{"id":"https://openalex.org/W2144100339","doi":"https://doi.org/10.1002/14651858.cd004448.pub5","title":"Phytomedicines (medicines derived from plants) for sickle cell disease","display_name":"Phytomedicines (medicines derived from plants) for sickle cell disease","publication_year":2015,"publication_date":"2015-04-06","ids":{"openalex":"https://openalex.org/W2144100339","doi":"https://doi.org/10.1002/14651858.cd004448.pub5","mag":"2144100339","pmid":"https://pubmed.ncbi.nlm.nih.gov/25844571"},"language":"en","primary_location":{"id":"doi:10.1002/14651858.cd004448.pub5","doi":"https://doi.org/10.1002/14651858.cd004448.pub5","is_oa":false,"landing_page_url":"https://doi.org/10.1002/14651858.cd004448.pub5","pdf_url":null,"source":{"id":"https://openalex.org/S4210172715","display_name":"Cochrane Database of Systematic Reviews","issn_l":"1361-6137","issn":["1361-6137","1464-780X","1465-184X","1465-1858","1469-493X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","jufo-2","ki-jl-2","medline","norway-1","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cochrane Database of Systematic Reviews","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8106534","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110967714","display_name":"Oluseyi Oniyangi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099503","display_name":"National Hospital Abuja","ror":"https://ror.org/014j33z40","country_code":"NG","type":"healthcare","lineage":["https://openalex.org/I4210099503"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Oluseyi Oniyangi","raw_affiliation_strings":["National Hospital; Paediatrics Department; Plot 132 Central District (Phase II) PMB 425 Garki Abuja Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Hospital; Paediatrics Department; Plot 132 Central District (Phase II) PMB 425 Garki Abuja Nigeria","institution_ids":["https://openalex.org/I4210099503"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015663919","display_name":"Damian Cohall","orcid":"https://orcid.org/0000-0002-2173-7322","observed_orcids":["https://orcid.org/0000-0002-2173-7322"]},"institutions":[{"id":"https://openalex.org/I4210088717","display_name":"University of the West Indies","ror":"https://ror.org/003kgv736","country_code":"TT","type":"education","lineage":["https://openalex.org/I137799390","https://openalex.org/I4210088717"]},{"id":"https://openalex.org/I4210129319","display_name":"University of the West Indies","ror":"https://ror.org/03fkc8c64","country_code":"JM","type":"education","lineage":["https://openalex.org/I137799390","https://openalex.org/I4210129319"]},{"id":"https://openalex.org/I4210158067","display_name":"University of the West Indies","ror":"https://ror.org/05p4f7w60","country_code":"BB","type":"education","lineage":["https://openalex.org/I137799390","https://openalex.org/I4210158067"]}],"countries":["BB","JM","TT"],"is_corresponding":false,"raw_author_name":"Damian H Cohall","raw_affiliation_strings":["University of the West Indies; Faculty of Medical Sciences; Cave Hill St Michael Barbados"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of the West Indies; Faculty of Medical Sciences; Cave Hill St Michael Barbados","institution_ids":["https://openalex.org/I4210088717","https://openalex.org/I4210129319","https://openalex.org/I4210158067"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5100,"currency":"USD","value_usd":5100},"apc_paid":null,"fwci":0.3718,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.25287356,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"9","issue":"4","first_page":"CD004448","last_page":"CD004448"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10902","display_name":"Complementary and Alternative Medicine Studies","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sickle-cell-disease","display_name":"sickle cell disease","score":0.984000027179718},{"id":"https://openalex.org/keywords/herbal-medicine","display_name":"herbal medicine","score":0.9789999723434448},{"id":"https://openalex.org/keywords/plant-based-drugs","display_name":"plant-derived drugs","score":0.718999981880188},{"id":"https://openalex.org/keywords/traditional-medicine","display_name":"traditional medicine","score":0.7919999957084656},{"id":"https://openalex.org/keywords/pfaffia-paniculata","display_name":"Pfaffia paniculata","score":0.7990000247955322},{"id":"https://openalex.org/keywords/vaso-occlusive-crisis","display_name":"vaso-occlusive crisis","score":0.7509999871253967},{"id":"https://openalex.org/keywords/hemoglobinopathies","display_name":"hemoglobinopathies","score":0.8109999895095825},{"id":"https://openalex.org/keywords/hydroxyurea","display_name":"hydroxyurea","score":0.8190000057220459},{"id":"https://openalex.org/keywords/blood-transfusion","display_name":"blood transfusion","score":0.9409999847412109},{"id":"https://openalex.org/keywords/alternative-medicine","display_name":"complementary and alternative medicine","score":0.5950000286102295}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8177443742752075},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.552745521068573},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5525177717208862},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5116463303565979},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5090894103050232},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.47693318128585815},{"id":"https://openalex.org/C2780976302","wikidata":"https://www.wikidata.org/wiki/Q4677915","display_name":"Acute chest syndrome","level":4,"score":0.4293971359729767},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2817264497280121},{"id":"https://openalex.org/C2778620579","wikidata":"https://www.wikidata.org/wiki/Q185034","display_name":"Sickle cell anemia","level":3,"score":0.273709774017334},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.20504644513130188},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0911763608455658}],"mesh":[{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000986","descriptor_name":"Antisickling Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008517","descriptor_name":"Phytotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D036561","descriptor_name":"Cajanus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1002/14651858.cd004448.pub5","doi":"https://doi.org/10.1002/14651858.cd004448.pub5","is_oa":false,"landing_page_url":"https://doi.org/10.1002/14651858.cd004448.pub5","pdf_url":null,"source":{"id":"https://openalex.org/S4210172715","display_name":"Cochrane Database of Systematic Reviews","issn_l":"1361-6137","issn":["1361-6137","1464-780X","1465-184X","1465-1858","1469-493X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","jufo-2","ki-jl-2","medline","norway-1","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cochrane Database of Systematic Reviews","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8106534","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8106534","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cochrane Database Syst Rev","raw_type":"Text"},{"id":"pmid:25844571","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25844571","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Cochrane database of systematic reviews","raw_type":"Journal Article"},{"id":"pmid:32977351","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32977351","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Cochrane database of systematic reviews","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:8106534","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8106534","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cochrane Database Syst Rev","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":61,"referenced_works":["https://openalex.org/W96680208","https://openalex.org/W127312041","https://openalex.org/W139992364","https://openalex.org/W1540284949","https://openalex.org/W1554040650","https://openalex.org/W1563674271","https://openalex.org/W1566270415","https://openalex.org/W1596902544","https://openalex.org/W1778466572","https://openalex.org/W1909631814","https://openalex.org/W1961807282","https://openalex.org/W1964528195","https://openalex.org/W1964620166","https://openalex.org/W1981207144","https://openalex.org/W1986215651","https://openalex.org/W1993813575","https://openalex.org/W1998427422","https://openalex.org/W1999936817","https://openalex.org/W2004240616","https://openalex.org/W2005586323","https://openalex.org/W2023608111","https://openalex.org/W2027294558","https://openalex.org/W2029056293","https://openalex.org/W2033434937","https://openalex.org/W2036060686","https://openalex.org/W2037781228","https://openalex.org/W2045260987","https://openalex.org/W2045875999","https://openalex.org/W2069460368","https://openalex.org/W2071220778","https://openalex.org/W2073246847","https://openalex.org/W2074901521","https://openalex.org/W2080978993","https://openalex.org/W2082598502","https://openalex.org/W2092398994","https://openalex.org/W2093254050","https://openalex.org/W2097805484","https://openalex.org/W2099735999","https://openalex.org/W2103208617","https://openalex.org/W2115657655","https://openalex.org/W2124240321","https://openalex.org/W2125435699","https://openalex.org/W2130235475","https://openalex.org/W2134086699","https://openalex.org/W2138719823","https://openalex.org/W2139900098","https://openalex.org/W2169800461","https://openalex.org/W2170086069","https://openalex.org/W2206567612","https://openalex.org/W2310558808","https://openalex.org/W2334263927","https://openalex.org/W2339873482","https://openalex.org/W2397230527","https://openalex.org/W2411957326","https://openalex.org/W2575118257","https://openalex.org/W2603390547","https://openalex.org/W4210439924","https://openalex.org/W4230154020","https://openalex.org/W4249400726","https://openalex.org/W4252200972","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W4408448986","https://openalex.org/W7093376064","https://openalex.org/W4392662911","https://openalex.org/W7165471894","https://openalex.org/W4402411163","https://openalex.org/W6922492022","https://openalex.org/W2149456943","https://openalex.org/W4392103582","https://openalex.org/W7116769076","https://openalex.org/W4300659260"],"abstract_inverted_index":{"BACKGROUND:":[0],"Sickle":[1],"cell":[2,113,217],"disease,":[3,218],"a":[4,32,95,283],"common":[5],"recessively":[6],"inherited":[7],"haemoglobin":[8],"disorder,":[9],"affects":[10],"people":[11,110],"from":[12,39,51],"sub-Saharan":[13],"Africa,":[14],"the":[15,48,55,103,128,139,148,157,198,223,269,277,314],"Middle":[16],"East,":[17],"Mediterranean":[18],"basin,":[19],"Indian":[20],"subcontinent,":[21],"Caribbean":[22],"and":[23,31,63,76,105,132,150,156,176,197,238,250,255,265,274,308,316],"South":[24],"America.":[25],"It":[26],"is":[27,90],"associated":[28],"with":[29,111,210,215,304],"complications":[30],"reduced":[33],"life":[34],"expectancy.":[35],"Phytomedicines":[36],"(medicine":[37],"derived":[38],"plants":[40],"in":[41,74,77,109,121,219,266,271,287,291,299,321],"their":[42,87],"original":[43],"state)":[44],"encompass":[45],"many":[46],"of":[47,71,86,94,107,115,118,169,212,225,268,276,318],"plant":[49],"remedies":[50],"traditional":[52],"healers":[53],"which":[54],"populations":[56],"most":[57,170],"affected":[58],"would":[59],"encounter.":[60],"Laboratory":[61],"research":[62],"limited":[64],"clinical":[65],"trials":[66,209,303],"have":[67,282],"suggested":[68],"positive":[69],"effects":[70],"phytomedicines":[72,108,280,319],"both":[73],"vivo":[75],"vitro.":[78],"However,":[79],"there":[80],"has":[81],"been":[82],"little":[83],"systematic":[84],"appraisal":[85],"benefits.":[88],"This":[89,293],"an":[91],"updated":[92],"version":[93],"previously":[96],"published":[97],"Cochrane":[98,129,173],"Review.":[99],"OBJECTIVES:":[100],"To":[101],"assess":[102],"benefits":[104],"risks":[106],"sickle":[112,216],"disease":[114],"all":[116,213,220],"types,":[117],"any":[119,122,228],"age,":[120],"setting.":[123],"SEARCH":[124],"METHODS:":[125],"We":[126],"searched":[127],"Cystic":[130,174],"Fibrosis":[131,175],"Genetic":[133,177],"Disorders":[134,178],"Group":[135],"Haemoglobinopathies":[136,179],"Trials":[137,164,180],"Register,":[138],"International":[140,162],"Standard":[141],"Randomised":[142,206],"Controlled":[143],"Trial":[144],"Number":[145],"Register":[146],"(ISRCTN),":[147],"Allied":[149],"Complimentary":[151],"Medicine":[152],"Database":[153],"(AMED),":[154],"ClinicalTrials.gov":[155],"World":[158],"Health":[159],"Organization":[160],"(WHO)":[161],"Clinical":[163],"Registry":[165],"Platform":[166],"(ICTRP).":[167],"Dates":[168],"recent":[171],"searches:":[172],"Register:":[181],"17":[182],"March":[183],"2020;":[184,188,192,196],"ISRCTN:":[185],"19":[186],"April":[187,195],"AMED:":[189],"18":[190],"May":[191],"ClinicalTrials.gov:":[193],"24":[194],"WHO":[199],"ICTRP:":[200],"27":[201],"July":[202],"2017.":[203],"SELECTION":[204],"CRITERIA:":[205],"or":[207,232],"quasi-randomised":[208],"participants":[211],"ages":[214],"settings,":[221],"comparing":[222],"administration":[224],"phytomedicines,":[226],"by":[227],"mode":[229],"to":[230,259,295],"placebo":[231],"conventional":[233],"treatment,":[234],"including":[235],"blood":[236],"transfusion":[237],"hydroxyurea.":[239],"DATA":[240],"COLLECTION":[241],"AND":[242],"ANALYSIS:":[243],"Both":[244],"authors":[245],"independently":[246],"assessed":[247],"trial":[248],"quality":[249],"extracted":[251],"data.":[252],"MAIN":[253],"RESULTS:":[254],"Pfaffia":[256],"paniculata":[257],"(low-":[258],"very":[260],"low-quality":[261],"evidence).":[262],"AUTHORS'":[263],"CONCLUSIONS:":[264],"view":[267],"limitations":[270],"data":[272,309],"collection":[273,310],"analysis":[275],"three":[278],"trials,":[279],"may":[281],"potential":[284],"beneficial":[285],"effect":[286],"reducing":[288],"painful":[289],"crises":[290],"SCD.":[292,323],"needs":[294],"be":[296],"further":[297],"validated":[298],"future":[300],"trials.":[301],"More":[302],"improved":[305],"study":[306],"design":[307],"are":[311],"required":[312],"on":[313],"safety":[315],"efficacy":[317],"used":[320],"managing":[322]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}