{"id":"https://openalex.org/W2144267044","doi":"https://doi.org/10.1371/journal.pone.0087864","title":"Construction of Drug Network Based on Side Effects and Its Application for Drug Repositioning","display_name":"Construction of Drug Network Based on Side Effects and Its Application for Drug Repositioning","publication_year":2014,"publication_date":"2014-02-04","ids":{"openalex":"https://openalex.org/W2144267044","doi":"https://doi.org/10.1371/journal.pone.0087864","mag":"2144267044","pmid":"https://pubmed.ncbi.nlm.nih.gov/24505324","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3913703"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0087864","doi":"https://doi.org/10.1371/journal.pone.0087864","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0087864","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0087864&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0087864&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100427161","display_name":"Hao Ye","orcid":"https://orcid.org/0000-0003-1544-1768","observed_orcids":["https://orcid.org/0000-0003-1544-1768","https://orcid.org/0009-0004-0535-207X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hao Ye","raw_affiliation_strings":["R&D Information, AstraZeneca, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"R&D Information, AstraZeneca, Shanghai, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100453248","display_name":"Qi Liu","orcid":"https://orcid.org/0000-0003-2578-1221","observed_orcids":["https://orcid.org/0000-0003-2578-1221"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qi Liu","raw_affiliation_strings":["School of Life Sciences and Technology, Tongji University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences and Technology, Tongji University, Shanghai, China","institution_ids":["https://openalex.org/I116953780"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100404644","display_name":"Wei Ping Jia","orcid":"https://orcid.org/0000-0002-3739-8994","observed_orcids":["https://orcid.org/0000-0002-3739-8994"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jia Wei","raw_affiliation_strings":["R&D Information, AstraZeneca, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"R&D Information, AstraZeneca, Shanghai, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100404644"],"corresponding_institution_ids":[],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":7.3715,"has_fulltext":true,"cited_by_count":123,"citation_normalized_percentile":{"value":0.98533239,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":92,"max":100},"biblio":{"volume":"9","issue":"2","first_page":"e87864","last_page":"e87864"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.01360000018030405,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.00800000037997961,"subfield":{"id":"https://openalex.org/subfields/2718","display_name":"Health Informatics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.7739999890327454},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.8859999775886536},{"id":"https://openalex.org/keywords/network-based-drug-discovery","display_name":"network-based drug discovery","score":0.5120000243186951},{"id":"https://openalex.org/keywords/drug-similarity","display_name":"drug similarity","score":0.4099999964237213},{"id":"https://openalex.org/keywords/diabetes-drugs","display_name":"diabetes drugs","score":0.4090000092983246},{"id":"https://openalex.org/keywords/obesity-drugs","display_name":"obesity drugs","score":0.9419999718666077},{"id":"https://openalex.org/keywords/laxatives","display_name":"laxatives","score":0.9739999771118164},{"id":"https://openalex.org/keywords/fda-approved-indications","display_name":"FDA-approved indications","score":0.546999990940094}],"concepts":[{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.7446554899215698},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6543429493904114},{"id":"https://openalex.org/C103637391","wikidata":"https://www.wikidata.org/wiki/Q5308921","display_name":"Drug repositioning","level":3,"score":0.4970381557941437},{"id":"https://openalex.org/C3454156","wikidata":"https://www.wikidata.org/wiki/Q1144241","display_name":"Side effect (computer science)","level":2,"score":0.4588203728199005},{"id":"https://openalex.org/C2910466267","wikidata":"https://www.wikidata.org/wiki/Q718753","display_name":"Drug-drug interaction","level":3,"score":0.43509572744369507},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.41578349471092224},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.33682551980018616},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D062313","descriptor_name":"Databases, Pharmaceutical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pone.0087864","doi":"https://doi.org/10.1371/journal.pone.0087864","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0087864","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0087864&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2901142","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3913703","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3913703","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3913703","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:24505324","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24505324","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.915.9297","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.915.9297","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://europepmc.org/backend/ptpmcrender.fcgi?accid%3DPMC3913703%26blobtype%3Dpdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:8c3a271d70b849d6929039fcfd6ed6c9","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/8c3a271d70b849d6929039fcfd6ed6c9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 9, Iss 2, p e87864 (2014)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/925165","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_Construction_of_Drug_Network_Based_on_Side_Effects_and_Its_Application_for_Drug_Repositioning_/925165","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0087864","doi":"https://doi.org/10.1371/journal.pone.0087864","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0087864","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0087864&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2144267044.pdf","grobid_xml":"https://content.openalex.org/works/W2144267044.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W393167415","https://openalex.org/W1782095941","https://openalex.org/W1895993106","https://openalex.org/W1970188324","https://openalex.org/W1972821149","https://openalex.org/W1977013407","https://openalex.org/W1979211090","https://openalex.org/W1982945330","https://openalex.org/W1987730034","https://openalex.org/W1993885194","https://openalex.org/W1994395341","https://openalex.org/W2006402375","https://openalex.org/W2018796817","https://openalex.org/W2020132970","https://openalex.org/W2025680797","https://openalex.org/W2029149156","https://openalex.org/W2040840616","https://openalex.org/W2041729187","https://openalex.org/W2044883760","https://openalex.org/W2046041236","https://openalex.org/W2051491327","https://openalex.org/W2055958700","https://openalex.org/W2056844136","https://openalex.org/W2062941476","https://openalex.org/W2063217892","https://openalex.org/W2069870183","https://openalex.org/W2076437528","https://openalex.org/W2077083535","https://openalex.org/W2083258699","https://openalex.org/W2087007217","https://openalex.org/W2087762274","https://openalex.org/W2088504456","https://openalex.org/W2088760487","https://openalex.org/W2094791588","https://openalex.org/W2096738301","https://openalex.org/W2100173292","https://openalex.org/W2103566527","https://openalex.org/W2103675811","https://openalex.org/W2105145113","https://openalex.org/W2113072832","https://openalex.org/W2117935381","https://openalex.org/W2121604817","https://openalex.org/W2127938920","https://openalex.org/W2142572836","https://openalex.org/W2143251418","https://openalex.org/W2158217645","https://openalex.org/W2166550586","https://openalex.org/W2327126277","https://openalex.org/W2374683108","https://openalex.org/W2904254275"],"related_works":["https://openalex.org/W2755703399","https://openalex.org/W2005314755","https://openalex.org/W2020132970","https://openalex.org/W6990669089","https://openalex.org/W2908973184","https://openalex.org/W2954071032","https://openalex.org/W2275092861","https://openalex.org/W7203582073","https://openalex.org/W7099727293","https://openalex.org/W2035977761"],"abstract_inverted_index":{"Drugs":[0],"with":[1,60,116,135,212,238],"similar":[2,7],"side-effect":[3],"profiles":[4],"may":[5,37,269],"share":[6],"therapeutic":[8],"properties":[9],"through":[10],"related":[11],"mechanisms":[12],"of":[13,34,45,67,74,90,120,159,224,233,245],"action.":[14],"In":[15,103,231,255],"this":[16],"study,":[17],"a":[18,35,71,147],"drug-drug":[19],"network":[20,64,194,267],"was":[21],"constructed":[22],"based":[23,261],"on":[24,201,262],"the":[25,41,50,68,80,91,99,130,183,193,196,219,225,234,263],"similarities":[26,214],"between":[27],"their":[28],"clinical":[29],"side":[30,206,277],"effects.":[31,278],"The":[32],"indications":[33,56,94,264],"drug":[36,274],"be":[38,163,175],"inferred":[39],"by":[40,127,165,249,266],"enriched":[42,265],"FDA-approved":[43,93],"functions":[44],"its":[46],"neighbouring":[47],"drugs":[48,59,69,105,179,189,211,217,226],"in":[49,79,182,192,218],"network.":[51,184,220],"We":[52,185],"systematically":[53],"screened":[54],"new":[55,271],"for":[57,106,273],"1234":[58],"more":[61,117],"than":[62,118],"2":[63],"neighbours,":[65],"36.87%":[66],"achieved":[70,227],"performance":[72,115],"score":[73,141,145,241],"Normalized":[75],"Discounted":[76],"Cumulative":[77],"Gain":[78],"top":[81,100],"5":[82,101],"positions":[83],"(NDCG@5)":[84],"\u2265":[85,124,229],"0.7,":[86],"which":[87,259],"means":[88],"most":[89],"known":[92],"were":[95],"well":[96],"predicted":[97,131],"at":[98],"positions.":[102],"particular,":[104],"diabetes,":[107],"obesity,":[108],"laxatives":[109],"and":[110],"antimycobacterials":[111],"had":[112],"extremely":[113],"high":[114],"80%":[119],"them":[121,246],"achieving":[122],"NDCG@5":[123,228],"0.7.":[125,230],"Additionally,":[126],"manually":[128],"checking":[129],"1858":[132],"drug-indication":[133,236],"pairs":[134,161,237],"Expression":[136],"Analysis":[137],"Systematic":[138],"Explorer":[139],"(EASE)":[140],"\u2264":[142,242],"10(-5)":[143],"(EASE":[144],"is":[146,260],"rigorously":[148],"modified":[149],"Fisher":[150],"exact":[151],"test":[152,197],"p":[153],"value),":[154],"we":[155,208],"found":[156],"that":[157],"80.73%":[158],"such":[160],"could":[162,174],"verified":[164],"preclinical/clinical":[166,253],"studies":[167],"or":[168,252],"scientific":[169],"literature.":[170],"Furthermore,":[171],"our":[172,202,257],"method":[173,258],"extended":[176],"to":[177,215],"predict":[178],"not":[180,190],"covered":[181,191],"took":[186],"98":[187],"external":[188],"as":[195],"sample":[198],"set.":[199],"Based":[200],"similarity":[203],"criteria":[204],"using":[205,276],"effects,":[207],"identified":[209],"41":[210],"significant":[213],"other":[216],"Among":[221],"them,":[222],"36.59%":[223],"all":[232],"106":[235],"an":[239],"EASE":[240],"0.05,":[243],"50.94%":[244],"are":[247],"supported":[248],"FDA":[250],"approval":[251],"studies.":[254],"summary,":[256],"neighbors":[268],"provide":[270],"clues":[272],"repositioning":[275]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":17},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":19},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
