{"id":"https://openalex.org/W2143996540","doi":"https://doi.org/10.1006/abbi.2000.2102","title":"Direct Evidence for apo B-100-Mediated Copper Reduction: Studies with Purified apo B-100 and Detection of Tryptophanyl Radicals","display_name":"Direct Evidence for apo B-100-Mediated Copper Reduction: Studies with Purified apo B-100 and Detection of Tryptophanyl Radicals","publication_year":2000,"publication_date":"2000-12-01","ids":{"openalex":"https://openalex.org/W2143996540","doi":"https://doi.org/10.1006/abbi.2000.2102","mag":"2143996540","pmid":"https://pubmed.ncbi.nlm.nih.gov/11368321"},"language":"en","primary_location":{"id":"doi:10.1006/abbi.2000.2102","doi":"https://doi.org/10.1006/abbi.2000.2102","is_oa":false,"landing_page_url":"https://doi.org/10.1006/abbi.2000.2102","pdf_url":null,"source":{"id":"https://openalex.org/S153476765","display_name":"Archives of Biochemistry and Biophysics","issn_l":"0003-9861","issn":["0003-9861","1096-0384"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Biochemistry and Biophysics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063685695","display_name":"Carlos Batthy\u00e1ny","orcid":"https://orcid.org/0000-0002-0627-1982","observed_orcids":["https://orcid.org/0000-0002-0627-1982"]},"institutions":[{"id":"https://openalex.org/I180910786","display_name":"Universidad de la Rep\u00fablica de Uruguay","ror":"https://ror.org/030bbe882","country_code":"UY","type":"education","lineage":["https://openalex.org/I180910786"]},{"id":"https://openalex.org/I4210157419","display_name":"Instituto de Investigaciones Biol\u00f3gicas Clemente Estable","ror":"https://ror.org/05b50ej63","country_code":"UY","type":"nonprofit","lineage":["https://openalex.org/I4210098830","https://openalex.org/I4210157419"]}],"countries":["UY"],"is_corresponding":false,"raw_author_name":"Carlos Batthy\u00e1ny","raw_affiliation_strings":["Departamento de Bioqu\u00edmica, Facultad de Medicina, Universidad de la Rep\u00fablica, Uruguay","Unidad de Bioqu\u00edmica Anal\u00edtica, Instituto de Investigaciones Biol\u00f3gicas Clemente Estable and Facultad de Ciencias, Universidad de la Rep\u00fablica, Uruguay"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Bioqu\u00edmica, Facultad de Medicina, Universidad de la Rep\u00fablica, Uruguay","institution_ids":["https://openalex.org/I180910786"]},{"raw_affiliation_string":"Unidad de Bioqu\u00edmica Anal\u00edtica, Instituto de Investigaciones Biol\u00f3gicas Clemente Estable and Facultad de Ciencias, Universidad de la Rep\u00fablica, Uruguay","institution_ids":["https://openalex.org/I180910786","https://openalex.org/I4210157419"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113556202","display_name":"C\u00e9lio X.C. Santos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"C\u00e9lio X.C. Santos","raw_affiliation_strings":["Departamento de Bioqu\u00edmica, Instituto de Qu\u00edmica, Universidade de S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Bioqu\u00edmica, Instituto de Qu\u00edmica, Universidade de S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007816225","display_name":"Horacio Botti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180910786","display_name":"Universidad de la Rep\u00fablica de Uruguay","ror":"https://ror.org/030bbe882","country_code":"UY","type":"education","lineage":["https://openalex.org/I180910786"]}],"countries":["UY"],"is_corresponding":false,"raw_author_name":"Horacio Botti","raw_affiliation_strings":["Departamento de Bioqu\u00edmica, Facultad de Medicina, Universidad de la Rep\u00fablica, Uruguay"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Bioqu\u00edmica, Facultad de Medicina, Universidad de la Rep\u00fablica, Uruguay","institution_ids":["https://openalex.org/I180910786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005891093","display_name":"Carlos \u010cerve\u00f1ansk\u00fd","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180910786","display_name":"Universidad de la Rep\u00fablica de Uruguay","ror":"https://ror.org/030bbe882","country_code":"UY","type":"education","lineage":["https://openalex.org/I180910786"]},{"id":"https://openalex.org/I4210157419","display_name":"Instituto de Investigaciones Biol\u00f3gicas Clemente Estable","ror":"https://ror.org/05b50ej63","country_code":"UY","type":"nonprofit","lineage":["https://openalex.org/I4210098830","https://openalex.org/I4210157419"]}],"countries":["UY"],"is_corresponding":false,"raw_author_name":"Carlos Cerve\u00f1ansky","raw_affiliation_strings":["Unidad de Bioqu\u00edmica Anal\u00edtica, Instituto de Investigaciones Biol\u00f3gicas Clemente Estable and Facultad de Ciencias, Universidad de la Rep\u00fablica, Uruguay"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unidad de Bioqu\u00edmica Anal\u00edtica, Instituto de Investigaciones Biol\u00f3gicas Clemente Estable and Facultad de Ciencias, Universidad de la Rep\u00fablica, Uruguay","institution_ids":["https://openalex.org/I180910786","https://openalex.org/I4210157419"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073926538","display_name":"Rafael Rad\u00ed","orcid":"https://orcid.org/0000-0002-1114-1875","observed_orcids":["https://orcid.org/0000-0002-1114-1875"]},"institutions":[{"id":"https://openalex.org/I180910786","display_name":"Universidad de la Rep\u00fablica de Uruguay","ror":"https://ror.org/030bbe882","country_code":"UY","type":"education","lineage":["https://openalex.org/I180910786"]}],"countries":["UY"],"is_corresponding":false,"raw_author_name":"Rafael Radi","raw_affiliation_strings":["Departamento de Bioqu\u00edmica, Facultad de Medicina, Universidad de la Rep\u00fablica, Uruguay"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Bioqu\u00edmica, Facultad de Medicina, Universidad de la Rep\u00fablica, Uruguay","institution_ids":["https://openalex.org/I180910786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064232275","display_name":"Oh\u00e1ra Augusto","orcid":"https://orcid.org/0000-0002-7220-4286","observed_orcids":["https://orcid.org/0000-0002-7220-4286"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ohara Augusto","raw_affiliation_strings":["Departamento de Bioqu\u00edmica, Instituto de Qu\u00edmica, Universidade de S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Bioqu\u00edmica, Instituto de Qu\u00edmica, Universidade de S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032637422","display_name":"Homero Rubbo","orcid":"https://orcid.org/0000-0002-7897-6551","observed_orcids":["https://orcid.org/0000-0002-7897-6551"]},"institutions":[{"id":"https://openalex.org/I180910786","display_name":"Universidad de la Rep\u00fablica de Uruguay","ror":"https://ror.org/030bbe882","country_code":"UY","type":"education","lineage":["https://openalex.org/I180910786"]}],"countries":["UY"],"is_corresponding":true,"raw_author_name":"Homero Rubbo","raw_affiliation_strings":["Departamento de Bioqu\u00edmica, Facultad de Medicina, Universidad de la Rep\u00fablica, Uruguay"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Bioqu\u00edmica, Facultad de Medicina, Universidad de la Rep\u00fablica, Uruguay","institution_ids":["https://openalex.org/I180910786"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5032637422"],"corresponding_institution_ids":["https://openalex.org/I180910786"],"apc_list":{"value":3170,"currency":"USD","value_usd":3170},"apc_paid":null,"fwci":2.6364,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.8882103,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"384","issue":"2","first_page":"335","last_page":"340"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.49000000953674316,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.49000000953674316,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.2628999948501587,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.03440000116825104,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apolipoprotein-b-100","display_name":"apolipoprotein B-100","score":0.9890000224113464},{"id":"https://openalex.org/keywords/copper-reduction","display_name":"copper reduction","score":0.9919999837875366},{"id":"https://openalex.org/keywords/low-density-lipoprotein","display_name":"low-density lipoprotein","score":0.8650000095367432},{"id":"https://openalex.org/keywords/cuprous-ions","display_name":"cuprous ions","score":0.777999997138977},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.8709999918937683},{"id":"https://openalex.org/keywords/alpha-tocopherol","display_name":"alpha-tocopherol","score":0.9459999799728394},{"id":"https://openalex.org/keywords/reduction-kinetics","display_name":"reduction kinetics","score":0.6110000014305115},{"id":"https://openalex.org/keywords/copper-binding","display_name":"copper binding","score":0.5299999713897705}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8401896953582764},{"id":"https://openalex.org/C544778455","wikidata":"https://www.wikidata.org/wiki/Q753","display_name":"Copper","level":2,"score":0.7951650619506836},{"id":"https://openalex.org/C2779620165","wikidata":"https://www.wikidata.org/wiki/Q28749","display_name":"Low-density lipoprotein","level":3,"score":0.582905650138855},{"id":"https://openalex.org/C139066938","wikidata":"https://www.wikidata.org/wiki/Q185056","display_name":"Radical","level":2,"score":0.5717694163322449},{"id":"https://openalex.org/C62746215","wikidata":"https://www.wikidata.org/wiki/Q14890615","display_name":"Apolipoprotein B","level":3,"score":0.5528125166893005},{"id":"https://openalex.org/C148898269","wikidata":"https://www.wikidata.org/wiki/Q1108792","display_name":"Kinetics","level":2,"score":0.5468846559524536},{"id":"https://openalex.org/C187961010","wikidata":"https://www.wikidata.org/wiki/Q260463","display_name":"Electron paramagnetic resonance","level":2,"score":0.5274712443351746},{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.44103577733039856},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.32457149028778076},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.317491352558136},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2372858226299286},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.19937938451766968},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.1807367503643036},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C46141821","wikidata":"https://www.wikidata.org/wiki/Q209402","display_name":"Nuclear magnetic resonance","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001055","descriptor_name":"Apolipoproteins B","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D001055","descriptor_name":"Apolipoproteins B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003300","descriptor_name":"Copper","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004578","descriptor_name":"Electron Spin Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005609","descriptor_name":"Free Radicals","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008077","descriptor_name":"Lipoproteins, LDL","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D008077","descriptor_name":"Lipoproteins, LDL","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009603","descriptor_name":"Nitroso Compounds","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014364","descriptor_name":"Tryptophan","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019097","descriptor_name":"Spin Trapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053299","descriptor_name":"Apolipoprotein B-100","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1006/abbi.2000.2102","doi":"https://doi.org/10.1006/abbi.2000.2102","is_oa":false,"landing_page_url":"https://doi.org/10.1006/abbi.2000.2102","pdf_url":null,"source":{"id":"https://openalex.org/S153476765","display_name":"Archives of Biochemistry and Biophysics","issn_l":"0003-9861","issn":["0003-9861","1096-0384"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Biochemistry and Biophysics","raw_type":"journal-article"},{"id":"pmid:11368321","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11368321","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of biochemistry and biophysics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334812","display_name":"Comisi\u00f3n Nacional de Investigaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","ror":"https://ror.org/02ap3w078"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":59,"referenced_works":["https://openalex.org/W13663154","https://openalex.org/W87080899","https://openalex.org/W95143196","https://openalex.org/W1489860413","https://openalex.org/W1495033991","https://openalex.org/W1509255658","https://openalex.org/W1584102526","https://openalex.org/W1593980522","https://openalex.org/W1631803278","https://openalex.org/W1838879151","https://openalex.org/W1840694762","https://openalex.org/W1857052429","https://openalex.org/W1874360846","https://openalex.org/W1890102384","https://openalex.org/W1965617246","https://openalex.org/W1965646898","https://openalex.org/W1970185441","https://openalex.org/W1981815722","https://openalex.org/W1983304194","https://openalex.org/W1985514851","https://openalex.org/W1987090125","https://openalex.org/W1995320376","https://openalex.org/W1995889718","https://openalex.org/W1997745709","https://openalex.org/W2003168867","https://openalex.org/W2005230846","https://openalex.org/W2012771428","https://openalex.org/W2013736773","https://openalex.org/W2014758223","https://openalex.org/W2015940667","https://openalex.org/W2017836919","https://openalex.org/W2021115743","https://openalex.org/W2022604481","https://openalex.org/W2029314163","https://openalex.org/W2032786707","https://openalex.org/W2034393548","https://openalex.org/W2038502138","https://openalex.org/W2047889521","https://openalex.org/W2056658522","https://openalex.org/W2059598675","https://openalex.org/W2060807115","https://openalex.org/W2065017757","https://openalex.org/W2070120470","https://openalex.org/W2073464812","https://openalex.org/W2078034671","https://openalex.org/W2079604571","https://openalex.org/W2079854536","https://openalex.org/W2083259778","https://openalex.org/W2113553969","https://openalex.org/W2125547999","https://openalex.org/W2138841151","https://openalex.org/W2144522249","https://openalex.org/W2152344920","https://openalex.org/W2164799061","https://openalex.org/W2183115385","https://openalex.org/W2313837936","https://openalex.org/W2326202471","https://openalex.org/W2419347412","https://openalex.org/W4298592957"],"related_works":["https://openalex.org/W1965626511","https://openalex.org/W2065017757","https://openalex.org/W2026067313","https://openalex.org/W1981171965","https://openalex.org/W2144522249","https://openalex.org/W2015940667","https://openalex.org/W2112419020","https://openalex.org/W2013736773","https://openalex.org/W1922324982","https://openalex.org/W2091977091"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}