://openalex.org/W1659736313","https://openalex.org/W1678272177","https://openalex.org/W1758106456","https://openalex.org/W1766118319","https://openalex.org/W1770051224","https://openalex.org/W1808877860","https://openalex.org/W1819850013","https://openalex.org/W1822126129","https://openalex.org/W1846528953","https://openalex.org/W1848757408","https://openalex.org/W1864048711","https://openalex.org/W1889749499","https://openalex.org/W1900520162","https://openalex.org/W1904553143","https://openalex.org/W1908347765","https://openalex.org/W1957566557","https://openalex.org/W1964801721","https://openalex.org/W1967477294","https://openalex.org/W1968781683","https://openalex.org/W1974302216","https://openalex.org/W1977673582","https://openalex.org/W1979583850","https://openalex.org/W1980761815","https://openalex.org/W1982449465","https://openalex.org/W1983902820","https://openalex.org/W1985379624","https://openalex.org/W1987855133","https://openalex.org/W1988055043","https://openalex.org/W1988245893","https://openalex.org/W1988537921","https://openalex.org/W1988548022","https://openalex.org/W1988585005","https://openalex.org/W1988775011","https://openalex.org/W1988970324","https://openalex.org/W1989157562","https://openalex.org/W1991663225","https://openalex.org/W1991948671","https://openalex.org/W1995586956","https://openalex.org/W1996211878","https://openalex.org/W1997669990","https://openalex.org/W1998302450","https://openalex.org/W1998746471","https://openalex.org/W2000074899","https://openalex.org/W2001754673","https://openalex.org/W2004506434","https://openalex.org/W2006260839","https://openalex.org/W2006417815","https://openalex.org/W2012549806","https://openalex.org/W2012718947","https://openalex.org/W2012747725","https://openalex.org/W2013075087","https://openalex.org/W2013198686","https://openalex.org/W2017771146","https://openalex.org/W2020769743","https://openalex.org/W2021532546","https://openalex.org/W2022597085","https://openalex.org/W2022642835","https://openalex.org/W2022998755","https://openalex.org/W2024510540","https://openalex.org/W2025509373","https://openalex.org/W2026796374","https://openalex.org/W2027448647","https://openalex.org/W2029001136","https://openalex.org/W2030415730","https://openalex.org/W2031966946","https://openalex.org/W2035737306","https://openalex.org/W2036103108","https://openalex.org/W2039365633","https://openalex.org/W2039388106","https://openalex.org/W2040665477","https://openalex.org/W2044655979","https://openalex.org/W2045785977","https://openalex.org/W2045802273","https://openalex.org/W2047673222","https://openalex.org/W2048052262","https://openalex.org/W2049902455","https://openalex.org/W2050571639","https://openalex.org/W2052434481","https://openalex.org/W2055544420","https://openalex.org/W2055545151","https://openalex.org/W2058752397","https://openalex.org/W2059267372","https://openalex.org/W2059670575","https://openalex.org/W2059869587","https://openalex.org/W2059875510","https://openalex.org/W2060998824","https://openalex.org/W2061677797","https://openalex.org/W2062620752","https://openalex.org/W2063714603","https://openalex.org/W2066327906","https://openalex.org/W2067366714","https://openalex.org/W2068346518","https://openalex.org/W2069916118","https://openalex.org/W2072866010","https://openalex.org/W2074063983","https://openalex.org/W2074803225","https://openalex.org/W2075368947","https://openalex.org/W2078005731","https://openalex.org/W2081232527","https://openalex.org/W2081539666","https://openalex.org/W2081972299","https://openalex.org/W2083421984","https://openalex.org/W2086677398","https://openalex.org/W2086822116","https://openalex.org/W2087954021","https://openalex.org/W2090432387","https://openalex.org/W2092738390","https://openalex.org/W2103987334","https://openalex.org/W2112951169","https://openalex.org/W2120815764","https://openalex.org/W2123245885","https://openalex.org/W2129328760","https://openalex.org/W2133898153","https://openalex.org/W2136393634","https://openalex.org/W2136477181","https://openalex.org/W2154476937","https://openalex.org/W2157665649","https://openalex.org/W2162795621","https://openalex.org/W2172725008","https://openalex.org/W2174979179","https://openalex.org/W2178358345","https://openalex.org/W2243452521","https://openalex.org/W2336362217","https://openalex.org/W2409807350","https://openalex.org/W2412188932","https://openalex.org/W2414844317","https://openalex.org/W2424262605","https://openalex.org/W2474755615","https://openalex.org/W2887318190","https://openalex.org/W2975991165","https://openalex.org/W3004756604","https://openalex.org/W3005472204","https://openalex.org/W3119999078","https://openalex.org/W3202518454","https://openalex.org/W4211022623","https://openalex.org/W4240627683","https://openalex.org/W4245256434","https://openalex.org/W4245698462","https://openalex.org/W4285826988"],"related_works":["https://openalex.org/W4401374893","https://openalex.org/W1593521921","https://openalex.org/W1983802034","https://openalex.org/W64300308","https://openalex.org/W1785506955","https://openalex.org/W2128898932","https://openalex.org/W113386856","https://openalex.org/W1988548022","https://openalex.org/W2799784280","https://openalex.org/W2070563230"],"abstract_inverted_index":{"We":[0],"know":[1],"of":[2,50,78,86,119,132,142,158,173],"three":[3],"routes":[4],"that":[5,105,168],"organisms":[6],"have":[7],"evolved":[8],"to":[9,62,72,80],"synthesize":[10],"complex":[11],"organic":[12],"molecules":[13],"from":[14,65,88],"CO2:":[15],"the":[16,19,25,32,37,42,47,73,106,120,133,143,155,174],"Calvin":[17],"cycle,":[18,23],"reverse":[20],"tricarboxylic":[21],"acid":[22],"and":[24,83,98,111,126,140,149],"reductive":[26],"acetyl-CoA":[27,38,57,64,74,87,163],"pathway.":[28],"This":[29,100,152],"review":[30,153],"describes":[31,154],"enzymatic":[33,159],"steps":[34,160],"involved":[35,161],"in":[36,104,162],"pathway,":[39,44],"also":[40,60],"called":[41],"Wood":[43],"which":[45],"is":[46,59,102,122,169],"major":[48,107],"mechanism":[49],"CO2":[51,79],"fixation":[52],"under":[53],"anaerobic":[54],"conditions.":[55],"The":[56],"pathway":[58,101,121,167],"able":[61],"form":[63],"carbon":[66,176],"monoxide.":[67],"There":[68],"are":[69,109,112],"two":[70],"parts":[71],"pathway:":[75],"(1)":[76],"reduction":[77],"methyltetrahydrofolate":[81],"(methyl-H4folate)":[82],"(2)":[84],"synthesis":[85],"methyl-H4folate,":[89],"a":[90,170],"carboxyl":[91],"donor":[92],"such":[93],"as":[94],"CO":[95],"or":[96],"CO2,":[97],"CoA.":[99],"unique":[103],"intermediates":[108,145],"enzyme-bound":[110,144],"often":[113],"organometallic":[114],"complexes.":[115],"Our":[116],"current":[117],"understanding":[118],"based":[123],"on":[124],"radioactive":[125],"stable":[127],"isotope":[128],"tracer":[129],"studies,":[130],"purification":[131],"component":[134,172],"enzymes":[135],"(some":[136],"extremely":[137],"oxygen":[138],"sensitive),":[139],"identification":[141],"by":[146,165],"chromatographic,":[147],"spectroscopic,":[148],"electrochemical":[150],"techniques.":[151],"remarkable":[156],"series":[157],"formation":[164],"this":[166],"key":[171],"global":[175],"cycle.":[177]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":13},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}