{"id":"https://openalex.org/W2144196643","doi":"https://doi.org/10.1042/bc20070116","title":"Cell\u2010penetrating peptides: from molecular mechanisms to therapeutics","display_name":"Cell\u2010penetrating peptides: from molecular mechanisms to therapeutics","publication_year":2008,"publication_date":"2008-03-19","ids":{"openalex":"https://openalex.org/W2144196643","doi":"https://doi.org/10.1042/bc20070116","mag":"2144196643","pmid":"https://pubmed.ncbi.nlm.nih.gov/18341479"},"language":"en","primary_location":{"id":"doi:10.1042/bc20070116","doi":"https://doi.org/10.1042/bc20070116","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bc20070116","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1042/BC20070116","source":{"id":"https://openalex.org/S91329243","display_name":"Biology of the Cell","issn_l":"0248-4900","issn":["0248-4900","1768-322X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology of the Cell","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2144196643"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1042/BC20070116","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018056053","display_name":"May  Catherine Morris","orcid":"https://orcid.org/0000-0001-8106-9728","observed_orcids":["https://orcid.org/0000-0001-8106-9728"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210113016","display_name":"Centre de Recherche en Biologie cellulaire de Montpellier","ror":"https://ror.org/01xpc6869","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210096427","https://openalex.org/I4210113016"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"May C. Morris","raw_affiliation_strings":["Centre de Recherches de Biochimie Macromol\u00e9culaire, UMR 5237, CNRS, UM-1, UM-2, CRBM Department of Molecular Biophysics and Therapeutics, 1919 Route de Mende, 34293 Montpellier, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de Recherches de Biochimie Macromol\u00e9culaire, UMR 5237, CNRS, UM-1, UM-2, CRBM Department of Molecular Biophysics and Therapeutics, 1919 Route de Mende, 34293 Montpellier, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210113016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059767937","display_name":"S\u00e9bastien Deshayes","orcid":"https://orcid.org/0000-0002-4684-9152","observed_orcids":["https://orcid.org/0000-0002-4684-9152"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210113016","display_name":"Centre de Recherche en Biologie cellulaire de Montpellier","ror":"https://ror.org/01xpc6869","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210096427","https://openalex.org/I4210113016"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sebastien Deshayes","raw_affiliation_strings":["Centre de Recherches de Biochimie Macromole\u0301culaire, UMR 5237, CNRS, UM-1, UM-2, CRBM Department of Molecular Biophysics and Therapeutics, 1919 Route de Mende, 34293 Montpellier, France","Centre de Recherches de Biochimie Macromol\u00e9culaire, UMR 5237, CNRS, UM-1, UM-2, CRBM Department of Molecular Biophysics and Therapeutics, 1919 Route de Mende, 34293 Montpellier, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de Recherches de Biochimie Macromole\u0301culaire, UMR 5237, CNRS, UM-1, UM-2, CRBM Department of Molecular Biophysics and Therapeutics, 1919 Route de Mende, 34293 Montpellier, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210113016"]},{"raw_affiliation_string":"Centre de Recherches de Biochimie Macromol\u00e9culaire, UMR 5237, CNRS, UM-1, UM-2, CRBM Department of Molecular Biophysics and Therapeutics, 1919 Route de Mende, 34293 Montpellier, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210113016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051380897","display_name":"F. Heitz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210113016","display_name":"Centre de Recherche en Biologie cellulaire de Montpellier","ror":"https://ror.org/01xpc6869","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210096427","https://openalex.org/I4210113016"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Frederic Heitz","raw_affiliation_strings":["Centre de Recherches de Biochimie Macromole\u0301culaire, UMR 5237, CNRS, UM-1, UM-2, CRBM Department of Molecular Biophysics and Therapeutics, 1919 Route de Mende, 34293 Montpellier, France","Centre de Recherches de Biochimie Macromol\u00e9culaire, UMR 5237, CNRS, UM-1, UM-2, CRBM Department of Molecular Biophysics and Therapeutics, 1919 Route de Mende, 34293 Montpellier, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de Recherches de Biochimie Macromole\u0301culaire, UMR 5237, CNRS, UM-1, UM-2, CRBM Department of Molecular Biophysics and Therapeutics, 1919 Route de Mende, 34293 Montpellier, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210113016"]},{"raw_affiliation_string":"Centre de Recherches de Biochimie Macromol\u00e9culaire, UMR 5237, CNRS, UM-1, UM-2, CRBM Department of Molecular Biophysics and Therapeutics, 1919 Route de Mende, 34293 Montpellier, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210113016"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057982935","display_name":"Gilles Divita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210113016","display_name":"Centre de Recherche en Biologie cellulaire de Montpellier","ror":"https://ror.org/01xpc6869","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210096427","https://openalex.org/I4210113016"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Gilles Divita","raw_affiliation_strings":["Centre de Recherches de Biochimie Macromol \u00e9culaire , UMR 5237 , CNRS , UM-1 , UM-2 , CRBM Department of Molecular Biophysics and Therapeutics , 1919 Route de Mende , 34293 Montpellier , France","Centre de recherche en Biologie Cellulaire"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de Recherches de Biochimie Macromol \u00e9culaire , UMR 5237 , CNRS , UM-1 , UM-2 , CRBM Department of Molecular Biophysics and Therapeutics , 1919 Route de Mende , 34293 Montpellier , France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210113016"]},{"raw_affiliation_string":"Centre de recherche en Biologie Cellulaire","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5057982935"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210113016"],"apc_list":{"value":3730,"currency":"USD","value_usd":3730},"apc_paid":null,"fwci":2.254,"has_fulltext":true,"cited_by_count":377,"citation_normalized_percentile":{"value":0.90569208,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"100","issue":"4","first_page":"201","last_page":"217"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9721999764442444,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9721999764442444,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.026000000536441803,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cell-penetrating-peptides","display_name":"cell-penetrating peptides","score":1.0},{"id":"https://openalex.org/keywords/bioavailability","display_name":"bioavailability","score":0.7120000123977661},{"id":"https://openalex.org/keywords/cellular-uptake","display_name":"cellular uptake","score":0.7200000286102295},{"id":"https://openalex.org/keywords/pep-1","display_name":"Pep-1","score":0.4740000069141388},{"id":"https://openalex.org/keywords/structure-function-relationship","display_name":"structure-function relationship","score":0.597000002861023},{"id":"https://openalex.org/keywords/endosomal-escape","display_name":"endosomal escape","score":0.6629999876022339},{"id":"https://openalex.org/keywords/protein-nanoparticles","display_name":"protein nanoparticles","score":0.38499999046325684},{"id":"https://openalex.org/keywords/nucleic-acid-delivery","display_name":"nucleic acid delivery","score":0.8880000114440918}],"concepts":[{"id":"https://openalex.org/C139770010","wikidata":"https://www.wikidata.org/wiki/Q1339807","display_name":"Internalization","level":3,"score":0.7431750893592834},{"id":"https://openalex.org/C102747710","wikidata":"https://www.wikidata.org/wiki/Q824237","display_name":"Endosome","level":3,"score":0.569123387336731},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5620964765548706},{"id":"https://openalex.org/C161624437","wikidata":"https://www.wikidata.org/wiki/Q1988322","display_name":"Small molecule","level":2,"score":0.5341225266456604},{"id":"https://openalex.org/C49853544","wikidata":"https://www.wikidata.org/wiki/Q206229","display_name":"Biomolecule","level":2,"score":0.49345722794532776},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.4917152225971222},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4873524606227875},{"id":"https://openalex.org/C2776929087","wikidata":"https://www.wikidata.org/wiki/Q189096","display_name":"Cell-penetrating peptide","level":3,"score":0.48345646262168884},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.48273131251335144},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.4752345383167267},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4382725954055786},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.43399810791015625},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.422531396150589},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.36064407229423523},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.34375208616256714},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.28858572244644165},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.28372305631637573},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.27790147066116333},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10789769887924194},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.10198581218719482}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001682","descriptor_name":"Biological Availability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020135","descriptor_name":"Peptide Nucleic Acids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D020135","descriptor_name":"Peptide Nucleic Acids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1042/bc20070116","doi":"https://doi.org/10.1042/bc20070116","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bc20070116","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1042/BC20070116","source":{"id":"https://openalex.org/S91329243","display_name":"Biology of the Cell","issn_l":"0248-4900","issn":["0248-4900","1768-322X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology of the Cell","raw_type":"journal-article"},{"id":"pmid:18341479","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18341479","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology of the cell","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-00351046v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-00351046","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biology of the Cell, 2008, 100 (4), pp.201-17. &#x27E8;10.1042/BC20070116&#x27E9;","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1042/bc20070116","doi":"https://doi.org/10.1042/bc20070116","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bc20070116","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1042/BC20070116","source":{"id":"https://openalex.org/S91329243","display_name":"Biology of the Cell","issn_l":"0248-4900","issn":["0248-4900","1768-322X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology of the Cell","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8728244408","display_name":"Peptide based nanostructure for the delivery of therapeutics: from mechanism to application","funder_award_id":"ANR-06-BLAN-0071","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"}],"funders":[{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"},{"id":"https://openalex.org/F4320322434","display_name":"Max-Planck-Gesellschaft","ror":"https://ror.org/01hhn8329"},{"id":"https://openalex.org/F4320322892","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2144196643.pdf","grobid_xml":"https://content.openalex.org/works/W2144196643.grobid-xml"},"referenced_works_count":160,"referenced_works":["https://openalex.org/W14759517","https://openalex.org/W112142372","https://openalex.org/W127183670","https://openalex.org/W204678935","https://openalex.org/W1549673200","https://openalex.org/W1580460289","https://openalex.org/W1584683177","https://openalex.org/W1611419331","https://openalex.org/W1640168389","https://openalex.org/W1963503258","https://openalex.org/W1963819255","https://openalex.org/W1966224201","https://openalex.org/W1966510891","https://openalex.org/W1966640620","https://openalex.org/W1970368422","https://openalex.org/W1971153130","https://openalex.org/W1971508290","https://openalex.org/W1971919281","https://openalex.org/W1973123208","https://openalex.org/W1974186613","https://openalex.org/W1974248986","https://openalex.org/W1974303227","https://openalex.org/W1974568640","https://openalex.org/W1976822357","https://openalex.org/W1977706869","https://openalex.org/W1981250567","https://openalex.org/W1982094328","https://openalex.org/W1982301681","https://openalex.org/W1985064062","https://openalex.org/W1988176449","https://openalex.org/W1991770248","https://openalex.org/W1992654115","https://openalex.org/W1996163490","https://openalex.org/W1996805840","https://openalex.org/W1997294121","https://openalex.org/W1997708534","https://openalex.org/W1998083723","https://openalex.org/W2001493784","https://openalex.org/W2001582257","https://openalex.org/W2002051720","https://openalex.org/W2002591579","https://openalex.org/W2003122526","https://openalex.org/W2003658370","https://openalex.org/W2005990393","https://openalex.org/W2008813620","https://openalex.org/W2009309713","https://openalex.org/W2009776461","https://openalex.org/W2009872788","https://openalex.org/W2010077741","https://openalex.org/W2010659535","https://openalex.org/W2011258326","https://openalex.org/W2011480379","https://openalex.org/W2011827048","https://openalex.org/W2012477296","https://openalex.org/W2012547585","https://openalex.org/W2013216622","https://openalex.org/W2013870905","https://openalex.org/W2015799188","https://openalex.org/W2016217936","https://openalex.org/W2019793524","https://openalex.org/W2020583390","https://openalex.org/W2022132303","https://openalex.org/W2023852578","https://openalex.org/W2026593599","https://openalex.org/W2028035233","https://openalex.org/W2028828598","https://openalex.org/W2029346749","https://openalex.org/W2029766213","https://openalex.org/W2031064824","https://openalex.org/W2031143008","https://openalex.org/W2033157388","https://openalex.org/W2036075451","https://openalex.org/W2036939362","https://openalex.org/W2037219974","https://openalex.org/W2040091761","https://openalex.org/W2041922085","https://openalex.org/W2042037824","https://openalex.org/W2042143995","https://openalex.org/W2045891730","https://openalex.org/W2046151114","https://openalex.org/W2046593812","https://openalex.org/W2047165821","https://openalex.org/W2049109647","https://openalex.org/W2050748316","https://openalex.org/W2052949014","https://openalex.org/W2053740745","https://openalex.org/W2055051767","https://openalex.org/W2056842925","https://openalex.org/W2058907087","https://openalex.org/W2059884965","https://openalex.org/W2061312545","https://openalex.org/W2061510929","https://openalex.org/W2062116648","https://openalex.org/W2066778206","https://openalex.org/W2070302990","https://openalex.org/W2070693578","https://openalex.org/W2072064961","https://openalex.org/W2072543946","https://openalex.org/W2073701436","https://openalex.org/W2076515838","https://openalex.org/W2077390784","https://openalex.org/W2077850392","https://openalex.org/W2079335891","https://openalex.org/W2079603374","https://openalex.org/W2080329421","https://openalex.org/W2081484482","https://openalex.org/W2087250116","https://openalex.org/W2088960285","https://openalex.org/W2089657872","https://openalex.org/W2093198351","https://openalex.org/W2096725993","https://openalex.org/W2097131232","https://openalex.org/W2101138844","https://openalex.org/W2102238490","https://openalex.org/W2103262726","https://openalex.org/W2105668301","https://openalex.org/W2107235611","https://openalex.org/W2108224709","https://openalex.org/W2110597706","https://openalex.org/W2111215173","https://openalex.org/W2112962172","https://openalex.org/W2116424844","https://openalex.org/W2119352721","https://openalex.org/W2119630077","https://openalex.org/W2122351668","https://openalex.org/W2123277882","https://openalex.org/W2123650819","https://openalex.org/W2123670081","https://openalex.org/W2124638053","https://openalex.org/W2128034242","https://openalex.org/W2130820069","https://openalex.org/W2131474484","https://openalex.org/W2131944695","https://openalex.org/W2134737833","https://openalex.org/W2139315767","https://openalex.org/W2141178875","https://openalex.org/W2141344072","https://openalex.org/W2146144253","https://openalex.org/W2147842059","https://openalex.org/W2148013194","https://openalex.org/W2148919642","https://openalex.org/W2151448282","https://openalex.org/W2153960365","https://openalex.org/W2160863389","https://openalex.org/W2163134721","https://openalex.org/W2164600807","https://openalex.org/W2166915947","https://openalex.org/W2167806590","https://openalex.org/W2170932434","https://openalex.org/W2171109371","https://openalex.org/W2291223536","https://openalex.org/W2319098975","https://openalex.org/W2327287238","https://openalex.org/W2497077522","https://openalex.org/W2505720681","https://openalex.org/W3148913165","https://openalex.org/W3212856653","https://openalex.org/W4211039187","https://openalex.org/W4239028853","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W1515068677","https://openalex.org/W2151163354","https://openalex.org/W2053281420","https://openalex.org/W1972729210","https://openalex.org/W2069414163","https://openalex.org/W4411191042","https://openalex.org/W2001493784","https://openalex.org/W1982519048","https://openalex.org/W4380569085","https://openalex.org/W2358989852"],"abstract_inverted_index":{"The":[0,118],"recent":[1],"discovery":[2],"of":[3,25,41,59,61,108,144,162,178,190],"new":[4,51],"potent":[5],"therapeutic":[6,30,42],"molecules":[7,26],"which":[8,48,127],"do":[9],"not":[10],"reach":[11],"the":[12,23,57,84,91,94,101,106,145,175],"clinic":[13],"due":[14],"to":[15,37,55,82],"poor":[16],"delivery":[17,24],"and":[18,52,68,93,100,120,133,138,148,181,184,192,197],"low":[19],"bioavailability":[20,60],"have":[21,34,69,79],"made":[22],"a":[27,50,153,159],"keystone":[28],"in":[29,74,152,168,194],"development.":[31],"Several":[32],"technologies":[33],"been":[35,70,80],"designed":[36],"improve":[38],"cellular":[39,97,188],"uptake":[40,189],"molecules,":[43],"including":[44],"CPPs":[45,63],"(cell-penetrating":[46],"peptides),":[47],"represent":[49],"innovative":[53],"concept":[54],"bypass":[56],"problem":[58],"drugs.":[62],"constitute":[64],"very":[65],"promising":[66],"tools":[67],"successfully":[71],"applied":[72],"for":[73,96,187],"vivo.":[75],"Two":[76],"CPP":[77],"strategies":[78],"described":[81],"date;":[83],"first":[85],"one":[86],"requires":[87],"chemical":[88,116],"linkage":[89],"between":[90],"drug":[92,98],"carrier":[95],"internalization,":[99],"second":[102],"is":[103],"based":[104],"on":[105,114,174],"formation":[107],"stable":[109,129],"complexes":[110],"with":[111,131],"drugs,":[112],"depending":[113],"their":[115,185],"nature.":[117],"Pep":[119],"MPG":[121,180],"families":[122],"are":[123],"short":[124],"amphipathic":[125],"peptides,":[126],"form":[128],"nanoparticles":[130,140],"proteins":[132],"nucleic":[134],"acids":[135],"respectively.":[136],"MPG-":[137],"Pep-based":[139],"enter":[141],"cells":[142,196],"independently":[143],"endosomal":[146],"pathway":[147],"efficiently":[149],"deliver":[150],"cargoes,":[151],"fully":[154],"biologically":[155],"active":[156],"form,":[157],"into":[158],"large":[160],"variety":[161],"cell":[163],"lines,":[164],"as":[165,167],"well":[166],"animal":[169,198],"models.":[170,199],"This":[171],"review":[172],"focuses":[173],"structure-function":[176],"relationship":[177],"non-covalent":[179],"Pep-1":[182],"strategies,":[183],"requirement":[186],"biomolecules":[191],"applications":[193],"cultured":[195]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":16},{"year":2018,"cited_by_count":27},{"year":2017,"cited_by_count":15},{"year":2016,"cited_by_count":23},{"year":2015,"cited_by_count":30},{"year":2014,"cited_by_count":27},{"year":2013,"cited_by_count":44},{"year":2012,"cited_by_count":28}],"updated_date":"2026-11-15T12:55:33.944570","created_date":"2016-06-24T00:00:00"}
