{"id":"https://openalex.org/W2144044549","doi":null,"title":"Conditioning: a new approach to immunotherapy.","display_name":"Conditioning: a new approach to immunotherapy.","publication_year":1990,"publication_date":"1990-07-15","ids":{"openalex":"https://openalex.org/W2144044549","mag":"2144044549","pmid":"https://pubmed.ncbi.nlm.nih.gov/2364386"},"language":"en","primary_location":{"id":"pmid:2364386","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2364386","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112133609","display_name":"Vithal K. Ghanta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"V K Ghanta","raw_affiliation_strings":["Department of Biology, University of Alabama, Birmingham 35294"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Alabama, Birmingham 35294","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024720329","display_name":"Nancy S. Hiramoto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N S Hiramoto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086421947","display_name":"H. Brent Solvason","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H B Solvason","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110027976","display_name":"Seng\u2010Jaw Soong","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S J Soong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111058379","display_name":"Raymond N. Hiramoto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R N Hiramoto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7633,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.68839019,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"50","issue":"14","first_page":"4295","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.00839999970048666,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.7120000123977661},{"id":"https://openalex.org/keywords/classical-conditioning","display_name":"classical conditioning","score":0.6510000228881836},{"id":"https://openalex.org/keywords/associative-learning","display_name":"associative learning","score":0.43299999833106995},{"id":"https://openalex.org/keywords/allogeneic-spleen-cells","display_name":"allogeneic spleen cells","score":0.9049999713897705},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.6610000133514404},{"id":"https://openalex.org/keywords/immunization","display_name":"immunization","score":0.3240000009536743}],"concepts":[{"id":"https://openalex.org/C45262634","wikidata":"https://www.wikidata.org/wiki/Q5159291","display_name":"Conditioning","level":2,"score":0.7393889427185059},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.6265578269958496},{"id":"https://openalex.org/C39617858","wikidata":"https://www.wikidata.org/wiki/Q212737","display_name":"Classical conditioning","level":3,"score":0.5887443423271179},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5534614324569702},{"id":"https://openalex.org/C2778916471","wikidata":"https://www.wikidata.org/wiki/Q485537","display_name":"Odor","level":2,"score":0.5186426043510437},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4933151304721832},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4499283730983734},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3301292657852173},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28855186700820923},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.13040095567703247},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.060245394706726074},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001245","descriptor_name":"Association Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002164","descriptor_name":"Camphor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003213","descriptor_name":"Conditioning, Psychological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008223","descriptor_name":"Lymphoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008223","descriptor_name":"Lymphoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008811","descriptor_name":"Mice, Inbred DBA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009812","descriptor_name":"Odorants","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014184","descriptor_name":"Transplantation, Homologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017710","descriptor_name":"Lymphocyte Transfusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2364386","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2364386","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:2144044549","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2364386","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[{"id":"https://openalex.org/G24388058","display_name":"REGULATION OF ONCOGENE EXPRESSION IN MYELOMA","funder_award_id":"R01CA042337","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2858078186","display_name":"CNS EFFECTS ON IFN PRODUCTION AND NK CELL ACTIVITY","funder_award_id":"R01CA037570","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W1607095921","https://openalex.org/W1670487437","https://openalex.org/W1906812433","https://openalex.org/W1992295767","https://openalex.org/W1997248061","https://openalex.org/W2016429415","https://openalex.org/W2036297025","https://openalex.org/W2052657880","https://openalex.org/W2796700885"],"related_works":["https://openalex.org/W2128151061","https://openalex.org/W2067373751","https://openalex.org/W1997248061","https://openalex.org/W2087988219","https://openalex.org/W2066016757","https://openalex.org/W2115632342","https://openalex.org/W2464693880","https://openalex.org/W2085991266","https://openalex.org/W2401593646","https://openalex.org/W2944888833"],"abstract_inverted_index":{"It":[0],"has":[1],"been":[2],"demonstrated":[3],"by":[4,28],"Parmiani":[5],"et":[6],"al.":[7],"(Int.":[8],"J.":[9],"Cancer,":[10],"29:":[11],"323-332,":[12],"1982)":[13],"that":[14,129],"a":[15,48,107,130],"significant":[16],"protective":[17],"effect":[18],"can":[19],"be":[20],"obtained":[21],"against":[22],"the":[23,61,66,79,91,97,116,122,136,141,146,149,152],"transplanted":[24],"syngeneic":[25],"YC8":[26],"lymphoma":[27],"prior":[29],"immunization":[30],"of":[31,52,63,99,133,151],"BALB/c":[32],"mice":[33],"with":[34,135],"normal":[35],"allogeneic":[36,70],"DBA/2":[37,71],"spleen":[38,72],"cells.":[39],"Using":[40],"this":[41,57,90],"well":[42],"established":[43],"tumor":[44,110],"model,":[45],"we":[46,59,105],"investigated":[47],"novel":[49],"approach,":[50],"conditioning":[51,67,80],"specific":[53],"immunotherapeutic":[54],"activity.":[55],"For":[56],"purpose,":[58],"used":[60],"odor":[62,98],"camphor":[64,100],"as":[65,74],"stimulus":[68],"and":[69,81,86,112,148],"cells":[73],"unconditioning":[75,82],"stimulus.":[76],"We":[77],"associated":[78],"stimuli":[83],"two,":[84],"three,":[85],"four":[87],"times.":[88],"Following":[89],"conditioned":[92,117],"animals":[93],"were":[94],"reexposed":[95],"to":[96],"only.":[101],"In":[102],"each":[103],"case,":[104],"observed":[106],"delay":[108],"in":[109,113,144],"growth":[111],"some":[114],"instances":[115],"group":[118],"performed":[119],"better":[120,139],"than":[121,140],"immunotherapy":[123],"control":[124],"group.":[125],"These":[126],"results":[127],"indicate":[128],"limited":[131],"number":[132],"treatments":[134],"antigen":[137],"is":[138],"continuous":[142],"treatment":[143],"maintaining":[145],"immunity":[147],"homeostasis":[150],"system.":[153]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}