{"id":"https://openalex.org/W2144132000","doi":null,"title":"NMDA receptor mediates proliferation and CREB phosphorylation in postnatal M\u00fcller glia-derived retinal progenitors.","display_name":"NMDA receptor mediates proliferation and CREB phosphorylation in postnatal M\u00fcller glia-derived retinal progenitors.","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2144132000","mag":"2144132000","pmid":"https://pubmed.ncbi.nlm.nih.gov/19365572","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2666774"},"language":"en","primary_location":{"id":"pmid:19365572","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19365572","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular vision","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2666774/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062951727","display_name":"M\u00f3nica Ram\u00edrez","orcid":"https://orcid.org/0000-0001-5386-8530","observed_orcids":["https://orcid.org/0000-0001-5386-8530"]},"institutions":[{"id":"https://openalex.org/I68368234","display_name":"Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional","ror":"https://ror.org/009eqmr18","country_code":"MX","type":"facility","lineage":["https://openalex.org/I59361560","https://openalex.org/I68368234"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"M\u00f3nica Ram\u00edrez","raw_affiliation_strings":["Departamento de Farmacobiolog\u00eda, Cinvestav Sede Sur, M\u00e9xico DF, M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Farmacobiolog\u00eda, Cinvestav Sede Sur, M\u00e9xico DF, M\u00e9xico","institution_ids":["https://openalex.org/I68368234"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025467471","display_name":"M\u00f3nica Lamas","orcid":"https://orcid.org/0000-0002-0297-4218","observed_orcids":["https://orcid.org/0000-0002-0297-4218"]},"institutions":[{"id":"https://openalex.org/I68368234","display_name":"Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional","ror":"https://ror.org/009eqmr18","country_code":"MX","type":"facility","lineage":["https://openalex.org/I59361560","https://openalex.org/I68368234"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"M\u00f3nica Lamas","raw_affiliation_strings":["CINVESTAV#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CINVESTAV#TAB#","institution_ids":["https://openalex.org/I68368234"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I68368234"],"apc_list":null,"apc_paid":null,"fwci":2.8659,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.8859378,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"15","issue":null,"first_page":"713","last_page":"21"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.01759999990463257,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nmda-receptor","display_name":"NMDA receptor","score":0.9390000104904175},{"id":"https://openalex.org/keywords/muller-cells","display_name":"M\u00fcller cells","score":0.9190000295639038},{"id":"https://openalex.org/keywords/retinal-progenitor-cells","display_name":"retinal progenitor cells","score":0.9290000200271606},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.8830000162124634},{"id":"https://openalex.org/keywords/creb-phosphorylation","display_name":"CREB phosphorylation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/glutamate-signaling","display_name":"glutamate signaling","score":0.777999997138977},{"id":"https://openalex.org/keywords/nmda-receptor-antagonist","display_name":"NMDA receptor antagonists","score":0.8209999799728394},{"id":"https://openalex.org/keywords/retinal-development","display_name":"retinal development","score":0.6240000128746033},{"id":"https://openalex.org/keywords/progenitor-self-renewal","display_name":"progenitor self-renewal","score":0.8320000171661377},{"id":"https://openalex.org/keywords/nestin","display_name":"nestin","score":0.6240000128746033},{"id":"https://openalex.org/keywords/long-evans-rats","display_name":"Long-Evans rats","score":0.6819999814033508}],"concepts":[{"id":"https://openalex.org/C2777102633","wikidata":"https://www.wikidata.org/wiki/Q735343","display_name":"Muller glia","level":4,"score":0.6358129382133484},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6337483525276184},{"id":"https://openalex.org/C1629964","wikidata":"https://www.wikidata.org/wiki/Q106950729","display_name":"CREB","level":4,"score":0.6177862882614136},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6130922436714172},{"id":"https://openalex.org/C67018056","wikidata":"https://www.wikidata.org/wiki/Q414896","display_name":"NMDA receptor","level":3,"score":0.6047447919845581},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.5200566649436951},{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.479302316904068},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.43218040466308594},{"id":"https://openalex.org/C4746552","wikidata":"https://www.wikidata.org/wiki/Q1456827","display_name":"Neurogenesis","level":2,"score":0.4228469729423523},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3456193208694458},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2767924666404724},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.2204573154449463},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.1281457245349884},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08555865287780762},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007381","descriptor_name":"Intermediate Filament Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016194","descriptor_name":"Receptors, N-Methyl-D-Aspartate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016202","descriptor_name":"N-Methylaspartate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017362","descriptor_name":"Cyclic AMP Response Element-Binding Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020318","descriptor_name":"Rats, Long-Evans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064231","descriptor_name":"Nestin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:19365572","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19365572","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular vision","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2666774","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2666774/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Vis","raw_type":"Text"},{"id":"mag:2144132000","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19365572","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2666774","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2666774/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Vis","raw_type":"Text"},"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1518322943","https://openalex.org/W1954025536","https://openalex.org/W1967448020","https://openalex.org/W1972893985","https://openalex.org/W1997248984","https://openalex.org/W2013359248","https://openalex.org/W2016508121","https://openalex.org/W2020816113","https://openalex.org/W2042493882","https://openalex.org/W2052599495","https://openalex.org/W2057608998","https://openalex.org/W2060248760","https://openalex.org/W2062942585","https://openalex.org/W2065501817","https://openalex.org/W2066556283","https://openalex.org/W2073269248","https://openalex.org/W2086030982","https://openalex.org/W2095802030","https://openalex.org/W2103172774","https://openalex.org/W2109876648","https://openalex.org/W2114967857","https://openalex.org/W2116869556","https://openalex.org/W2117506912","https://openalex.org/W2131416478","https://openalex.org/W2135986867","https://openalex.org/W2138754505","https://openalex.org/W2140472933","https://openalex.org/W2160205444","https://openalex.org/W2170960097"],"related_works":["https://openalex.org/W2024765072","https://openalex.org/W2916576554","https://openalex.org/W2127029677","https://openalex.org/W2065501817","https://openalex.org/W2086030982","https://openalex.org/W3099949936","https://openalex.org/W3101290419","https://openalex.org/W1998100172","https://openalex.org/W1507954300","https://openalex.org/W1972469962"],"abstract_inverted_index":{"PURPOSE:":[0],"Postnatal":[1],"retinal":[2,9,23,163,241,273,296],"M\u00fcller":[3,78,90,271],"glia":[4,24],"are":[5,34,55],"considered":[6],"to":[7,16,21,57,250],"be":[8,192],"progenitors":[10,80,297],"as":[11,299],"they":[12],"retain":[13],"the":[14,45,51,71,74,84,102,106,110,179,232,238,260,291,309,320,324],"ability":[15],"dedifferentiate,":[17],"proliferate,":[18],"and":[19,25,31,40,48,64,109,121,136,187,214,277,285,303,313,319],"differentiate":[20],"new":[22],"neurons":[26],"after":[27,81,243,256],"injury.":[28],"The":[29,115,149,288],"proliferation":[30,75,125,180,276],"differentiation":[32],"processes":[33],"coordinated":[35],"by":[36,97,128,137,159,194,237],"several":[37],"extrinsic":[38],"factors":[39],"neurotransmitters,":[41],"including":[42],"glutamate.":[43],"Thus,":[44],"appropriate":[46],"numbers":[47],"proportions":[49],"of":[50,76,83,105,117,139,151,165,182,219,227,234,240,290,294,311,315,323],"different":[52],"cell":[53,93,112,124,134,274,317],"types":[54],"generated":[56],"form":[58],"a":[59,224],"functional":[60],"retina":[61],"during":[62,65],"development":[63],"injury":[66],"repair.":[67],"Here":[68],"we":[69,199,263],"analyze":[70],"changes":[72],"in":[73,157,162,206,212,223,246,283,286,328],"postnatal":[77,270],"glia-derived":[79,91,272],"activation":[82,154,176,268],"N-methyl-D-aspartate":[85],"(NMDA)":[86],"glutamate":[87,118],"receptors.":[88],"METHODS:":[89],"progenitor":[92,111,185,210,275,316,329],"cultures":[94,318],"were":[95],"characterized":[96],"immunocytochemistry":[98],"with":[99],"antibodies":[100],"against":[101],"NR1":[103],"subunit":[104],"NMDA":[107,152,167,174,195,244,266,304],"receptor":[108,119,153,175,196,267],"marker":[113],"nestin.":[114],"effect":[116,150],"agonists":[120],"antagonists":[122],"on":[123],"was":[126,155],"analyzed":[127,156],"BrdU":[129],"incorporation":[130],"or":[131],"Ki67":[132],"immunostaining,":[133],"counting,":[135],"immunolabeling":[138],"phosphorylated":[140,251],"cAMP":[141],"response":[142],"element":[143],"binding":[144],"protein":[145],"(P-CREB)":[146],"transcription":[147,278,300],"factor.":[148],"vivo":[158,247],"P-CREB":[160],"immunohistochemistry":[161],"sections":[164,242],"Long-Evans":[166],"injected":[168],"rats.":[169],"RESULTS:":[170],"We":[171,230],"show":[172,200,264],"that":[173,188,201,215,265],"significantly":[177],"increases":[178],"rate":[181],"M\u00fcller-glia":[183,208],"derived":[184,209],"cells":[186,211],"this":[189],"increase":[190],"can":[191],"blocked":[193],"antagonists.":[197],"Furthermore,":[198],"CREB":[202,220,252,280,302],"phosphorylation":[203,221,281],"is":[204,253],"induced":[205],"NMDA-treated":[207],"culture":[213,284],"specific":[216],"pharmacological":[217],"inhibition":[218],"results":[222],"decreased":[225],"number":[226],"proliferating":[228],"cells.":[229],"confirmed":[231],"relevance":[233],"these":[235],"observations":[236],"analysis":[239],"injection":[245],"where":[248],"immunoreactivity":[249],"also":[254],"increased":[255],"treatment.":[257],"CONCLUSIONS:":[258],"In":[259],"present":[261],"study":[262],"induces":[269],"factor":[279,301],"both":[282],"vivo.":[287],"identification":[289,322],"molecular":[292,325],"determinants":[293],"mature":[295],"such":[298],"receptor-induced":[305],"players":[306],"should":[307],"facilitate":[308],"control":[310],"growth":[312],"manipulation":[314],"possible":[321],"mechanisms":[326],"involved":[327],"self-renewal.":[330]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}