{"id":"https://openalex.org/W2144052244","doi":null,"title":"Type 2 Diabetes and Vascular Complications: A pathophysiologic view","display_name":"Type 2 Diabetes and Vascular Complications: A pathophysiologic view","publication_year":2010,"publication_date":"2010-10-01","ids":{"openalex":"https://openalex.org/W2144052244","mag":"2144052244"},"language":"en","primary_location":{"id":"pmh:oai:CiteSeerX.psu:10.1.1.724.7538","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.724.7538","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://umexpert.um.edu.my/file/publication/00000559_52943.pdf","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034845736","display_name":"Khaled Abdul\u2010Aziz Ahmed","orcid":"https://orcid.org/0000-0002-2194-6669","observed_orcids":["https://orcid.org/0000-0002-2194-6669"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Khaled Abdul\u2010Aziz Ahmed","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2194-6669","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004597569","display_name":"Sekaran Muniandy","orcid":"https://orcid.org/0000-0003-1310-3634","observed_orcids":["https://orcid.org/0000-0003-1310-3634"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sekaran Muniandy","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1310-3634","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5073303366","display_name":"Ikram Shah Ismail","orcid":"https://orcid.org/0000-0001-8796-1936","observed_orcids":["https://orcid.org/0000-0001-8796-1936"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ikram Shah Ismail","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8796-1936","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1644,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.78176683,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"21","issue":"2","first_page":"0","last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.7109000086784363,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.7109000086784363,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":0.09520000219345093,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.05719999969005585,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9509999752044678},{"id":"https://openalex.org/keywords/vascular-complications","display_name":"vascular complications","score":0.8889999985694885},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.8159999847412109},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.8050000071525574},{"id":"https://openalex.org/keywords/microvascular-complications","display_name":"microvascular complications","score":0.6650000214576721},{"id":"https://openalex.org/keywords/macrovascular-complications","display_name":"macrovascular complications","score":0.9570000171661377},{"id":"https://openalex.org/keywords/diabetic-neuropathy","display_name":"diabetic neuropathy","score":0.8330000042915344},{"id":"https://openalex.org/keywords/diabetic-nephropathy","display_name":"diabetic nephropathy","score":0.9990000128746033},{"id":"https://openalex.org/keywords/diabetic-retinopathy","display_name":"diabetic retinopathy","score":0.996999979019165},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.8169999718666077},{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"coronary artery disease","score":0.7960000038146973},{"id":"https://openalex.org/keywords/stroke","display_name":"stroke","score":0.9869999885559082},{"id":"https://openalex.org/keywords/peripheral-vascular-disease","display_name":"peripheral vascular disease","score":0.9359999895095825},{"id":"https://openalex.org/keywords/pathophysiology","display_name":"pathophysiology","score":0.8429999947547913}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8760223388671875},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.8559551239013672},{"id":"https://openalex.org/C2781184683","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Nephropathy","level":3,"score":0.6575274467468262},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.6473748683929443},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.6066763997077942},{"id":"https://openalex.org/C2778313320","wikidata":"https://www.wikidata.org/wiki/Q550455","display_name":"Retinopathy","level":3,"score":0.5838574171066284},{"id":"https://openalex.org/C2777466421","wikidata":"https://www.wikidata.org/wiki/Q1266890","display_name":"Vascular disease","level":2,"score":0.5728936195373535},{"id":"https://openalex.org/C2779829184","wikidata":"https://www.wikidata.org/wiki/Q631361","display_name":"Diabetic retinopathy","level":3,"score":0.5624353885650635},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5112268924713135},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.49049466848373413},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.48938220739364624},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.4475829005241394},{"id":"https://openalex.org/C2779901536","wikidata":"https://www.wikidata.org/wiki/Q945238","display_name":"Peripheral neuropathy","level":3,"score":0.43458643555641174},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.4265156686306},{"id":"https://openalex.org/C2777660278","wikidata":"https://www.wikidata.org/wiki/Q489997","display_name":"Diabetic angiopathy","level":3,"score":0.4208473563194275},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3537813425064087},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3484524190425873},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:CiteSeerX.psu:10.1.1.724.7538","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.724.7538","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://umexpert.um.edu.my/file/publication/00000559_52943.pdf","raw_type":"text"},{"id":"mag:2144052244","doi":null,"is_oa":false,"landing_page_url":"http://eprints.um.edu.my/7215/1/type_2_diabetes_and_vascular.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S90794122","display_name":"Biomedical Research-tokyo","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4322697010","host_organization_name":"Biomedical Research Foundation","host_organization_lineage":["https://openalex.org/P4322697010"],"host_organization_lineage_names":["Biomedical Research Foundation"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Biomedical Research-tokyo","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":87,"referenced_works":["https://openalex.org/W150772031","https://openalex.org/W151658691","https://openalex.org/W189003358","https://openalex.org/W1483242733","https://openalex.org/W1485442318","https://openalex.org/W1525234895","https://openalex.org/W1573126284","https://openalex.org/W1579347021","https://openalex.org/W1593114880","https://openalex.org/W1933897045","https://openalex.org/W1963654630","https://openalex.org/W1967172766","https://openalex.org/W1971141707","https://openalex.org/W1977301030","https://openalex.org/W1977879939","https://openalex.org/W1979112282","https://openalex.org/W1981361766","https://openalex.org/W1991694904","https://openalex.org/W1996424575","https://openalex.org/W2001800329","https://openalex.org/W2015859975","https://openalex.org/W2020267609","https://openalex.org/W2022589777","https://openalex.org/W2022985174","https://openalex.org/W2025407758","https://openalex.org/W2025430697","https://openalex.org/W2031484324","https://openalex.org/W2039374034","https://openalex.org/W2041176514","https://openalex.org/W2050456578","https://openalex.org/W2053786863","https://openalex.org/W2054346876","https://openalex.org/W2055168506","https://openalex.org/W2057651652","https://openalex.org/W2060596699","https://openalex.org/W2065779552","https://openalex.org/W2066888335","https://openalex.org/W2067301008","https://openalex.org/W2077149049","https://openalex.org/W2078156869","https://openalex.org/W2081615229","https://openalex.org/W2086204342","https://openalex.org/W2086946222","https://openalex.org/W2087882379","https://openalex.org/W2092877335","https://openalex.org/W2094376340","https://openalex.org/W2095171970","https://openalex.org/W2096120926","https://openalex.org/W2096773810","https://openalex.org/W2097532633","https://openalex.org/W2099852272","https://openalex.org/W2100359816","https://openalex.org/W2100500261","https://openalex.org/W2102267931","https://openalex.org/W2108225698","https://openalex.org/W2108606693","https://openalex.org/W2111827011","https://openalex.org/W2115268091","https://openalex.org/W2115480613","https://openalex.org/W2119076089","https://openalex.org/W2119964748","https://openalex.org/W2122608005","https://openalex.org/W2123946565","https://openalex.org/W2125495722","https://openalex.org/W2125805218","https://openalex.org/W2126018769","https://openalex.org/W2134293572","https://openalex.org/W2135027079","https://openalex.org/W2137637641","https://openalex.org/W2138969187","https://openalex.org/W2140937253","https://openalex.org/W2147139493","https://openalex.org/W2154067841","https://openalex.org/W2160234008","https://openalex.org/W2164146664","https://openalex.org/W2165256339","https://openalex.org/W2239832141","https://openalex.org/W2272194862","https://openalex.org/W2328847723","https://openalex.org/W2332612176","https://openalex.org/W2337454357","https://openalex.org/W2410505691","https://openalex.org/W2414298364","https://openalex.org/W2491061016","https://openalex.org/W3192365919","https://openalex.org/W4239570539","https://openalex.org/W4240304626"],"related_works":["https://openalex.org/W7097763004","https://openalex.org/W2925939191","https://openalex.org/W2939034184","https://openalex.org/W4320070400","https://openalex.org/W1584674887","https://openalex.org/W2118016685","https://openalex.org/W2042214270","https://openalex.org/W1994680773","https://openalex.org/W4205095008","https://openalex.org/W2108606693"],"abstract_inverted_index":{"Diabetes":[0,129],"mellitus":[1],"(DM)":[2],"represents":[3],"a":[4,117,138,176],"range":[5],"of":[6,26,33,76,83,123,140,143,160,189],"metabolic":[7],"disorders":[8],"characterized":[9],"by":[10,39],"hypergly-cemia":[11],"resulting":[12],"from":[13,73],"insulin":[14,17],"deficiency":[15],"or":[16,19,147],"resistance":[18],"both.":[20],"Hyperglycemia,":[21],"the":[22,34,44,149,155,158],"pri-mary":[23],"clinical":[24],"manifestation":[25],"diabetes,":[27,69],"is":[28,63],"strongly":[29],"associated":[30],"with":[31,100,111],"development":[32],"diabetic":[35],"complications.":[36],"Complications":[37],"caused":[38],"hyperglycaemia":[40],"involve":[41],"damage":[42,136],"to":[43,119,132,181],"small":[45],"vessels":[46,57],"such":[47],"as":[48,58,175],"in":[49,59,68,98,105,166,192],"neuropathy,":[50],"nephropathy,":[51],"and":[52,54,90,125,134,170,187],"retinopathy,":[53],"large":[55],"blood":[56],"cardiovas-cular":[60],"diseases.":[61],"It":[62],"well":[64],"known":[65],"established":[66],"that":[67],"long-term":[70],"complications":[71,163,191],"ensue":[72],"abnormal":[74],"regulation":[75],"glucose":[77],"metabolism.":[78],"In":[79],"fact,":[80],"all":[81],"manifestations":[82],"cardiovascular":[84],"disease,":[85,88],"coronary":[86,127],"heart":[87],"stroke":[89],"peripheral":[91],"vascular":[92,162],"disease":[93],"are":[94],"substantially":[95],"more":[96],"common":[97],"patients":[99],"type":[101,112,167],"2":[102,113,168],"diabetes":[103,114,169],"than":[104],"non-diabetic":[106],"individuals.":[107],"For":[108],"example,":[109],"pa-tients":[110],"(T2DM)":[115],"have":[116],"two-":[118],"fourfold":[120],"increased":[121],"risk":[122],"fatal":[124],"non-fatal":[126],"events.":[128],"can":[130],"lead":[131],"microvascular":[133],"macrovascular":[135],"through":[137],"number":[139],"mechanisms,":[141],"each":[142],"which":[144],"may":[145],"worsen":[146],"accelerate":[148],"others.":[150],"The":[151],"present":[152],"re-view":[153],"summarizes":[154],"information":[156],"on":[157],"mechanisms":[159],"how":[161],"will":[164],"de-velop":[165],"this":[171],"might":[172],"be":[173],"useful":[174],"direction":[177],"for":[178,185],"further":[179],"research":[180],"provide":[182],"new":[183],"strategies":[184],"prevention":[186],"treatment":[188],"these":[190],"their":[193],"early":[194],"stages.":[195]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
