{"id":"https://openalex.org/W2144036680","doi":"https://doi.org/10.1002/chem.201203251","title":"Rapid Preparation of Mycobacterium N\u2010Glycolyl Lipid I and Lipid II Derivatives: A Biocatalytic Approach","display_name":"Rapid Preparation of Mycobacterium N\u2010Glycolyl Lipid I and Lipid II Derivatives: A Biocatalytic Approach","publication_year":2012,"publication_date":"2012-12-11","ids":{"openalex":"https://openalex.org/W2144036680","doi":"https://doi.org/10.1002/chem.201203251","mag":"2144036680","pmid":"https://pubmed.ncbi.nlm.nih.gov/23229320"},"language":"en","primary_location":{"id":"doi:10.1002/chem.201203251","doi":"https://doi.org/10.1002/chem.201203251","is_oa":false,"landing_page_url":"https://doi.org/10.1002/chem.201203251","pdf_url":null,"source":{"id":"https://openalex.org/S68911691","display_name":"Chemistry - A European Journal","issn_l":"0947-6539","issn":["0947-6539","1521-3765"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry \u2013 A European Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065403604","display_name":"Kuo\u2010Ting Chen","orcid":"https://orcid.org/0000-0003-2432-2074","observed_orcids":["https://orcid.org/0000-0003-2432-2074"]},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]},{"id":"https://openalex.org/I4210087491","display_name":"Genomics Research Center, Academia Sinica","ror":"https://ror.org/002mmyt85","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210087491","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I84653119","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784","country_code":"TW","type":"facility","lineage":["https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Kuo\u2010Ting Chen","raw_affiliation_strings":["Genomics Research Center, Academia Sinica, 128 Academia Road, Section 2, Nankang,Taipei, 115, Taiwan","Department of Pharmacy, National Taiwan University, 1, Jen-Ai Road, Section 1, Taipei 10051 (Taiwan)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomics Research Center, Academia Sinica, 128 Academia Road, Section 2, Nankang,Taipei, 115, Taiwan","institution_ids":["https://openalex.org/I4210087491","https://openalex.org/I84653119"]},{"raw_affiliation_string":"Department of Pharmacy, National Taiwan University, 1, Jen-Ai Road, Section 1, Taipei 10051 (Taiwan)","institution_ids":["https://openalex.org/I16733864"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ye\u2010Ching Kuan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087491","display_name":"Genomics Research Center, Academia Sinica","ror":"https://ror.org/002mmyt85","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210087491","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I84653119","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784","country_code":"TW","type":"facility","lineage":["https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Ye\u2010Ching Kuan","raw_affiliation_strings":["Genomics Research Center, Academia Sinica, 128, Academia Road, Section 2, Nankang, Taipei 115 (Taiwan)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomics Research Center, Academia Sinica, 128, Academia Road, Section 2, Nankang, Taipei 115 (Taiwan)","institution_ids":["https://openalex.org/I4210087491","https://openalex.org/I84653119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003195480","display_name":"Wei\u2010Chen Fu","orcid":"https://orcid.org/0009-0008-5763-1520","observed_orcids":["https://orcid.org/0009-0008-5763-1520"]},"institutions":[{"id":"https://openalex.org/I4210087491","display_name":"Genomics Research Center, Academia Sinica","ror":"https://ror.org/002mmyt85","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210087491","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I84653119","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784","country_code":"TW","type":"facility","lineage":["https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Wei\u2010Chen Fu","raw_affiliation_strings":["Genomics Research Center, Academia Sinica, 128, Academia Road, Section 2, Nankang, Taipei 115 (Taiwan)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomics Research Center, Academia Sinica, 128, Academia Road, Section 2, Nankang, Taipei 115 (Taiwan)","institution_ids":["https://openalex.org/I4210087491","https://openalex.org/I84653119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044370285","display_name":"Pi\u2010Hui Liang","orcid":"https://orcid.org/0000-0001-6668-4642","observed_orcids":["https://orcid.org/0000-0001-6668-4642"]},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Pi\u2010Hui Liang","raw_affiliation_strings":["Department of Pharmacy, National Taiwan University, 1, Jen-Ai Road, Section 1, Taipei 10051 (Taiwan)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, National Taiwan University, 1, Jen-Ai Road, Section 1, Taipei 10051 (Taiwan)","institution_ids":["https://openalex.org/I16733864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041499508","display_name":"Ting-Jen Rachel Cheng","orcid":"https://orcid.org/0000-0003-4297-018X","observed_orcids":["https://orcid.org/0000-0003-4297-018X"]},"institutions":[{"id":"https://openalex.org/I4210087491","display_name":"Genomics Research Center, Academia Sinica","ror":"https://ror.org/002mmyt85","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210087491","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I84653119","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784","country_code":"TW","type":"facility","lineage":["https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Ting\u2010Jen R. Cheng","raw_affiliation_strings":["Genomics Research Center, Academia Sinica, 128, Academia Road, Section 2, Nankang, Taipei 115 (Taiwan)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomics Research Center, Academia Sinica, 128, Academia Road, Section 2, Nankang, Taipei 115 (Taiwan)","institution_ids":["https://openalex.org/I4210087491","https://openalex.org/I84653119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056753239","display_name":"Chi\u2010Huey Wong","orcid":"https://orcid.org/0000-0002-9961-7865","observed_orcids":["https://orcid.org/0000-0002-9961-7865"]},"institutions":[{"id":"https://openalex.org/I4210087491","display_name":"Genomics Research Center, Academia Sinica","ror":"https://ror.org/002mmyt85","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210087491","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I84653119","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784","country_code":"TW","type":"facility","lineage":["https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chi\u2010Huey Wong","raw_affiliation_strings":["Genomics Research Center, Academia Sinica, 128, Academia Road, Section 2, Nankang, Taipei 115 (Taiwan)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomics Research Center, Academia Sinica, 128, Academia Road, Section 2, Nankang, Taipei 115 (Taiwan)","institution_ids":["https://openalex.org/I4210087491","https://openalex.org/I84653119"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035371907","display_name":"Wei\u2010Chieh Cheng","orcid":"https://orcid.org/0000-0002-9319-3010","observed_orcids":["https://orcid.org/0000-0002-9319-3010"]},"institutions":[{"id":"https://openalex.org/I4210087491","display_name":"Genomics Research Center, Academia Sinica","ror":"https://ror.org/002mmyt85","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210087491","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I84653119","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784","country_code":"TW","type":"facility","lineage":["https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Wei\u2010Chieh Cheng","raw_affiliation_strings":["Genomics Research Center, Academia Sinica, 128, Academia Road, Section 2, Nankang, Taipei 115 (Taiwan)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomics Research Center, Academia Sinica, 128, Academia Road, Section 2, Nankang, Taipei 115 (Taiwan)","institution_ids":["https://openalex.org/I4210087491","https://openalex.org/I84653119"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5035371907"],"corresponding_institution_ids":["https://openalex.org/I4210087491","https://openalex.org/I84653119"],"apc_list":{"value":4640,"currency":"USD","value_usd":4640},"apc_paid":null,"fwci":1.0936,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.72235048,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"19","issue":"3","first_page":"834","last_page":"838"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10835","display_name":"Carbohydrate Chemistry and Synthesis","score":0.76419997215271,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10835","display_name":"Carbohydrate Chemistry and Synthesis","score":0.76419997215271,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.1460999995470047,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.017899999395012856,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biotransformation","display_name":"biotransformation","score":0.7620000243186951},{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis","display_name":"Mycobacterium tuberculosis","score":0.8659999966621399},{"id":"https://openalex.org/keywords/mycobacterial-cell-wall-lipids","display_name":"mycobacterial cell wall lipids","score":0.7789999842643738},{"id":"https://openalex.org/keywords/enzymatic-synthesis","display_name":"enzymatic synthesis","score":0.628000020980835}],"concepts":[{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.6234297156333923},{"id":"https://openalex.org/C191503008","wikidata":"https://www.wikidata.org/wiki/Q16007026","display_name":"Biocatalysis","level":4,"score":0.4898476302623749},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.443452388048172},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.33900633454322815},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.33314359188079834},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2619975209236145},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.2370256781578064},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.18679392337799072},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09828415513038635},{"id":"https://openalex.org/C65024703","wikidata":"https://www.wikidata.org/wiki/Q373406","display_name":"Reaction mechanism","level":3,"score":0.08847972750663757},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001425","descriptor_name":"Bacterial Outer Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006017","descriptor_name":"Glycolipids","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D006017","descriptor_name":"Glycolipids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006017","descriptor_name":"Glycolipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D014166","descriptor_name":"Transferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017351","descriptor_name":"N-Acetylglucosaminyltransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017855","descriptor_name":"Transferases (Other Substituted Phosphate Groups)","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055162","descriptor_name":"Biocatalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/chem.201203251","doi":"https://doi.org/10.1002/chem.201203251","is_oa":false,"landing_page_url":"https://doi.org/10.1002/chem.201203251","pdf_url":null,"source":{"id":"https://openalex.org/S68911691","display_name":"Chemistry - A European Journal","issn_l":"0947-6539","issn":["0947-6539","1521-3765"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry \u2013 A European Journal","raw_type":"journal-article"},{"id":"pmid:23229320","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23229320","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry (Weinheim an der Bergstrasse, Germany)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321040","display_name":"National Science Council","ror":"https://ror.org/02kv4zf79"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1964136489","https://openalex.org/W1968397983","https://openalex.org/W1980413740","https://openalex.org/W2007223619","https://openalex.org/W2010148230","https://openalex.org/W2017467623","https://openalex.org/W2038185394","https://openalex.org/W2057744100","https://openalex.org/W2061747034","https://openalex.org/W2064216759","https://openalex.org/W2071794577","https://openalex.org/W2072137144","https://openalex.org/W2083152791","https://openalex.org/W2097075466","https://openalex.org/W2111740468","https://openalex.org/W2116969841","https://openalex.org/W2135555383","https://openalex.org/W2154550041","https://openalex.org/W2155398486","https://openalex.org/W2158023121","https://openalex.org/W2272837046","https://openalex.org/W4244042677"],"related_works":["https://openalex.org/W2057744100","https://openalex.org/W2074893936","https://openalex.org/W3208037222","https://openalex.org/W1554862624","https://openalex.org/W2116969841","https://openalex.org/W2010187475","https://openalex.org/W2114560760","https://openalex.org/W2026091821","https://openalex.org/W2189121628","https://openalex.org/W7097891095"],"abstract_inverted_index":{"Breaking":[0],"down":[1],"barriers:":[2],"A":[3],"rapid,":[4],"inexpensive":[5],"preparation":[6],"of":[7,23,62],"the":[8],"structurally":[9],"complex":[10],"mycobacterial":[11],"N-glycolyl":[12,26,69],"Lipid":[13,15,54,70],"I,":[14],"II,":[16],"and":[17,27,68],"their":[18],"analogues":[19],"from":[20,45],"a":[21,40,46,60,73],"range":[22],"different":[24],"synthetic":[25],"N-glycinyl":[28,53],"Park's":[29],"nucleotides":[30],"is":[31],"described":[32],"(see":[33],"scheme).":[34],"The":[35,51],"biotransformations":[36],"were":[37],"catalyzed":[38],"by":[39],"readily":[41],"available":[42],"biocatalyst":[43],"obtained":[44],"bacterial":[47],"cell-free":[48],"membrane":[49],"fraction.":[50],"unnatural":[52],"II":[55],"was":[56,72],"found":[57],"to":[58],"be":[59],"substrate":[61],"Mycobacterium":[63],"tuberculosis":[64],"(Mtb)":[65],"transglycosylase,":[66],"PonA,":[67],"I":[71],"weak":[74],"inhibitor":[75],"against":[76],"PonA.":[77]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
